LOCUS       NM_199498               1380 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Rattus norvegicus keratin 19 (Krt19), mRNA.
ACCESSION   NM_199498 XM_340900
VERSION     NM_199498.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1380)
  AUTHORS   Falix,F.A., Weeda,V.B., Labruyere,W.T., Poncy,A., de Waart,D.R.,
            Hakvoort,T.B., Lemaigre,F., Gaemers,I.C., Aronson,D.C. and
            Lamers,W.H.
  TITLE     Hepatic Notch2 deficiency leads to bile duct agenesis perinatally
            and secondary bile duct formation after weaning
  JOURNAL   Dev Biol 396 (2), 201-213 (2014)
   PUBMED   25446530
REFERENCE   2  (bases 1 to 1380)
  AUTHORS   Wogenstein,K.L., Szabo,S., Lunova,M., Wiche,G., Haybaeck,J.,
            Strnad,P., Boor,P., Wagner,M. and Fuchs,P.
  TITLE     Epiplakin deficiency aggravates murine caerulein-induced acute
            pancreatitis and favors the formation of acinar keratin granules
  JOURNAL   PLoS One 9 (9), e108323 (2014)
   PUBMED   25232867
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1380)
  AUTHORS   Gkegkes,I.D., Aroni,K., Agrogiannis,G., Patsouris,E.S. and
            Konstantinidou,A.E.
  TITLE     Expression of caspase-14 and keratin-19 in the human epidermis and
            appendages during fetal skin development
  JOURNAL   Arch Dermatol Res 305 (5), 379-387 (2013)
   PUBMED   23377137
REFERENCE   4  (bases 1 to 1380)
  AUTHORS   Grimm-Gunter,E.M., Revenu,C., Ramos,S., Hurbain,I., Smyth,N.,
            Ferrary,E., Louvard,D., Robine,S. and Rivero,F.
  TITLE     Plastin 1 binds to keratin and is required for terminal web
            assembly in the intestinal epithelium
  JOURNAL   Mol Biol Cell 20 (10), 2549-2562 (2009)
   PUBMED   19321664
REFERENCE   5  (bases 1 to 1380)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   6  (bases 1 to 1380)
  AUTHORS   Ursitti,J.A., Lee,P.C., Resneck,W.G., McNally,M.M., Bowman,A.L.,
            O'Neill,A., Stone,M.R. and Bloch,R.J.
  TITLE     Cloning and characterization of cytokeratins 8 and 19 in adult rat
            striated muscle. Interaction with the dystrophin glycoprotein
            complex
  JOURNAL   J Biol Chem 279 (40), 41830-41838 (2004)
   PUBMED   15247274
  REMARK    GeneRIF: cytokeratins 8 and 19 are expressed in adult striated
            muscle, where they may contribute to the organization of both the
            myoplasm and sarcolemma
REFERENCE   7  (bases 1 to 1380)
  AUTHORS   Hesse,M., Zimek,A., Weber,K. and Magin,T.M.
  TITLE     Comprehensive analysis of keratin gene clusters in humans and
            rodents
  JOURNAL   Eur J Cell Biol 83 (1), 19-26 (2004)
   PUBMED   15085952
REFERENCE   8  (bases 1 to 1380)
  AUTHORS   Tamai,Y., Ishikawa,T., Bosl,M.R., Mori,M., Nozaki,M., Baribault,H.,
            Oshima,R.G. and Taketo,M.M.
  TITLE     Cytokeratins 8 and 19 in the mouse placental development
  JOURNAL   J Cell Biol 151 (3), 563-572 (2000)
   PUBMED   11062258
REFERENCE   9  (bases 1 to 1380)
  AUTHORS   Yang,G.P., Ross,D.T., Kuang,W.W., Brown,P.O. and Weigel,R.J.
  TITLE     Combining SSH and cDNA microarrays for rapid identification of
            differentially expressed genes
  JOURNAL   Nucleic Acids Res 27 (6), 1517-1523 (1999)
   PUBMED   10037815
REFERENCE   10 (bases 1 to 1380)
  AUTHORS   Fridmacher,V., Le Bert,M., Guillou,F. and Magre,S.
  TITLE     Switch in the expression of the K19/K18 keratin genes as a very
            early evidence of testicular differentiation in the rat
  JOURNAL   Mech Dev 52 (2-3), 199-207 (1995)
   PUBMED   8541209
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY464140.1.
            
            On Feb 4, 2015 this sequence version replaced NM_199498.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY464140.1, BC088424.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676784, SAMN16676786
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1380              AY464140.1         6-1385
FEATURES             Location/Qualifiers
     source          1..1380
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q31"
     gene            1..1380
                     /gene="Krt19"
                     /gene_synonym="Ka19; Krt1-19"
                     /note="keratin 19"
                     /db_xref="GeneID:360626"
                     /db_xref="RGD:619936"
     exon            1..485
                     /gene="Krt19"
                     /gene_synonym="Ka19; Krt1-19"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..1268
                     /gene="Krt19"
                     /gene_synonym="Ka19; Krt1-19"
                     /note="keratin complex 1, acidic, gene 19; cytokeratin 19;
                     type I keratin KA19; K19; CK-19; keratin 19, type I"
                     /codon_start=1
                     /product="keratin, type I cytoskeletal 19"
                     /protein_id="NP_955792.1"
                     /db_xref="GeneID:360626"
                     /db_xref="RGD:619936"
                     /translation="MTSYSYRQSSAMSSYGGMGGGPVRFGSGGVFRAPSIHGGSGGRG
                     VSVSSTRIVSSSSGGYVGGRGGSFSGALTVTDGLLGGNEKITMQNLNDRLASYLDKVR
                     ALEQANGELEVKIRDWYQKQGPGPFRDYSQYFKTIEDLRDKILGATIENSKIVLQIDN
                     ARLAADDFRTKFETEQALRMSVEADINGLRRVLDELTLARTDLEMQIENLKEELAYLK
                     KNHEEEISALRSQVGGQVSVEVDSTPGIDLAKILSEMRSQYEAMAEKNRKDAEAWYLT
                     QIDELNTQVAVHTTQIQINKTEVTELRRKVQDLEIELQSQLSMKAALEGTVAEIEARY
                     GAQLSHIQGVISSIEVQLSNVRADTERQNQEYQQLMDIKSRLEQEIATYRSLLEGQEA
                     HYNSLSIAKAL"
     exon            486..568
                     /gene="Krt19"
                     /gene_synonym="Ka19; Krt1-19"
                     /inference="alignment:Splign:2.1.0"
     exon            569..725
                     /gene="Krt19"
                     /gene_synonym="Ka19; Krt1-19"
                     /inference="alignment:Splign:2.1.0"
     exon            726..887
                     /gene="Krt19"
                     /gene_synonym="Ka19; Krt1-19"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1013
                     /gene="Krt19"
                     /gene_synonym="Ka19; Krt1-19"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1380
                     /gene="Krt19"
                     /gene_synonym="Ka19; Krt1-19"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcagcagttc tcagacctgc gtcccttatc cctctgctca ggtcttcctc ctcaccatga
       61 cttcctatag ctatcgccag tcctcagcca tgtcttccta tgggggcatg ggcgggggtc
      121 ccgtgcgctt tgggtcaggg ggtgttttcc gcgcacctag catccatggg ggctcaggtg
      181 gccgtggcgt gtccgtgtcc tcgacccgca tcgtgtcctc atcctccggg ggctatgtcg
      241 gaggacgcgg tggaagtttt agtggggccc tgactgtgac cgatgggctg ctgggtggca
      301 atgagaagat caccatgcag aacctgaacg atcgcctcgc ctcctacttg gacaaggtgc
      361 gcgccctgga gcaggctaat ggcgagctgg aggtgaagat tcgcgactgg taccagaagc
      421 agggacccgg gcccttccgt gattacagcc agtacttcaa gaccatcgag gacttgcgcg
      481 acaagatcct tggcgccacc attgagaact ccaagatagt cctacagatc gacaatgccc
      541 gcctggctgc agatgacttc cggaccaagt ttgagacaga acaggccctg cgcatgagtg
      601 tggaggccga catcaacggc ctgcgccggg tgctggatga gctgaccctg gccaggaccg
      661 acctggagat gcagatagag aacctgaagg aggagctggc ctacctgaag aagaaccacg
      721 aggaggaaat tagtgccctg aggagccagg tgggtggcca ggtcagtgtg gaggtggatt
      781 ccacaccagg cattgaccta gccaagatcc tgagtgagat gagaagtcag tatgaggcca
      841 tggcagagaa gaaccggaag gatgctgaag cctggtacct tactcagatt gatgagctga
      901 acacccaggt cgctgtccac actacgcaga tccagataaa caagactgag gtcacggaac
      961 tccgacgtaa ggtccaggac cttgagattg aattgcagtc tcagctcagc atgaaagctg
     1021 ccctggaagg cactgtggca gagatagagg cccgttacgg agcccagctg tcacacatcc
     1081 agggtgtgat cagcagtatt gaagtccagc tgagtaacgt gcgtgctgac acagagcgcc
     1141 agaaccagga gtatcagcag ctcatggaca tcaagtcgag gctggagcag gagatcgcca
     1201 cctaccgaag cctgcttgag ggccaggaag cccactacaa cagtctgtcc atcgccaagg
     1261 ccctctgagc tgatcctggc ctcctacctt gctaccagtg cgacttcccc agggaggggc
     1321 atgataaagt tcacaccagc ccttccctcg acttgtcaat aaaactatcc tccaagggaa
//
