LOCUS       NP_942021                538 aa            linear   ROD 24-JUN-2024
DEFINITION  importin subunit alpha-5 [Rattus norvegicus].
ACCESSION   NP_942021 XP_213607
VERSION     NP_942021.2
DBSOURCE    REFSEQ: accession NM_198726.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 538)
  AUTHORS   Choo,H.J., Cutler,A., Rother,F., Bader,M. and Pavlath,G.K.
  TITLE     Karyopherin Alpha 1 Regulates Satellite Cell Proliferation and
            Survival by Modulating Nuclear Import
  JOURNAL   Stem Cells 34 (11), 2784-2797 (2016)
   PUBMED   27434733
REFERENCE   2  (residues 1 to 538)
  AUTHORS   Dieterich,D.C., Karpova,A., Mikhaylova,M., Zdobnova,I., Konig,I.,
            Landwehr,M., Kreutz,M., Smalla,K.H., Richter,K., Landgraf,P.,
            Reissner,C., Boeckers,T.M., Zuschratter,W., Spilker,C.,
            Seidenbecher,C.I., Garner,C.C., Gundelfinger,E.D. and Kreutz,M.R.
  TITLE     Caldendrin-Jacob: a protein liaison that couples NMDA receptor
            signalling to the nucleus
  JOURNAL   PLoS Biol 6 (2), e34 (2008)
   PUBMED   18303947
  REMARK    Erratum:[PLoS Biol. 2009 Jan;7(1):e1000022]
REFERENCE   3  (residues 1 to 538)
  AUTHORS   Plant,K.E., Everett,D.M., Gordon Gibson,G., Lyon,J. and Plant,N.J.
  TITLE     Transcriptomic and phylogenetic analysis of Kpna genes: a family of
            nuclear import factors modulated in xenobiotic-mediated liver
            growth
  JOURNAL   Pharmacogenet Genomics 16 (9), 647-658 (2006)
   PUBMED   16906019
REFERENCE   4  (residues 1 to 538)
  AUTHORS   Pickard,B.W., Hodsman,A.B., Fraher,L.J. and Watson,P.H.
  TITLE     Type 1 parathyroid hormone receptor (PTH1R) nuclear trafficking:
            association of PTH1R with importin alpha1 and beta
  JOURNAL   Endocrinology 147 (7), 3326-3332 (2006)
   PUBMED   16574786
  REMARK    GeneRIF: PTH1R forms a complex with the transport regulatory
            proteins, importin alpha(1) and importin beta, and nuclear PTH1R is
            associated with the nucleoplasm
REFERENCE   5  (residues 1 to 538)
  AUTHORS   Thompson,K.R., Otis,K.O., Chen,D.Y., Zhao,Y., O'Dell,T.J. and
            Martin,K.C.
  TITLE     Synapse to nucleus signaling during long-term synaptic plasticity;
            a role for the classical active nuclear import pathway
  JOURNAL   Neuron 44 (6), 997-1009 (2004)
   PUBMED   15603742
REFERENCE   6  (residues 1 to 538)
  AUTHORS   Wang,B., Li,Z., Xu,L., Goggi,J., Yu,Y. and Zhou,J.
  TITLE     Molecular cloning and characterization of rat karyopherin alpha 1
            gene: structure and expression
  JOURNAL   Gene 331, 149-157 (2004)
   PUBMED   15094201
  REMARK    GeneRIF: Results suggest involvement of KPNA1 in the striatal
            responses to denervation following 6-hydroxydopamine
            (6-OHDA)-induced lesion.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY779025.1.
            
            On Jun 10, 2007 this sequence version replaced NP_942021.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY779025.1, AY351984.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..538
                     /organism="Rattus norvegicus"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q22"
     Protein         1..538
                     /product="importin subunit alpha-5"
                     /note="importin subunit alpha-1; karyopherin/importin
                     alpha-1; importin alpha-5; karyopherin alpha 1"
                     /calculated_mol_wt=60066
     Region          1..41
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P83953.1)"
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:P52294; propagated from
                     UniProtKB/Swiss-Prot (P83953.1)"
     Site            3
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P52294; propagated from
                     UniProtKB/Swiss-Prot (P83953.1)"
     Region          33..516
                     /region_name="SRP1"
                     /note="Karyopherin (importin) alpha [Intracellular
                     trafficking and secretion]; COG5064"
                     /db_xref="CDD:227396"
     Region          42..51
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000250|UniProtKB:P52293"
                     /note="propagated from UniProtKB/Swiss-Prot (P83953.1)"
     Site            63
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P52294; propagated from
                     UniProtKB/Swiss-Prot (P83953.1)"
     Region          77..117
                     /region_name="ARM 1, truncated"
                     /note="propagated from UniProtKB/Swiss-Prot (P83953.1)"
     Region          118..161
                     /region_name="ARM 2. /evidence=ECO:0000305"
                     /note="propagated from UniProtKB/Swiss-Prot (P83953.1)"
     Region          128..154
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Site            order(145,149,153,187,191,195,230,234,238)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293788"
     Region          149..241
                     /region_name="NLS binding site (major).
                     /evidence=ECO:0000250|UniProtKB:P52293"
                     /note="propagated from UniProtKB/Swiss-Prot (P83953.1)"
     Region          162..198
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          204..239
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          207..245
                     /region_name="ARM 4. /evidence=ECO:0000305"
                     /note="propagated from UniProtKB/Swiss-Prot (P83953.1)"
     Region          245..437
                     /region_name="Binding to RAG1.
                     /evidence=ECO:0000250|UniProtKB:P52294"
                     /note="propagated from UniProtKB/Swiss-Prot (P83953.1)"
     Region          256..281
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          289..325
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          318..406
                     /region_name="NLS binding site (minor).
                     /evidence=ECO:0000250|UniProtKB:P52293"
                     /note="propagated from UniProtKB/Swiss-Prot (P83953.1)"
     Site            order(356,360,364,398,402,406,441,445,449)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293788"
     Region          373..409
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          413..457
                     /region_name="ARM 9. /evidence=ECO:0000305"
                     /note="propagated from UniProtKB/Swiss-Prot (P83953.1)"
     Region          416..450
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          460..504
                     /region_name="ARM 10, atypical"
                     /note="propagated from UniProtKB/Swiss-Prot (P83953.1)"
     CDS             1..538
                     /gene="Kpna1"
                     /coded_by="NM_198726.2:2..1618"
                     /db_xref="GeneID:288064"
                     /db_xref="RGD:735064"
ORIGIN      
        1 mstpgkenfr lksyknksln pdemrrrree eglqlrkqkr eeqlfkrrnv ataeeeteee
       61 vmsdggfhea qinnmemapg gvitsdmtem ifsnspeqql satqkfrkll skepnppide
      121 vintpgvvar fveflkrken ctlqfesawv ltniasgnsl qtriviqaga vpifiellss
      181 efedvqeqav walgniagds tmcrdyvldc nilppllqlf skqnrltmtr navwalsnlc
      241 rgkspppefa kvspclnvls wllfvsdtdv ladacwalsy lsdgpndkiq avidagvcrr
      301 lvellmhndy kvvspalrav gnivtgddiq tqvilncsal qsllhllssp kesikkeacw
      361 tisnitagnr aqiqtvidan mfpalisilq taefrtrkea awaitnatsg gsaeqikylv
      421 elgcikplcd lltvmdakiv qvalngleni lrlgeqeakr ngsginpyca lieeaygldk
      481 ieflqshenq eiyqkafdli ehyfgteded ssiapqvdls qqqyifqqce apmegfql
//
