LOCUS       NP_036828                430 aa            linear   ROD 02-JUN-2024
DEFINITION  T-kininogen 1 precursor [Rattus norvegicus].
ACCESSION   NP_036828 XP_003752573
VERSION     NP_036828.2
DBSOURCE    REFSEQ: accession NM_012696.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 430)
  AUTHORS   Barallobre-Barreiro,J., Gupta,S.K., Zoccarato,A.,
            Kitazume-Taneike,R., Fava,M., Yin,X., Werner,T., Hirt,M.N.,
            Zampetaki,A., Viviano,A., Chong,M., Bern,M., Kourliouros,A.,
            Domenech,N., Willeit,P., Shah,A.M., Jahangiri,M., Schaefer,L.,
            Fischer,J.W., Iozzo,R.V., Viner,R., Thum,T., Heineke,J.,
            Kichler,A., Otsu,K. and Mayr,M.
  TITLE     Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin
            Activity in Human Atrial Fibrillation
  JOURNAL   Circulation 134 (11), 817-832 (2016)
   PUBMED   27559042
REFERENCE   2  (residues 1 to 430)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   3  (residues 1 to 430)
  AUTHORS   Hu,Z., Liu,J., Song,Z., Hou,Q., Fan,X. and Hou,D.
  TITLE     Variants in the Atherogenic ALOX5AP, THBD, and KNG1 Genes
            Potentiate the Risk of Ischemic Stroke via a Genetic Main Effect
            and Epistatic Interactions in a Chinese Population
  JOURNAL   J Stroke Cerebrovasc Dis 24 (9), 2060-2068 (2015)
   PUBMED   26159646
REFERENCE   4  (residues 1 to 430)
  AUTHORS   He,X., Yin,W., Ding,Y., Cui,S.J., Luan,J., Zhao,P., Yue,X., Yu,C.,
            Laing,X. and Zhao,Y.
  TITLE     Higher Serum Angiotensinogen Is an Indicator of IgA Vasculitis with
            Nephritis Revealed by Comparative Proteomes Analysis
  JOURNAL   PLoS One 10 (6), e0130536 (2015)
   PUBMED   26098644
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 430)
  AUTHORS   Bruzelius,M., Bottai,M., Sabater-Lleal,M., Strawbridge,R.J.,
            Bergendal,A., Silveira,A., Sundstrom,A., Kieler,H., Hamsten,A. and
            Odeberg,J.
  TITLE     Predicting venous thrombosis in women using a combination of
            genetic markers and clinical risk factors
  JOURNAL   J Thromb Haemost 13 (2), 219-227 (2015)
   PUBMED   25472531
REFERENCE   6  (residues 1 to 430)
  AUTHORS   Enjyoji,K. and Kato,H.
  TITLE     Purification and characterization of two isoforms of T-kininogens
            from rat liver microsomes
  JOURNAL   J Biochem 111 (5), 670-675 (1992)
   PUBMED   1639765
REFERENCE   7  (residues 1 to 430)
  AUTHORS   Damas,J., Delree,P. and Bourdon,V.
  TITLE     Distribution of immunoreactive T-kininogen in rat nervous tissues
  JOURNAL   Brain Res 569 (1), 63-70 (1992)
   PUBMED   1611479
REFERENCE   8  (residues 1 to 430)
  AUTHORS   Mann,E.A., Croyle,M.L. and Lingrel,J.B.
  TITLE     Identification of sequences mediating interleukin-6 induction of a
            rat T kininogen gene
  JOURNAL   J Biol Chem 266 (25), 16931-16934 (1991)
   PUBMED   1653251
REFERENCE   9  (residues 1 to 430)
  AUTHORS   DeLa Cadena,R.A., Laskin,K.J., Pixley,R.A., Sartor,R.B.,
            Schwab,J.H., Back,N., Bedi,G.S., Fisher,R.S. and Colman,R.W.
  TITLE     Role of kallikrein-kinin system in pathogenesis of bacterial cell
            wall-induced inflammation
  JOURNAL   Am J Physiol 260 (2 Pt 1), G213-G219 (1991)
   PUBMED   1996642
REFERENCE   10 (residues 1 to 430)
  AUTHORS   Pasquale,C.P., Martins,M.A., Bozza,P.T., Silva,P.M., Faria
            Neto,H.C., Pires,A.L. and Cordeiro,R.S.
  TITLE     Bradykinin induces eosinophil accumulation in the rat pleural
            cavity
  JOURNAL   Int Arch Allergy Appl Immunol 95 (2-3), 244-247 (1991)
   PUBMED   1937926
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC087028.1.
            
            On or before Jun 26, 2012 this sequence version replaced
            XP_003752573.1, NP_036828.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087028.1, M11883.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..430
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     Protein         1..430
                     /product="T-kininogen 1 precursor"
                     /note="LMW T-kininogen I; T-kininogen 1; thiostatin;
                     alpha-1-MAP; major acute phase protein; K-kininogen,
                     differential splicing leads to HMW Kngk; kininogen II"
                     /calculated_mol_wt=45784
     sig_peptide     1..18
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=1999
     Site            19
                     /site_type="pyrrolidone-carboxylic-acid"
                     /note="Pyrrolidone carboxylic acid.
                     /evidence=ECO:0000269|PubMed:3121623; propagated from
                     UniProtKB/Swiss-Prot (P01048.2)"
     Region          21..125
                     /region_name="CY"
                     /note="Cystatin-like domain; smart00043"
                     /db_xref="CDD:214484"
     Site            order(65..67,69)
                     /site_type="active"
                     /note="putative proteinase inhibition site [active]"
                     /db_xref="CDD:238002"
     Site            82
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P01048.2)"
     Region          140..248
                     /region_name="CY"
                     /note="Cystatin-like domain; smart00043"
                     /db_xref="CDD:214484"
     Site            order(143,187..189,191)
                     /site_type="active"
                     /note="putative proteinase inhibition site [active]"
                     /db_xref="CDD:238002"
     Site            168
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P01048.2)"
     Site            204
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P01048.2)"
     Region          262..370
                     /region_name="CY"
                     /note="Cystatin-like domain; smart00043"
                     /db_xref="CDD:214484"
     Site            order(265,309..311,313)
                     /site_type="active"
                     /note="putative proteinase inhibition site [active]"
                     /db_xref="CDD:238002"
     Site            326
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P01048.2)"
     CDS             1..430
                     /gene="Kng2"
                     /gene_synonym="KINKG; KINKH; KINT1G; Kng; Kng1; Kng1_v1;
                     Kngk; Kngt; Kngt1; Kng_v1; Map1; Tkg; TKG6"
                     /coded_by="NM_012696.2:248..1540"
                     /db_xref="GeneID:24903"
                     /db_xref="RGD:2980"
ORIGIN      
        1 mklitilllc srllpslaqe egaqelncnd etvfqavdta lkkynaeles gnqfvlyrvt
       61 kgtkkdgaet lysfkyqike gncsvqsglt wqdcdfkdae eaatgecttt lgkkenkfsv
      121 atqicnitpg kgpkkteedl cvgcfqpipm dssdlkpvlk havehfnnnt khthlfalre
      181 vksahsqvva gmnykiiysi vqtncskedf pslredcvpl pygdhgectg hthvdihnti
      241 agfsqscdly pgddlfellp kncrgcprei pvdspelkea lghsiaqlna qhnhifyfki
      301 dtvkkatsqv vagviyvief iaretncskq skteltadce tkhlgqslnc nanvymrpwe
      361 nkvvptvrcq aldmmisrpp gfspfrlvrv qetkegttrl lnsceykgrl skaragpapd
      421 hqaeastvts
//
