LOCUS       NM_001413356            2100 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus keratin 10 (Krt10), mRNA.
ACCESSION   NM_001413356 XM_008768091
VERSION     NM_001413356.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2100)
  AUTHORS   Bunick,C.G. and Milstone,L.M.
  TITLE     The X-Ray Crystal Structure of the Keratin 1-Keratin 10 Helix 2B
            Heterodimer Reveals Molecular Surface Properties and Biochemical
            Insights into Human Skin Disease
  JOURNAL   J Invest Dermatol 137 (1), 142-150 (2017)
   PUBMED   27595935
REFERENCE   2  (bases 1 to 2100)
  AUTHORS   Fischer,H., Langbein,L., Reichelt,J., Buchberger,M., Tschachler,E.
            and Eckhart,L.
  TITLE     Keratins K2 and K10 are essential for the epidermal integrity of
            plantar skin
  JOURNAL   J Dermatol Sci 81 (1), 10-16 (2016)
   PUBMED   26603179
REFERENCE   3  (bases 1 to 2100)
  AUTHORS   Fischer,H., Langbein,L., Reichelt,J., Praetzel-Wunder,S.,
            Buchberger,M., Ghannadan,M., Tschachler,E. and Eckhart,L.
  TITLE     Loss of keratin K2 expression causes aberrant aggregation of K10,
            hyperkeratosis, and inflammation
  JOURNAL   J Invest Dermatol 134 (10), 2579-2588 (2014)
   PUBMED   24751727
REFERENCE   4  (bases 1 to 2100)
  AUTHORS   Pieragostino,D., Agnifili,L., Fasanella,V., D'Aguanno,S.,
            Mastropasqua,R., Di Ilio,C., Sacchetta,P., Urbani,A. and Del
            Boccio,P.
  TITLE     Shotgun proteomics reveals specific modulated protein patterns in
            tears of patients with primary open angle glaucoma naive to therapy
  JOURNAL   Mol Biosyst 9 (6), 1108-1116 (2013)
   PUBMED   23580065
REFERENCE   5  (bases 1 to 2100)
  AUTHORS   Mantel,A., Carpenter-Mendini,A.B., Vanbuskirk,J.B., De
            Benedetto,A., Beck,L.A. and Pentland,A.P.
  TITLE     Aldo-keto reductase 1C3 is expressed in differentiated human
            epidermis, affects keratinocyte differentiation, and is upregulated
            in atopic dermatitis
  JOURNAL   J Invest Dermatol 132 (4), 1103-1110 (2012)
   PUBMED   22170488
REFERENCE   6  (bases 1 to 2100)
  AUTHORS   Cheng,X., Mihindukulasuriya,K., Den,Z., Kowalczyk,A.P.,
            Calkins,C.C., Ishiko,A., Shimizu,A. and Koch,P.J.
  TITLE     Assessment of splice variant-specific functions of desmocollin 1 in
            the skin
  JOURNAL   Mol Cell Biol 24 (1), 154-163 (2004)
   PUBMED   14673151
REFERENCE   7  (bases 1 to 2100)
  AUTHORS   van Niel,G., Raposo,G., Candalh,C., Boussac,M., Hershberg,R.,
            Cerf-Bensussan,N. and Heyman,M.
  TITLE     Intestinal epithelial cells secrete exosome-like vesicles
  JOURNAL   Gastroenterology 121 (2), 337-349 (2001)
   PUBMED   11487543
REFERENCE   8  (bases 1 to 2100)
  AUTHORS   Steinert,P.M. and Marekov,L.N.
  TITLE     The proteins elafin, filaggrin, keratin intermediate filaments,
            loricrin, and small proline-rich proteins 1 and 2 are isodipeptide
            cross-linked components of the human epidermal cornified cell
            envelope
  JOURNAL   J Biol Chem 270 (30), 17702-17711 (1995)
   PUBMED   7543090
REFERENCE   9  (bases 1 to 2100)
  AUTHORS   Syder,A.J., Yu,Q.C., Paller,A.S., Giudice,G., Pearson,R. and
            Fuchs,E.
  TITLE     Genetic mutations in the K1 and K10 genes of patients with
            epidermolytic hyperkeratosis. Correlation between location and
            disease severity
  JOURNAL   J Clin Invest 93 (4), 1533-1542 (1994)
   PUBMED   7512983
REFERENCE   10 (bases 1 to 2100)
  AUTHORS   Kartasova,T., Roop,D.R., Holbrook,K.A. and Yuspa,S.H.
  TITLE     Mouse differentiation-specific keratins 1 and 10 require a
            preexisting keratin scaffold to form a filament network
  JOURNAL   J Cell Biol 120 (5), 1251-1261 (1993)
   PUBMED   7679677
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Oct 31, 2022 this sequence version replaced XM_008768091.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643294.41721.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN11044071, SAMN16093045
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-653               JAXUCZ010000010.1  84838508-84839160   c
            654-736             JAXUCZ010000010.1  84837657-84837739   c
            737-893             JAXUCZ010000010.1  84837043-84837199   c
            894-1055            JAXUCZ010000010.1  84836775-84836936   c
            1056-1181           JAXUCZ010000010.1  84836556-84836681   c
            1182-1399           JAXUCZ010000010.1  84836106-84836323   c
            1400-1722           JAXUCZ010000010.1  84835523-84835845   c
            1723-2100           JAXUCZ010000010.1  84834865-84835242   c
FEATURES             Location/Qualifiers
     source          1..2100
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q31"
     gene            1..2100
                     /gene="Krt10"
                     /gene_synonym="Ka10"
                     /note="keratin 10"
                     /db_xref="GeneID:450225"
                     /db_xref="RGD:1359092"
     exon            1..653
                     /gene="Krt10"
                     /gene_synonym="Ka10"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..1829
                     /gene="Krt10"
                     /gene_synonym="Ka10"
                     /note="type I keratin KA10; CK-10; cytokeratin-10; K10;
                     keratin 10, type I"
                     /codon_start=1
                     /product="keratin, type I cytoskeletal 10"
                     /protein_id="NP_001400285.1"
                     /db_xref="GeneID:450225"
                     /db_xref="RGD:1359092"
                     /translation="MSVRFSSNSRQYSSARSGGGGGGGGGGSSIRVSSTKSSLGGGYS
                     SGGFSGGSFSRGSSSGGCFGGSSGGYGGFGGGSFGGGYGGGSFGGGYGGGSFGGGYGG
                     GSFGGGYGGGSFGGGSFGGGSFGGGSFGGGLGGDGGGLLSGNEKVTMQNLNDRLASYM
                     NKVRDLEESNYELEGKIKEWYEKHGNSSQREPRDYSKYYKTIEDLKGQIVNLTTDNAN
                     VLLQIDNARLAADDFRLKYENEVALRQSVEADINGLRRVLDELTLSKADLEMQIESLT
                     EELAYLKKNHEEEMKDLQNVSTGDVNVEMNAAPGVDLTQLLNNMRNQYEQLAEKNRKD
                     AEAWFNEKSKELTTEIDSNIEQMSSHKSEITELRRTVQGLEIELQSQLALKQSLEASL
                     AETEGRYCVQLSQIQSQISALEEQLQQIRAETECQNAEYQQLLDIKTRLENEIQTYRS
                     LLEGEGGSGGGSYGGGGRGGGGHGGSYGGGSTGGGGGSGSYGGGSSGGGGHGGSSGGG
                     YGGGSSSGGGHGGSSGGGYGGGSSSGGQSGSGGFKTSGSGGGDQSSKGPRSAETSWDT
                     NKTRVIKTIIEEVTPEGRVLSSMIESETKKHFY"
     exon            654..736
                     /gene="Krt10"
                     /gene_synonym="Ka10"
                     /inference="alignment:Splign:2.1.0"
     exon            737..893
                     /gene="Krt10"
                     /gene_synonym="Ka10"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1055
                     /gene="Krt10"
                     /gene_synonym="Ka10"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1181
                     /gene="Krt10"
                     /gene_synonym="Ka10"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1399
                     /gene="Krt10"
                     /gene_synonym="Ka10"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1722
                     /gene="Krt10"
                     /gene_synonym="Ka10"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..2100
                     /gene="Krt10"
                     /gene_synonym="Ka10"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagcactcct cgggctacac tacaccacca tgtctgttcg attcagctcc aacagcaggc
       61 agtactcctc cgcccgcagt ggaggaggag gaggaggtgg tggtggtgga tcatccatca
      121 gagtttccag caccaaaagc tcccttggtg gagggtacag ctcagggggg ttcagcggtg
      181 gctcttttag ccgtgggagc tctagcggag gttgctttgg gggctcatca ggtggctatg
      241 gaggctttgg agggggcagc ttcgggggtg gctatggagg aggcagcttt ggtggaggct
      301 acggaggagg cagctttggt ggaggctatg gaggaggcag cttcggtgga ggatatggag
      361 gaggcagctt cggtggaggc agcttcggtg gaggaagctt cggtggagga agcttcggcg
      421 gtgggcttgg aggagatggt ggtggccttc tctctggaaa tgaaaaggtg accatgcaga
      481 acctgaatga ccgcctggcc tcctacatga acaaggtccg ggatctggaa gagtcaaact
      541 atgagctgga gggtaaaatc aaggagtggt acgagaagca cggcaactcc agccagcgag
      601 agccccggga ctacagcaaa tactacaaaa ccatcgaaga ccttaaaggg cagatcgtca
      661 acctgacaac tgacaatgcc aatgtcctgc tgcagattga caatgccaga ctggcagctg
      721 atgacttcag gctgaagtat gagaatgaag tagccctgcg ccagagtgtg gaggccgaca
      781 ttaatggcct gcgcagggtg ctggacgaac tgaccctcag caaggctgac ctggagatgc
      841 agatcgaaag tttgactgaa gagctggctt acctgaagaa gaaccacgaa gaggaaatga
      901 aagaccttca aaatgtatcc actggtgatg tgaacgtgga aatgaacgct gccccagggg
      961 tggacctgac tcagctgctc aacaacatga gaaaccaata cgaacaactt gcagaaaaga
     1021 atcgcaagga cgcagaagcc tggttcaatg agaagagcaa ggaactcacc acagaaatcg
     1081 acagcaacat tgaacaaatg tccagccata agagtgaaat cactgaattg agacgcactg
     1141 ttcagggtct ggagatcgaa ctacagtccc agctggccct gaaacaatcg ctggaagcct
     1201 ccttggcaga aacagaagga cgctactgcg tgcagctctc ccagattcaa agccagatct
     1261 ccgccctgga ggaacaactg caacagattc gggctgaaac cgagtgccag aacgccgagt
     1321 accaacaact cctagacatt aagacccgcc tggagaacga gatccaaacc taccgcagcc
     1381 tgctagaagg agaaggaggt tccggaggcg gatcctacgg cggcggcgga cgtggcggcg
     1441 gcggccacgg cggcagctac ggcggcggaa gtaccggcgg cggcggcgga agcggaagct
     1501 acggcggtgg aagctccggc ggcggtggcc acggaggcag ttccggtggc ggctacggcg
     1561 gcggaagttc cagcggcggt ggtcacggcg gcagttccgg tggtggctac ggcggcggaa
     1621 gttccagtgg aggccagagc ggaagcggag ggttcaagac ttccgggtcc ggtggcgggg
     1681 accaatcgtc taaaggccca aggtcagcag aaactagctg ggatactaat aaaaccagag
     1741 tgatcaagac gattattgag gaggtgacac ctgagggtag agtcctttcg tctatgattg
     1801 aatcagaaac caagaaacac ttctactaag ctgcttagaa gagtctctaa acacaggcca
     1861 actgtacaga cgtgtggaaa acaaaatgtc caggaaaaca cttctgtctt aatggtctat
     1921 ggaaataggt tcgctccttg aaattaaggg tctaaaaggt gttttgtggt ttctgtattt
     1981 cttcttttca tttatcagaa agtgttcttt tgtggagaaa aaaaagaaaa ctttctcatt
     2041 tactaatgaa tttctcattt actaatgaat ttcaataaac tttctcactc atgcaaacta
//
