LOCUS       NM_001008899            2519 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus keratin 2 (Krt2), mRNA.
ACCESSION   NM_001008899
VERSION     NM_001008899.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2519)
  AUTHORS   Fischer,H., Langbein,L., Reichelt,J., Buchberger,M., Tschachler,E.
            and Eckhart,L.
  TITLE     Keratins K2 and K10 are essential for the epidermal integrity of
            plantar skin
  JOURNAL   J Dermatol Sci 81 (1), 10-16 (2016)
   PUBMED   26603179
REFERENCE   2  (bases 1 to 2519)
  AUTHORS   Fischer,H., Langbein,L., Reichelt,J., Praetzel-Wunder,S.,
            Buchberger,M., Ghannadan,M., Tschachler,E. and Eckhart,L.
  TITLE     Loss of keratin K2 expression causes aberrant aggregation of K10,
            hyperkeratosis, and inflammation
  JOURNAL   J Invest Dermatol 134 (10), 2579-2588 (2014)
   PUBMED   24751727
REFERENCE   3  (bases 1 to 2519)
  AUTHORS   Pieragostino,D., Agnifili,L., Fasanella,V., D'Aguanno,S.,
            Mastropasqua,R., Di Ilio,C., Sacchetta,P., Urbani,A. and Del
            Boccio,P.
  TITLE     Shotgun proteomics reveals specific modulated protein patterns in
            tears of patients with primary open angle glaucoma naive to therapy
  JOURNAL   Mol Biosyst 9 (6), 1108-1116 (2013)
   PUBMED   23580065
REFERENCE   4  (bases 1 to 2519)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   5  (bases 1 to 2519)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (bases 1 to 2519)
  AUTHORS   Lan,L., Hayes,C.S., Laury-Kleintop,L. and Gilmour,S.K.
  TITLE     Suprabasal induction of ornithine decarboxylase in adult mouse skin
            is sufficient to activate keratinocytes
  JOURNAL   J Invest Dermatol 124 (3), 602-614 (2005)
   PUBMED   15737202
REFERENCE   7  (bases 1 to 2519)
  AUTHORS   Hesse,M., Zimek,A., Weber,K. and Magin,T.M.
  TITLE     Comprehensive analysis of keratin gene clusters in humans and
            rodents
  JOURNAL   Eur J Cell Biol 83 (1), 19-26 (2004)
   PUBMED   15085952
REFERENCE   8  (bases 1 to 2519)
  AUTHORS   Bloor,B.K., Tidman,N., Leigh,I.M., Odell,E., Dogan,B., Wollina,U.,
            Ghali,L. and Waseem,A.
  TITLE     Expression of keratin K2e in cutaneous and oral lesions:
            association with keratinocyte activation, proliferation, and
            keratinization
  JOURNAL   Am J Pathol 162 (3), 963-975 (2003)
   PUBMED   12598329
REFERENCE   9  (bases 1 to 2519)
  AUTHORS   Steinert,P.M. and Marekov,L.N.
  TITLE     The proteins elafin, filaggrin, keratin intermediate filaments,
            loricrin, and small proline-rich proteins 1 and 2 are isodipeptide
            cross-linked components of the human epidermal cornified cell
            envelope
  JOURNAL   J Biol Chem 270 (30), 17702-17711 (1995)
   PUBMED   7543090
REFERENCE   10 (bases 1 to 2519)
  AUTHORS   Rothnagel,J.A., Traupe,H., Wojcik,S., Huber,M., Hohl,D.,
            Pittelkow,M.R., Saeki,H., Ishibashi,Y. and Roop,D.R.
  TITLE     Mutations in the rod domain of keratin 2e in patients with
            ichthyosis bullosa of Siemens
  JOURNAL   Nat Genet 7 (4), 485-490 (1994)
   PUBMED   7524919
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Jul 30, 2021 this sequence version replaced NM_001008899.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643289.22058.1,
                                           SRR26643285.29792.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760393,
                                           SAMEA5760400 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-710               JAXUCZ010000007.1  134826027-134826736 c
            711-925             JAXUCZ010000007.1  134824857-134825071 c
            926-986             JAXUCZ010000007.1  134824503-134824563 c
            987-1082            JAXUCZ010000007.1  134823634-134823729 c
            1083-1247           JAXUCZ010000007.1  134822886-134823050 c
            1248-1373           JAXUCZ010000007.1  134822489-134822614 c
            1374-1594           JAXUCZ010000007.1  134821630-134821850 c
            1595-1629           JAXUCZ010000007.1  134820561-134820595 c
            1630-2519           JAXUCZ010000007.1  134819584-134820473 c
FEATURES             Location/Qualifiers
     source          1..2519
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..2519
                     /gene="Krt2"
                     /gene_synonym="CK 2e; Kb2"
                     /note="keratin 2"
                     /db_xref="GeneID:406228"
                     /db_xref="RGD:1303297"
     exon            1..710
                     /gene="Krt2"
                     /gene_synonym="CK 2e; Kb2"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..2123
                     /gene="Krt2"
                     /gene_synonym="CK 2e; Kb2"
                     /note="type II keratin Kb2; K2e; cytokeratin-2e; CK-2e;
                     keratin-2e; keratin-2 epidermis; epithelial keratin-2e;
                     keratin 2, type II"
                     /codon_start=1
                     /product="keratin, type II cytoskeletal 2 epidermal"
                     /protein_id="NP_001008899.2"
                     /db_xref="GeneID:406228"
                     /db_xref="RGD:1303297"
                     /translation="MSCQISCKSRRGGGGGGGGGFRGFSSGSAVVSGGSRRSTSGFSC
                     LSRHGGGRGGSGGGGFGSQSLVGLGGYKSISSSVAGYGGGFGGRSYGGFGGGSGFGGS
                     GGFGGGSGFGGGRGFGGGSGFGGGSGFGGGSGFGGGSGFGGGGFGGGRFGGGPGGFGG
                     PGGFPGGGIHEVSVNQSLLQPLDVKVDPEIQNVKSQEREQIKTLNNKFASFIDTVRFL
                     EQQNQVLHTKWELLQQLDVGTRTTNLDPVFQAYIGILKKQVDRLTAERNSQDSELNNM
                     QDLVEDFKKKYEDEINKRTSAENDFVTIKKDVDSCYMDKTELQAKMEMLTQEVDFLRT
                     LYDTELSQLQQNVTDTNVILSMDNNRNLDLDSIIAEVQSQYEIIAHKSKAESEELYHS
                     KYEELQVTAVKHGDSLKEIKMEISELNRTIQRLQGEISHVKKQCKGVQDSIADAEQRG
                     EHAIKDARGKLTDLEEALQQGRENLARLLRDYQELMNVKLALDVEIATYRKLLEGEEC
                     RMSGDFSDNVSVSVTSSTISSSVASKAGFGSGGQSSGGRGSYGGRGGGSTYGSGGRSS
                     GVRGSGSGSGGGGYSSGGGSRGGSGGGGYSTGGGSRGGSSSGGGGYSSGGGSRGDSSS
                     GGGSRGGSGGGSRGGSGGGGYSSGGGSRGGSSSGGAVSGSERGGSGSGEGCGSGVTFS
                     FR"
     exon            711..925
                     /gene="Krt2"
                     /gene_synonym="CK 2e; Kb2"
                     /inference="alignment:Splign:2.1.0"
     exon            926..986
                     /gene="Krt2"
                     /gene_synonym="CK 2e; Kb2"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1082
                     /gene="Krt2"
                     /gene_synonym="CK 2e; Kb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1247
                     /gene="Krt2"
                     /gene_synonym="CK 2e; Kb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1373
                     /gene="Krt2"
                     /gene_synonym="CK 2e; Kb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..1594
                     /gene="Krt2"
                     /gene_synonym="CK 2e; Kb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1595..1629
                     /gene="Krt2"
                     /gene_synonym="CK 2e; Kb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1630..2519
                     /gene="Krt2"
                     /gene_synonym="CK 2e; Kb2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcacagttt agtctccagc cttggatctg ctcaggaacg gtcacttgtc ttgctgagca
       61 aaaccatcat gagttgccag atctcctgca agtcccggag aggaggaggc ggaggaggag
      121 gcggtggatt caggggcttc agtagtggct cagctgtggt ctctggaggg agccggagat
      181 cgacttccgg cttctcctgc ctgagccgcc acggtggtgg cagaggaggc tctggtggag
      241 gtggctttgg cagtcagagt cttgttggcc ttggagggta caagagcatc tctagtagcg
      301 tggctggcta cggtggtgga tttggtggca gaagctacgg tggcttcgga ggcggcagcg
      361 gctttggagg cagcggtggc ttcggaggtg gctctggctt tggaggaggc cgaggatttg
      421 gaggtggtag cggtttcgga ggcggcagcg gctttggagg tggcagcggc tttggaggtg
      481 gcagcggctt cggaggcggt ggatttggcg gaggacgctt tggaggtggc cctggaggtt
      541 ttgggggccc tggaggattc cctggtggag gcatccatga agtgtctgtc aatcagagcc
      601 tcttgcagcc tcttgatgtt aaagtggacc cagagattca gaacgtgaag tctcaggaac
      661 gggagcagat caaaaccctc aacaacaaat ttgcctcttt cattgacacg gtgcgattcc
      721 tggagcagca gaaccaggtg ttgcacacca aatgggagct gctgcagcag ctggatgtag
      781 gcacccgtac caccaacctg gaccccgtct tccaggccta cattggcata ctcaagaagc
      841 aggtggacag gctaactgcg gaaaggaact cacaggattc agagctgaac aacatgcagg
      901 atctcgtgga agactttaag aagaagtacg aggacgagat caacaagcgc acgtctgcgg
      961 agaatgattt cgtgaccatc aaaaaggacg tggacagttg ctacatggac aagacagagc
     1021 tgcaggccaa gatggagatg ctgacacagg aagtcgattt cctgagaaca ctctacgaca
     1081 cggaactgtc ccagctacag cagaatgtca ccgacaccaa tgtcatcctg tccatggaca
     1141 acaaccggaa ccttgacctg gacagcatca ttgctgaagt tcagagccaa tacgagatca
     1201 tcgcccacaa gagcaaggct gagtcggagg agctgtacca cagcaagtat gaagaactcc
     1261 aggtcaccgc tgtgaaacat ggggacagct tgaaagagat caagatggag atcagcgagt
     1321 tgaaccgaac aatccagagg ctgcaagggg agatatcaca tgtgaagaag cagtgtaaag
     1381 gtgtgcaaga ctccattgca gatgcagagc agcgtgggga gcacgccatc aaagatgcca
     1441 ggggcaagct cactgacctg gaggaggccc tgcagcaggg ccgagagaac ctggctcggc
     1501 tgctgcggga ctaccaggag ctcatgaacg tcaagctggc cctggatgtg gagatcgcca
     1561 cctaccgcaa gctactggag ggggaggagt gcaggatgtc tggagacttc agcgacaatg
     1621 tgtctgtctc cgtgacaagc agcaccatct cctcatctgt ggcatctaag gctggctttg
     1681 gctccggagg tcaaagttca ggaggaagag ggtcttacgg cggaagagga ggaggaagca
     1741 cctatggctc tggaggcaga agctctggtg tcagaggatc tggatcagga tctggaggag
     1801 gcggatacag ttctggagga ggctccaggg gaggatctgg aggaggagga tacagcactg
     1861 gaggaggttc tagaggaggc tccagctctg gagggggagg atacagctct ggagggggct
     1921 ctagaggtga ctccagctct ggaggaggct ccaggggagg atctggagga ggctccaggg
     1981 gaggatctgg aggaggagga tacagctctg gaggaggctc tagaggaggc tccagctctg
     2041 gaggggcagt gtccggctct gaaaggggtg gttctgggtc aggggaaggt tgcggctccg
     2101 gcgtgacctt ctcctttaga tagaaatggg tcctctctct actctttgat ttccagaatg
     2161 tcagctgtgt ctctaactca gatcaacccc aatatctgta atccaccaat gatgtcattt
     2221 tctttttctt ttcgagaggg ggtggtaaaa gatctctcct aacagttaga gtcagagata
     2281 ctcactgtgt tctgggcaag aatctgcatt gtccaagtgt gtcttcaacc gcgtcccatt
     2341 cctggtctct cgcattgtcc gcctggcagt ccctccccga tagtggtgta ctgaggaccc
     2401 cagggtagcc tccctattcc accccccaac agtggtctag ggaactatgc ttttttgtac
     2461 atagcctctt gaatggactc tgctttctga gtgctggggt ctgggtctct gcataataa
//
