LOCUS       NM_001009628            1519 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus kininogen 1 (Kng1), mRNA.
ACCESSION   NM_001009628 XM_212691
VERSION     NM_001009628.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1519)
  AUTHORS   Kaschina,E., Stoll,M., Sommerfeld,M., Steckelings,U.M., Kreutz,R.
            and Unger,T.
  TITLE     Genetic kininogen deficiency contributes to aortic aneurysm
            formation but not to atherosclerosis
  JOURNAL   Physiol Genomics 19 (1), 41-49 (2004)
   PUBMED   15238617
REFERENCE   2  (bases 1 to 1519)
  AUTHORS   Rhaleb,N.E., Yang,X.P., Nanba,M., Shesely,E.G. and Carretero,O.A.
  TITLE     Effect of Chronic Blockade of the Kallikrein-Kinin System on the
            Development of Hypertension in Rats
  JOURNAL   Hypertension 37 (1), 121-128 (2001)
   PUBMED   11208766
REFERENCE   3  (bases 1 to 1519)
  AUTHORS   Kageyama,R., Kitamura,N., Ohkubo,H. and Nakanishi,S.
  TITLE     Differing utilization of homologous transcription initiation sites
            of rat K and T kininogen genes under inflammation condition
  JOURNAL   J Biol Chem 262 (5), 2345-2351 (1987)
   PUBMED   3818598
REFERENCE   4  (bases 1 to 1519)
  AUTHORS   Anderson,K.P. and Heath,E.C.
  TITLE     The relationship between rat major acute phase protein and the
            kininogens
  JOURNAL   J Biol Chem 260 (22), 12065-12071 (1985)
   PUBMED   2413019
REFERENCE   5  (bases 1 to 1519)
  AUTHORS   Furuto-Kato,S., Matsumoto,A., Kitamura,N. and Nakanishi,S.
  TITLE     Primary structures of the mRNAs encoding the rat precursors for
            bradykinin and T-kinin. Structural relationship of kininogens with
            major acute phase protein and alpha 1-cysteine proteinase inhibitor
  JOURNAL   J Biol Chem 260 (22), 12054-12059 (1985)
   PUBMED   2413018
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC088161.1.
            
            On Jan 13, 2005 this sequence version replaced XM_212691.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088161.1, M11661.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1519
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..1519
                     /gene="Kng1"
                     /gene_synonym="kininogen; Kng1l1"
                     /note="kininogen 1"
                     /db_xref="GeneID:288001"
                     /db_xref="RGD:1359376"
     exon            1..286
                     /gene="Kng1"
                     /gene_synonym="kininogen; Kng1l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..1384
                     /gene="Kng1"
                     /gene_synonym="kininogen; Kng1l1"
                     /note="T-kininogen 2; major acute phase protein
                     (alpha-1-MAP); low molecular weight (LMW) T-kininogen II;
                     thiostatin; kininogen 1-like 1"
                     /codon_start=1
                     /product="T-kininogen 2 precursor"
                     /protein_id="NP_001009628.1"
                     /db_xref="GeneID:288001"
                     /db_xref="RGD:1359376"
                     /translation="MKLITILLLCSRLLPSLAQEEGAQEMDCNDETVFQAVDTALKKY
                     NAELESGNQFLLYRVTEGTKKDGAETLYSFKYQIKEGNCSVQSGLTWQDCDFKDAEEA
                     ATGECTTTLGKKENKFSVATQICNITPGKGPKKTEEDLCVGCFQPIPMDSSDLKPVLK
                     HAVEHFNNNTKHTHLFALTEVKSAHSQVVAGMNYKIIYSIVQTNCSKEDFPFLREDCV
                     PLPYGDHGECRGHTYVDIHNTIAGFSQSCDLYPGDDLFSLLPKKCFGCPKNIPVDSPE
                     LKEALGHSIAQLNAQHNHLFYFKIDTVKKATSQVVAGTKYVIEFIARETNCSKQTNTE
                     LTADCETKHLGQSLNCNANVYMRPWENKVVPTVRCQALDMMISRPPGFSPFRLVQVQE
                     TKEGTTRLLNSCEYKGRLSKAGAGPAPDHQAEASTVTP"
     exon            287..397
                     /gene="Kng1"
                     /gene_synonym="kininogen; Kng1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            398..479
                     /gene="Kng1"
                     /gene_synonym="kininogen; Kng1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            480..652
                     /gene="Kng1"
                     /gene_synonym="kininogen; Kng1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            653..760
                     /gene="Kng1"
                     /gene_synonym="kininogen; Kng1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            761..845
                     /gene="Kng1"
                     /gene_synonym="kininogen; Kng1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            846..1018
                     /gene="Kng1"
                     /gene_synonym="kininogen; Kng1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1126
                     /gene="Kng1"
                     /gene_synonym="kininogen; Kng1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1213
                     /gene="Kng1"
                     /gene_synonym="kininogen; Kng1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1285
                     /gene="Kng1"
                     /gene_synonym="kininogen; Kng1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1495
                     /gene="Kng1"
                     /gene_synonym="kininogen; Kng1l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcagagac tggaggctgc taaaagcagc ttctgagttg gtttcccttt ttggcaaaac
       61 aattcctcaa ttccagaggg aacctttaat catgaagcta attactatcc tgctcctctg
      121 ctccaggctc ctgccaagtt tagcgcagga agaaggtgcc caggaaatgg actgcaatga
      181 tgagactgta tttcaggctg tggatactgc tctgaagaaa tataatgctg agttagaaag
      241 tggcaaccag tttctgttgt accgagtgac tgagggcact aagaaggatg gcgctgaaac
      301 attgtattcc ttcaagtatc aaatcaagga gggcaactgc tctgttcaga gtggcctcac
      361 ctggcaggac tgtgacttca aggacgctga ggaagctgct actggcgaat gcacaacaac
      421 tttggggaag aaagaaaata aattctccgt agccacccag atctgcaata ttactccagg
      481 taagggtcct aagaagacag aggaggacct ctgtgtcggg tgtttccaac ccataccgat
      541 ggatagctca gacctgaagc ctgttctgaa acacgctgtg gagcatttca acaacaacac
      601 gaagcacacc cacctctttg ctctcacaga agtaaagagt gcccactcac aggtggtggc
      661 tggcatgaat tataaaatta tctactccat tgtgcaaaca aattgttcaa aggaggattt
      721 tcctttcctc cgtgaagact gtgtacccct tccctatggc gatcatggtg agtgtagggg
      781 tcatacctac gtggatattc ataacacaat tgctggcttc tcacagagct gtgaccttta
      841 tccaggagac gatttgtttt cactacttcc caagaaatgc tttggctgcc ccaagaacat
      901 acctgtagac agcccggagc tcaaggaggc acttggtcat tcaattgcac agcttaatgc
      961 acagcataat catcttttct atttcaagat tgacaccgtg aaaaaggcaa catcacaggt
     1021 ggttgctgga acaaaatatg tgattgagtt catagccaga gaaaccaatt gttccaaaca
     1081 aactaacaca gaactgacag cggactgtga gaccaaacac ctcggtcaaa gcctcaactg
     1141 caatgctaac gtgtacatga gaccttggga gaacaaagtc gtcccgactg tcagatgcca
     1201 agcgctagac atgatgattt ctaggcctcc aggattttca cctttccggc tggtgcaagt
     1261 acaagaaact aaagaaggaa caactaggct cctaaactca tgtgagtaca agggcagact
     1321 ctcaaaggca ggggcaggcc cagcgcctga ccatcaggca gaagcttcaa ccgtgacacc
     1381 atagcctggc aaagacccgg agtggaagga ccagaagact cctgggatgt gtgcagtatg
     1441 gaagcatgtt tcttcatcac ctgatcctgg gtgaaataaa gttcagactc gacgaaaaaa
     1501 aaaaaaaaaa aaaaaaaaa
//
