LOCUS       NM_001004264            1490 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus kinetochore-localized astrin/SPAG5 binding
            protein (Knstrn), mRNA.
ACCESSION   NM_001004264 XM_230532
VERSION     NM_001004264.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1490)
  AUTHORS   Schmitz,L., Grinblat,B., Novak,B., Hoeh,A.K., Handschke,K., von
            Dobbeler,C., Bierhoff,E., Szeimies,R.M., Gambichler,T., Torezan,L.,
            Festa-Neto,C., Stockfleth,E. and Dirschka,T.
  TITLE     Somatic mutations in kinetochore gene KNSTRN are associated with
            basal proliferating actinic keratoses and cutaneous squamous cell
            carcinoma
  JOURNAL   J Eur Acad Dermatol Venereol 33 (8), 1535-1540 (2019)
   PUBMED   30972880
REFERENCE   2  (bases 1 to 1490)
  AUTHORS   Tochigi,Y., Iwasaki,Y., Sano,M., Yasuda,H., Katayama,K. and
            Suzuki,H.
  TITLE     Critical roles of Astrin in the mitosis of immature rat Sertoli
            cells
  JOURNAL   Biochem Biophys Res Commun 486 (4), 958-964 (2017)
   PUBMED   28351621
  REMARK    GeneRIF: These results indicate that Astrin is required for normal
            mitotic progression in immature Sertoli cells and that the most
            severe type of testicullar dysplasia in hgn/hgn rats is caused by
            mitotic cell death of immature Sertoli cells due to lack of Astrin.
REFERENCE   3  (bases 1 to 1490)
  AUTHORS   Lee,C.S., Bhaduri,A., Mah,A., Johnson,W.L., Ungewickell,A.,
            Aros,C.J., Nguyen,C.B., Rios,E.J., Siprashvili,Z., Straight,A.,
            Kim,J., Aasi,S.Z. and Khavari,P.A.
  TITLE     Recurrent point mutations in the kinetochore gene KNSTRN in
            cutaneous squamous cell carcinoma
  JOURNAL   Nat Genet 46 (10), 1060-1062 (2014)
   PUBMED   25194279
REFERENCE   4  (bases 1 to 1490)
  AUTHORS   Dunsch,A.K., Linnane,E., Barr,F.A. and Gruneberg,U.
  TITLE     The astrin-kinastrin/SKAP complex localizes to microtubule plus
            ends and facilitates chromosome alignment
  JOURNAL   J Cell Biol 192 (6), 959-968 (2011)
   PUBMED   21402792
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079438.1.
            
            On Sep 10, 2004 this sequence version replaced XM_230532.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079438.1, FQ226275.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1490
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q35"
     gene            1..1490
                     /gene="Knstrn"
                     /gene_synonym="C15orf23; SKAP; Traf4af1"
                     /note="kinetochore-localized astrin/SPAG5 binding protein"
                     /db_xref="GeneID:311325"
                     /db_xref="RGD:1303240"
     exon            1..278
                     /gene="Knstrn"
                     /gene_synonym="C15orf23; SKAP; Traf4af1"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..1008
                     /gene="Knstrn"
                     /gene_synonym="C15orf23; SKAP; Traf4af1"
                     /note="putative TRAF4-associated factor 1; kinastrin;
                     kinetochore-localized astrin-binding protein"
                     /codon_start=1
                     /product="small kinetochore-associated protein"
                     /protein_id="NP_001004264.1"
                     /db_xref="GeneID:311325"
                     /db_xref="RGD:1303240"
                     /translation="MATHKAEAQETDFRTTGPPTDLEQCPFPPSSRKFPFESVAADST
                     EGWAVAAEHHLKRSGEDGGWEQPASGVEPSRPTTMASSKTVCDAQPHSMPSCGLSADT
                     QTRATSKLPVKSKDAEMLRHLHTGGLEPDVTKVTKPRRENGQGKAAETASRRNIRSSY
                     KPLSKQKPEEDLKDKNELLEAVNKQLHQKLTETQGELKDLTQKVELLEKFQDNCLAIL
                     ESKGLNSGQETQESKQEPSTDPTDSMLLLETLKDELKLFNETAKKQMEELQALKVKLK
                     LKEKERIQFLEQQTLGKDEASDFTIILEEMEQLLEM"
     exon            279..370
                     /gene="Knstrn"
                     /gene_synonym="C15orf23; SKAP; Traf4af1"
                     /inference="alignment:Splign:2.1.0"
     exon            371..497
                     /gene="Knstrn"
                     /gene_synonym="C15orf23; SKAP; Traf4af1"
                     /inference="alignment:Splign:2.1.0"
     exon            498..545
                     /gene="Knstrn"
                     /gene_synonym="C15orf23; SKAP; Traf4af1"
                     /inference="alignment:Splign:2.1.0"
     exon            546..651
                     /gene="Knstrn"
                     /gene_synonym="C15orf23; SKAP; Traf4af1"
                     /inference="alignment:Splign:2.1.0"
     exon            652..745
                     /gene="Knstrn"
                     /gene_synonym="C15orf23; SKAP; Traf4af1"
                     /inference="alignment:Splign:2.1.0"
     exon            746..801
                     /gene="Knstrn"
                     /gene_synonym="C15orf23; SKAP; Traf4af1"
                     /inference="alignment:Splign:2.1.0"
     exon            802..876
                     /gene="Knstrn"
                     /gene_synonym="C15orf23; SKAP; Traf4af1"
                     /inference="alignment:Splign:2.1.0"
     exon            877..1454
                     /gene="Knstrn"
                     /gene_synonym="C15orf23; SKAP; Traf4af1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcccagtgca cccctagccc ggccttgacc agcaggctgg agcaacaccc tacgaacctt
       61 ccgtacagca tggcgactca caaggccgag gcacaggaga cagacttccg tacaacaggg
      121 ccgcccacag acttggaaca gtgccccttt ccgcccagct cccggaagtt tccttttgaa
      181 agcgtggcgg cagactctac tgagggctgg gcagttgctg cggagcatca tttgaaaagg
      241 agcggagagg acggcggatg ggagcagccg gcatcggggg tcgagccaag ccgcccgact
      301 acgatggcca gttctaagac ggtgtgcgac gcgcagcccc attcgatgcc gagctgcggc
      361 ttgtccgcag atacacaaac tcgagctact tctaagctac ctgttaaatc caaagacgct
      421 gagatgctta gacatcttca tacgggaggc ttagagcctg acgttacaaa agtcaccaaa
      481 ccaagacgag agaacgggca ggggaaagct gcggagactg ccagccggag gaacatcaga
      541 agcagctaca aaccactgag taagcaaaag ccagaggagg atctgaagga taaaaacgag
      601 ctgctggagg ctgtcaacaa gcagctacac cagaagctga cagagactca gggagagctg
      661 aaggacctga cacagaaggt ggagctcctg gagaagtttc aggataactg cttagcaatt
      721 ttggagagca aaggtctcaa ctcaggccaa gagacccagg aatcaaagca ggaacccagc
      781 acagatccca cggactccat gctgctgcta gaaactttga aagatgaact gaagcttttc
      841 aatgaaactg ccaagaagca gatggaggag ctacaggcct tgaaggtgaa gttgaagttg
      901 aaagaaaaag aaaggatcca gttcctggaa cagcaaacct taggtaagga cgaagccagt
      961 gacttcacaa taatcctgga ggaaatggag cagctcttag aaatgtaatg caaggcaagc
     1021 gtccagacag cttcttcctg cataaactct catcggaggc cacttaggat atcttcaagg
     1081 actcaccgtc ccttaggtaa agaccttctg tagcagttga tccgataagg gcagttgatg
     1141 ctgggggtcc tcctttaagc agattgcccc accttcagat ggctcagctc tcctgcaaga
     1201 gaggaacctg ggagtttgac tccacttcct gcacaacaga gagagcaaca accttagaac
     1261 taggatagta aaccagccat ggagactctc gagactctta cttggaaaca cgggaggaaa
     1321 gcccacaccg agacagcacg tgcgctgtgc gggagctgtc acttcaagct atgctgtccc
     1381 ctttgtctgg ttgagctaag tttatgaact tgaaatcctt gaagtctttt ggcgtaataa
     1441 attgggtgga ggtaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
