LOCUS       NP_001257731             529 aa            linear   ROD 03-APR-2024
DEFINITION  importin subunit alpha-1 [Rattus norvegicus].
ACCESSION   NP_001257731
VERSION     NP_001257731.1
DBSOURCE    REFSEQ: accession NM_001270802.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 529)
  AUTHORS   Bertram,S., Thiele,S., Dreier,C., Resa-Infante,P., Preuss,A., van
            Riel,D., Mok,C.K.P., Schwalm,F., Peiris,J.S.M., Klenk,H.D. and
            Gabriel,G.
  TITLE     H7N9 Influenza A Virus Exhibits Importin-alpha7-Mediated
            Replication in the Mammalian Respiratory Tract
  JOURNAL   Am J Pathol 187 (4), 831-840 (2017)
   PUBMED   28189564
REFERENCE   2  (residues 1 to 529)
  AUTHORS   Mahboubi,H., Koromilas,A.E. and Stochaj,U.
  TITLE     AMP Kinase Activation Alters Oxidant-Induced Stress Granule
            Assembly by Modulating Cell Signaling and Microtubule Organization
  JOURNAL   Mol Pharmacol 90 (4), 460-468 (2016)
   PUBMED   27430620
REFERENCE   3  (residues 1 to 529)
  AUTHORS   Xu,Z., Chen,J., Shi,J., Zhao,J., Wang,J., Ji,Y., Han,L., Zhu,L.,
            Li,X. and Zhang,D.
  TITLE     Upregulated Expression of Karyopherin alpha2 is Involved in
            Neuronal Apoptosis Following Intracerebral Hemorrhage in Adult Rats
  JOURNAL   Cell Mol Neurobiol 36 (5), 755-765 (2016)
   PUBMED   26340948
  REMARK    GeneRIF: Karyopherin alpha2 co-localized well with active caspase-3
            in neurons, indicating its potential role in neuronal apoptosis
REFERENCE   4  (residues 1 to 529)
  AUTHORS   Cai,Y., Shen,Y., Gao,L., Chen,M., Xiao,M., Huang,Z. and Zhang,D.
  TITLE     Karyopherin Alpha 2 Promotes the Inflammatory Response in Rat
            Pancreatic Acinar Cells Via Facilitating NF-kappaB Activation
  JOURNAL   Dig Dis Sci 61 (3), 747-757 (2016)
   PUBMED   26526450
  REMARK    GeneRIF: KPNA2-facilitated p65 nuclear translocation promotes
            NF-kappaB activation and inflammation in acute pancreatitis.
REFERENCE   5  (residues 1 to 529)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   6  (residues 1 to 529)
  AUTHORS   Thompson,K.R., Otis,K.O., Chen,D.Y., Zhao,Y., O'Dell,T.J. and
            Martin,K.C.
  TITLE     Synapse to nucleus signaling during long-term synaptic plasticity;
            a role for the classical active nuclear import pathway
  JOURNAL   Neuron 44 (6), 997-1009 (2004)
   PUBMED   15603742
REFERENCE   7  (residues 1 to 529)
  AUTHORS   Cassany,A., Guillemain,G., Klein,C., Dalet,V., Brot-Laroche,E. and
            Leturque,A.
  TITLE     A karyopherin alpha2 nuclear transport pathway is regulated by
            glucose in hepatic and pancreatic cells
  JOURNAL   Traffic 5 (1), 10-19 (2004)
   PUBMED   14675421
  REMARK    GeneRIF: Data show that extracellular glucose regulates a nuclear
            transport pathway by increasing the nuclear efflux and shuttling of
            karyopherin alpha2 in cells in which glucose can stimulate the
            transcription of sugar-responsive genes.
REFERENCE   8  (residues 1 to 529)
  AUTHORS   Fontes,M.R., Teh,T., Jans,D., Brinkworth,R.I. and Kobe,B.
  TITLE     Structural basis for the specificity of bipartite nuclear
            localization sequence binding by importin-alpha
  JOURNAL   J Biol Chem 278 (30), 27981-27987 (2003)
   PUBMED   12695505
REFERENCE   9  (residues 1 to 529)
  AUTHORS   Guillemain,G., Munoz-Alonso,M.J., Cassany,A., Loizeau,M.,
            Faussat,A.M., Burnol,A.F. and Leturque,A.
  TITLE     Karyopherin alpha2: a control step of glucose-sensitive gene
            expression in hepatic cells
  JOURNAL   Biochem J 364 (Pt 1), 201-209 (2002)
   PUBMED   11988093
  REMARK    GeneRIF: Karyopherin alpha2: a control step of glucose-sensitive
            gene expression in hepatic cells
REFERENCE   10 (residues 1 to 529)
  AUTHORS   Grozinger,C.M. and Schreiber,S.L.
  TITLE     Regulation of histone deacetylase 4 and 5 and transcriptional
            activity by 14-3-3-dependent cellular localization
  JOURNAL   Proc Natl Acad Sci U S A 97 (14), 7835-7840 (2000)
   PUBMED   10869435
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FM083931.1, FM115539.1 and BC089787.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 both encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062026.1, SRR8487231.88323.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..529
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     Protein         1..529
                     /product="importin subunit alpha-1"
                     /note="nuclear import protein; importin subunit alpha-2;
                     karyopherin (importin) alpha 2; karyopherin alpha 2"
                     /calculated_mol_wt=57706
     Region          12..528
                     /region_name="SRP1"
                     /note="Karyopherin (importin) alpha [Intracellular
                     trafficking and secretion]; COG5064"
                     /db_xref="CDD:227396"
     Region          115..147
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Site            order(138,142,146,180,184,188,227,231,235)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293788"
     Region          155..191
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          197..236
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          253..278
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          288..320
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Site            order(311,315,319,353,357,361,395,399,403)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293788"
     Region          328..364
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          370..404
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          413..447
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          457..494
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     CDS             1..529
                     /gene="Kpna2"
                     /gene_synonym="importin"
                     /coded_by="NM_001270802.1:134..1723"
                     /db_xref="GeneID:85245"
                     /db_xref="RGD:621419"
ORIGIN      
        1 mstnenanst aarlnrfknk gkdstemrrr rievnvelrk akkddqmlkr rnvssfpdda
       61 tsplqenrnn qgtvnwsved ivkginsnnl esqlqatqaa rkllsrekqp pidniiragl
      121 ipkfvsflgk tdcspiqfes awaltniasg tseqtkavvd ggaipafisl lasphahise
      181 qavwalgnia gdgsvfrdlv ikhgaidpll allavpdlss lacgylrnlt wtlsnlcrnk
      241 npappldave qilptlvrll hhndpevlad scwaisyltd gpneriemvv kkgvvpqlvk
      301 llgatelpiv tpalraigni vtgtdeqtqk vidagalavf pslltnpktn iqkeatwtms
      361 nitagrqdqi qqvvnhglvp flvgvlskad fktqkeaawa itnytsggtv eqivylvhcg
      421 iieplmnlls akdtkiiqvi ldaisnifqa aeklgetekl simieecggl dkiealqshe
      481 nesvykasln liekyfsvee eedqnvvpet tsegfafqvq dgapgtfnf
//
