LOCUS       NM_001014792            2075 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus karyopherin subunit alpha 3 (Kpna3), mRNA.
ACCESSION   NM_001014792 XM_341335
VERSION     NM_001014792.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2075)
  AUTHORS   Chen WB, Zhang LX, Zhao YK, Li J and Jiao Y.
  TITLE     C/EBPalpha-mediated transcriptional activation of miR-134-5p
            entails KPNA3 inhibition and modulates focal hypoxic-ischemic brain
            damage in neonatal rats
  JOURNAL   Brain Res Bull 164, 350-360 (2020)
   PUBMED   32814091
  REMARK    GeneRIF: C/EBPalpha-mediated transcriptional activation of
            miR-134-5p entails KPNA3 inhibition and modulates focal
            hypoxic-ischemic brain damage in neonatal rats.
REFERENCE   2  (bases 1 to 2075)
  AUTHORS   Senol SP, Temiz M, Guden DS, Cecen P, Sari AN, Sahan-Firat S, Falck
            JR, Dakarapu R, Malik KU and Tunctan B.
  TITLE     Contribution of PPARalpha/beta/gamma, AP-1, importin-alpha3, and
            RXRalpha to the protective effect of 5,14-HEDGE, a 20-HETE mimetic,
            against hypotension, tachycardia, and inflammation in a rat model
            of septic shock
  JOURNAL   Inflamm Res 65 (5), 367-387 (2016)
   PUBMED   26875149
  REMARK    GeneRIF: The results suggest that an increase in the expression of
            PPARalpha/beta/gamma and RXRalpha as well as a decrease in AP-1 and
            importin-alpha3 expression/activity participates in the protective
            effect of 5,14-HEDGE against hypotension, tachycardia, and
            inflammation during endotoxemia and thus have a beneficial effect
            in septic shock treatment
REFERENCE   3  (bases 1 to 2075)
  AUTHORS   Plant KE, Everett DM, Gordon Gibson G, Lyon J and Plant NJ.
  TITLE     Transcriptomic and phylogenetic analysis of Kpna genes: a family of
            nuclear import factors modulated in xenobiotic-mediated liver
            growth
  JOURNAL   Pharmacogenet Genomics 16 (9), 647-658 (2006)
   PUBMED   16906019
REFERENCE   4  (bases 1 to 2075)
  AUTHORS   Kobayashi M, Kishida S, Fukui A, Michiue T, Miyamoto Y, Okamoto T,
            Yoneda Y, Asashima M and Kikuchi A.
  TITLE     Nuclear localization of Duplin, a beta-catenin-binding protein, is
            essential for its inhibitory activity on the Wnt signaling pathway
  JOURNAL   J Biol Chem 277 (8), 5816-5822 (2002)
   PUBMED   11744694
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY779027.1.
            
            On Apr 20, 2005 this sequence version replaced XM_341335.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY779027.1, BC111706.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2075
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p12"
     gene            1..2075
                     /gene="Kpna3"
                     /gene_synonym="importin"
                     /note="karyopherin subunit alpha 3"
                     /db_xref="GeneID:361055"
                     /db_xref="RGD:1311339"
     exon            1..76
                     /gene="Kpna3"
                     /gene_synonym="importin"
                     /inference="alignment:Splign:2.1.0"
     CDS             8..1573
                     /gene="Kpna3"
                     /gene_synonym="importin"
                     /note="predicted role in nuclear import; karyopherin
                     (importin) alpha 3; importin subunit alpha-3; karyopherin
                     alpha 3"
                     /codon_start=1
                     /product="importin subunit alpha-4"
                     /protein_id="NP_001014792.1"
                     /db_xref="GeneID:361055"
                     /db_xref="RGD:1311339"
                     /translation="MAENPGLENHRIKSFKNKGRDVETMRRHRNEVTVELRKNKRDEH
                     LLKKRNVPQEESLEDSDVDADFKAQNVTLEAILQNATSDNPVVQLSAVQAARKLLSSD
                     RNPPIDDLIKSGILPILVKCLERDDNPSLQFEAAWALTNIASGTSAQTQAVVQSNAVP
                     LFLRLLHSPHQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFINPSIPITFLR
                     NVTWVIVNLCRNKDPPPPMETVQEILPALCVLIYHTDINILVDTVWALSYLTDGGNEQ
                     IQMVIDSGVVPFLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDVLSHFPNL
                     LSHPKEKINKEAVWFLSNITAGNQQQVQAVIDAGLIPMIIHQLAKGDFGTQKEAAWAI
                     SNLTISGRKDQVEYLVQQNVIPPFCNLLSVKDSQVVQVVLDGLKNILIMAGDEASTIA
                     EIIEECGGLEKIEVLQQHENEDIYKLAFEIIDQYFSGDDIDEDPSLIPEATQGGTYNF
                     DPTANLQTKEFNF"
     exon            77..121
                     /gene="Kpna3"
                     /gene_synonym="importin"
                     /inference="alignment:Splign:2.1.0"
     exon            122..211
                     /gene="Kpna3"
                     /gene_synonym="importin"
                     /inference="alignment:Splign:2.1.0"
     exon            212..241
                     /gene="Kpna3"
                     /gene_synonym="importin"
                     /inference="alignment:Splign:2.1.0"
     exon            242..294
                     /gene="Kpna3"
                     /gene_synonym="importin"
                     /inference="alignment:Splign:2.1.0"
     exon            295..390
                     /gene="Kpna3"
                     /gene_synonym="importin"
                     /inference="alignment:Splign:2.1.0"
     exon            391..476
                     /gene="Kpna3"
                     /gene_synonym="importin"
                     /inference="alignment:Splign:2.1.0"
     exon            477..563
                     /gene="Kpna3"
                     /gene_synonym="importin"
                     /inference="alignment:Splign:2.1.0"
     exon            564..733
                     /gene="Kpna3"
                     /gene_synonym="importin"
                     /inference="alignment:Splign:2.1.0"
     exon            734..778
                     /gene="Kpna3"
                     /gene_synonym="importin"
                     /inference="alignment:Splign:2.1.0"
     exon            779..910
                     /gene="Kpna3"
                     /gene_synonym="importin"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1039
                     /gene="Kpna3"
                     /gene_synonym="importin"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1144
                     /gene="Kpna3"
                     /gene_synonym="importin"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1216
                     /gene="Kpna3"
                     /gene_synonym="importin"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1379
                     /gene="Kpna3"
                     /gene_synonym="importin"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1474
                     /gene="Kpna3"
                     /gene_synonym="importin"
                     /inference="alignment:Splign:2.1.0"
     exon            1475..2075
                     /gene="Kpna3"
                     /gene_synonym="importin"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcagccatg gccgagaacc ccggcttgga gaaccaccgc attaagagct tcaagaacaa
       61 gggccgcgat gtggagacaa tgcgaagaca cagaaatgag gtgacagtgg aactccggaa
      121 gaacaaaaga gacgaacact tactgaaaaa gagaaatgtt ccccaagaag aaagcttaga
      181 agattcagat gttgatgctg attttaaagc acaaaatgta acactagaag ctatattaca
      241 gaatgctaca agtgataatc ccgtagtcca gttgagtgct gtgcaggcag caaggaaact
      301 attatccagt gacagaaatc caccaattga tgacctaata aaatctggga ttttaccaat
      361 tctagtcaaa tgtctagaaa gggatgataa cccttcatta cagtttgaag ctgcttgggc
      421 cctaactaat atagcatcag gaacttctgc acagactcaa gctgttgtac agtctaatgc
      481 cgtaccactt ttcctgcgac tcctccattc cccacatcag aatgtttgtg aacaagcagt
      541 gtgggctttg ggaaacatta taggtgatgg tcctcaatgt agagattatg tcatatcact
      601 gggagttgtc aaacctcttc tgtccttcat caatccctcc attcccatca ccttccttcg
      661 gaacgtcaca tgggtcattg tcaatctctg caggaataaa gaccccccac cgcctatgga
      721 gacagttcag gagattttgc cagctttatg tgtcctcatc taccacacgg acataaatat
      781 tcttgtagac actgtttggg cgctgtcata cttgacagac ggagggaatg agcagataca
      841 gatggttatt gactcagggg ttgtaccctt cctcgtgccc cttctgagcc accaggaagt
      901 caaagttcaa accgcagcac tcagagcagt agggaacata gtgactggca ctgatgagca
      961 gacccaggtg gtcctcaact gcgatgtcct gtcccacttc ccaaacctct tgtcacaccc
     1021 aaaagagaaa ataaacaagg aagcagtgtg gttcctttcc aatataacag caggcaatca
     1081 gcagcaagtt caggctgtga tcgatgctgg gttaatccct atgattattc atcagctcgc
     1141 taagggggat tttggaacac aaaaggaagc tgcttgggca atcagcaact taacgataag
     1201 tggcagaaaa gaccaagttg aataccttgt acaacagaat gtaataccgc cattctgtaa
     1261 cttactgtca gtaaaagatt ctcaagtggt gcaggtggtt ctggatggtc taaaaaacat
     1321 cctgataatg gctggtgatg aagcaagcac aatagctgag atcatagaag agtgtggagg
     1381 tttggagaaa atagaagttt tgcagcaaca tgaaaatgaa gacatatata aattagcatt
     1441 tgaaatcata gatcaatatt tctctggtga tgatattgat gaagatccta gcctcattcc
     1501 tgaagcaaca caaggaggta cttacaattt tgacccaaca gccaaccttc aaacaaaaga
     1561 atttaatttc taaggtcaat taagtgcagc atctttgatt caatatgaaa caccaccaga
     1621 tggccaccaa gcgataagac agcaagcaac agaaggctcc cagcattctt gcctcttcat
     1681 tttgatgctt ctaaagcaag ccatgtctca gtcactttgc agttgccaaa agtcactctc
     1741 acatggactg taaatgcata tgcatgattt cctaaactgt tttagaattc tccttaacca
     1801 tctcaactcc cctatatttt ccatgctccc tggtgccaca tgctgacaac tgcagtctcc
     1861 agttagaata ttccatagtg gtggtttatc agctgcccac tgatacagcc tttggaaaaa
     1921 ggtgcgctgt ggatcaagac actttggtat gatgtatact catgttggaa gactacagag
     1981 gtgcagtgtg atctgagcct ccatcactgt cctccacaaa catattttcg tattcttatg
     2041 tggaagaatt aaagtacaag ccaaatgatt ttcat
//
