LOCUS       NM_017063               3635 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus karyopherin subunit beta 1 (Kpnb1), mRNA.
ACCESSION   NM_017063 XM_001081365
VERSION     NM_017063.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3635)
  AUTHORS   Mahboubi,H., Koromilas,A.E. and Stochaj,U.
  TITLE     AMP Kinase Activation Alters Oxidant-Induced Stress Granule
            Assembly by Modulating Cell Signaling and Microtubule Organization
  JOURNAL   Mol Pharmacol 90 (4), 460-468 (2016)
   PUBMED   27430620
REFERENCE   2  (bases 1 to 3635)
  AUTHORS   Bird,S.L., Heald,R. and Weis,K.
  TITLE     RanGTP and CLASP1 cooperate to position the mitotic spindle
  JOURNAL   Mol Biol Cell 24 (16), 2506-2514 (2013)
   PUBMED   23783028
REFERENCE   3  (bases 1 to 3635)
  AUTHORS   Perry,R.B., Doron-Mandel,E., Iavnilovitch,E., Rishal,I.,
            Dagan,S.Y., Tsoory,M., Coppola,G., McDonald,M.K., Gomes,C.,
            Geschwind,D.H., Twiss,J.L., Yaron,A. and Fainzilber,M.
  TITLE     Subcellular knockout of importin beta1 perturbs axonal retrograde
            signaling
  JOURNAL   Neuron 75 (2), 294-305 (2012)
   PUBMED   22841314
REFERENCE   4  (bases 1 to 3635)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 3635)
  AUTHORS   Di Paola,S., Micaroni,M., Di Tullio,G., Buccione,R. and Di
            Girolamo,M.
  TITLE     PARP16/ARTD15 is a novel endoplasmic-reticulum-associated
            mono-ADP-ribosyltransferase that interacts with, and modifies
            karyopherin-ss1
  JOURNAL   PLoS One 7 (6), e37352 (2012)
   PUBMED   22701565
REFERENCE   6  (bases 1 to 3635)
  AUTHORS   Delphin,C., Guan,T., Melchior,F. and Gerace,L.
  TITLE     RanGTP targets p97 to RanBP2, a filamentous protein localized at
            the cytoplasmic periphery of the nuclear pore complex
  JOURNAL   Mol Biol Cell 8 (12), 2379-2390 (1997)
   PUBMED   9398662
REFERENCE   7  (bases 1 to 3635)
  AUTHORS   Hu,T., Guan,T. and Gerace,L.
  TITLE     Molecular and functional characterization of the p62 complex, an
            assembly of nuclear pore complex glycoproteins
  JOURNAL   J Cell Biol 134 (3), 589-601 (1996)
   PUBMED   8707840
REFERENCE   8  (bases 1 to 3635)
  AUTHORS   Moroianu,J., Hijikata,M., Blobel,G. and Radu,A.
  TITLE     Mammalian karyopherin alpha 1 beta and alpha 2 beta heterodimers:
            alpha 1 or alpha 2 subunit binds nuclear localization signal and
            beta subunit interacts with peptide repeat-containing nucleoporins
  JOURNAL   Proc Natl Acad Sci U S A 92 (14), 6532-6536 (1995)
   PUBMED   7604027
REFERENCE   9  (bases 1 to 3635)
  AUTHORS   Chi,N.C., Adam,E.J. and Adam,S.A.
  TITLE     Sequence and characterization of cytoplasmic nuclear protein import
            factor p97
  JOURNAL   J Cell Biol 130 (2), 265-274 (1995)
   PUBMED   7615630
REFERENCE   10 (bases 1 to 3635)
  AUTHORS   Radu,A., Blobel,G. and Moore,M.S.
  TITLE     Identification of a protein complex that is required for nuclear
            protein import and mediates docking of import substrate to distinct
            nucleoporins
  JOURNAL   Proc Natl Acad Sci U S A 92 (5), 1769-1773 (1995)
   PUBMED   7878057
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Nov 20, 2020 this sequence version replaced NM_017063.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L38644.1, SRR26643294.41442.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-139               JAXUCZ010000010.1  82670718-82670856   c
            140-198             JAXUCZ010000010.1  82670563-82670621   c
            199-381             JAXUCZ010000010.1  82668214-82668396   c
            382-582             JAXUCZ010000010.1  82664566-82664766   c
            583-735             JAXUCZ010000010.1  82663452-82663604   c
            736-795             JAXUCZ010000010.1  82661813-82661872   c
            796-885             JAXUCZ010000010.1  82661203-82661292   c
            886-996             JAXUCZ010000010.1  82660103-82660213   c
            997-1098            JAXUCZ010000010.1  82658854-82658955   c
            1099-1323           JAXUCZ010000010.1  82655759-82655983   c
            1324-1515           JAXUCZ010000010.1  82653692-82653883   c
            1516-1646           JAXUCZ010000010.1  82651975-82652105   c
            1647-1794           JAXUCZ010000010.1  82651242-82651389   c
            1795-1866           JAXUCZ010000010.1  82650924-82650995   c
            1867-2011           JAXUCZ010000010.1  82649009-82649153   c
            2012-2094           JAXUCZ010000010.1  82647405-82647487   c
            2095-2202           JAXUCZ010000010.1  82646770-82646877   c
            2203-2346           JAXUCZ010000010.1  82646322-82646465   c
            2347-2452           JAXUCZ010000010.1  82646102-82646207   c
            2453-2567           JAXUCZ010000010.1  82645301-82645415   c
            2568-2729           JAXUCZ010000010.1  82643873-82644034   c
            2730-3635           JAXUCZ010000010.1  82642082-82642987   c
FEATURES             Location/Qualifiers
     source          1..3635
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q31"
     gene            1..3635
                     /gene="Kpnb1"
                     /gene_synonym="Impnb"
                     /note="karyopherin subunit beta 1"
                     /db_xref="GeneID:24917"
                     /db_xref="RGD:2909"
     exon            1..139
                     /gene="Kpnb1"
                     /gene_synonym="Impnb"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..2730
                     /gene="Kpnb1"
                     /gene_synonym="Impnb"
                     /note="nuclear factor P97; PTAC97; pore targeting complex
                     97 kDa subunit; karyopherin,beta 1; Importin beta;
                     karyopherin (importin) beta 1"
                     /codon_start=1
                     /product="importin subunit beta-1"
                     /protein_id="NP_058759.2"
                     /db_xref="GeneID:24917"
                     /db_xref="RGD:2909"
                     /translation="MELITILEKTVSPDRLELEAAQKFLERAAVENLPTFLVELSRVL
                     ANPGNSQVARVAAGLQIKNSLTSKDPDIKAQYQQRWLAIDANARREVKNYVLQTLGTE
                     TYRPSSASQCVAGIACAEIPVSQWPELIPQLVANVTNPNSTEHMKESTLEAIGYICQD
                     IDPEQLQDKSNEILTAIIQGMRKEEPSNNVKLAATNALLNSLEFTKANFDKESERHFI
                     MQVVCEATQCPDTRVRVAALQNLVKIMSLYYQYMETYMGPALFAITIEAMKSDIDEVA
                     LQGIEFWSNVCDEEMDLAIEASEAAEQGRPPEHTSKFYAKGALQYLVPILTQTLTKQD
                     ENDDDDDWNPCKAAGVCLMLLSTCCEDDIVPHVLPFIKEHIKNPDWRYRDAAVMAFGS
                     ILEGPEPNQLKPLVIQAMPTLIELMKDPSVVVRDTTAWTVGRICELLPEAAINDVYLA
                     PLLQCLIEGLSAEPRVASNVCWAFSSLAEAAYEAADVADDQEEPATYCLSSSFELIVQ
                     KLLETTDRPDGHQNNLRSSAYESLMEIVKNSAKDCYPAVQKTTLVIMERLQQVLQMES
                     HIQSTSDRIQFNDLQSLLCATLQNVLRKVQHQDALQISDVVMASLLRMFQSTAGSGGV
                     QEDALMAVSTLVEVLGGEFLKYMEAFKPFLGIGLKNYAEYQVCLAAVGLVGDLCRALQ
                     SNILPFCDEVMQLLLENLGNENVHRSVKPQILSVFGDIALAIGGEFKKYLEVVLNTLQ
                     QASQAQVDKSDFDMVDYLNELRESCLEAYTGIVQGLKGDQENVHPDVMLVQPRVEFIL
                     SFIDHIAGDEDHTDGVVACAAGLIGDLCTAFGKDVLKLVEARPMIHELLTEGRRSKTN
                     KAKTLATWATKELRKLKNQA"
     exon            140..198
                     /gene="Kpnb1"
                     /gene_synonym="Impnb"
                     /inference="alignment:Splign:2.1.0"
     exon            199..381
                     /gene="Kpnb1"
                     /gene_synonym="Impnb"
                     /inference="alignment:Splign:2.1.0"
     exon            382..582
                     /gene="Kpnb1"
                     /gene_synonym="Impnb"
                     /inference="alignment:Splign:2.1.0"
     exon            583..735
                     /gene="Kpnb1"
                     /gene_synonym="Impnb"
                     /inference="alignment:Splign:2.1.0"
     exon            736..795
                     /gene="Kpnb1"
                     /gene_synonym="Impnb"
                     /inference="alignment:Splign:2.1.0"
     exon            796..885
                     /gene="Kpnb1"
                     /gene_synonym="Impnb"
                     /inference="alignment:Splign:2.1.0"
     exon            886..996
                     /gene="Kpnb1"
                     /gene_synonym="Impnb"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1098
                     /gene="Kpnb1"
                     /gene_synonym="Impnb"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1323
                     /gene="Kpnb1"
                     /gene_synonym="Impnb"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1515
                     /gene="Kpnb1"
                     /gene_synonym="Impnb"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1646
                     /gene="Kpnb1"
                     /gene_synonym="Impnb"
                     /inference="alignment:Splign:2.1.0"
     exon            1647..1794
                     /gene="Kpnb1"
                     /gene_synonym="Impnb"
                     /inference="alignment:Splign:2.1.0"
     exon            1795..1866
                     /gene="Kpnb1"
                     /gene_synonym="Impnb"
                     /inference="alignment:Splign:2.1.0"
     exon            1867..2011
                     /gene="Kpnb1"
                     /gene_synonym="Impnb"
                     /inference="alignment:Splign:2.1.0"
     exon            2012..2094
                     /gene="Kpnb1"
                     /gene_synonym="Impnb"
                     /inference="alignment:Splign:2.1.0"
     exon            2095..2202
                     /gene="Kpnb1"
                     /gene_synonym="Impnb"
                     /inference="alignment:Splign:2.1.0"
     exon            2203..2346
                     /gene="Kpnb1"
                     /gene_synonym="Impnb"
                     /inference="alignment:Splign:2.1.0"
     exon            2347..2452
                     /gene="Kpnb1"
                     /gene_synonym="Impnb"
                     /inference="alignment:Splign:2.1.0"
     exon            2453..2567
                     /gene="Kpnb1"
                     /gene_synonym="Impnb"
                     /inference="alignment:Splign:2.1.0"
     exon            2568..2729
                     /gene="Kpnb1"
                     /gene_synonym="Impnb"
                     /inference="alignment:Splign:2.1.0"
     exon            2730..3635
                     /gene="Kpnb1"
                     /gene_synonym="Impnb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttcccaccc gacccccaac ccccatcccc agttggagcc gccgcccgag aggccgggcc
       61 gtcgtcttgg gaggagtccc cgccgccgtc acctccgcca tggagctcat aaccatcctc
      121 gagaagaccg tgtctccgga tcggctggag ctggaagcgg cgcagaagtt ccttgagcgt
      181 gcggctgtgg agaatctgcc cacgttcctt gtggaactgt ccagagtgct ggcaaatccc
      241 ggaaacagtc aggttgccag agttgcagct ggtctacaaa ttaagaactc tttgacatcg
      301 aaggatccag atatcaaggc acagtaccag cagaggtggc ttgctattga tgctaatgct
      361 cggcgggaag tcaagaacta tgttttgcag actttgggca cagagactta ccggcctagt
      421 tcagcctcac agtgtgtggc tggtatcgct tgtgcagaga tcccagtaag ccagtggccg
      481 gaactaattc ctcagctggt agccaatgtc accaacccca acagcacgga gcacatgaaa
      541 gagtccacac tggaagccat cggttacatt tgccaagata tagacccgga gcagctgcag
      601 gataaatcca atgagatcct gactgccata atccagggca tgcggaagga agagcctagt
      661 aacaatgtga agctggccgc taccaacgcg ctcctgaact cactggagtt caccaaagca
      721 aacttcgaca aagagtctga acggcacttt atcatgcaag tggtctgtga agccacacag
      781 tgtccagata caagggtaag agtggctgct ttacagaatc tagtgaagat aatgtccttg
      841 tattaccagt acatggagac atacatgggc cctgccctct ttgcaatcac aattgaagca
      901 atgaaaagtg acattgatga ggtagctctc caagggatag agttctggtc caatgtctgt
      961 gatgaggaaa tggatttggc cattgaggct tcagaggcag cagaacaagg acggcccccg
     1021 gagcacacca gcaaatttta cgccaaggga gcgctgcagt acctggtgcc catcctcaca
     1081 cagacactaa ctaaacagga tgaaaacgat gacgacgatg actggaaccc ttgcaaagca
     1141 gctggggtgt gcctcatgct cctgtctacc tgctgtgaag atgacattgt gccacatgtc
     1201 cttcccttta ttaaagagca catcaagaac cctgactggc ggtaccggga tgcagcagtg
     1261 atggcttttg gcagcatctt ggaaggacca gagcctaacc agcttaaacc attagtcata
     1321 caggctatgc ccaccctgat agaattaatg aaagacccca gtgtagttgt tcgagataca
     1381 acagcatgga ctgtgggcag gatctgtgag ctgctgcctg aagctgccat caatgatgtc
     1441 tacttggcac cccttttaca gtgtctgatt gagggtctca gtgctgaacc cagagtggct
     1501 tcaaatgtgt gctgggcttt ttccagtctg gctgaagctg cttacgaagc tgcagatgta
     1561 gctgatgatc aggaagaacc agccacctat tgcttgtctt cttcctttga acttatagtt
     1621 cagaagctgc tggagaccac cgacagacct gatggacacc agaacaacct gagaagttct
     1681 gcatatgaat ctctaatgga aattgtaaaa aacagtgcca aggattgtta ccctgcggtg
     1741 cagaagacca ccctggtcat tatggaacgg ttgcagcagg tgcttcagat ggagtcccac
     1801 atccagagca cgtcggacag gatccaattc aatgacctcc agtctctact ctgtgcaact
     1861 cttcagaatg ttctccggaa agtgcagcat caagatgctt tgcagatctc tgatgtggtc
     1921 atggcctccc tgttaaggat gttccaaagc acagctgggt ctggcggagt gcaagaagac
     1981 gccctgatgg cagtcagcac actggtggaa gtgttgggtg gtgaattcct caagtacatg
     2041 gaggccttta aaccattcct gggcattgga ttgaaaaatt atgctgaata ccaggtatgt
     2101 ttggcagctg ttggcttagt tggagacttg tgccgagccc tgcagtctaa catcttacct
     2161 ttctgtgatg aggtgatgca gctgctccta gagaacttgg ggaatgagaa tgtccacagg
     2221 tctgtgaaac cacagattct gtctgtgttt ggtgacattg ctcttgccat tggtggagaa
     2281 tttaagaaat acttggaggt tgtactgaat acactgcagc aggcctccca agcccaagtg
     2341 gacaagtcag actttgacat ggtggattat ctgaatgagc taagagaaag ctgcttggaa
     2401 gcttatacgg gaatcgtcca gggattgaag ggagaccagg aaaacgtaca ccctgatgta
     2461 atgctggtgc aacccagagt agaatttatt ttgtctttta ttgatcacat tgctggagat
     2521 gaggatcata cggatggagt ggtagcttgt gctgctggac tgatagggga cttgtgtaca
     2581 gcatttggaa aggatgtact gaaattagta gaagctaggc caatgatcca tgaactatta
     2641 actgaagggc ggagatcgaa gactaacaaa gcaaagaccc ttgctacgtg ggcaacaaag
     2701 gaactgagga aactgaagaa ccaagcttga tctggtacca ttgggatgat gacctgagac
     2761 ccccactgga aatctccaat cttttgaaaa aacccggaag tgaggagtgt gcacggatgc
     2821 tgaatgtttg ggaatgagag gatgagtgag tgaggcttga aaacaccaca ctgaaaatcc
     2881 tgccacagcc aacagcagca gcgctgttag tgagctaagt aagcactgac tttgtagaaa
     2941 acataacatc agccatcttg gaacagagaa acaatggatt tacttactta ttaaaaacaa
     3001 aaaaagctgt ctcttcccag gggaaggcta gaactagctt tcctatcttg gccggtgccg
     3061 aatgggatga ctgatttggg agaggaggac ctgggttcac ctgtggggct gtgttgtgaa
     3121 aggcaaccct ggcccccgct actgaggaga aagatggagc ccgggtcttg agcccacctt
     3181 cactgtaccg ttgcacttgg tactgtatat gtgcccttga gaaggcgcgt gggggatttc
     3241 acagtctgag aatgagtgtg tgtgagtgag gcggtaccca cattctcaac ttcaagtcat
     3301 tgcagtttct ttttcccaga agacaaaggg gtttgatgtt gcatttcata aactaactga
     3361 agttctggct actgatgcag cacaagaggc tgtctcacaa aacgaggaaa gacgctgttt
     3421 atgtttggtt tggtttcatt ttaattattc tagggaaaac actgacgaat ggtcagagtt
     3481 cctgtcctga tcttttcatc aaggcgcctt tcctgataat atggttcagc tgtgaatgta
     3541 gctatggggg gaggggggaa aaaagaaaac tctggagtta gaggatatag aaaattaaaa
     3601 gtacagttgt tacaaataaa acgcagactt caaag
//
