LOCUS       NM_001008752            1608 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus keratin 16 (Krt16), mRNA.
ACCESSION   NM_001008752 XM_220971
VERSION     NM_001008752.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1608)
  AUTHORS   Lessard,J.C., Pina-Paz,S., Rotty,J.D., Hickerson,R.P., Kaspar,R.L.,
            Balmain,A. and Coulombe,P.A.
  TITLE     Keratin 16 regulates innate immunity in response to epidermal
            barrier breach
  JOURNAL   Proc Natl Acad Sci U S A 110 (48), 19537-19542 (2013)
   PUBMED   24218583
REFERENCE   2  (bases 1 to 1608)
  AUTHORS   Choi,H.I., Choi,G.I., Kim,E.K., Choi,Y.J., Sohn,K.C., Lee,Y.,
            Kim,C.D., Yoon,T.J., Sohn,H.J., Han,S.H., Kim,S., Lee,J.H. and
            Lee,Y.H.
  TITLE     Hair greying is associated with active hair growth
  JOURNAL   Br J Dermatol 165 (6), 1183-1189 (2011)
   PUBMED   21916889
REFERENCE   3  (bases 1 to 1608)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   4  (bases 1 to 1608)
  AUTHORS   Trost,A., Desch,P., Wally,V., Haim,M., Maier,R.H., Reitsamer,H.A.,
            Hintner,H., Bauer,J.W. and Onder,K.
  TITLE     Aberrant heterodimerization of keratin 16 with keratin 6A in HaCaT
            keratinocytes results in diminished cellular migration
  JOURNAL   Mech Ageing Dev 131 (5), 346-353 (2010)
   PUBMED   20403371
REFERENCE   5  (bases 1 to 1608)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   6  (bases 1 to 1608)
  AUTHORS   Hesse,M., Zimek,A., Weber,K. and Magin,T.M.
  TITLE     Comprehensive analysis of keratin gene clusters in humans and
            rodents
  JOURNAL   Eur J Cell Biol 83 (1), 19-26 (2004)
   PUBMED   15085952
REFERENCE   7  (bases 1 to 1608)
  AUTHORS   Bernot,K.M., Coulombe,P.A. and McGowan,K.M.
  TITLE     Keratin 16 expression defines a subset of epithelial cells during
            skin morphogenesis and the hair cycle
  JOURNAL   J Invest Dermatol 119 (5), 1137-1149 (2002)
   PUBMED   12445204
REFERENCE   8  (bases 1 to 1608)
  AUTHORS   Wawersik,M. and Coulombe,P.A.
  TITLE     Forced expression of keratin 16 alters the adhesion,
            differentiation, and migration of mouse skin keratinocytes
  JOURNAL   Mol Biol Cell 11 (10), 3315-3327 (2000)
   PUBMED   11029038
REFERENCE   9  (bases 1 to 1608)
  AUTHORS   Wang,D.Y., Xiang,Y.Y., Tanaka,M., Shen,Q. and Sugimura,H.
  TITLE     Identification of cytokeratin subspecies altered in rat
            experimental esophageal tumors by subtractive cloning
  JOURNAL   Cancer Lett 108 (1), 119-127 (1996)
   PUBMED   8950218
REFERENCE   10 (bases 1 to 1608)
  AUTHORS   McLean,W.H., Rugg,E.L., Lunny,D.P., Morley,S.M., Lane,E.B.,
            Swensson,O., Dopping-Hepenstal,P.J., Griffiths,W.A., Eady,R.A.,
            Higgins,C. et al.
  TITLE     Keratin 16 and keratin 17 mutations cause pachyonychia congenita
  JOURNAL   Nat Genet 9 (3), 273-278 (1995)
   PUBMED   7539673
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Oct 29, 2022 this sequence version replaced NM_001008752.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BK004049.1, SRR22582416.1658656.1
                                           [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5760475,
                                           SAMN09345330 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-570               JAXUCZ010000010.1  85671642-85672211   c
            571-653             JAXUCZ010000010.1  85671128-85671210   c
            654-810             JAXUCZ010000010.1  85670744-85670900   c
            811-972             JAXUCZ010000010.1  85670498-85670659   c
            973-1098            JAXUCZ010000010.1  85670293-85670418   c
            1099-1319           JAXUCZ010000010.1  85669801-85670021   c
            1320-1369           JAXUCZ010000010.1  85669655-85669704   c
            1370-1608           JAXUCZ010000010.1  85669276-85669514   c
FEATURES             Location/Qualifiers
     source          1..1608
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q31"
     gene            1..1608
                     /gene="Krt16"
                     /gene_synonym="Ka16; Krt14; Krt14l"
                     /note="keratin 16"
                     /db_xref="GeneID:303530"
                     /db_xref="RGD:1590901"
     exon            1..570
                     /gene="Krt16"
                     /gene_synonym="Ka16; Krt14; Krt14l"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..1464
                     /gene="Krt16"
                     /gene_synonym="Ka16; Krt14; Krt14l"
                     /note="type I keratin KA16; keratin 14-like; keratin 16,
                     type I"
                     /codon_start=1
                     /product="keratin, type I cytoskeletal 16"
                     /protein_id="NP_001008752.1"
                     /db_xref="GeneID:303530"
                     /db_xref="RGD:1590901"
                     /translation="MATCSRQFTSSSSMKSSCGIGGGSSRMSSVLAGGSCRAPSTYGG
                     MSVTSSRFSSGAACGIGGGYSGGFSSSSFGGGFGGGLGGGFGGGLGGGFGGGLGDGLL
                     VGSEKVTMQNLNDRLATYLDKVRALEEANSDLEVKIRDWYQRQRPTEIKDYTPFFRTI
                     EDLQSKIVRAKQENAQSVLQIDNARLAANDFRTKYDNETSLRQLVESDINNLRRVLDE
                     LTMSRADLEMQIESLREELAYLKKNHEEEMLALRGQTGGDVNVEMDAAPGVDLSRILN
                     EMRDQYEQMAEKNRRDVEAWFQSKTEELNQEVASNHELIQSGRSEVSELRRVFQGLEI
                     ELQSQLSMKASLENSLEETKGRYCVQLSQIQGLIGSLEEQLAQLRCEMEQQSQEYNIL
                     LDVKTRLEQEIATYRRLLDGENVHSSSSQHSSGQSYSSGEVFSSSSRQPRSILKEQGS
                     TSFSQSQSQSSGY"
     exon            571..653
                     /gene="Krt16"
                     /gene_synonym="Ka16; Krt14; Krt14l"
                     /inference="alignment:Splign:2.1.0"
     exon            654..810
                     /gene="Krt16"
                     /gene_synonym="Ka16; Krt14; Krt14l"
                     /inference="alignment:Splign:2.1.0"
     exon            811..972
                     /gene="Krt16"
                     /gene_synonym="Ka16; Krt14; Krt14l"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1098
                     /gene="Krt16"
                     /gene_synonym="Ka16; Krt14; Krt14l"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1319
                     /gene="Krt16"
                     /gene_synonym="Ka16; Krt14; Krt14l"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1369
                     /gene="Krt16"
                     /gene_synonym="Ka16; Krt14; Krt14l"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1608
                     /gene="Krt16"
                     /gene_synonym="Ka16; Krt14; Krt14l"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcatctgca ccctccactg agcagttctc tcttctccct gctcacttac ccacactctc
       61 acgttcctca gcatggccac ctgcagccgt cagttcacct cctccagctc catgaagagc
      121 tcctgtggca tcggtggtgg ctctagccgc atgtcctccg tcctggctgg aggatcctgc
      181 cgggctccca gcacttatgg gggcatgtcg gtcacctcct ctcgcttctc ctctggggca
      241 gcctgtggga ttggaggtgg ctatagtggg ggcttcagca gcagcagttt tggtggtgga
      301 tttggtggag gacttggtgg tggatttggt ggaggacttg gtggtggatt tggtggtggt
      361 cttggcgatg ggctcctggt tggcagtgag aaagtgacca tgcaaaacct caatgaccgc
      421 ttggccacct acctggataa ggtgcgtgcc ctggaagagg ccaacagtga cctggaggtg
      481 aagatccgtg actggtacca gaggcagcgt cccactgaga tcaaagacta cacccccttc
      541 ttcaggacca tcgaggacct gcagagcaag atcgttagag ccaagcagga gaatgcgcag
      601 tccgttttgc agatcgacaa tgccaggctg gcagctaatg acttcaggac caagtatgat
      661 aatgagacgt ccttgcgtca gttagtggaa agtgacatca acaaccttcg ccgtgtgctg
      721 gatgaactga ctatgtccag ggcagacctg gagatgcaga tcgagagtct cagggaggag
      781 ctggcctacc tgaagaagaa tcacgaggag gagatgcttg ccttgagggg tcagactggt
      841 ggggacgtca acgtggagat ggacgcagct cctggtgtgg acctgagccg catcctgaac
      901 gagatgaggg accagtatga gcagatggca gagaagaacc gcagagatgt ggaggcctgg
      961 ttccagagca agaccgagga gctgaaccaa gaggtggctt ctaaccatga gctgatacag
     1021 agcggccgca gcgaggtgtc tgagctccgc agggtgttcc agggcctgga gatcgaactg
     1081 cagtcccagc tcagcatgaa agcatccttg gagaacagcc tagaagagac caaaggcaga
     1141 tactgcgtgc agctgtccca gatccagggt ttgatcggca gcctggagga gcagctggct
     1201 cagctgcgct gcgagatgga gcagcagagc caggagtaca acatcttgtt ggatgtgaag
     1261 actcggctgg agcaggagat cgccacctac cgccgtctgc tggatggcga gaatgtccac
     1321 agctcctcct cacagcactc ctctgggcag tcctattctt ctggagaagt cttctcctca
     1381 tcctcccggc agccccggtc catcctcaag gagcaaggct caaccagctt cagccagagc
     1441 caaagtcaga gttccgggta ctaatccggt ttgcccagcg cctcctgacc ctcaccagcc
     1501 tctcatcctg gcctcttggg gcaggaccct gttttcttaa tgtggtcccc aactgtctcc
     1561 cttacccctc atggtgatag tctaataaag ctttctggtt gatgcaaa
//
