LOCUS       NM_001108618            3045 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus KRIT1, ankyrin repeat containing (Krit1), mRNA.
ACCESSION   NM_001108618 XM_001064073 XM_342634
VERSION     NM_001108618.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3045)
  AUTHORS   Calderwood DA, Campbell ID and Critchley DR.
  TITLE     Talins and kindlins: partners in integrin-mediated adhesion
  JOURNAL   Nat Rev Mol Cell Biol 14 (8), 503-517 (2013)
   PUBMED   23860236
  REMARK    Review article
REFERENCE   2  (bases 1 to 3045)
  AUTHORS   Bouvard D, Pouwels J, De Franceschi N and Ivaska J.
  TITLE     Integrin inactivators: balancing cellular functions in vitro and in
            vivo
  JOURNAL   Nat Rev Mol Cell Biol 14 (7), 430-442 (2013)
   PUBMED   23719537
  REMARK    Review article
REFERENCE   3  (bases 1 to 3045)
  AUTHORS   Gingras AR, Liu JJ and Ginsberg MH.
  TITLE     Structural basis of the junctional anchorage of the cerebral
            cavernous malformations complex
  JOURNAL   J Cell Biol 199 (1), 39-48 (2012)
   PUBMED   23007647
REFERENCE   4  (bases 1 to 3045)
  AUTHORS   Bohm D, Keller K, Pieter J, Boehm N, Wolters D, Siggelkow W,
            Lebrecht A, Schmidt M, Kolbl H, Pfeiffer N and Grus FH.
  TITLE     Comparison of tear protein levels in breast cancer patients and
            healthy controls using a de novo proteomic approach
  JOURNAL   Oncol Rep 28 (2), 429-438 (2012)
   PUBMED   22664934
REFERENCE   5  (bases 1 to 3045)
  AUTHORS   Guazzi P, Goitre L, Ferro E, Cutano V, Martino C, Trabalzini L and
            Retta SF.
  TITLE     Identification of the Kelch family protein Nd1-L as a novel
            molecular interactor of KRIT1
  JOURNAL   PLoS One 7 (9), e44705 (2012)
   PUBMED   22970292
REFERENCE   6  (bases 1 to 3045)
  AUTHORS   Guclu B, Ozturk AK, Pricola KL, Seker A, Ozek M and Gunel M.
  TITLE     Cerebral venous malformations have distinct genetic origin from
            cerebral cavernous malformations
  JOURNAL   Stroke 36 (11), 2479-2480 (2005)
   PUBMED   16239636
REFERENCE   7  (bases 1 to 3045)
  AUTHORS   Verlaan DJ, Laurent SB, Sure U, Bertalanffy H, Andermann E,
            Andermann F, Rouleau GA and Siegel AM.
  TITLE     CCM1 mutation screen of sporadic cases with cerebral cavernous
            malformations
  JOURNAL   Neurology 62 (7), 1213-1215 (2004)
   PUBMED   15079030
REFERENCE   8  (bases 1 to 3045)
  AUTHORS   Denier C, Labauge P, Brunereau L, Cave-Riant F, Marchelli F,
            Arnoult M, Cecillon M, Maciazek J, Joutel A and Tournier-Lasserve
            E.
  CONSRTM   Societe Francaise de Neurochirgurgie; Societe de Neurochirurgie de
            Langue Francaise
  TITLE     Clinical features of cerebral cavernous malformations patients with
            KRIT1 mutations
  JOURNAL   Ann Neurol 55 (2), 213-220 (2004)
   PUBMED   14755725
REFERENCE   9  (bases 1 to 3045)
  AUTHORS   Marini V, Ferrera L, Dorcaratto A, Viale G, Origone P, Mareni C and
            Garre C.
  TITLE     Identification of a novel KRIT1 mutation in an Italian family with
            cerebral cavernous malformation by the protein truncation test
  JOURNAL   J Neurol Sci 212 (1-2), 75-78 (2003)
   PUBMED   12810002
REFERENCE   10 (bases 1 to 3045)
  AUTHORS   Lucas M, Costa AF, Garcia-Moreno JM, Solano F, Gamero MA and
            Izquierdo G.
  TITLE     Variable expression of cerebral cavernous malformations in carriers
            of a premature termination codon in exon 17 of the Krit1 gene
  JOURNAL   BMC Neurol 3, 5 (2003)
   PUBMED   12877753
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474013.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_342634.3, XM_001064073.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168923.1, SRR8487231.17752.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3045
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q13"
     gene            1..3045
                     /gene="Krit1"
                     /gene_synonym="RGD1305929"
                     /note="KRIT1, ankyrin repeat containing"
                     /db_xref="GeneID:362317"
                     /db_xref="RGD:1305929"
     exon            1..297
                     /gene="Krit1"
                     /gene_synonym="RGD1305929"
                     /inference="alignment:Splign:2.1.0"
     exon            298..447
                     /gene="Krit1"
                     /gene_synonym="RGD1305929"
                     /inference="alignment:Splign:2.1.0"
     CDS             346..2556
                     /gene="Krit1"
                     /gene_synonym="RGD1305929"
                     /codon_start=1
                     /product="krev interaction trapped protein 1"
                     /protein_id="NP_001102088.1"
                     /db_xref="GeneID:362317"
                     /db_xref="RGD:1305929"
                     /translation="MGNPENIEDVYVAVIRPKNTASLNSREYRAKSYEILLHEVPIEG
                     QKKKRKKVLLETKLQGNSEIAQGILDYVVETTKPISPANQGIKGKRVVLMKKFPLDGE
                     KTGREAALFIVPSVVKDNTKYAYTPGCPIFYCLQDIMRVCSESSTHFATLTARMLIAL
                     DKWLDERHAQSHFIPALFRPSPLERIKTNVINPAYAAELGQIENSLHMGYSALEIKSK
                     MLALEKADTCIYNPLFGSDLQYTNRVDKVVINPYFGLGAPDYSKIQIPKQEKWQRSMS
                     SVVEDKERQWVDDFPLHRNACEGDSELLSHLLDKGFSVNQLDNDHWAPIHYACWYGKV
                     EATRILLEKGKCNPNLLNGQLSSPLHFAAGGGHSEIVQILLTHPDIDRHITDQQGRSP
                     LNVCEENKQNNWEEAAKLLKEAINKPYEKVRIYRMDGSYRSVELKHGNNTTAQQIMEG
                     MRLSQETQQCFTIWICSENLSLQFKPYHKPLQQVRDWPEILAELTNLDPQRETPQLFL
                     RRDVGLPLEVEKKIEDPLAILILFDEARYNLLKGFYTAPDAKLITLASLLLQIVYGNY
                     ESKKHKQGFLNEENLKSIVPITKLKSKAPHWINRILHEYKNLSMSEGVSKEMHHLQRM
                     FLQNCWEIPTYGAAFFTGQIFTKASPSNHKVIPVYVGVNIKGLHLLNMETKALLISLK
                     YCCFTWQLGDAGTCFQIHSMENKMSFIVHTKQAGLVVKLLMKLNGQLMPSERNS"
     exon            448..607
                     /gene="Krit1"
                     /gene_synonym="RGD1305929"
                     /inference="alignment:Splign:2.1.0"
     exon            608..700
                     /gene="Krit1"
                     /gene_synonym="RGD1305929"
                     /inference="alignment:Splign:2.1.0"
     exon            701..830
                     /gene="Krit1"
                     /gene_synonym="RGD1305929"
                     /inference="alignment:Splign:2.1.0"
     exon            831..1074
                     /gene="Krit1"
                     /gene_synonym="RGD1305929"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1190
                     /gene="Krit1"
                     /gene_synonym="RGD1305929"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1334
                     /gene="Krit1"
                     /gene_synonym="RGD1305929"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1491
                     /gene="Krit1"
                     /gene_synonym="RGD1305929"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1599
                     /gene="Krit1"
                     /gene_synonym="RGD1305929"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..1756
                     /gene="Krit1"
                     /gene_synonym="RGD1305929"
                     /inference="alignment:Splign:2.1.0"
     exon            1757..1908
                     /gene="Krit1"
                     /gene_synonym="RGD1305929"
                     /inference="alignment:Splign:2.1.0"
     exon            1909..2075
                     /gene="Krit1"
                     /gene_synonym="RGD1305929"
                     /inference="alignment:Splign:2.1.0"
     exon            2076..2163
                     /gene="Krit1"
                     /gene_synonym="RGD1305929"
                     /inference="alignment:Splign:2.1.0"
     exon            2164..2370
                     /gene="Krit1"
                     /gene_synonym="RGD1305929"
                     /inference="alignment:Splign:2.1.0"
     exon            2371..2487
                     /gene="Krit1"
                     /gene_synonym="RGD1305929"
                     /inference="alignment:Splign:2.1.0"
     exon            2488..3045
                     /gene="Krit1"
                     /gene_synonym="RGD1305929"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggcgggatg gcgagctgag gccttgggat ccccgagctt gtggagaggc tgaagggttc
       61 gtggggccga ggaaaaggaa agacagtgga gaacaggtgc tcagagactc gaactcgagg
      121 ggcggcttct gatgacaacc ctggggcttc ctgctacagg aagttgggtt gggcctctag
      181 acctttagaa aggcagaagg aatgagaaaa cggtgacggg ctcctccatc caccggttgc
      241 cgccccaccc tctgacttgg atgtagcggc ttgtgagaag atccgccgcc ggctcggtta
      301 tgccatttcc tcttccaagg aactttttgt ttgttttata aagcaatggg aaatccagaa
      361 aacatagaag atgtatacgt tgcagttatc cgaccaaaga acactgccag tctcaactct
      421 cgggagtata gagctaagtc ctatgaaatt ttattgcatg aagttcccat tgaaggacag
      481 aaaaagaaga gaaagaaagt tttgctggaa actaaacttc aaggcaatag tgaaatagca
      541 caaggcatat tggactatgt agtagaaact accaaaccaa tttctcctgc aaaccagggg
      601 atcaaaggaa aacgagtggt gctgatgaag aaatttcctc tggatggaga gaagacaggc
      661 agggaagcag cactatttat tgttccatca gtcgtcaaag ataatactaa atatgcatat
      721 actcccggat gtccaatctt ttactgctta caagatatta tgagagtttg tagtgaatcc
      781 agtactcact ttgcaacact tacagcaaga atgttaatag ccttggataa gtggttagat
      841 gaacgtcatg cacaatctca ctttattcca gctttattcc gaccttctcc ccttgaacgg
      901 ataaagacaa atgtcataaa ccctgcgtat gctgctgaac taggtcagat agaaaactca
      961 ctacatatgg gctatagtgc actagaaata aagagtaaaa tgctagccct agagaaagca
     1021 gacacctgca tttataaccc tttgtttggg tcagatcttc agtatacaaa tcgggtagat
     1081 aaagtggtaa taaatccata ctttggtctc ggagctccag actactcaaa aatccaaatt
     1141 cccaaacagg aaaagtggca gcgaagcatg agcagtgttg tggaggacaa agaacgacaa
     1201 tgggttgatg actttccttt acatcgaaat gcctgtgaag gagattcaga attactaagc
     1261 catcttctgg ataaaggatt ttcagtcaac caactagata atgaccactg ggcacccatt
     1321 cattatgcat gctggtatgg aaaggttgag gccactcgca tattattaga gaaaggaaag
     1381 tgcaatccaa accttttaaa tggccagctc agctcaccgc ttcattttgc tgctggaggg
     1441 ggacattcgg aaatagtaca gatccttcta actcacccag acattgacag acacataaca
     1501 gaccaacaag gaagatcccc attaaatgtt tgtgaagaaa acaaacaaaa taactgggaa
     1561 gaagctgcaa aattgttgaa agaagccatt aacaagccat atgaaaaagt ccgaatctac
     1621 agaatggatg ggtcatatcg ttctgttgaa ctcaagcacg gcaataatac cacggcgcag
     1681 cagataatgg aaggaatgag actctctcag gaaactcagc aatgcttcac tatttggatc
     1741 tgttcagaga atcttagtct tcagttcaag ccttatcata aacccttgca acaagttcgt
     1801 gactggccag aaatacttgc tgaattgact aatttggatc cacaaagaga aacaccacag
     1861 cttttcctaa gaagagatgt gggacttcct ttagaagttg agaaaaagat tgaagaccca
     1921 ctagctattc ttattctctt tgatgaagcc agatataatt tactgaaggg cttttatacg
     1981 gctcctgatg ctaaactgat aacactggca agtctactgt tacaaatagt ttatgggaat
     2041 tatgagagta aaaaacacaa acaaggtttc ttaaatgaag aaaatctgaa atccatcgta
     2101 cctattacta aactgaaaag taaggcacct cactggataa atcggatact ccatgagtac
     2161 aagaacctta gcatgagtga gggtgtcagt aaggaaatgc atcacctgca acgcatgttt
     2221 ctacagaact gctgggaaat tcctacatac ggagcagctt ttttcacagg acagatattt
     2281 acaaaggcaa gcccaagcaa tcataaagtc atccctgtgt atgtgggagt gaacatcaaa
     2341 ggacttcatc tcctaaacat ggaaactaag gccttactca tcagccttaa gtactgttgc
     2401 tttacgtggc agctgggaga tgctggtact tgttttcaaa tccacagtat ggaaaataaa
     2461 atgagcttta tagtacacac aaaacaggct ggtcttgtgg taaagctgct aatgaagtta
     2521 aatggacaac taatgccctc tgaaagaaat tcatgaaaag aatttgagtt tgagtatgaa
     2581 ccaccacctt ttgcaatgta gaatttttcc atgaaagatt tctgaaaata tgacctaaca
     2641 aggcatgtag tctcatgtag tatgtgtatg ctgttacatt attgtacaga atctgtactc
     2701 gtgtttggtg tgtaatatac cacttagttt tgtatgatat gctcataagc tcttctaatt
     2761 tttgagagaa acacataaaa atagatcagc aatctgtatt atattagaca aaaatagtaa
     2821 gctttataaa aagttatttt tggtaaacag taaagaattt agtgtggagt gggctgagat
     2881 taaaatatag ctttgatata attttgtgtg ttacttcaaa atattctgaa aaccaacatg
     2941 atttgaataa ataaaatgta ttttgtactt agatctgtta cttaaaccat ttcttctgtg
     3001 atctctaaac atgtctcaag gtgtttctaa acgtcttcac taaag
//
