LOCUS       NM_212545               1536 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus keratin 17 (Krt17), mRNA.
ACCESSION   NM_212545 XM_213478
VERSION     NM_212545.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1536)
  AUTHORS   Saunders,S.P., Goh,C.S., Brown,S.J., Palmer,C.N., Porter,R.M.,
            Cole,C., Campbell,L.E., Gierlinski,M., Barton,G.J., Schneider,G.,
            Balmain,A., Prescott,A.R., Weidinger,S., Baurecht,H., Kabesch,M.,
            Gieger,C., Lee,Y.A., Tavendale,R., Mukhopadhyay,S., Turner,S.W.,
            Madhok,V.B., Sullivan,F.M., Relton,C., Burn,J., Meggitt,S.,
            Smith,C.H., Allen,M.A., Barker,J.N., Reynolds,N.J., Cordell,H.J.,
            Irvine,A.D., McLean,W.H., Sandilands,A. and Fallon,P.G.
  TITLE     Tmem79/Matt is the matted mouse gene and is a predisposing gene for
            atopic dermatitis in human subjects
  JOURNAL   J Allergy Clin Immunol 132 (5), 1121-1129 (2013)
   PUBMED   24084074
  REMARK    Erratum:[J Allergy Clin Immunol. 2015 Dec;136(6):1710. doi:
            10.1016/j.jaci.2015.10.002.. PMID: 28843836]
REFERENCE   2  (bases 1 to 1536)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   3  (bases 1 to 1536)
  AUTHORS   Andl,T., Murchison,E.P., Liu,F., Zhang,Y., Yunta-Gonzalez,M.,
            Tobias,J.W., Andl,C.D., Seykora,J.T., Hannon,G.J. and Millar,S.E.
  TITLE     The miRNA-processing enzyme dicer is essential for the
            morphogenesis and maintenance of hair follicles
  JOURNAL   Curr Biol 16 (10), 1041-1049 (2006)
   PUBMED   16682203
REFERENCE   4  (bases 1 to 1536)
  AUTHORS   Kim,S., Wong,P. and Coulombe,P.A.
  TITLE     A keratin cytoskeletal protein regulates protein synthesis and
            epithelial cell growth
  JOURNAL   Nature 441 (7091), 362-365 (2006)
   PUBMED   16710422
REFERENCE   5  (bases 1 to 1536)
  AUTHORS   Tong,X. and Coulombe,P.A.
  TITLE     Keratin 17 modulates hair follicle cycling in a TNFalpha-dependent
            fashion
  JOURNAL   Genes Dev 20 (10), 1353-1364 (2006)
   PUBMED   16702408
REFERENCE   6  (bases 1 to 1536)
  AUTHORS   Shen,Z., Wang,G., Fan,J.Y., Li,W. and Liu,Y.F.
  TITLE     HLA DR B1*04, *07-restricted epitopes on Keratin 17 for
            autoreactive T cells in psoriasis
  JOURNAL   J Dermatol Sci 38 (1), 25-39 (2005)
   PUBMED   15795121
REFERENCE   7  (bases 1 to 1536)
  AUTHORS   Wong,P., Domergue,R. and Coulombe,P.A.
  TITLE     Overcoming functional redundancy to elicit pachyonychia
            congenita-like nail lesions in transgenic mice
  JOURNAL   Mol Cell Biol 25 (1), 197-205 (2005)
   PUBMED   15601842
REFERENCE   8  (bases 1 to 1536)
  AUTHORS   Hesse,M., Zimek,A., Weber,K. and Magin,T.M.
  TITLE     Comprehensive analysis of keratin gene clusters in humans and
            rodents
  JOURNAL   Eur J Cell Biol 83 (1), 19-26 (2004)
   PUBMED   15085952
REFERENCE   9  (bases 1 to 1536)
  AUTHORS   McGowan,K.M., Tong,X., Colucci-Guyon,E., Langa,F., Babinet,C. and
            Coulombe,P.A.
  TITLE     Keratin 17 null mice exhibit age- and strain-dependent alopecia
  JOURNAL   Genes Dev 16 (11), 1412-1422 (2002)
   PUBMED   12050118
REFERENCE   10 (bases 1 to 1536)
  AUTHORS   McLean,W.H., Rugg,E.L., Lunny,D.P., Morley,S.M., Lane,E.B.,
            Swensson,O., Dopping-Hepenstal,P.J., Griffiths,W.A., Eady,R.A.,
            Higgins,C. et al.
  TITLE     Keratin 16 and keratin 17 mutations cause pachyonychia congenita
  JOURNAL   Nat Genet 9 (3), 273-278 (1995)
   PUBMED   7539673
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC100058.1.
            
            On Aug 7, 2005 this sequence version replaced NM_212545.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC100058.1, BK004050.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132280,
                                           SAMD00132281 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1536
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q31"
     gene            1..1536
                     /gene="Krt17"
                     /gene_synonym="Ka17"
                     /note="keratin 17"
                     /db_xref="GeneID:287702"
                     /db_xref="RGD:1303181"
     exon            1..485
                     /gene="Krt17"
                     /gene_synonym="Ka17"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..1355
                     /gene="Krt17"
                     /gene_synonym="Ka17"
                     /note="K17; CK-17; cytokeratin-17; type I keratin KA17;
                     keratin 17, type I"
                     /codon_start=1
                     /product="keratin, type I cytoskeletal 17"
                     /protein_id="NP_997710.1"
                     /db_xref="GeneID:287702"
                     /db_xref="RGD:1303181"
                     /translation="MTTTIRQFTSSSSIKGSSGLGGGSSRTSCRLSGSLGAGSCRLGS
                     ASGLGSALGGNSYSSCYSFGTGSGYGGNFGGVDGLLAGGEKATMQNLNDRLASYLDKV
                     RALEEANTELEVKIRDWYQKQAPGPARDYSAYYQTIEDLKNKILVATVDNASILLQID
                     NARLAADDFRTKFETEQALRMSVEADINGLRRVLDELTLARADLEMQIENLKEELAYL
                     KKNHEEEMNALRGQVGGEINVEMDAAPGVDLSRILSEMRDQYEKMAEKNRKDAEDWFF
                     SKTEELNREVATNSELVQSGKSEISELRRTMQALEIELQSQLSMKASLEGSLAETENR
                     YCVQLSQIQGLIGSVEEQLAQLRCEMEQQNQEYKILLDVKTRLEQEIATYRRLLEGED
                     AHLTQYKPKEPVTTRQVRTIVEEVQDGKVISSREQVHQTTR"
     exon            486..568
                     /gene="Krt17"
                     /gene_synonym="Ka17"
                     /inference="alignment:Splign:2.1.0"
     exon            569..725
                     /gene="Krt17"
                     /gene_synonym="Ka17"
                     /inference="alignment:Splign:2.1.0"
     exon            726..887
                     /gene="Krt17"
                     /gene_synonym="Ka17"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1013
                     /gene="Krt17"
                     /gene_synonym="Ka17"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1234
                     /gene="Krt17"
                     /gene_synonym="Ka17"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1260
                     /gene="Krt17"
                     /gene_synonym="Ka17"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1507
                     /gene="Krt17"
                     /gene_synonym="Ka17"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcctctctt cctcctaagc cttccagctc cacatccgtt gcccgctgcc accatgacta
       61 ccaccatccg ccagttcacg tcctccagct ccatcaaggg ctcctctggc ctgggtggcg
      121 gctcatctag gacctcctgc cgactgtctg gcagcctggg tgcaggctcc tgcaggctgg
      181 ggtcagctag tggcctgggc agtgctcttg ggggcaacag ttactccagc tgctacagct
      241 ttggtactgg cagtggttat ggaggcaact ttgggggtgt tgatgggctg ctggctggag
      301 gggagaaggc caccatgcag aacctcaacg accgcctggc ctcctacctg gacaaggtgc
      361 gtgccctgga agaggccaac accgagctgg aggtgaagat ccgagactgg taccagaagc
      421 aggccccagg gccagcccgc gactacagtg cttattacca gaccattgag gatctgaaga
      481 acaagatcct cgtggccact gtggataatg ccagcatcct actccagatt gacaatgccc
      541 gcttggcagc tgatgacttc cgtaccaagt ttgagacgga gcaggccctg cgcatgagtg
      601 tggaggcgga catcaatggc ctacgccggg tgctggatga gctgaccctg gccagagctg
      661 acctggagat gcagattgag aatctcaagg aggagctggc ctacctgaag aagaaccatg
      721 aggaggagat gaatgctctg agaggccagg tgggcggcga aatcaacgtg gagatggacg
      781 cagcccctgg tgtggacctg agccgcatcc tgtcagagat gcgggatcag tacgagaaga
      841 tggctgagaa gaaccgcaag gatgccgaag attggttctt cagcaagact gaggagctaa
      901 accgcgaggt ggccaccaac agcgagctgg tgcagagcgg caagagcgag atctctgagc
      961 tccggcgcac catgcaggcc ctggagatcg agctgcagtc ccagctcagc atgaaagcat
     1021 ccctggaggg cagcctggca gagacagaga accgctactg cgtgcagctg tcccagatcc
     1081 agggtttgat tggcagcgtg gaggagcagc tggctcagct gcgctgcgag atggagcagc
     1141 agaatcagga gtacaagatc ctgctggatg tgaagactcg gctggagcag gagatcgcca
     1201 cctaccgccg tctgctggag ggcgaggatg cccacctgac tcagtacaag ccaaaagaac
     1261 ctgtgaccac ccgccaggtg cgcaccattg tggaagaggt ccaggatggc aaggtcatct
     1321 catcccggga gcaggtccac cagaccaccc gctaaggacc cagctccttc tgcccagttc
     1381 cctgaggctg cagagaggca gctcccctct cggcttggca gcctgtaacc tctccagcaa
     1441 cagactcctg tttcagcctc ttccccgcat ccccctgctc aacaccatta aagcttgctg
     1501 atctgaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa
//
