LOCUS       NM_031515                661 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus KRAS proto-oncogene, GTPase (Kras), mRNA.
ACCESSION   NM_031515
VERSION     NM_031515.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 661)
  AUTHORS   Hong,J.H., Ding,Y.Y., Li,J.M., Pan,X.C., Liu,Y. and Zhang,H.G.
  TITLE     Self-limiting bidirectional positive feedback between P53 and P21
            is involved in cardiac hypertrophy
  JOURNAL   Eur J Pharmacol 932, 175239 (2022)
   PUBMED   36044972
  REMARK    GeneRIF: Self-limiting bidirectional positive feedback between P53
            and P21 is involved in cardiac hypertrophy.
REFERENCE   2  (bases 1 to 661)
  AUTHORS   Cao,Y., Huang,W., Wu,F., Shang,J., Ping,F., Wang,W., Li,Y., Zhao,X.
            and Zhang,X.
  TITLE     ZFP36 protects lungs from intestinal I/R-induced injury and
            fibrosis through the CREBBP/p53/p21/Bax pathway
  JOURNAL   Cell Death Dis 12 (7), 685 (2021)
   PUBMED   34238924
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 661)
  AUTHORS   Park,E.S., Kim,S., Huang,S., Yoo,J.Y., Korbelin,J., Lee,T.J.,
            Kaur,B., Dash,P.K., Chen,P.R. and Kim,E.
  TITLE     Selective Endothelial Hyperactivation of Oncogenic KRAS Induces
            Brain Arteriovenous Malformations in Mice
  JOURNAL   Ann Neurol 89 (5), 926-941 (2021)
   PUBMED   33675084
  REMARK    GeneRIF: Selective Endothelial Hyperactivation of Oncogenic KRAS
            Induces Brain Arteriovenous Malformations in Mice.
REFERENCE   4  (bases 1 to 661)
  AUTHORS   Feng,F., Wu,X., Shi,X., Gao,Q., Wu,Y., Yu,Y., Cheng,Q., Li,B.,
            Yi,B., Liu,C., Hao,Q., Zhang,L., Gao,C. and Jiang,X.
  TITLE     Comprehensive analysis of genomic alterations of Chinese hilar
            cholangiocarcinoma patients
  JOURNAL   Int J Clin Oncol 26 (4), 717-727 (2021)
   PUBMED   33387086
REFERENCE   5  (bases 1 to 661)
  AUTHORS   Iida,K., Naiki,T., Naiki-Ito,A., Suzuki,S., Kato,H., Nozaki,S.,
            Nagai,T., Etani,T., Nagayasu,Y., Ando,R., Kawai,N., Yasui,T. and
            Takahashi,S.
  TITLE     Luteolin suppresses bladder cancer growth via regulation of
            mechanistic target of rapamycin pathway
  JOURNAL   Cancer Sci 111 (4), 1165-1179 (2020)
   PUBMED   31994822
  REMARK    GeneRIF: teolin, and in particular its metabolized product, may
            represent another natural product-derived therapeutic agent that
            acts against bladder cancer by upregulating p21 and inhibiting mTOR
            signaling
REFERENCE   6  (bases 1 to 661)
  AUTHORS   Jansen,H., van Tol,A., Auwerx,J., Skretting,G. and Staels,B.
  TITLE     Opposite regulation of hepatic lipase and lecithin: cholesterol
            acyltransferase by glucocorticoids in rats
  JOURNAL   Biochim Biophys Acta 1128 (2-3), 181-185 (1992)
   PUBMED   1420288
REFERENCE   7  (bases 1 to 661)
  AUTHORS   Palejwala,S. and Goldsmith,L.T.
  TITLE     Ovarian expression of cellular Ki-ras p21 varies with physiological
            status
  JOURNAL   Proc Natl Acad Sci U S A 89 (9), 4202-4206 (1992)
   PUBMED   1570348
REFERENCE   8  (bases 1 to 661)
  AUTHORS   Chan,S.O., Wong,S.S. and Yeung,D.C.
  TITLE     Expression of c-Ki-ras in developing rat liver
  JOURNAL   Comp Biochem Physiol B 102 (1), 111-117 (1992)
   PUBMED   1526114
REFERENCE   9  (bases 1 to 661)
  AUTHORS   Grimmond,S.M., Raghavan,D. and Russell,P.J.
  TITLE     Detection of a rare point mutation in Ki-ras of a human bladder
            cancer xenograft by polymerase chain reaction and direct sequencing
  JOURNAL   Urol Res 20 (2), 121-126 (1992)
   PUBMED   1553789
REFERENCE   10 (bases 1 to 661)
  AUTHORS   Leibovitch,S.A., Leibovitch,M.P., Guillier,M., Hillion,J. and
            Harel,J.
  TITLE     Differential expression of protooncogenes related to transformation
            and cancer progression in rat myoblasts
  JOURNAL   Cancer Res 46 (8), 4097-4103 (1986)
   PUBMED   2425941
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U09793.1.
            
            On Jun 10, 2007 this sequence version replaced NM_031515.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U09793.1, BC126086.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760396, SAMEA5760434
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..661
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Noble"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q44"
     gene            1..661
                     /gene="Kras"
                     /gene_synonym="c-Ki-ras; K-ras; Kras2; p21"
                     /note="KRAS proto-oncogene, GTPase"
                     /db_xref="GeneID:24525"
                     /db_xref="RGD:2981"
     CDS             1..567
                     /gene="Kras"
                     /gene_synonym="c-Ki-ras; K-ras; Kras2; p21"
                     /EC_number="3.6.5.2"
                     /note="c-K-ras2 protein; c-Kirsten-ras proto-oncogene;
                     ki-Ras; K-Ras 2; Kirsten rat sarcoma viral oncogene
                     homologue 2 (active); v-Ki-ras2 Kirsten rat sarcoma viral
                     oncogene homolog"
                     /codon_start=1
                     /product="GTPase KRas"
                     /protein_id="NP_113703.1"
                     /db_xref="GeneID:24525"
                     /db_xref="RGD:2981"
                     /translation="MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQV
                     VIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKR
                     VKDSEDVPMVLVGNKCDLPSRTVDTKQAQELARSYGIPFIETSAKTRQGVDDAFYTLV
                     REIRKHKEKMSKDGKKKKKKSRTRCIVM"
     exon            1..111
                     /gene="Kras"
                     /gene_synonym="c-Ki-ras; K-ras; Kras2; p21"
                     /inference="alignment:Splign:2.1.0"
     exon            112..290
                     /gene="Kras"
                     /gene_synonym="c-Ki-ras; K-ras; Kras2; p21"
                     /inference="alignment:Splign:2.1.0"
     exon            291..450
                     /gene="Kras"
                     /gene_synonym="c-Ki-ras; K-ras; Kras2; p21"
                     /inference="alignment:Splign:2.1.0"
     exon            451..661
                     /gene="Kras"
                     /gene_synonym="c-Ki-ras; K-ras; Kras2; p21"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgactgagt ataaacttgt ggtagttgga gctggtggcg taggcaagag tgccttgacg
       61 atacagctaa ttcagaatca ctttgtggat gaatatgatc ctacgataga ggactcctac
      121 aggaaacaag tagtaattga tggagaaacc tgtctcttgg atattctcga cacagcaggt
      181 caagaggagt acagtgcaat gagggaccag tacatgagaa ctggggaggg ctttctttgt
      241 gtatttgcca taaataatac taaatcattt gaagatattc accattatag agaacaaatt
      301 aaaagagtaa aggactctga agatgtgcct atggtcctag tagggaataa gtgtgacttg
      361 ccttctagaa cagtagacac gaaacaggct caggagttag caaggagtta tgggattcca
      421 ttcattgaga cctcagcgaa gacaagacag ggtgttgacg atgccttcta tacattagtc
      481 cgagaaattc gaaaacataa agaaaagatg agcaaagatg ggaaaaagaa gaagaagaag
      541 tcaaggacaa ggtgtatagt catgtgaata gtttgtactc tttcttaagg cacacttaag
      601 taaagtgtga tttttgtaca ttacactaaa ttattagcat ttgttttagc attacctaat
      661 c
//
