LOCUS       NM_001008751            1668 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus keratin 14 (Krt14), mRNA.
ACCESSION   NM_001008751 XM_213477
VERSION     NM_001008751.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1668)
  AUTHORS   Khedgikar,V., Kushwaha,P., Gautam,J., Sharma,S., Verma,A.,
            Choudhary,D., Mishra,P.R. and Trivedi,R.
  TITLE     Kaempferol targets Krt-14 and induces cytoskeletal mineralization
            in osteoblasts: A mechanistic approach
  JOURNAL   Life Sci 151, 207-217 (2016)
   PUBMED   26956522
  REMARK    GeneRIF: These findings strongly suggest that Krt-14 regulates
            osteoblast mineralization by organizing osteoblast derived ECM.
REFERENCE   2  (bases 1 to 1668)
  AUTHORS   Kokado,M., Okada,Y., Goto,M., Ishikawa,K., Miyamoto,T.,
            Yamanaka,O., Fujiwara,S. and Saika,S.
  TITLE     Increased fragility, impaired differentiation, and acceleration of
            migration of corneal epithelium of epiplakin-null mice
  JOURNAL   Invest Ophthalmol Vis Sci 54 (5), 3780-3789 (2013)
   PUBMED   23599337
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1668)
  AUTHORS   Krolewski,R.C., Packard,A., Jang,W., Wildner,H. and Schwob,J.E.
  TITLE     Ascl1 (Mash1) knockout perturbs differentiation of nonneuronal
            cells in olfactory epithelium
  JOURNAL   PLoS One 7 (12), e51737 (2012)
   PUBMED   23284756
REFERENCE   4  (bases 1 to 1668)
  AUTHORS   Choi,H.I., Choi,G.I., Kim,E.K., Choi,Y.J., Sohn,K.C., Lee,Y.,
            Kim,C.D., Yoon,T.J., Sohn,H.J., Han,S.H., Kim,S., Lee,J.H. and
            Lee,Y.H.
  TITLE     Hair greying is associated with active hair growth
  JOURNAL   Br J Dermatol 165 (6), 1183-1189 (2011)
   PUBMED   21916889
REFERENCE   5  (bases 1 to 1668)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   6  (bases 1 to 1668)
  AUTHORS   Ogawa,Y., Yamauchi,S., Ohnishi,A., Ito,R. and Ijuhin,N.
  TITLE     Immunohistochemistry of myoepithelial cells during development of
            the rat salivary glands
  JOURNAL   Anat Embryol (Berl) 200 (2), 215-228 (1999)
   PUBMED   10424878
REFERENCE   7  (bases 1 to 1668)
  AUTHORS   Bisgaard,H.C., Mackay,A.R., Gomez,D.E., Ton,P.T., Thorgeirsson,S.S.
            and Thorgeirsson,U.P.
  TITLE     Spontaneous metastasis of rat liver epithelial cells transformed
            with v-raf and v-raf/v-myc: association with different phenotypic
            properties
  JOURNAL   Invasion Metastasis 17 (5), 240-250 (1997)
   PUBMED   9876218
REFERENCE   8  (bases 1 to 1668)
  AUTHORS   Wang,D.Y., Xiang,Y.Y., Tanaka,M., Shen,Q. and Sugimura,H.
  TITLE     Identification of cytokeratin subspecies altered in rat
            experimental esophageal tumors by subtractive cloning
  JOURNAL   Cancer Lett 108 (1), 119-127 (1996)
   PUBMED   8950218
REFERENCE   9  (bases 1 to 1668)
  AUTHORS   Kartasova,T., Roop,D.R., Holbrook,K.A. and Yuspa,S.H.
  TITLE     Mouse differentiation-specific keratins 1 and 10 require a
            preexisting keratin scaffold to form a filament network
  JOURNAL   J Cell Biol 120 (5), 1251-1261 (1993)
   PUBMED   7679677
REFERENCE   10 (bases 1 to 1668)
  AUTHORS   Coulombe,P.A., Hutton,M.E., Letai,A., Hebert,A., Paller,A.S. and
            Fuchs,E.
  TITLE     Point mutations in human keratin 14 genes of epidermolysis bullosa
            simplex patients: genetic and functional analyses
  JOURNAL   Cell 66 (6), 1301-1311 (1991)
   PUBMED   1717157
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Oct 27, 2022 this sequence version replaced NM_001008751.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BK004047.1, SRR22582419.1040705.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN11044071 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-610               JAXUCZ010000010.1  85641841-85642450   c
            611-693             JAXUCZ010000010.1  85640601-85640683   c
            694-850             JAXUCZ010000010.1  85640007-85640163   c
            851-1012            JAXUCZ010000010.1  85639724-85639885   c
            1013-1138           JAXUCZ010000010.1  85639515-85639640   c
            1139-1359           JAXUCZ010000010.1  85639199-85639419   c
            1360-1424           JAXUCZ010000010.1  85639043-85639107   c
            1425-1668           JAXUCZ010000010.1  85638182-85638425   c
FEATURES             Location/Qualifiers
     source          1..1668
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q31"
     gene            1..1668
                     /gene="Krt14"
                     /gene_synonym="Ka14; Krt1-14"
                     /note="keratin 14"
                     /db_xref="GeneID:287701"
                     /db_xref="RGD:1307463"
     exon            1..610
                     /gene="Krt14"
                     /gene_synonym="Ka14; Krt1-14"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..1522
                     /gene="Krt14"
                     /gene_synonym="Ka14; Krt1-14"
                     /note="K14; CK-14; cytokeratin-14; type I keratin Ka14;
                     keratin 14 (epidermolysis bullosa simplex, Dowling-Meara,
                     Koebner); keratin complex 1, acidic, gene 14; keratin 14,
                     type I"
                     /codon_start=1
                     /product="keratin, type I cytoskeletal 14"
                     /protein_id="NP_001008751.1"
                     /db_xref="GeneID:287701"
                     /db_xref="RGD:1307463"
                     /translation="MATCSRQFTSSSSMKGSCGIGGGSSRMSSVLAGGSCRAPSTYGG
                     MSRFSSAGAYAVGSGYGGGFSSSSFGGGFGGGIGGGIGGGLGGGIGGGFGGGIGGGFG
                     GGIGSGFGGGLGDGLLVGSEKVTMQNLNDRLATYLDKVRALEEANSDLEVKIRDWYQR
                     QRPTEIKDYSPYFKTIEDLKSKILAATVDNANVLLQIDNARLAADDFRTKFETEQSLR
                     INVESDINGLRRVLDELTLARADLEMQIESLKEELAYLKKNHEEEMASMRGQVGGDVN
                     VEMDAAPGVDLSRILNEMRDQYEKMAEKNRKDAEDWFFTKTEELNREVATNSELVQSG
                     KSEISELRRTMQNLEIELQSQLSMKASLENNLEETKGRYCMQLAQIQEMIGSVEEQLA
                     QLRCEMEQQNQEYKILLDVKTRLEQEIATYRRLLEGEDAHLSSAQFSSSSQFSSGSQS
                     SRDVTSTNRQIRTKVMDVHDGKVVSTHEQVLRTKN"
     exon            611..693
                     /gene="Krt14"
                     /gene_synonym="Ka14; Krt1-14"
                     /inference="alignment:Splign:2.1.0"
     exon            694..850
                     /gene="Krt14"
                     /gene_synonym="Ka14; Krt1-14"
                     /inference="alignment:Splign:2.1.0"
     exon            851..1012
                     /gene="Krt14"
                     /gene_synonym="Ka14; Krt1-14"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1138
                     /gene="Krt14"
                     /gene_synonym="Ka14; Krt1-14"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1359
                     /gene="Krt14"
                     /gene_synonym="Ka14; Krt1-14"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1424
                     /gene="Krt14"
                     /gene_synonym="Ka14; Krt1-14"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1668
                     /gene="Krt14"
                     /gene_synonym="Ka14; Krt1-14"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acctgagcag ctctctcttc tctctgccca ctcacttgtt cacttgctca cctctctcaa
       61 agccatggcc acctgcagcc gtcagttcac ctcctccagc tccatgaagg gctcctgtgg
      121 catcggtggt ggctctagcc gcatgtcctc cgtcctggct ggaggatcct gccgggctcc
      181 cagcacctac gggggcatgt ctcgtttctc ctctgcggga gcctatgcgg ttggaagtgg
      241 ctatggtggg ggcttcagca gcagcagttt tggtggtgga tttggtggag gaattggtgg
      301 tggtattggt ggaggacttg gtggtggtat tggtggtgga tttggtggtg gtattggtgg
      361 tggatttggt ggtggtattg gtagtggatt tggtggtggt cttggcgatg ggctcctggt
      421 tggcagtgag aaagtgacca tgcagaacct caatgaccgc ttggccacct acctggataa
      481 ggtgcgtgcc ctggaagagg ccaacagtga cctggaggtg aagatccgtg actggtacca
      541 gaggcagcgc cccactgaga tcaaagacta cagcccctac ttcaagacca tcgaggacct
      601 gaagagcaag atcctggcag ccactgtgga caatgccaat gtcctcctgc agattgacaa
      661 tgcccgcctg gcggctgatg acttccgtac caagtttgag acagagcaga gcctgcgcat
      721 aaatgtggag tctgacatca atggcctacg ccgggtgctg gatgagctga ccctggccag
      781 agctgacctg gagatgcaga ttgagagcct caaggaagag ctggcctacc tgaagaagaa
      841 ccacgaggag gaaatggctt ccatgagagg ccaggtgggc ggggacgtca acgtggagat
      901 ggatgcggcc cctggtgtgg acctgagccg catcctgaac gagatgcggg atcagtatga
      961 gaagatggca gagaagaacc gcaaggatgc cgaagattgg ttcttcacca agacagagga
     1021 gctgaaccgc gaggtggcca ccaacagcga actggtgcag agcggcaaga gcgagatctc
     1081 cgagctccgg cgcacgatgc agaacctgga gatcgagctg cagtcccagc tcagcatgaa
     1141 agcatccctg gagaataacc tggaggagac caaaggccgt tactgcatgc agctggccca
     1201 gatccaggag atgatcggca gcgtggagga gcagctggct cagctgcgct gcgagatgga
     1261 gcagcagaat caggagtaca agatcctgct ggatgtgaag actcggctgg agcaggagat
     1321 cgccacctac cgccgtctgc tggagggcga ggatgctcac ctttcatctg cccaattctc
     1381 ctcatcgtct caattctcct ctggctctca atcatccaga gatgtgacct ccaccaaccg
     1441 ccagatccgc accaaggtca tggatgtgca cgatggcaag gtggtctcca cccacgagca
     1501 ggtcctgcgc accaagaact aaggctgcta gatgctgctc aggcttgagg ggctcctgcg
     1561 tcgatgcaga tactgttgga agagcccctg cattgtccct acatgcttca ccccctgctt
     1621 gaccctcgtc ctggcaagca ataaagcttc tttttctgag ttgcacaa
//
