LOCUS       NM_012696               1674 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus kininogen 2 (Kng2), mRNA.
ACCESSION   NM_012696 XM_003752525
VERSION     NM_012696.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1674)
  AUTHORS   Barallobre-Barreiro,J., Gupta,S.K., Zoccarato,A.,
            Kitazume-Taneike,R., Fava,M., Yin,X., Werner,T., Hirt,M.N.,
            Zampetaki,A., Viviano,A., Chong,M., Bern,M., Kourliouros,A.,
            Domenech,N., Willeit,P., Shah,A.M., Jahangiri,M., Schaefer,L.,
            Fischer,J.W., Iozzo,R.V., Viner,R., Thum,T., Heineke,J.,
            Kichler,A., Otsu,K. and Mayr,M.
  TITLE     Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin
            Activity in Human Atrial Fibrillation
  JOURNAL   Circulation 134 (11), 817-832 (2016)
   PUBMED   27559042
REFERENCE   2  (bases 1 to 1674)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   3  (bases 1 to 1674)
  AUTHORS   Hu,Z., Liu,J., Song,Z., Hou,Q., Fan,X. and Hou,D.
  TITLE     Variants in the Atherogenic ALOX5AP, THBD, and KNG1 Genes
            Potentiate the Risk of Ischemic Stroke via a Genetic Main Effect
            and Epistatic Interactions in a Chinese Population
  JOURNAL   J Stroke Cerebrovasc Dis 24 (9), 2060-2068 (2015)
   PUBMED   26159646
REFERENCE   4  (bases 1 to 1674)
  AUTHORS   He,X., Yin,W., Ding,Y., Cui,S.J., Luan,J., Zhao,P., Yue,X., Yu,C.,
            Laing,X. and Zhao,Y.
  TITLE     Higher Serum Angiotensinogen Is an Indicator of IgA Vasculitis with
            Nephritis Revealed by Comparative Proteomes Analysis
  JOURNAL   PLoS One 10 (6), e0130536 (2015)
   PUBMED   26098644
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1674)
  AUTHORS   Bruzelius,M., Bottai,M., Sabater-Lleal,M., Strawbridge,R.J.,
            Bergendal,A., Silveira,A., Sundstrom,A., Kieler,H., Hamsten,A. and
            Odeberg,J.
  TITLE     Predicting venous thrombosis in women using a combination of
            genetic markers and clinical risk factors
  JOURNAL   J Thromb Haemost 13 (2), 219-227 (2015)
   PUBMED   25472531
REFERENCE   6  (bases 1 to 1674)
  AUTHORS   Enjyoji,K. and Kato,H.
  TITLE     Purification and characterization of two isoforms of T-kininogens
            from rat liver microsomes
  JOURNAL   J Biochem 111 (5), 670-675 (1992)
   PUBMED   1639765
REFERENCE   7  (bases 1 to 1674)
  AUTHORS   Damas,J., Delree,P. and Bourdon,V.
  TITLE     Distribution of immunoreactive T-kininogen in rat nervous tissues
  JOURNAL   Brain Res 569 (1), 63-70 (1992)
   PUBMED   1611479
REFERENCE   8  (bases 1 to 1674)
  AUTHORS   Mann,E.A., Croyle,M.L. and Lingrel,J.B.
  TITLE     Identification of sequences mediating interleukin-6 induction of a
            rat T kininogen gene
  JOURNAL   J Biol Chem 266 (25), 16931-16934 (1991)
   PUBMED   1653251
REFERENCE   9  (bases 1 to 1674)
  AUTHORS   DeLa Cadena,R.A., Laskin,K.J., Pixley,R.A., Sartor,R.B.,
            Schwab,J.H., Back,N., Bedi,G.S., Fisher,R.S. and Colman,R.W.
  TITLE     Role of kallikrein-kinin system in pathogenesis of bacterial cell
            wall-induced inflammation
  JOURNAL   Am J Physiol 260 (2 Pt 1), G213-G219 (1991)
   PUBMED   1996642
REFERENCE   10 (bases 1 to 1674)
  AUTHORS   Pasquale,C.P., Martins,M.A., Bozza,P.T., Silva,P.M., Faria
            Neto,H.C., Pires,A.L. and Cordeiro,R.S.
  TITLE     Bradykinin induces eosinophil accumulation in the rat pleural
            cavity
  JOURNAL   Int Arch Allergy Appl Immunol 95 (2-3), 244-247 (1991)
   PUBMED   1937926
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC087028.1.
            
            On or before Jun 26, 2012 this sequence version replaced
            XM_003752525.1, NM_012696.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087028.1, M11883.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1674
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..1674
                     /gene="Kng2"
                     /gene_synonym="KINKG; KINKH; KINT1G; Kng; Kng1; Kng1_v1;
                     Kngk; Kngt; Kngt1; Kng_v1; Map1; Tkg; TKG6"
                     /note="kininogen 2"
                     /db_xref="GeneID:24903"
                     /db_xref="RGD:2980"
     exon            1..442
                     /gene="Kng2"
                     /gene_synonym="KINKG; KINKH; KINT1G; Kng; Kng1; Kng1_v1;
                     Kngk; Kngt; Kngt1; Kng_v1; Map1; Tkg; TKG6"
                     /inference="alignment:Splign:2.1.0"
     CDS             248..1540
                     /gene="Kng2"
                     /gene_synonym="KINKG; KINKH; KINT1G; Kng; Kng1; Kng1_v1;
                     Kngk; Kngt; Kngt1; Kng_v1; Map1; Tkg; TKG6"
                     /note="LMW T-kininogen I; T-kininogen 1; thiostatin;
                     alpha-1-MAP; major acute phase protein; K-kininogen,
                     differential splicing leads to HMW Kngk; kininogen II"
                     /codon_start=1
                     /product="T-kininogen 1 precursor"
                     /protein_id="NP_036828.2"
                     /db_xref="GeneID:24903"
                     /db_xref="RGD:2980"
                     /translation="MKLITILLLCSRLLPSLAQEEGAQELNCNDETVFQAVDTALKKY
                     NAELESGNQFVLYRVTKGTKKDGAETLYSFKYQIKEGNCSVQSGLTWQDCDFKDAEEA
                     ATGECTTTLGKKENKFSVATQICNITPGKGPKKTEEDLCVGCFQPIPMDSSDLKPVLK
                     HAVEHFNNNTKHTHLFALREVKSAHSQVVAGMNYKIIYSIVQTNCSKEDFPSLREDCV
                     PLPYGDHGECTGHTHVDIHNTIAGFSQSCDLYPGDDLFELLPKNCRGCPREIPVDSPE
                     LKEALGHSIAQLNAQHNHIFYFKIDTVKKATSQVVAGVIYVIEFIARETNCSKQSKTE
                     LTADCETKHLGQSLNCNANVYMRPWENKVVPTVRCQALDMMISRPPGFSPFRLVRVQE
                     TKEGTTRLLNSCEYKGRLSKARAGPAPDHQAEASTVTS"
     exon            443..553
                     /gene="Kng2"
                     /gene_synonym="KINKG; KINKH; KINT1G; Kng; Kng1; Kng1_v1;
                     Kngk; Kngt; Kngt1; Kng_v1; Map1; Tkg; TKG6"
                     /inference="alignment:Splign:2.1.0"
     exon            554..635
                     /gene="Kng2"
                     /gene_synonym="KINKG; KINKH; KINT1G; Kng; Kng1; Kng1_v1;
                     Kngk; Kngt; Kngt1; Kng_v1; Map1; Tkg; TKG6"
                     /inference="alignment:Splign:2.1.0"
     exon            636..808
                     /gene="Kng2"
                     /gene_synonym="KINKG; KINKH; KINT1G; Kng; Kng1; Kng1_v1;
                     Kngk; Kngt; Kngt1; Kng_v1; Map1; Tkg; TKG6"
                     /inference="alignment:Splign:2.1.0"
     exon            809..916
                     /gene="Kng2"
                     /gene_synonym="KINKG; KINKH; KINT1G; Kng; Kng1; Kng1_v1;
                     Kngk; Kngt; Kngt1; Kng_v1; Map1; Tkg; TKG6"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1001
                     /gene="Kng2"
                     /gene_synonym="KINKG; KINKH; KINT1G; Kng; Kng1; Kng1_v1;
                     Kngk; Kngt; Kngt1; Kng_v1; Map1; Tkg; TKG6"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1174
                     /gene="Kng2"
                     /gene_synonym="KINKG; KINKH; KINT1G; Kng; Kng1; Kng1_v1;
                     Kngk; Kngt; Kngt1; Kng_v1; Map1; Tkg; TKG6"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1282
                     /gene="Kng2"
                     /gene_synonym="KINKG; KINKH; KINT1G; Kng; Kng1; Kng1_v1;
                     Kngk; Kngt; Kngt1; Kng_v1; Map1; Tkg; TKG6"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1369
                     /gene="Kng2"
                     /gene_synonym="KINKG; KINKH; KINT1G; Kng; Kng1; Kng1_v1;
                     Kngk; Kngt; Kngt1; Kng_v1; Map1; Tkg; TKG6"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1441
                     /gene="Kng2"
                     /gene_synonym="KINKG; KINKH; KINT1G; Kng; Kng1; Kng1_v1;
                     Kngk; Kngt; Kngt1; Kng_v1; Map1; Tkg; TKG6"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1648
                     /gene="Kng2"
                     /gene_synonym="KINKG; KINKH; KINT1G; Kng; Kng1; Kng1_v1;
                     Kngk; Kngt; Kngt1; Kng_v1; Map1; Tkg; TKG6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggtcaacaa ccccttgttg caatgcccca gctgggtacc tgcttggacg tggagcagag
       61 tcctgtttgt tctctgagaa gagggcaaac aaggggtgac tgcaggaatc taaaagggac
      121 cagagtggcg agacagagag agcataggca ggagaagtca gagactggag gctgctaaaa
      181 gcagcttctg agttggtttc ctggtcttgg caaaacaatt cctcaattcc agagggaacc
      241 tttaatcatg aagctaatta ctatcctgct cctctgctcc aggctcctgc caagtttagc
      301 gcaggaagaa ggcgcccagg aattgaactg caatgatgag actgtatttc aggctgtgga
      361 tactgctctg aagaaatata acgctgagtt agaaagcggc aaccagtttg tgttgtaccg
      421 agtgactaag ggcactaaga aggatggcgc tgaaacattg tattccttca agtatcaaat
      481 caaggagggc aactgctctg ttcagagtgg cctcacctgg caggactgtg acttcaagga
      541 cgctgaggaa gccgctactg gcgaatgcac aacaactttg gggaagaaag aaaataaatt
      601 ctccgtagcc acccagatct gcaatattac tccaggtaag ggtcctaaga agacagagga
      661 ggacctctgt gtcgggtgtt tccaacccat accgatggat agctcagacc tgaagcctgt
      721 tctgaaacac gctgtggagc atttcaacaa caacacgaag cacacccacc tctttgctct
      781 cagagaagta aagagtgccc actcacaggt ggtggctggc atgaattata aaattatcta
      841 ctccattgtg caaacaaatt gttcaaagga ggattttcct tccctccgtg aagactgtgt
      901 accccttccc tatggcgatc atggtgagtg tacgggtcat acccacgtgg atattcataa
      961 cacaattgcc ggcttctcac agagctgtga cctttatcca ggagatgatt tgtttgaact
     1021 acttcccaag aattgccgtg gctgccccag ggagatacct gtagacagcc cggagctgaa
     1081 ggaggcactt ggtcattcca ttgcacagct taatgcacag cataaccata ttttctattt
     1141 caagattgac accgtgaaaa aggcaacatc acaggtggtt gctggagtaa tatatgtgat
     1201 tgagttcata gccagagaaa ctaactgttc caagcaaagt aaaacagaac tgacagcgga
     1261 ttgtgagacc aaacacctcg gtcaaagcct caactgcaat gctaacgtgt acatgagacc
     1321 ttgggagaac aaagtcgtcc cgactgtcag atgccaagca ctagatatga tgatttctag
     1381 gcctccagga ttttcacctt tccggctggt gcgagtacaa gaaactaaag aaggaacaac
     1441 taggctccta aactcatgtg agtacaaggg cagactctca aaggcaaggg caggcccagc
     1501 acctgaccat caggcagaag cttcaaccgt gacatcatag cctggcaaag acccggagtg
     1561 gaaggaccag aagactcctg ggatgtgtgc agtatggaag catgtttctt catcacctga
     1621 tcctgggtga aataaagttc agactcgaaa aaaaaaaaaa aaaaaaaaaa aaaa
//
