LOCUS       NM_173128               1515 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus keratin 20 (Krt20), mRNA.
ACCESSION   NM_173128 XM_346404
VERSION     NM_173128.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1515)
  AUTHORS   Tunca,B., Tezcan,G., Cecener,G., Egeli,U., Zorluoglu,A.,
            Yilmazlar,T., Ak,S., Yerci,O., Ozturk,E., Umut,G. and Evrensel,T.
  TITLE     Overexpression of CK20, MAP3K8 and EIF5A correlates with poor
            prognosis in early-onset colorectal cancer patients
  JOURNAL   J Cancer Res Clin Oncol 139 (4), 691-702 (2013)
   PUBMED   23322277
REFERENCE   2  (bases 1 to 1515)
  AUTHORS   Zhou,Q., Cadrin,M., Herrmann,H., Chen,C.H., Chalkley,R.J.,
            Burlingame,A.L. and Omary,M.B.
  TITLE     Keratin 20 serine 13 phosphorylation is a stress and intestinal
            goblet cell marker
  JOURNAL   J Biol Chem 281 (24), 16453-16461 (2006)
   PUBMED   16608857
REFERENCE   3  (bases 1 to 1515)
  AUTHORS   Zhou,Q., Toivola,D.M., Feng,N., Greenberg,H.B., Franke,W.W. and
            Omary,M.B.
  TITLE     Keratin 20 helps maintain intermediate filament organization in
            intestinal epithelia
  JOURNAL   Mol Biol Cell 14 (7), 2959-2971 (2003)
   PUBMED   12857878
REFERENCE   4  (bases 1 to 1515)
  AUTHORS   Barrett,A.W., Cort,E.M., Patel,P. and Berkovitz,B.K.
  TITLE     An immunohistological study of cytokeratin 20 in human and
            mammalian oral epithelium
  JOURNAL   Arch Oral Biol 45 (10), 879-887 (2000)
   PUBMED   10973561
REFERENCE   5  (bases 1 to 1515)
  AUTHORS   Shimonishi,T., Miyazaki,K. and Nakanuma,Y.
  TITLE     Cytokeratin profile relates to histological subtypes and
            intrahepatic location of intrahepatic cholangiocarcinoma and
            primary sites of metastatic adenocarcinoma of liver
  JOURNAL   Histopathology 37 (1), 55-63 (2000)
   PUBMED   10931219
REFERENCE   6  (bases 1 to 1515)
  AUTHORS   Chandler,J.S., Calnek,D. and Quaroni,A.
  TITLE     Identification and characterization of rat intestinal keratins.
            Molecular cloning of cDNAs encoding cytokeratins 8, 19, and a new
            49-kDa type I cytokeratin (cytokeratin 21) expressed by
            differentiated intestinal epithelial cells
  JOURNAL   J Biol Chem 266 (18), 11932-11938 (1991)
   PUBMED   1711044
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Mar 5, 2021 this sequence version replaced NM_173128.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M63665.1, SRR26643299.45498.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760494
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-444               JAXUCZ010000010.1  84889842-84890285   c
            445-527             JAXUCZ010000010.1  84887537-84887619   c
            528-684             JAXUCZ010000010.1  84885195-84885351   c
            685-846             JAXUCZ010000010.1  84884350-84884511   c
            847-972             JAXUCZ010000010.1  84884032-84884157   c
            973-1193            JAXUCZ010000010.1  84882997-84883217   c
            1194-1231           JAXUCZ010000010.1  84882288-84882325   c
            1232-1515           JAXUCZ010000010.1  84880952-84881235   c
FEATURES             Location/Qualifiers
     source          1..1515
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q31"
     gene            1..1515
                     /gene="Krt20"
                     /gene_synonym="Krt21"
                     /note="keratin 20"
                     /db_xref="GeneID:286912"
                     /db_xref="RGD:628646"
     exon            1..444
                     /gene="Krt20"
                     /gene_synonym="Krt21"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..1329
                     /gene="Krt20"
                     /gene_synonym="Krt21"
                     /note="K20; CK-20; CK-21; cytokeratin-20; cytokeratin-21;
                     keratin 20, type I"
                     /codon_start=1
                     /product="keratin, type I cytoskeletal 20"
                     /protein_id="NP_775151.2"
                     /db_xref="GeneID:286912"
                     /db_xref="RGD:628646"
                     /translation="MDFSRRSFHRSLSSSSQGPALSTSGSLYRKGTMQRLGVAPSVYG
                     GAGGHGTRISVSKTTMSYGNHLSNGGDLFGGNEKLAMQNLNDRLASYLEKVRSLEQSN
                     SKLEAQIKQWYETNAPSTIRDYSSYYAQIKELQDQIKDAQIENARCVLQIDNAKLAAE
                     DFRLKFETERGMRITVEADLQGLSKVYDDLTLQKTDLEIQIEELNKDLALLKKEHQEE
                     VEVLRRQLGNNVNVEVDAAPGLNLGEIMNEMRQKYEILAQKNLQEAKEQFERQTQTLE
                     KQVTVNIEELRGTEVQVTELRRSYQTLEIELQSQLSMKESLERTLEETKARYASQLAA
                     IQEMLSSLEAQLMQIRSDTERQNQEYNILLDIKTRLEQEIATYRRLLEGEDIKTTEYQ
                     LNTLEAKDIKKTRKIKTVVEEVVDGKVVSSEVKEIEENI"
     exon            445..527
                     /gene="Krt20"
                     /gene_synonym="Krt21"
                     /inference="alignment:Splign:2.1.0"
     exon            528..684
                     /gene="Krt20"
                     /gene_synonym="Krt21"
                     /inference="alignment:Splign:2.1.0"
     exon            685..846
                     /gene="Krt20"
                     /gene_synonym="Krt21"
                     /inference="alignment:Splign:2.1.0"
     exon            847..972
                     /gene="Krt20"
                     /gene_synonym="Krt21"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1193
                     /gene="Krt20"
                     /gene_synonym="Krt21"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1231
                     /gene="Krt20"
                     /gene_synonym="Krt21"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1515
                     /gene="Krt20"
                     /gene_synonym="Krt21"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tccaggctac aggtgttgcc tcccgggatc aagatggact tcagtcgtcg aagtttccac
       61 agaagtctga gttcctcctc acaaggccca gcactcagca cgagtggctc cctgtataga
      121 aaggggacca tgcagcgtct gggggttgca cccagcgtct acggtggggc tggaggccac
      181 ggcacccgca tctctgtctc caaaaccaca atgagctacg ggaaccatct ctccaacgga
      241 ggggacctgt ttgggggcaa tgagaaattg gcaatgcaga acctcaatga cagattggca
      301 agctacctag aaaaagtgcg ctccctggag caatccaatt ccaaacttga agcccagatc
      361 aagcagtggt acgaaaccaa tgcaccgagc accatccggg actacagttc ctactacgca
      421 cagatcaaag agctgcaaga tcagattaag gatgctcaaa tagaaaacgc ccgatgcgtc
      481 ttgcaaattg acaatgctaa gctggccgca gaggacttca gattgaagtt tgagactgaa
      541 aggggcatgc ggataactgt ggaagccgat ctccaaggcc tgagcaaggt ctatgatgac
      601 ctgacccttc aaaagacaga cttggaaatt cagattgaag aactgaacaa ggacctggcc
      661 ctcctcaaaa aagagcatca agaggaagtc gaggtccttc gccggcagct gggcaacaat
      721 gtcaacgtgg aggtggatgc cgctccaggc ctgaacctgg gtgagatcat gaatgagatg
      781 agacagaaat atgaaatcct ggcccagaag aacctgcagg aggccaaaga acagtttgag
      841 agacagactc aaactctgga gaaacaagtc acagtgaaca ttgaggagct gagaggaacc
      901 gaggttcaag tcacggaact gagacgcagc taccagaccc tggaaataga gctccagtcc
      961 caactaagca tgaaagagtc tctggagcgc accctggagg agaccaaggc tcgttatgcc
     1021 agccagttgg cggccatcca ggaaatgctg agttccctgg aggcccaact gatgcagatc
     1081 cggagcgaca ctgaacgcca gaaccaagag tacaatatcc tccttgacat aaagacccgg
     1141 cttgagcagg agatcgccac ctaccgccgc cttctggaag gagaggacat aaaaactaca
     1201 gagtaccagc taaacacttt ggaagcaaaa gatatcaaga aaaccaggaa gattaagacg
     1261 gtcgtggagg aagtggtaga cggcaaggtc gtgtcctctg aagtcaagga gatagaagaa
     1321 aacatataaa cagctgccaa tggggaggct gctccagctg tggcgtccgg aaaccgcatc
     1381 aatactgtgc ggtgactgcg aagcggggag aagtctattt accgggctct gtaattaaat
     1441 ataaacgttt tcactctggg gagctgtaaa gggcttgtaa gattaaagcc agtgaatcct
     1501 ggaacattta agcca
//
