LOCUS       NM_001107457             473 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus kaptin (actin binding protein) (Kptn), mRNA.
ACCESSION   NM_001107457 XM_001074187 XM_217806
VERSION     NM_001107457.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 473)
  AUTHORS   Wolfson RL, Chantranupong L, Wyant GA, Gu X, Orozco JM, Shen K,
            Condon KJ, Petri S, Kedir J, Scaria SM, Abu-Remaileh M, Frankel WN
            and Sabatini DM.
  TITLE     KICSTOR recruits GATOR1 to the lysosome and is necessary for
            nutrients to regulate mTORC1
  JOURNAL   Nature 543 (7645), 438-442 (2017)
   PUBMED   28199306
REFERENCE   2  (bases 1 to 473)
  AUTHORS   Baple EL, Maroofian R, Chioza BA, Izadi M, Cross HE, Al-Turki S,
            Barwick K, Skrzypiec A, Pawlak R, Wagner K, Coblentz R, Zainy T,
            Patton MA, Mansour S, Rich P, Qualmann B, Hurles ME, Kessels MM and
            Crosby AH.
  TITLE     Mutations in KPTN cause macrocephaly, neurodevelopmental delay, and
            seizures
  JOURNAL   Am J Hum Genet 94 (1), 87-94 (2014)
   PUBMED   24239382
REFERENCE   3  (bases 1 to 473)
  AUTHORS   Bearer EL and Abraham MT.
  TITLE     2E4 (kaptin): a novel actin-associated protein from human blood
            platelets found in lamellipodia and the tips of the stereocilia of
            the inner ear
  JOURNAL   Eur J Cell Biol 78 (2), 117-126 (1999)
   PUBMED   10099934
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473979.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001074187.1, XM_217806.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB734880.1, CB810022.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..473
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..473
                     /gene="Kptn"
                     /gene_synonym="Kptnl1"
                     /note="kaptin (actin binding protein)"
                     /db_xref="GeneID:308107"
                     /db_xref="RGD:1310341"
     exon            1..297
                     /gene="Kptn"
                     /gene_synonym="Kptnl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..389
                     /gene="Kptn"
                     /gene_synonym="Kptnl1"
                     /note="kaptin-like 1"
                     /codon_start=1
                     /product="KICSTOR complex protein kaptin"
                     /protein_id="NP_001100927.1"
                     /db_xref="GeneID:308107"
                     /db_xref="RGD:1310341"
                     /translation="MGEAAVAEGPCPLREDSFTRFSSQSNVYGLAGGADGRGELLAAT
                     LKGKVLGFRYQDLRQKIRPVAKELQFNYIPVDAEIVSIDTFNKSPPKRGLVVGITFIK
                     VP"
     exon            298..473
                     /gene="Kptn"
                     /gene_synonym="Kptnl1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtatgcgct agtggaggtt ccctgacagg ttggggagca tcgggccagc tgggaccgat
       61 cgcggagggc caggatgggg gaggcggccg tggcagaagg gccctgtcca ctgcgagagg
      121 acagcttcac gcgcttctcg tcgcagagca acgtgtatgg gcttgctgga ggcgccgacg
      181 ggcgagggga gttgctggcc gccactctta aaggcaaggt gctcggcttc cgctatcaag
      241 acctccgaca gaaaatcagg cctgtggcca aagagctgca attcaactac atccccgtgg
      301 atgctgagat cgtctccatc gacactttca acaagtcacc cccaaaacgg ggcctggttg
      361 tgggcatcac ttttataaag gtaccatagc accctccacc tgtccacgtc ctcttcctta
      421 gtccctgtgg atcccaccaa gtctatccca agtgctctga atctacagaa aat
//
