LOCUS       NM_001014793            2016 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus karyopherin subunit alpha 4 (Kpna4), mRNA.
ACCESSION   NM_001014793 XM_342260
VERSION     NM_001014793.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2016)
  AUTHORS   Young JC, Ly-Huynh JD, Lescesen H, Miyamoto Y, Browne C, Yoneda Y,
            Koopman P, Loveland KL and Jans DA.
  TITLE     The nuclear import factor importin alpha4 can protect against
            oxidative stress
  JOURNAL   Biochim Biophys Acta 1833 (10), 2348-2356 (2013)
   PUBMED   23773962
REFERENCE   2  (bases 1 to 2016)
  AUTHORS   Pradeepa MM, Manjunatha S, Sathish V, Agrawal S and Rao MR.
  TITLE     Involvement of importin-4 in the transport of transition protein 2
            into the spermatid nucleus
  JOURNAL   Mol Cell Biol 28 (13), 4331-4341 (2008)
   PUBMED   17682055
  REMARK    GeneRIF: A detailed analysis to characterize the molecular
            components underlying the nuclear translocation of TP2, was carried
            out.
REFERENCE   3  (bases 1 to 2016)
  AUTHORS   Plant KE, Everett DM, Gordon Gibson G, Lyon J and Plant NJ.
  TITLE     Transcriptomic and phylogenetic analysis of Kpna genes: a family of
            nuclear import factors modulated in xenobiotic-mediated liver
            growth
  JOURNAL   Pharmacogenet Genomics 16 (9), 647-658 (2006)
   PUBMED   16906019
REFERENCE   4  (bases 1 to 2016)
  AUTHORS   Sakakida Y, Miyamoto Y, Nagoshi E, Akashi M, Nakamura TJ, Mamine T,
            Kasahara M, Minami Y, Yoneda Y and Takumi T.
  TITLE     Importin alpha/beta mediates nuclear transport of a mammalian
            circadian clock component, mCRY2, together with mPER2, through a
            bipartite nuclear localization signal
  JOURNAL   J Biol Chem 280 (14), 13272-13278 (2005)
   PUBMED   15689618
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY779028.1.
            
            On Apr 20, 2005 this sequence version replaced XM_342260.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY779028.1, FQ224515.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2016
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q32"
     gene            1..2016
                     /gene="Kpna4"
                     /gene_synonym="importin"
                     /note="karyopherin subunit alpha 4"
                     /db_xref="GeneID:361959"
                     /db_xref="RGD:1311483"
     exon            1..72
                     /gene="Kpna4"
                     /gene_synonym="importin"
                     /inference="alignment:Splign:2.1.0"
     CDS             4..1569
                     /gene="Kpna4"
                     /gene_synonym="importin"
                     /note="predicted role in nuclear import; karyopherin
                     (importin) alpha 4; importin subunit alpha-4; karyopherin
                     alpha 4 (importin alpha 3)"
                     /codon_start=1
                     /product="importin subunit alpha-3"
                     /protein_id="NP_001014793.1"
                     /db_xref="GeneID:361959"
                     /db_xref="RGD:1311483"
                     /translation="MADNEKLDNQRLKNFKNKGRDLETMRRQRNEVVVELRKNKRDEH
                     LLKRRNVPQEDICEDSDIDGDYRVQNTSLEAIVQNASSDNQGIQLSAVQAARKLLSSD
                     RNPPIDDLIKSGILPILVHCLERDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNAVP
                     LFLRLLHSPHQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFISPSIPITFLR
                     NVTWVMVNLCRHKDPPPPMETIQEILPALCVLIHHTDVNILVDTVWALSYLTDAGNEQ
                     IQMVIDSGIVPHLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDALSHFPAL
                     LTHPKEKINKEAVWFLSNITAGNQQQVQAVIDANLVPMIIHLLDKGDFGTQKEAAWAI
                     SNLTISGRKDQVAYLIQQNVIPPFCNLLTVKDAQVVQVVLDGLSNILKMAEDQAETIA
                     NLIEECGGLEKIEQLQNHENEDIYKLAYEIIDQFFSSDDIDEDPSLVPESVQGGTFGF
                     NSSTNVPTEGFQF"
     exon            73..117
                     /gene="Kpna4"
                     /gene_synonym="importin"
                     /inference="alignment:Splign:2.1.0"
     exon            118..207
                     /gene="Kpna4"
                     /gene_synonym="importin"
                     /inference="alignment:Splign:2.1.0"
     exon            208..237
                     /gene="Kpna4"
                     /gene_synonym="importin"
                     /inference="alignment:Splign:2.1.0"
     exon            238..290
                     /gene="Kpna4"
                     /gene_synonym="importin"
                     /inference="alignment:Splign:2.1.0"
     exon            291..386
                     /gene="Kpna4"
                     /gene_synonym="importin"
                     /inference="alignment:Splign:2.1.0"
     exon            387..472
                     /gene="Kpna4"
                     /gene_synonym="importin"
                     /inference="alignment:Splign:2.1.0"
     exon            473..559
                     /gene="Kpna4"
                     /gene_synonym="importin"
                     /inference="alignment:Splign:2.1.0"
     exon            560..729
                     /gene="Kpna4"
                     /gene_synonym="importin"
                     /inference="alignment:Splign:2.1.0"
     exon            730..774
                     /gene="Kpna4"
                     /gene_synonym="importin"
                     /inference="alignment:Splign:2.1.0"
     exon            775..906
                     /gene="Kpna4"
                     /gene_synonym="importin"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1035
                     /gene="Kpna4"
                     /gene_synonym="importin"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1140
                     /gene="Kpna4"
                     /gene_synonym="importin"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1212
                     /gene="Kpna4"
                     /gene_synonym="importin"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1375
                     /gene="Kpna4"
                     /gene_synonym="importin"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1470
                     /gene="Kpna4"
                     /gene_synonym="importin"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..2016
                     /gene="Kpna4"
                     /gene_synonym="importin"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccatggcgg acaacgagaa attggacaac caacggctca agaattttaa gaacaaaggc
       61 cgcgacttgg agactatgag aagacaacga aatgaagttg tagttgaatt aagaaagaat
      121 aaaagagatg aacatctctt aaagagaagg aatgtaccac aagaagatat ctgtgaagac
      181 tctgatatag acggtgatta tagagtgcaa aatacctctc tagaagctat tgttcaaaat
      241 gcttcaagtg ataaccaagg aattcaatta agtgcagttc aagctgctag gaagctttta
      301 tccagtgatc gaaatccacc aattgatgac ttaataaaat ctggaatatt gcctatttta
      361 gttcattgtc ttgaaagaga tgacaatcct tctttacagt ttgaagctgc atgggctttg
      421 acaaacattg catctggaac gtctgaacag acgcaagcag tggttcagtc caatgctgtc
      481 ccacttttcc tgaggcttct gcattcaccc catcagaatg tctgtgaaca ggcagtgtgg
      541 gcattgggaa atattatagg tgatggacct cagtgtagag attatgtgat aagccttgga
      601 gttgtaaaac ctctgctttc attcataagt ccatctattc ctataacatt cttaagaaat
      661 gttacctggg tcatggtcaa cttatgtcgc cacaaggacc caccaccacc aatggagaca
      721 attcaggaga ttcttccagc tctttgtgta ttaattcatc acacagatgt aaatatactg
      781 gtagatactg tctgggccct atcttacctt acggatgctg gcaatgagca gatacagatg
      841 gtaatagact ctggaatagt tcctcatttg gttccgctac tcagccacca ggaagttaaa
      901 gttcagactg ctgcactgcg agctgtgggc aacattgtca ctggaactga tgagcaaaca
      961 caagtagttt taaactgtga tgctctctca cacttcccag cactcctcac tcatcccaaa
     1021 gagaaaatta ataaggaagc agtgtggttc ctctccaaca tcaccgcagg aaatcaacag
     1081 caggttcagg cagtaattga tgccaatctt gtaccaatga taatacacct tttggataag
     1141 ggagattttg gcactcagaa agaagctgct tgggccataa gtaacttaac aattagtggg
     1201 aggaaagacc aagtcgccta tctcatccaa caaaatgtta ttccaccttt ttgcaatttg
     1261 ctgactgtaa aagatgcaca agtcgtgcaa gtagtgcttg atggactaag taatatatta
     1321 aaaatggctg aagatcaagc ggaaaccata gccaatctca tagaagaatg tggtggactg
     1381 gagaaaattg aacaacttca gaatcatgaa aatgaggaca tctacaaatt ggcctatgag
     1441 atcattgacc agttcttctc ttcagatgat attgatgaag atcctagcct tgttccagag
     1501 tcagttcaag gtggaacatt tggtttcaat tcatctacca atgtaccaac agaggggttc
     1561 cagttttaga gagatgttgt ggaagttagg tacaatgcag caccgagaaa tatatatata
     1621 tatacacata tatataaaaa ggtttgatcc atcaagcttg gctcatggga tctgctgctg
     1681 cattaaatcg ggagagaaaa tgtgaagatt tcatttggaa tcacagaaaa tgcccaaatg
     1741 agtcaaggtg gcgagtgggt gcgagtgaga atgagtggca atgtaaggaa agcgtgacac
     1801 aaatgcttat ttaggttgag agtaaagggc tacaggtcac ttcggtgcct gagacggagc
     1861 attgacttac tctatcaatt gagaagtgaa atgccatcat catcaagcct tgtaagcata
     1921 aaagcgatgc ccatataagt caaggaaaat gagcccaggc ctcgctgtga agcagtgtat
     1981 gaatgaacag tgttgaatga atgtctggct ccgtgg
//
