LOCUS       NM_053649               2045 bp    mRNA    linear   ROD 27-JUL-2024
DEFINITION  Rattus norvegicus kringle containing transmembrane protein 1
            (Kremen1), mRNA.
ACCESSION   NM_053649
VERSION     NM_053649.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2045)
  AUTHORS   Causeret,F., Sumia,I. and Pierani,A.
  TITLE     Kremen1 and Dickkopf1 control cell survival in a Wnt-independent
            manner
  JOURNAL   Cell Death Differ 23 (2), 323-332 (2016)
   PUBMED   26206087
REFERENCE   2  (bases 1 to 2045)
  AUTHORS   Wu,D. and Murashov,A.K.
  TITLE     MicroRNA-431 regulates axon regeneration in mature sensory neurons
            by targeting the Wnt antagonist Kremen1
  JOURNAL   Front Mol Neurosci 6, 35 (2013)
   PUBMED   24167472
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2045)
  AUTHORS   Ellwanger,K., Saito,H., Clement-Lacroix,P., Maltry,N.,
            Niedermeyer,J., Lee,W.K., Baron,R., Rawadi,G., Westphal,H. and
            Niehrs,C.
  TITLE     Targeted disruption of the Wnt regulator Kremen induces limb
            defects and high bone density
  JOURNAL   Mol Cell Biol 28 (15), 4875-4882 (2008)
   PUBMED   18505822
REFERENCE   4  (bases 1 to 2045)
  AUTHORS   Niehrs,C.
  TITLE     Function and biological roles of the Dickkopf family of Wnt
            modulators
  JOURNAL   Oncogene 25 (57), 7469-7481 (2006)
   PUBMED   17143291
  REMARK    Review article
REFERENCE   5  (bases 1 to 2045)
  AUTHORS   Nakamura,T., Aoki,S., Kitajima,K., Takahashi,T., Matsumoto,K. and
            Nakamura,T.
  TITLE     Molecular cloning and characterization of Kremen, a novel
            kringle-containing transmembrane protein
  JOURNAL   Biochim Biophys Acta 1518 (1-2), 63-72 (2001)
   PUBMED   11267660
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB065090.1.
            
            [WARNING] On Oct 7, 2024 this sequence was replaced by NM_053649.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB065090.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2045
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..2045
                     /gene="Kremen1"
                     /gene_synonym="Kremen"
                     /note="kringle containing transmembrane protein 1"
                     /db_xref="GeneID:114107"
                     /db_xref="RGD:620789"
     exon            1..107
                     /gene="Kremen1"
                     /gene_synonym="Kremen"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..1438
                     /gene="Kremen1"
                     /gene_synonym="Kremen"
                     /EC_number="2.3.2.27"
                     /note="kremen protein 1; dickkopf receptor; kringle
                     domain-containing transmembrane protein 1;
                     kringle-containing protein marking the eye and the nose;
                     kringle-coding gene marking the eye and the nose"
                     /codon_start=1
                     /product="kremen protein 1 precursor"
                     /protein_id="NP_446101.1"
                     /db_xref="GeneID:114107"
                     /db_xref="RGD:620789"
                     /translation="MAPPAARLALLSAAALTLAARPAPGPRPSPECFTANGADYRGTQ
                     SWTALQGGKPCLFWNETFQHPYNTLKYPNGEGGLGEHNYCRNPDGDVSPWCYVAEHED
                     GVYWKYCEIPACQMPGNLGCYKDHGNPPPLTGTSKTSNKLTIQTCISFCRSQRFKFAG
                     MESGYACFCGNNPDYWKHGEAASTECNNVCFGDHTQPCGGDGRIILFDTLVGACGGNY
                     SSMAAVVYSPDFPDTYATGRVCYWTIRVPGASRIHFNFTIFDIRDSADMVELLDGYTH
                     RVLVRFDGRSRPPLSFNVSLDFVILYFFSDRINQAQGFAVLYQATKEEPPQERPAINQ
                     TLAEVITEQANLSVSAAHSSKVLYVITSSPSHPPQTVPGSHSWVPSVGASGHRVEGWT
                     VYGLATLLILTVTAVVAKILLHVTFKSHRVTASGDLRDCRQPGTSGEIWTIFYEPSTT
                     ISIFKKKLKGQSQQDDRNPLVSD"
     exon            108..270
                     /gene="Kremen1"
                     /gene_synonym="Kremen"
                     /inference="alignment:Splign:2.1.0"
     exon            271..362
                     /gene="Kremen1"
                     /gene_synonym="Kremen"
                     /inference="alignment:Splign:2.1.0"
     exon            363..487
                     /gene="Kremen1"
                     /gene_synonym="Kremen"
                     /inference="alignment:Splign:2.1.0"
     exon            488..641
                     /gene="Kremen1"
                     /gene_synonym="Kremen"
                     /inference="alignment:Splign:2.1.0"
     exon            642..974
                     /gene="Kremen1"
                     /gene_synonym="Kremen"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1184
                     /gene="Kremen1"
                     /gene_synonym="Kremen"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1269
                     /gene="Kremen1"
                     /gene_synonym="Kremen"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..2045
                     /gene="Kremen1"
                     /gene_synonym="Kremen"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccgcactga cggcccatgg cgccgcccgc cgcccgcctc gcgctgctct ccgccgctgc
       61 gctcactctg gcggcccggc ccgcacccgg tccccgcccc agccccgagt gtttcacagc
      121 caatggtgca gattataggg gaacacagag ctggacagca ctgcaaggtg gcaagccatg
      181 tctgttctgg aacgagactt tccagcatcc atacaacaca ctgaaatacc ccaacgggga
      241 aggaggtctg ggtgagcata actattgcag aaatccagat ggagatgtga gcccttggtg
      301 ctacgtggca gagcatgagg atggcgtcta ctggaagtac tgtgaaattc ctgcgtgtca
      361 gatgcctgga aaccttggct gctacaagga tcatggaaac ccacctcctc tcacgggcac
      421 cagtaagacg tccaacaagc tcaccatcca aacctgtatc agcttttgtc ggagtcagag
      481 attcaagttt gctgggatgg agtcaggcta cgcatgcttc tgtgggaata atcctgacta
      541 ctggaagcac ggggaggcag ccagcaccga gtgcaataat gtctgcttcg gggaccacac
      601 gcagccctgc ggtggggacg gcaggattat cctctttgac actctcgtgg gcgcctgcgg
      661 tgggaactac tcctccatgg cagctgtggt ctactctcct gacttccctg acacctacgc
      721 cactgggagg gtctgctact ggactatccg ggttccagga gcctctcgca tccatttcaa
      781 cttcacgata ttcgatatca gggattctgc agacatggtg gagctgctgg acggctacac
      841 ccaccgcgtc ctggtccgct tcgacggcag gagccgtcca cctctgtcct tcaatgtctc
      901 tctggacttc gtcattttat atttcttctc tgatcgcatc aaccaggccc agggatttgc
      961 tgtcttgtac caagccacca aggaagaacc tccacaggag aggcctgcta tcaaccagac
     1021 cctggcagag gtgatcacgg aacaagccaa cctcagcgtc agcgctgccc actcttccaa
     1081 agtcctctat gtcatcacct ccagccccag ccacccaccg cagaccgtcc caggtagcca
     1141 ttcctgggta ccatcagttg gggccagcgg ccacagagtg gaaggatgga ccgtgtatgg
     1201 cctggccacc ctcctcatcc tcacagtcac agccgttgtg gcaaagatcc ttctgcacgt
     1261 gacgtttaaa tctcatcgag ttactgcttc aggagacctt agggactgtc gccagcctgg
     1321 gacttctggg gagatctgga ccattttcta tgaaccctcc actacaatct ctatctttaa
     1381 gaagaagctc aagggtcaga gtcaacaaga tgaccgtaac cccctcgtga gtgactgaag
     1441 cctggccaca cctggatggg aggctccact ccaagctcca gcttgctggg acccctcccc
     1501 ctgaggtttc ctcagaactc cctgcccctc cagtcacctc catctctttt gggggcaccc
     1561 tgttgccgag gcagcacagc atggggtcct ccatcacctt ctctacccta gccgccctgc
     1621 atctctgtcc ccaccgggga tgctaagact ggggctgggc tgacaggacg cagctgggcc
     1681 tggttctcga agactcctgg gtggcgggta ggcatagtgt atgatgagtt ttcttgcttc
     1741 ttctctattt tgtctgcata cagatcagtt ccccctggtc cttacagttt ggaacagagc
     1801 cagactaaaa gacttctcag gttttcttaa aggctgacct ggttcccctc caagtttgtt
     1861 ctcacaaggg atagcaccct ggattagagc tttctctggt gccgattaag gtatgtcgtc
     1921 tagtctgaga ggactgagac agggccacac caggtgtctt cttcctagag gggtcttttc
     1981 aatacccaat gtcgtatggg gcaagcctga tccatgggac agacacagtg aacttcttgt
     2041 gtact
//
