LOCUS       NM_001270802            2002 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus karyopherin subunit alpha 2 (Kpna2), transcript
            variant 1, mRNA.
ACCESSION   NM_001270802
VERSION     NM_001270802.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2002)
  AUTHORS   Bertram,S., Thiele,S., Dreier,C., Resa-Infante,P., Preuss,A., van
            Riel,D., Mok,C.K.P., Schwalm,F., Peiris,J.S.M., Klenk,H.D. and
            Gabriel,G.
  TITLE     H7N9 Influenza A Virus Exhibits Importin-alpha7-Mediated
            Replication in the Mammalian Respiratory Tract
  JOURNAL   Am J Pathol 187 (4), 831-840 (2017)
   PUBMED   28189564
REFERENCE   2  (bases 1 to 2002)
  AUTHORS   Mahboubi,H., Koromilas,A.E. and Stochaj,U.
  TITLE     AMP Kinase Activation Alters Oxidant-Induced Stress Granule
            Assembly by Modulating Cell Signaling and Microtubule Organization
  JOURNAL   Mol Pharmacol 90 (4), 460-468 (2016)
   PUBMED   27430620
REFERENCE   3  (bases 1 to 2002)
  AUTHORS   Xu,Z., Chen,J., Shi,J., Zhao,J., Wang,J., Ji,Y., Han,L., Zhu,L.,
            Li,X. and Zhang,D.
  TITLE     Upregulated Expression of Karyopherin alpha2 is Involved in
            Neuronal Apoptosis Following Intracerebral Hemorrhage in Adult Rats
  JOURNAL   Cell Mol Neurobiol 36 (5), 755-765 (2016)
   PUBMED   26340948
  REMARK    GeneRIF: Karyopherin alpha2 co-localized well with active caspase-3
            in neurons, indicating its potential role in neuronal apoptosis
REFERENCE   4  (bases 1 to 2002)
  AUTHORS   Cai,Y., Shen,Y., Gao,L., Chen,M., Xiao,M., Huang,Z. and Zhang,D.
  TITLE     Karyopherin Alpha 2 Promotes the Inflammatory Response in Rat
            Pancreatic Acinar Cells Via Facilitating NF-kappaB Activation
  JOURNAL   Dig Dis Sci 61 (3), 747-757 (2016)
   PUBMED   26526450
  REMARK    GeneRIF: KPNA2-facilitated p65 nuclear translocation promotes
            NF-kappaB activation and inflammation in acute pancreatitis.
REFERENCE   5  (bases 1 to 2002)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   6  (bases 1 to 2002)
  AUTHORS   Thompson,K.R., Otis,K.O., Chen,D.Y., Zhao,Y., O'Dell,T.J. and
            Martin,K.C.
  TITLE     Synapse to nucleus signaling during long-term synaptic plasticity;
            a role for the classical active nuclear import pathway
  JOURNAL   Neuron 44 (6), 997-1009 (2004)
   PUBMED   15603742
REFERENCE   7  (bases 1 to 2002)
  AUTHORS   Cassany,A., Guillemain,G., Klein,C., Dalet,V., Brot-Laroche,E. and
            Leturque,A.
  TITLE     A karyopherin alpha2 nuclear transport pathway is regulated by
            glucose in hepatic and pancreatic cells
  JOURNAL   Traffic 5 (1), 10-19 (2004)
   PUBMED   14675421
  REMARK    GeneRIF: Data show that extracellular glucose regulates a nuclear
            transport pathway by increasing the nuclear efflux and shuttling of
            karyopherin alpha2 in cells in which glucose can stimulate the
            transcription of sugar-responsive genes.
REFERENCE   8  (bases 1 to 2002)
  AUTHORS   Fontes,M.R., Teh,T., Jans,D., Brinkworth,R.I. and Kobe,B.
  TITLE     Structural basis for the specificity of bipartite nuclear
            localization sequence binding by importin-alpha
  JOURNAL   J Biol Chem 278 (30), 27981-27987 (2003)
   PUBMED   12695505
REFERENCE   9  (bases 1 to 2002)
  AUTHORS   Guillemain,G., Munoz-Alonso,M.J., Cassany,A., Loizeau,M.,
            Faussat,A.M., Burnol,A.F. and Leturque,A.
  TITLE     Karyopherin alpha2: a control step of glucose-sensitive gene
            expression in hepatic cells
  JOURNAL   Biochem J 364 (Pt 1), 201-209 (2002)
   PUBMED   11988093
  REMARK    GeneRIF: Karyopherin alpha2: a control step of glucose-sensitive
            gene expression in hepatic cells
REFERENCE   10 (bases 1 to 2002)
  AUTHORS   Grozinger,C.M. and Schreiber,S.L.
  TITLE     Regulation of histone deacetylase 4 and 5 and transcriptional
            activity by 14-3-3-dependent cellular localization
  JOURNAL   Proc Natl Acad Sci U S A 97 (14), 7835-7840 (2000)
   PUBMED   10869435
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FM083931.1, FM115539.1 and BC089787.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 both encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062026.1, SRR8487231.88323.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 FM083931.1         1-3
            4-689               FM115539.1         1-686
            690-2002            BC089787.1         616-1928
FEATURES             Location/Qualifiers
     source          1..2002
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     gene            1..2002
                     /gene="Kpna2"
                     /gene_synonym="importin"
                     /note="karyopherin subunit alpha 2"
                     /db_xref="GeneID:85245"
                     /db_xref="RGD:621419"
     exon            1..103
                     /gene="Kpna2"
                     /gene_synonym="importin"
                     /inference="alignment:Splign:2.1.0"
     exon            104..208
                     /gene="Kpna2"
                     /gene_synonym="importin"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..1723
                     /gene="Kpna2"
                     /gene_synonym="importin"
                     /note="nuclear import protein; importin subunit alpha-2;
                     karyopherin (importin) alpha 2; karyopherin alpha 2"
                     /codon_start=1
                     /product="importin subunit alpha-1"
                     /protein_id="NP_001257731.1"
                     /db_xref="GeneID:85245"
                     /db_xref="RGD:621419"
                     /translation="MSTNENANSTAARLNRFKNKGKDSTEMRRRRIEVNVELRKAKKD
                     DQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVEDIVKGINSNNLESQLQATQAARK
                     LLSREKQPPIDNIIRAGLIPKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVD
                     GGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKHGAIDPLLALLAVPDL
                     SSLACGYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVLADSCWAIS
                     YLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIVTGTDEQTQKVIDA
                     GALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVGVLSKADFK
                     TQKEAAWAITNYTSGGTVEQIVYLVHCGIIEPLMNLLSAKDTKIIQVILDAISNIFQA
                     AEKLGETEKLSIMIEECGGLDKIEALQSHENESVYKASLNLIEKYFSVEEEEDQNVVP
                     ETTSEGFAFQVQDGAPGTFNF"
     exon            209..346
                     /gene="Kpna2"
                     /gene_synonym="importin"
                     /inference="alignment:Splign:2.1.0"
     exon            347..435
                     /gene="Kpna2"
                     /gene_synonym="importin"
                     /inference="alignment:Splign:2.1.0"
     exon            436..704
                     /gene="Kpna2"
                     /gene_synonym="importin"
                     /inference="alignment:Splign:2.1.0"
     exon            705..799
                     /gene="Kpna2"
                     /gene_synonym="importin"
                     /inference="alignment:Splign:2.1.0"
     exon            800..1063
                     /gene="Kpna2"
                     /gene_synonym="importin"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1297
                     /gene="Kpna2"
                     /gene_synonym="importin"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1480
                     /gene="Kpna2"
                     /gene_synonym="importin"
                     /inference="alignment:Splign:2.1.0"
     exon            1481..1630
                     /gene="Kpna2"
                     /gene_synonym="importin"
                     /inference="alignment:Splign:2.1.0"
     exon            1631..1978
                     /gene="Kpna2"
                     /gene_synonym="importin"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acaaagtctg agggctgagg gctagtggac gtttcgacag ccgccgaccc gcagcttgag
       61 agccctgcac cgactttcgt ggaagtctga accggctgtg cagctttcct tcctccttgt
      121 tcctgcagca accatgtcca ccaatgagaa tgctaactca acagctgccc ggcttaacag
      181 attcaagaac aaggggaaag acagtacaga aatgcggcgc cgccgaatag aggttaatgt
      241 ggaacttagg aaagctaaaa aagatgacca gatgctgaaa aggaggaatg tcagctcatt
      301 ccctgatgac gctacttctc cactacagga aaaccgaaac aaccagggta ctgtaaattg
      361 gtctgttgag gacattgtta aaggcataaa cagtaacaat ttggaaagcc agctccaagc
      421 tactcaagct gctcggaaac tgctttcaag agagaagcag cctcctatag acaacatcat
      481 ccgggctggt ttgatcccaa aatttgtgtc cttcttgggc aaaacggatt gtagtcccat
      541 tcagtttgaa tctgcttggg cgctcaccaa cattgcttct ggaacatccg aacagaccaa
      601 agctgtggtg gatggaggtg ctatcccagc atttatttct ctcttggcgt cgccccatgc
      661 tcacatcagc gagcaagctg tgtgggctct tggaaacatt gcaggtgatg gctcagtttt
      721 ccgagacttg gttatcaaac atggtgcaat tgacccactg ttggcacttc tcgcagttcc
      781 tgatctgtca tccttggcat gtggttactt gcggaatctt acctggacac tttcaaacct
      841 ctgtcggaac aagaatcccg cacccccctt agatgctgtt gagcagatcc ttcctactct
      901 agttcgactc ctacaccaca acgatccaga agtattagca gactcctgct gggccatttc
      961 ctatctgact gatgggccga atgagcgcat cgagatggtt gtgaagaagg gagttgttcc
     1021 ccaacttgtg aagcttttag gagctactga actgcccatt gtgacgccgg cactgagagc
     1081 catagggaat attgtcaccg gaacagatga acagactcag aaagtgatcg atgcaggggc
     1141 acttgcagtc tttcccagcc tgctgacaaa ccccaaaact aatattcaga aggaggccac
     1201 atggacaatg tcgaacatta ccgccgggcg ccaggaccag atacagcaag tggtgaatca
     1261 cggcctcgtc ccatttctcg ttggtgtcct ctctaaggca gactttaaga cacagaagga
     1321 agccgcatgg gctataacca actacaccag cggcgggact gttgaacaga ttgtgtatct
     1381 ggttcattgt ggaataatag aacccttgat gaacctcttg agtgcaaaag ataccaaaat
     1441 tattcaggtt attcttgatg ctatttcaaa tatctttcag gctgcagaga aactaggtga
     1501 gacagaaaaa ctcagtataa tgattgaaga gtgtggaggc ttggataaaa ttgaagccct
     1561 acagagccat gagaacgagt ctgtgtacaa ggcctcgttg aacctaattg agaagtactt
     1621 ctcagtggag gaagaggaag atcaaaatgt ggtgccagaa actacctctg aaggcttcgc
     1681 cttccaagtt caggatggag ctcccgggac ctttaacttc taatgtccag ccaaagcaca
     1741 aagttgttag ctatgtgctg tgctgtgctg tgttctcata aatttgtctt actgtttctc
     1801 tactaagaac tctttttaaa tgtggtttgt tattgtagca ctttttacaa aagaaactat
     1861 acttgaacag ttataaactg tacatactct atgaagctgt cctctgagtt tatttctatg
     1921 tggaatttcg taccctgtcg tgtcctgtaa ataaagattt aagttccatt cttctttaaa
     1981 aaaaaaaaaa aaaaaaaaaa aa
//
