LOCUS       NM_198726               1644 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus karyopherin subunit alpha 1 (Kpna1), mRNA.
ACCESSION   NM_198726 XM_213607
VERSION     NM_198726.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1644)
  AUTHORS   Choo,H.J., Cutler,A., Rother,F., Bader,M. and Pavlath,G.K.
  TITLE     Karyopherin Alpha 1 Regulates Satellite Cell Proliferation and
            Survival by Modulating Nuclear Import
  JOURNAL   Stem Cells 34 (11), 2784-2797 (2016)
   PUBMED   27434733
REFERENCE   2  (bases 1 to 1644)
  AUTHORS   Dieterich,D.C., Karpova,A., Mikhaylova,M., Zdobnova,I., Konig,I.,
            Landwehr,M., Kreutz,M., Smalla,K.H., Richter,K., Landgraf,P.,
            Reissner,C., Boeckers,T.M., Zuschratter,W., Spilker,C.,
            Seidenbecher,C.I., Garner,C.C., Gundelfinger,E.D. and Kreutz,M.R.
  TITLE     Caldendrin-Jacob: a protein liaison that couples NMDA receptor
            signalling to the nucleus
  JOURNAL   PLoS Biol 6 (2), e34 (2008)
   PUBMED   18303947
  REMARK    Erratum:[PLoS Biol. 2009 Jan;7(1):e1000022]
REFERENCE   3  (bases 1 to 1644)
  AUTHORS   Plant,K.E., Everett,D.M., Gordon Gibson,G., Lyon,J. and Plant,N.J.
  TITLE     Transcriptomic and phylogenetic analysis of Kpna genes: a family of
            nuclear import factors modulated in xenobiotic-mediated liver
            growth
  JOURNAL   Pharmacogenet Genomics 16 (9), 647-658 (2006)
   PUBMED   16906019
REFERENCE   4  (bases 1 to 1644)
  AUTHORS   Pickard,B.W., Hodsman,A.B., Fraher,L.J. and Watson,P.H.
  TITLE     Type 1 parathyroid hormone receptor (PTH1R) nuclear trafficking:
            association of PTH1R with importin alpha1 and beta
  JOURNAL   Endocrinology 147 (7), 3326-3332 (2006)
   PUBMED   16574786
  REMARK    GeneRIF: PTH1R forms a complex with the transport regulatory
            proteins, importin alpha(1) and importin beta, and nuclear PTH1R is
            associated with the nucleoplasm
REFERENCE   5  (bases 1 to 1644)
  AUTHORS   Thompson,K.R., Otis,K.O., Chen,D.Y., Zhao,Y., O'Dell,T.J. and
            Martin,K.C.
  TITLE     Synapse to nucleus signaling during long-term synaptic plasticity;
            a role for the classical active nuclear import pathway
  JOURNAL   Neuron 44 (6), 997-1009 (2004)
   PUBMED   15603742
REFERENCE   6  (bases 1 to 1644)
  AUTHORS   Wang,B., Li,Z., Xu,L., Goggi,J., Yu,Y. and Zhou,J.
  TITLE     Molecular cloning and characterization of rat karyopherin alpha 1
            gene: structure and expression
  JOURNAL   Gene 331, 149-157 (2004)
   PUBMED   15094201
  REMARK    GeneRIF: Results suggest involvement of KPNA1 in the striatal
            responses to denervation following 6-hydroxydopamine
            (6-OHDA)-induced lesion.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY779025.1.
            
            On Jun 10, 2007 this sequence version replaced NM_198726.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY779025.1, AY351984.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1644
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q22"
     gene            1..1644
                     /gene="Kpna1"
                     /note="karyopherin subunit alpha 1"
                     /db_xref="GeneID:288064"
                     /db_xref="RGD:735064"
     exon            1..130
                     /gene="Kpna1"
                     /inference="alignment:Splign:2.1.0"
     CDS             2..1618
                     /gene="Kpna1"
                     /note="importin subunit alpha-1; karyopherin/importin
                     alpha-1; importin alpha-5; karyopherin alpha 1"
                     /codon_start=1
                     /product="importin subunit alpha-5"
                     /protein_id="NP_942021.2"
                     /db_xref="GeneID:288064"
                     /db_xref="RGD:735064"
                     /translation="MSTPGKENFRLKSYKNKSLNPDEMRRRREEEGLQLRKQKREEQL
                     FKRRNVATAEEETEEEVMSDGGFHEAQINNMEMAPGGVITSDMTEMIFSNSPEQQLSA
                     TQKFRKLLSKEPNPPIDEVINTPGVVARFVEFLKRKENCTLQFESAWVLTNIASGNSL
                     QTRIVIQAGAVPIFIELLSSEFEDVQEQAVWALGNIAGDSTMCRDYVLDCNILPPLLQ
                     LFSKQNRLTMTRNAVWALSNLCRGKSPPPEFAKVSPCLNVLSWLLFVSDTDVLADACW
                     ALSYLSDGPNDKIQAVIDAGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVI
                     LNCSALQSLLHLLSSPKESIKKEACWTISNITAGNRAQIQTVIDANMFPALISILQTA
                     EFRTRKEAAWAITNATSGGSAEQIKYLVELGCIKPLCDLLTVMDAKIVQVALNGLENI
                     LRLGEQEAKRNGSGINPYCALIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGTED
                     EDSSIAPQVDLSQQQYIFQQCEAPMEGFQL"
     exon            131..238
                     /gene="Kpna1"
                     /inference="alignment:Splign:2.1.0"
     exon            239..338
                     /gene="Kpna1"
                     /inference="alignment:Splign:2.1.0"
     exon            339..433
                     /gene="Kpna1"
                     /inference="alignment:Splign:2.1.0"
     exon            434..565
                     /gene="Kpna1"
                     /inference="alignment:Splign:2.1.0"
     exon            566..654
                     /gene="Kpna1"
                     /inference="alignment:Splign:2.1.0"
     exon            655..754
                     /gene="Kpna1"
                     /inference="alignment:Splign:2.1.0"
     exon            755..918
                     /gene="Kpna1"
                     /inference="alignment:Splign:2.1.0"
     exon            919..997
                     /gene="Kpna1"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1123
                     /gene="Kpna1"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1251
                     /gene="Kpna1"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1430
                     /gene="Kpna1"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..1644
                     /gene="Kpna1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 catgtccacg ccaggaaaag agaactttcg cctgaaaagt tacaagaaca aatctctgaa
       61 tcctgatgag atgcgcagga ggagggagga agaaggactg cagttacgga agcagaaaag
      121 ggaagaacag ttattcaaga gaagaaatgt tgctacagca gaagaagaaa cagaagaaga
      181 agttatgtct gatggtggct ttcatgaggc ccagataaat aacatggaga tggcaccagg
      241 gggagtcatt acctctgaca tgactgagat gatattctcc aatagcccag aacagcagct
      301 ttctgcaaca cagaaattta ggaaactact ttcaaaagaa cctaatcctc ctattgatga
      361 agtcatcaac acaccaggag tagtggccag gtttgtggag ttcctcaaac gaaaagaaaa
      421 ttgtacactg cagtttgaat cagcttgggt cctgacaaat attgcttcag gaaactctct
      481 tcagacccgg attgtgattc aggcaggagc tgttcctatc ttcatcgagt tgcttagctc
      541 agagtttgaa gatgtccagg agcaggcagt ctgggctctt ggcaacattg ctggagatag
      601 caccatgtgc agggactacg tcttagactg caatatcctt ccccctctgc tgcagttatt
      661 ttcaaagcaa aaccgcttga ccatgacccg gaatgcagtg tgggctttat ctaatctatg
      721 tagagggaag agtccacctc cagaatttgc taaggtttct ccctgtctga atgtcctttc
      781 ttggttgctg tttgtcagtg acactgatgt actggctgat gcttgctggg ctctctcata
      841 cctgtcagat ggacccaatg ataaaatcca agcagtcatc gatgcaggag tatgcaggag
      901 acttgtggag cttctgatgc acaatgatta taaagtggtt tctcctgctt tgcgggctgt
      961 gggaaacatt gttacagggg atgacattca gacacaggta attttgaatt gctcagctct
     1021 tcagagttta ttgcatctgc tgagtagccc aaaggaatct atcaaaaaag aagcatgttg
     1081 gacaatctct aatattacag ctggaaatag ggcacagatc cagactgtga tagacgctaa
     1141 catgttccca gctctcatca gtatattgca aacagcagag ttccggacga gaaaggaagc
     1201 tgcttgggcc atcacaaatg caacttctgg aggatcagct gagcagatca agtacctagt
     1261 agaactgggt tgtatcaagc cactctgtga tctcctcact gtcatggatg caaaaattgt
     1321 acaggttgcc ctaaatggct tagaaaacat cctgaggctt ggggaacaag aagccaaaag
     1381 aaatggctca ggaattaacc cttactgtgc tttgattgag gaagcatatg gtctggataa
     1441 aattgagttt ttacagagtc atgaaaacca ggagatctat cagaaggctt ttgatcttat
     1501 tgagcattac tttgggacgg aggacgagga cagcagcatc gcaccccagg ttgaccttag
     1561 ccagcagcag tacatcttcc agcagtgtga ggctcccatg gaaggtttcc agctctgaag
     1621 caaccctctg ctttcttgtt cctg
//
