LOCUS       NP_446101                473 aa            linear   ROD 27-JUL-2024
DEFINITION  kremen protein 1 precursor [Rattus norvegicus].
ACCESSION   NP_446101
VERSION     NP_446101.1
DBSOURCE    REFSEQ: accession NM_053649.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 473)
  AUTHORS   Causeret,F., Sumia,I. and Pierani,A.
  TITLE     Kremen1 and Dickkopf1 control cell survival in a Wnt-independent
            manner
  JOURNAL   Cell Death Differ 23 (2), 323-332 (2016)
   PUBMED   26206087
REFERENCE   2  (residues 1 to 473)
  AUTHORS   Wu,D. and Murashov,A.K.
  TITLE     MicroRNA-431 regulates axon regeneration in mature sensory neurons
            by targeting the Wnt antagonist Kremen1
  JOURNAL   Front Mol Neurosci 6, 35 (2013)
   PUBMED   24167472
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 473)
  AUTHORS   Ellwanger,K., Saito,H., Clement-Lacroix,P., Maltry,N.,
            Niedermeyer,J., Lee,W.K., Baron,R., Rawadi,G., Westphal,H. and
            Niehrs,C.
  TITLE     Targeted disruption of the Wnt regulator Kremen induces limb
            defects and high bone density
  JOURNAL   Mol Cell Biol 28 (15), 4875-4882 (2008)
   PUBMED   18505822
REFERENCE   4  (residues 1 to 473)
  AUTHORS   Niehrs,C.
  TITLE     Function and biological roles of the Dickkopf family of Wnt
            modulators
  JOURNAL   Oncogene 25 (57), 7469-7481 (2006)
   PUBMED   17143291
  REMARK    Review article
REFERENCE   5  (residues 1 to 473)
  AUTHORS   Nakamura,T., Aoki,S., Kitajima,K., Takahashi,T., Matsumoto,K. and
            Nakamura,T.
  TITLE     Molecular cloning and characterization of Kremen, a novel
            kringle-containing transmembrane protein
  JOURNAL   Biochim Biophys Acta 1518 (1-2), 63-72 (2001)
   PUBMED   11267660
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB065090.1.
            
            [WARNING] On Oct 7, 2024 this sequence was replaced by NP_446101.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB065090.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..473
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     Protein         1..473
                     /product="kremen protein 1 precursor"
                     /EC_number="2.3.2.27"
                     /note="kremen protein 1; dickkopf receptor; kringle
                     domain-containing transmembrane protein 1;
                     kringle-containing protein marking the eye and the nose;
                     kringle-coding gene marking the eye and the nose"
                     /calculated_mol_wt=50066
     sig_peptide     1..19
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=1822
     mat_peptide     20..473
                     /product="Kremen protein 1. /id=PRO_0000021566"
                     /note="propagated from UniProtKB/Swiss-Prot (Q924S4.1)"
                     /calculated_mol_wt=50066
     Region          29..114
                     /region_name="KR"
                     /note="Kringle domain; Kringle domains are believed to
                     play a role in binding mediators, such as peptides, other
                     proteins, membranes, or phospholipids. They are autonomous
                     structural domains, found in a varying number of copies,
                     in blood clotting and...; cd00108"
                     /db_xref="CDD:238056"
     Site            41
                     /site_type="active"
                     /note="putative domain interaction site [active]"
                     /db_xref="CDD:238056"
     Site            order(58,66,94,96,106)
                     /site_type="other"
                     /note="ligand binding site [chemical binding]"
                     /db_xref="CDD:238056"
     Site            59
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q924S4.1)"
     Region          119..200
                     /region_name="WSC"
                     /note="WSC domain; pfam01822"
                     /db_xref="CDD:460348"
     Region          214..320
                     /region_name="CUB"
                     /note="CUB domain; extracellular domain; present in
                     proteins mostly known to be involved in development; not
                     found in prokaryotes, plants and yeast; cd00041"
                     /db_xref="CDD:238001"
     Site            217
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q924S4.1)"
     Site            order(223,224,226,253,258,291,315,317,319..320)
                     /site_type="other"
                     /note="heterodimerization interface [polypeptide binding]"
                     /db_xref="CDD:238001"
     Site            255
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q924S4.1)"
     Site            293
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q924S4.1)"
     Site            333
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q924S4.1)"
     Site            345
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q924S4.1)"
     Site            393..413
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q924S4.1)"
     Region          414..473
                     /region_name="Essential for apoptotic activity.
                     /evidence=ECO:0000250|UniProtKB:Q99N43"
                     /note="propagated from UniProtKB/Swiss-Prot (Q924S4.1)"
     CDS             1..473
                     /gene="Kremen1"
                     /gene_synonym="Kremen"
                     /coded_by="NM_053649.1:17..1438"
                     /db_xref="GeneID:114107"
                     /db_xref="RGD:620789"
ORIGIN      
        1 mappaarlal lsaaaltlaa rpapgprpsp ecftangady rgtqswtalq ggkpclfwne
       61 tfqhpyntlk ypngegglge hnycrnpdgd vspwcyvaeh edgvywkyce ipacqmpgnl
      121 gcykdhgnpp pltgtsktsn kltiqtcisf crsqrfkfag mesgyacfcg nnpdywkhge
      181 aastecnnvc fgdhtqpcgg dgriilfdtl vgacggnyss maavvyspdf pdtyatgrvc
      241 ywtirvpgas rihfnftifd irdsadmvel ldgythrvlv rfdgrsrppl sfnvsldfvi
      301 lyffsdrinq aqgfavlyqa tkeeppqerp ainqtlaevi teqanlsvsa ahsskvlyvi
      361 tsspshppqt vpgshswvps vgasghrveg wtvyglatll iltvtavvak illhvtfksh
      421 rvtasgdlrd crqpgtsgei wtifyepstt isifkkklkg qsqqddrnpl vsd
//
