LOCUS       NM_001008802            2429 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus keratin 1 (Krt1), mRNA.
ACCESSION   NM_001008802
VERSION     NM_001008802.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2429)
  AUTHORS   Zhang,L., Zeng,X.X., Li,Y.M., Chen,S.K., Tang,L.Y., Wang,N.,
            Yang,X. and Lin,M.J.
  TITLE     Keratin 1 attenuates hypoxic pulmonary artery hypertension by
            suppressing pulmonary artery media smooth muscle expansion
  JOURNAL   Acta Physiol (Oxf) 231 (2), e13558 (2021)
   PUBMED   32920982
  REMARK    GeneRIF: Keratin 1 attenuates hypoxic pulmonary artery hypertension
            by suppressing pulmonary artery media smooth muscle expansion.
REFERENCE   2  (bases 1 to 2429)
  AUTHORS   Bunick,C.G. and Milstone,L.M.
  TITLE     The X-Ray Crystal Structure of the Keratin 1-Keratin 10 Helix 2B
            Heterodimer Reveals Molecular Surface Properties and Biochemical
            Insights into Human Skin Disease
  JOURNAL   J Invest Dermatol 137 (1), 142-150 (2017)
   PUBMED   27595935
REFERENCE   3  (bases 1 to 2429)
  AUTHORS   Soteriou,D., Iskender,B., Byron,A., Humphries,J.D.,
            Borg-Bartolo,S., Haddock,M.C., Baxter,M.A., Knight,D.,
            Humphries,M.J. and Kimber,S.J.
  TITLE     Comparative proteomic analysis of supportive and unsupportive
            extracellular matrix substrates for human embryonic stem cell
            maintenance
  JOURNAL   J Biol Chem 288 (26), 18716-18731 (2013)
   PUBMED   23658023
REFERENCE   4  (bases 1 to 2429)
  AUTHORS   Pieragostino,D., Agnifili,L., Fasanella,V., D'Aguanno,S.,
            Mastropasqua,R., Di Ilio,C., Sacchetta,P., Urbani,A. and Del
            Boccio,P.
  TITLE     Shotgun proteomics reveals specific modulated protein patterns in
            tears of patients with primary open angle glaucoma naive to therapy
  JOURNAL   Mol Biosyst 9 (6), 1108-1116 (2013)
   PUBMED   23580065
REFERENCE   5  (bases 1 to 2429)
  AUTHORS   Roth,W., Kumar,V., Beer,H.D., Richter,M., Wohlenberg,C., Reuter,U.,
            Thiering,S., Staratschek-Jox,A., Hofmann,A., Kreusch,F.,
            Schultze,J.L., Vogl,T., Roth,J., Reichelt,J., Hausser,I. and
            Magin,T.M.
  TITLE     Keratin 1 maintains skin integrity and participates in an
            inflammatory network in skin through interleukin-18
  JOURNAL   J Cell Sci 125 (Pt 22), 5269-5279 (2012)
   PUBMED   23132931
REFERENCE   6  (bases 1 to 2429)
  AUTHORS   van Niel,G., Raposo,G., Candalh,C., Boussac,M., Hershberg,R.,
            Cerf-Bensussan,N. and Heyman,M.
  TITLE     Intestinal epithelial cells secrete exosome-like vesicles
  JOURNAL   Gastroenterology 121 (2), 337-349 (2001)
   PUBMED   11487543
REFERENCE   7  (bases 1 to 2429)
  AUTHORS   Mahdi,F., Shariat-Madar,Z., Todd,R.F. 3rd, Figueroa,C.D. and
            Schmaier,A.H.
  TITLE     Expression and colocalization of cytokeratin 1 and urokinase
            plasminogen activator receptor on endothelial cells
  JOURNAL   Blood 97 (8), 2342-2350 (2001)
   PUBMED   11290596
REFERENCE   8  (bases 1 to 2429)
  AUTHORS   Sprecher,E., Ishida-Yamamoto,A., Becker,O.M., Marekov,L.,
            Miller,C.J., Steinert,P.M., Neldner,K. and Richard,G.
  TITLE     Evidence for novel functions of the keratin tail emerging from a
            mutation causing ichthyosis hystrix
  JOURNAL   J Invest Dermatol 116 (4), 511-519 (2001)
   PUBMED   11286616
REFERENCE   9  (bases 1 to 2429)
  AUTHORS   Steinert,P.M. and Marekov,L.N.
  TITLE     The proteins elafin, filaggrin, keratin intermediate filaments,
            loricrin, and small proline-rich proteins 1 and 2 are isodipeptide
            cross-linked components of the human epidermal cornified cell
            envelope
  JOURNAL   J Biol Chem 270 (30), 17702-17711 (1995)
   PUBMED   7543090
REFERENCE   10 (bases 1 to 2429)
  AUTHORS   Itoh,N., Yonehara,S., Schreurs,J., Gorman,D.M., Maruyama,K.,
            Ishii,A., Yahara,I., Arai,K. and Miyajima,A.
  TITLE     Cloning of an interleukin-3 receptor gene: a member of a distinct
            receptor gene family
  JOURNAL   Science 247 (4940), 324-327 (1990)
   PUBMED   2404337
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC127464.1.
            
            On Dec 31, 2006 this sequence version replaced NM_001008802.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC127464.1, BK001580.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132262,
                                           SAMD00132264 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2429
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..2429
                     /gene="Krt1"
                     /gene_synonym="Kb1"
                     /note="keratin 1"
                     /db_xref="GeneID:300250"
                     /db_xref="RGD:1359664"
     exon            1..636
                     /gene="Krt1"
                     /gene_synonym="Kb1"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..1926
                     /gene="Krt1"
                     /gene_synonym="Kb1"
                     /note="K1; CK-1; cytokeratin-1; type-II keratin Kb1;
                     keratin 1, type II"
                     /codon_start=1
                     /product="keratin, type II cytoskeletal 1"
                     /protein_id="NP_001008802.2"
                     /db_xref="GeneID:300250"
                     /db_xref="RGD:1359664"
                     /translation="MSFQCSSRSLCRSGGGGGGRNFSSGSAGLVSFQRRSTSSSMRRS
                     GGGGGGRFSGGGFCGSSGGGFGSKSLVNLGGGRSISISVAGGGSSYGGGFGGGSYGGG
                     SFGGGSFGGGVGGGFGGGGFGGGGFGSGGGFGGGRFGGGFGPVCPPGGIQEVTINQSL
                     LQPLNVEVDPQIQKVKSQEREQIKSLNDKFASFIDKVRFLEQQNQVLQTKWELLQQVD
                     TSTRTQNLDPFFESYISNLRRQVDSLKNDQSRMDSELKNMQDLVEEYRTKYEDEINKR
                     TNAENEFVTIKKDVDSAYMNKAELQARVDNLQQDIDFFSTLYQMELSQMQTQISETNV
                     VLSMDNNRTLDLDGIIAEVKAQYDSICQRSKAEAETFYQSKYEELQITAGKHGDSVKN
                     TKMEISELNRVIQRLRSEIDSVKKQISQMQQNISDAEQRGEKALKDAQNKLNEIEDAL
                     TQAKEELTRLLRDYQELMNTKLALDMEIATYRKLLEGEEIRMSGECTPNVSVSVSTSH
                     TSMSGSSSRGGGRYGSGGGGGGGSYGGGSRGGSYGGGSGGGSYGGGSSGGGSGGGSYG
                     GGSSGGHRGGSGGGGGSSGGSYGGSSGGGRGGSSSGGGVKSSGSSSVKFVSTTYSRGT
                     N"
     exon            637..851
                     /gene="Krt1"
                     /gene_synonym="Kb1"
                     /inference="alignment:Splign:2.1.0"
     exon            852..912
                     /gene="Krt1"
                     /gene_synonym="Kb1"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1008
                     /gene="Krt1"
                     /gene_synonym="Kb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1173
                     /gene="Krt1"
                     /gene_synonym="Kb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1299
                     /gene="Krt1"
                     /gene_synonym="Kb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1520
                     /gene="Krt1"
                     /gene_synonym="Kb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..1555
                     /gene="Krt1"
                     /gene_synonym="Kb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..2404
                     /gene="Krt1"
                     /gene_synonym="Kb1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagctccttc cgcttcttgt ctttgctctt gcttctctct aagccaccat gagttttcag
       61 tgtagttcca ggtccctgtg ccggagcggt ggtggcggcg gcggcaggaa ctttagctca
      121 ggttctgcag gcctagtcag cttccaacgc agatccacca gcagctccat gcgccgcagc
      181 ggcggaggag gaggtggtag attttcggga ggaggcttct gtgggagctc tggtggtggc
      241 tttggaagta aaagtctggt caacctcgga ggtggcagga gcatctccat aagtgtggct
      301 ggaggtggta gcagctacgg tggtggcttt gggggcggca gctacggtgg cggtagcttt
      361 gggggtggca gttttggtgg aggtgtcggc ggtggttttg gtggtggtgg ttttggtggt
      421 ggcggctttg gtagtggagg tggttttggt ggtggtagat ttgggggtgg tttcgggcct
      481 gtctgtcccc ctggtggcat ccaggaagtg accatcaacc agagccttct gcaacccctc
      541 aatgtcgagg tggaccctca gatccaaaaa gtgaagtctc aggagagaga acagatcaag
      601 tcgctcaatg acaaatttgc ctccttcatc gacaaggtgc gcttcctaga gcaacaaaac
      661 caggtgctac agaccaaatg ggagctgctg cagcaggtag acacctcaac ccggacccaa
      721 aacttagatc ctttcttcga gtcatacatc agcaacctca ggaggcaagt ggactcactg
      781 aagaacgacc aatcacggat ggattccgaa ctgaagaaca tgcaagacct ggtggaagag
      841 tacaggacca agtacgagga tgaaatcaac aagagaacca acgcagagaa tgaattcgtg
      901 accatcaaga aggatgtgga ttcggcttat atgaacaaag cagagcttca ggccagggtg
      961 gataacctcc aacaagatat cgacttcttc tccacactct accaaatgga attgtctcag
     1021 atgcaaactc aaatcagcga aaccaacgtt gtcctgtcca tggacaacaa ccgcactttg
     1081 gacctggacg gcatcattgc agaagtcaag gcccagtatg atagcatttg ccagaggagc
     1141 aaggccgaag ccgagacctt ttaccagagc aagtatgaag agctgcagat cactgctggt
     1201 aaacacggag acagcgtgaa aaataccaag atggagattt ccgagctgaa cagagtgatc
     1261 cagagacttc gatctgaaat cgatagcgtc aagaagcaga tctcccaaat gcagcagaat
     1321 atcagtgatg cagagcagcg tggtgagaaa gcactcaaag atgctcagaa caagctgaat
     1381 gagatagagg acgctttgac acaagccaag gaggagctca ccaggttgct gcgtgactac
     1441 caggagctga tgaacaccaa gctggccctg gacatggaga tcgccaccta caggaaactt
     1501 ctggaaggag aggagatcag gatgtctgga gaatgcaccc ccaacgtgag cgtgtctgtg
     1561 agcaccagcc acactagcat gagcggaagc agcagccgag gtggcggcag atacggctcc
     1621 ggaggcggcg gcggtggcgg cagctacggc ggcggctcca gaggcggcag ctacggaggt
     1681 ggttccggag gcggcagcta cggaggtggc agctctggag gcggctccgg aggcggcagc
     1741 tacggcggcg gcagcagtgg gggccacaga ggtggctctg gagggggcgg tggcagctcc
     1801 ggaggcagct atggtggttc ctctggggga ggccggggag gatccagctc cggtggcggc
     1861 gttaagtcct ctggcagttc tagtgtgaag tttgtttcca ccacttactc ccgagggacc
     1921 aactaaagag gtgcccacca caccattagc tctccctttc catcaaggct aaacgtggcg
     1981 ggcaaaacca aaaccaattg caccagcctt attagagaaa agagctatgg ttaaatgctc
     2041 agattaggct tatttccccc gcgctttctt ttctgctcag cttgcaaaga agttttcata
     2101 ttagtagcag tctgagtccc ctggtaacaa ccccactctt atgttttgct gagaaacagc
     2161 ttagagctgc catcaccaac atgacatttc aaagaggact tcagatccag aactttgcct
     2221 ggcacgccca gagcactgga ctgcccctta gcatcctgta tcctgcagca cacagagctg
     2281 cttttggttt tgtacataag gtgtttgcga gtgtctttta cggagcgctc tgaacaaccc
     2341 ctcccctgcc caccctgccc catttctttg ttttgctgca ataaactgca tttgaaactc
     2401 tcaaaaaaaa aaaaaaaaaa aaaaaaaaa
//
