LOCUS       NM_053976               1397 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus keratin 18 (Krt18), mRNA.
ACCESSION   NM_053976 XM_215513
VERSION     NM_053976.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1397)
  AUTHORS   Cui,J., Ma,Q., Zhang,C., Li,Y., Liu,J., Xie,K., Luo,E., Zhai,M. and
            Tang,C.
  TITLE     Keratin 18 Depletion as a Possible Mechanism for the Induction of
            Apoptosis and Ferroptosis in the Rat Hippocampus After Hypobaric
            Hypoxia
  JOURNAL   Neuroscience 513, 64-75 (2023)
   PUBMED   36395917
  REMARK    GeneRIF: Keratin 18 Depletion as a Possible Mechanism for the
            Induction of Apoptosis and Ferroptosis in the Rat Hippocampus After
            Hypobaric Hypoxia.
REFERENCE   2  (bases 1 to 1397)
  AUTHORS   Darweesh,S.K., AbdElAziz,R.A., Abd-ElFatah,D.S., AbdElazim,N.A.,
            Fathi,S.A., Attia,D. and AbdAllah,M.
  TITLE     Serum cytokeratin-18 and its relation to liver fibrosis and
            steatosis diagnosed by FibroScan and controlled attenuation
            parameter in nonalcoholic fatty liver disease and hepatitis C virus
            patients
  JOURNAL   Eur J Gastroenterol Hepatol 31 (5), 633-641 (2019)
   PUBMED   30839434
REFERENCE   3  (bases 1 to 1397)
  AUTHORS   Chang,Y.H., Lin,H.C., Hwu,D.W., Chang,D.M., Lin,K.C. and Lee,Y.J.
  TITLE     Elevated serum cytokeratin-18 concentration in patients with type 2
            diabetes mellitus and non-alcoholic fatty liver disease
  JOURNAL   Ann Clin Biochem 56 (1), 141-147 (2019)
   PUBMED   30089409
REFERENCE   4  (bases 1 to 1397)
  AUTHORS   Aloia,T.P.A., Cogliati,B., Monteiro,J.M., Goldberg,A.C.K. and de
            Oliveira Salvalaggio,P.R.
  TITLE     Recovery of the Cholangiocytes After Ischemia and Reperfusion
            Injury: Ultra-Structural, Hystological and Molecular Assessment in
            Rats
  JOURNAL   J Clin Exp Hepatol 8 (4), 380-389 (2018)
   PUBMED   30563999
REFERENCE   5  (bases 1 to 1397)
  AUTHORS   Xue,L., Lu,X., He,J., Zhang,T., Wu,X., Zhang,Y., Wang,N., An,Z.,
            Xu,J. and Geng,Y.
  TITLE     Serum CK 18-M30 reflect liver pathological severity during NAFLD
            progression in a rat model
  JOURNAL   Pathol Res Pract 214 (11), 1778-1786 (2018)
   PUBMED   30149902
REFERENCE   6  (bases 1 to 1397)
  AUTHORS   Caulin,C., Ware,C.F., Magin,T.M. and Oshima,R.G.
  TITLE     Keratin-dependent, epithelial resistance to tumor necrosis
            factor-induced apoptosis
  JOURNAL   J Cell Biol 149 (1), 17-22 (2000)
   PUBMED   10747083
REFERENCE   7  (bases 1 to 1397)
  AUTHORS   Wells,M.J., Hatton,M.W., Hewlett,B., Podor,T.J., Sheffield,W.P. and
            Blajchman,M.A.
  TITLE     Cytokeratin 18 is expressed on the hepatocyte plasma membrane
            surface and interacts with thrombin-antithrombin complexes
  JOURNAL   J Biol Chem 272 (45), 28574-28581 (1997)
   PUBMED   9353322
REFERENCE   8  (bases 1 to 1397)
  AUTHORS   Ku,N.O., Wright,T.L., Terrault,N.A., Gish,R. and Omary,M.B.
  TITLE     Mutation of human keratin 18 in association with cryptogenic
            cirrhosis
  JOURNAL   J Clin Invest 99 (1), 19-23 (1997)
   PUBMED   9011570
REFERENCE   9  (bases 1 to 1397)
  AUTHORS   Fridmacher,V., Le Bert,M., Guillou,F. and Magre,S.
  TITLE     Switch in the expression of the K19/K18 keratin genes as a very
            early evidence of testicular differentiation in the rat
  JOURNAL   Mech Dev 52 (2-3), 199-207 (1995)
   PUBMED   8541209
REFERENCE   10 (bases 1 to 1397)
  AUTHORS   Yano,T., Tokui,T., Nishi,Y., Nishizawa,K., Shibata,M., Kikuchi,K.,
            Tsuiki,S., Yamauchi,T. and Inagaki,M.
  TITLE     Phosphorylation of keratin intermediate filaments by protein kinase
            C, by calmodulin-dependent protein kinase and by cAMP-dependent
            protein kinase
  JOURNAL   Eur J Biochem 197 (2), 281-290 (1991)
   PUBMED   1709097
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC091275.1.
            
            On Jul 4, 2005 this sequence version replaced XM_215513.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC091275.1, FQ228967.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1397
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..1397
                     /gene="Krt18"
                     /gene_synonym="Krt1-18"
                     /note="keratin 18"
                     /db_xref="GeneID:294853"
                     /db_xref="RGD:619935"
     exon            1..436
                     /gene="Krt18"
                     /gene_synonym="Krt1-18"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..1312
                     /gene="Krt18"
                     /gene_synonym="Krt1-18"
                     /note="keratin complex 1, acidic, gene 18; K18; CK-18;
                     cytokeratin-18; keratin 18, type I"
                     /codon_start=1
                     /product="keratin, type I cytoskeletal 18"
                     /protein_id="NP_446428.1"
                     /db_xref="GeneID:294853"
                     /db_xref="RGD:619935"
                     /translation="MSFTTRSTTFSTNYRSLGSVRTPSQRVRPASSAASVYAGAGGSG
                     SRISVSRSVWGGSVGSAGLAGMGGVQTEKETMQDLNDRLASYLDKVKNLETENRRLES
                     KIREYLEKRGPQGVRDWGHYFKTIEDLRAQIFANSVDNARIVLQIDNARLAADDFRVK
                     YETELAMRQSVESDIHGLRKVVDDTNITRLQLETEIEALKEELLFMKKNHEEEVQGLE
                     AQIASSGLTVEVDAPKSQDLSKIMADIRAQYEQLAQKNREELDKYWSQQIEESTTVVT
                     TKSAEIRDAETTLLELRRTLQTLEIDLDSMKNQNINLENNLGEVEARYRVQMEQLNGV
                     LLHLESELAQTRAEGQRQTQEYEALLNIKVKLEAEIATYRRLLEDGDDFSLNDALDSS
                     NSMQTVQRTTTRKVVDGKVVSETNDTRVLRH"
     exon            437..519
                     /gene="Krt18"
                     /gene_synonym="Krt1-18"
                     /inference="alignment:Splign:2.1.0"
     exon            520..676
                     /gene="Krt18"
                     /gene_synonym="Krt1-18"
                     /inference="alignment:Splign:2.1.0"
     exon            677..841
                     /gene="Krt18"
                     /gene_synonym="Krt1-18"
                     /inference="alignment:Splign:2.1.0"
     exon            842..967
                     /gene="Krt18"
                     /gene_synonym="Krt1-18"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1191
                     /gene="Krt18"
                     /gene_synonym="Krt1-18"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1369
                     /gene="Krt18"
                     /gene_synonym="Krt1-18"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccaatcctgg tctctcgctt cgttctcctc tccagacaag atgagcttca ccacccgctc
       61 caccaccttc tccaccaact accggtccct gggctctgtg cggactccca gccagcgggt
      121 ccggcctgcc agcagcgcag ccagcgtcta tgcaggtgct gggggctcag ggtcccggat
      181 atccgtgtcc cgctctgtct ggggtggctc cgtggggtcc gcaggcctgg cgggaatggg
      241 tggggtccag actgagaagg agaccatgca agacctgaac gaccgcctgg ccagctacct
      301 agacaaggtg aagaacctgg aaaccgagaa caggagacta gagagcaaaa tccgggaata
      361 tctggagaaa aggggtcccc agggcgtcag agactggggc cactacttca agaccatcga
      421 agatctgagg gctcagatct ttgcgaattc tgtggacaat gcccgcatcg tcctgcagat
      481 cgacaatgcc cgtcttgccg ctgatgactt tagagtcaag tatgagacgg aactggccat
      541 gcgccagtct gtggagagtg acattcatgg actccgcaag gtggtggatg acaccaacat
      601 cacgaggttg cagctggaga cagaaatcga agcgctcaag gaggagctgc tgttcatgaa
      661 gaagaatcat gaggaggaag tccaaggcct ggaagctcag attgccagtt ctgggttgac
      721 tgtggaagtg gatgctccca aatctcagga cctcagcaag atcatggcgg acatccgtgc
      781 ccagtatgaa cagctggctc agaagaaccg tgaggaactg gacaagtact ggtctcagca
      841 gattgaagag agtaccacgg tagtcaccac caagtctgcc gaaatcaggg acgctgagac
      901 cacactcttg gagctgagac gcaccctcca gaccttggag attgacctgg actcgatgaa
      961 aaaccagaac atcaacttgg agaacaacct cggggaagtg gaggccagat acagggtgca
     1021 gatggagcaa ctcaatgggg tccttctgca tctggaatca gagctggcac aaactcgggc
     1081 agaaggacag cgccagaccc aggaatacga agccctgttg aacatcaagg tcaagcttga
     1141 ggcggagatt gccacctacc gccgcttgct ggaggatggg gacgatttca gtctcaacga
     1201 cgccctggac tccagcaact ccatgcaaac tgtccagagg acaactaccc gtaaggtcgt
     1261 ggatggcaaa gtggtgtccg agaccaatga taccagagtt ctgaggcact aaggctcaga
     1321 agaagggaac cccttgggga ctgagggacc aataaaagtt tagaatccaa aaaaaaaaaa
     1381 aaaaaaaaaa aaaaaaa
//
