LOCUS       NM_001107475            2411 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus lysine methyltransferase 5C (Kmt5c), mRNA.
ACCESSION   NM_001107475 XM_001058818 XM_218221
VERSION     NM_001107475.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2411)
  AUTHORS   Bromberg,K.D., Mitchell,T.R., Upadhyay,A.K., Jakob,C.G.,
            Jhala,M.A., Comess,K.M., Lasko,L.M., Li,C., Tuzon,C.T., Dai,Y.,
            Li,F., Eram,M.S., Nuber,A., Soni,N.B., Manaves,V., Algire,M.A.,
            Sweis,R.F., Torrent,M., Schotta,G., Sun,C., Michaelides,M.R.,
            Shoemaker,A.R., Arrowsmith,C.H., Brown,P.J., Santhakumar,V.,
            Martin,A., Rice,J.C., Chiang,G.G., Vedadi,M., Barsyte-Lovejoy,D.
            and Pappano,W.N.
  TITLE     The SUV4-20 inhibitor A-196 verifies a role for epigenetics in
            genomic integrity
  JOURNAL   Nat Chem Biol 13 (3), 317-324 (2017)
   PUBMED   28114273
REFERENCE   2  (bases 1 to 2411)
  AUTHORS   Shen,J., Jia,W., Yu,Y., Chen,J., Cao,X., Du,Y., Zhang,X., Zhu,S.,
            Chen,W., Xi,J., Wei,T., Wang,G., Yuan,D., Duan,T., Jiang,C. and
            Kang,J.
  TITLE     Pwp1 is required for the differentiation potential of mouse
            embryonic stem cells through regulating Stat3 signaling
  JOURNAL   Stem Cells 33 (3), 661-673 (2015)
   PUBMED   25335925
REFERENCE   3  (bases 1 to 2411)
  AUTHORS   Southall,S.M., Cronin,N.B. and Wilson,J.R.
  TITLE     A novel route to product specificity in the Suv4-20 family of
            histone H4K20 methyltransferases
  JOURNAL   Nucleic Acids Res 42 (1), 661-671 (2014)
   PUBMED   24049080
REFERENCE   4  (bases 1 to 2411)
  AUTHORS   Wu,H., Siarheyeva,A., Zeng,H., Lam,R., Dong,A., Wu,X.H., Li,Y.,
            Schapira,M., Vedadi,M. and Min,J.
  TITLE     Crystal structures of the human histone H4K20 methyltransferases
            SUV420H1 and SUV420H2
  JOURNAL   FEBS Lett 587 (23), 3859-3868 (2013)
   PUBMED   24396869
REFERENCE   5  (bases 1 to 2411)
  AUTHORS   Black,J.C., Van Rechem,C. and Whetstine,J.R.
  TITLE     Histone lysine methylation dynamics: establishment, regulation, and
            biological impact
  JOURNAL   Mol Cell 48 (4), 491-507 (2012)
   PUBMED   23200123
  REMARK    Review article
REFERENCE   6  (bases 1 to 2411)
  AUTHORS   Zhong,Q. and Kowluru,R.A.
  TITLE     Epigenetic changes in mitochondrial superoxide dismutase in the
            retina and the development of diabetic retinopathy
  JOURNAL   Diabetes 60 (4), 1304-1313 (2011)
   PUBMED   21357467
REFERENCE   7  (bases 1 to 2411)
  AUTHORS   Souza,P.P., Volkel,P., Trinel,D., Vandamme,J., Rosnoblet,C.,
            Heliot,L. and Angrand,P.O.
  TITLE     The histone methyltransferase SUV420H2 and Heterochromatin Proteins
            HP1 interact but show different dynamic behaviours
  JOURNAL   BMC Cell Biol 10, 41 (2009)
   PUBMED   19486527
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2411)
  AUTHORS   Pogribny,I.P., Tryndyak,V.P., Muskhelishvili,L., Rusyn,I. and
            Ross,S.A.
  TITLE     Methyl deficiency, alterations in global histone modifications, and
            carcinogenesis
  JOURNAL   J Nutr 137 (1 Suppl), 216S-222S (2007)
   PUBMED   17182829
REFERENCE   9  (bases 1 to 2411)
  AUTHORS   Pogribny,I.P., Ross,S.A., Tryndyak,V.P., Pogribna,M., Poirier,L.A.
            and Karpinets,T.V.
  TITLE     Histone H3 lysine 9 and H4 lysine 20 trimethylation and the
            expression of Suv4-20h2 and Suv-39h1 histone methyltransferases in
            hepatocarcinogenesis induced by methyl deficiency in rats
  JOURNAL   Carcinogenesis 27 (6), 1180-1186 (2006)
   PUBMED   16497704
  REMARK    GeneRIF: Suv4-20h2 and Suv-39h1 histone methyltransferases are
            expressed and Histone H3 lysine 9 and H4 lysine 20 are
            trimethylated in hepatocarcinogenesis induced by methyl deficiency
            in rats [Suv4-20h2 and Suv-39h1]
REFERENCE   10 (bases 1 to 2411)
  AUTHORS   Schotta,G., Lachner,M., Sarma,K., Ebert,A., Sengupta,R., Reuter,G.,
            Reinberg,D. and Jenuwein,T.
  TITLE     A silencing pathway to induce H3-K9 and H4-K20 trimethylation at
            constitutive heterochromatin
  JOURNAL   Genes Dev 18 (11), 1251-1262 (2004)
   PUBMED   15145825
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474075.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_218221.4, XM_001058818.1.
            
            ##Evidence-Data-START##
            CDS exon combination :: AY724526.1 [ECO:0000331]
            RNAseq introns       :: partial sample support SAMD00132261,
                                    SAMD00132262 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2411
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..2411
                     /gene="Kmt5c"
                     /gene_synonym="Suv420h2"
                     /note="lysine methyltransferase 5C"
                     /db_xref="GeneID:308345"
                     /db_xref="RGD:1305226"
     exon            1..155
                     /gene="Kmt5c"
                     /gene_synonym="Suv420h2"
                     /inference="alignment:Splign:2.1.0"
     exon            156..254
                     /gene="Kmt5c"
                     /gene_synonym="Suv420h2"
                     /inference="alignment:Splign:2.1.0"
     exon            255..464
                     /gene="Kmt5c"
                     /gene_synonym="Suv420h2"
                     /inference="alignment:Splign:2.1.0"
     CDS             355..1767
                     /gene="Kmt5c"
                     /gene_synonym="Suv420h2"
                     /EC_number="2.1.1.361"
                     /EC_number="2.1.1.362"
                     /note="histone-lysine N-methyltransferase SUV420H2;
                     suv4-20h2; su(var)4-20 homolog 2; suppressor of
                     variegation 4-20 homolog 2; lysine (K)-specific
                     methyltransferase 5C; lysine-specific methyltransferase
                     5C; [histone H4]-lysine20 N-methyltransferase KMT5B;
                     [histone H4]-N-methyl-L-lysine20 N-methyltransferase
                     KMT5B"
                     /codon_start=1
                     /product="histone-lysine N-methyltransferase KMT5C"
                     /protein_id="NP_001100945.1"
                     /db_xref="GeneID:308345"
                     /db_xref="RGD:1305226"
                     /translation="MGPDRVTARELCENDDLATSLVLDPYLGFRTHKMNVSPVPTLRR
                     QHHLRSALEAFLRQRDLEAAFRALTLGGWMAHYFQNRAPRQEAALKNHIFCYLRAFLP
                     ESGFTILPCTRYSMETNGAKIVSTRAWKKNEKLELLVGCIAELREEDEYLLRAGENDF
                     SVMYSTRKRSAQLWLGPAAFINHDCKPNCKFVPSDGNTACVKVLRDIEPGDEVTCFYG
                     EGFFGEKNEHCECYTCERKGEGAFRLQPREPELRPRPLDKYELRETKRRLQQCLDSSQ
                     QNLLSLRACSHLSPLRPDPFCAACQPSCLLPVSPHMDYLPLWLQWVPQPQPRVRPRKR
                     RRRRRRRPRIPQASLSPDLHTACVSLHRWGGCGPHCQLRAEAMVTLHLLPQTRWTPKQ
                     DWYWARRYGLPSVVRVELSPLAPALPAAPAPAGNLGPTPTPDLIPKQALAFAPFCPPK
                     RLRLVVSHGSIDLDINSGEP"
     exon            465..630
                     /gene="Kmt5c"
                     /gene_synonym="Suv420h2"
                     /inference="alignment:Splign:2.1.0"
     exon            631..740
                     /gene="Kmt5c"
                     /gene_synonym="Suv420h2"
                     /inference="alignment:Splign:2.1.0"
     exon            741..904
                     /gene="Kmt5c"
                     /gene_synonym="Suv420h2"
                     /inference="alignment:Splign:2.1.0"
     exon            905..924
                     /gene="Kmt5c"
                     /gene_synonym="Suv420h2"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1061
                     /gene="Kmt5c"
                     /gene_synonym="Suv420h2"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1246
                     /gene="Kmt5c"
                     /gene_synonym="Suv420h2"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..2411
                     /gene="Kmt5c"
                     /gene_synonym="Suv420h2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggttgagttg tctgtctttc cggccgaggg gaggcgcggc ggctgtatct gacgagagcc
       61 ggaggaggcg gtgggtggag gtggcggctg caacgcgggc gccggaggag gaggaggagg
      121 aggaggagga ggaggagaag gaggaggaga agcgggagtt cccccaaacc ctgcttggaa
      181 ccgctaagcc cttcccttgg accctgggcg tatgtaccct ttggatttcg tggtctcctc
      241 ccttgcaacc gcagataagc aggctctggg gcccacagac atcccatgta gcttctgagt
      301 ggcatatcca tgtgccctgt tctgtgccag aagcagcatg gtttatagag caccatgggg
      361 cctgaccgag tgacagcccg agaactgtgc gagaatgatg acctggccac cagccttgtt
      421 cttgacccct acctcggctt ccgcacccat aagatgaatg tcagccctgt gcccaccctc
      481 cgacgacaac accaccttcg ctcagcactg gaagctttcc taaggcaacg ggacctggaa
      541 gctgcattcc gggccctgac actgggaggc tggatggccc actactttca gaaccgtgct
      601 cctcggcagg aggctgccct caagaaccac attttttgct acctccgcgc cttcctgcct
      661 gagagtggct tcaccattct gccctgcacc cgctactcca tggagaccaa tggggccaag
      721 attgtgtcta cccgtgcttg gaagaagaat gagaagctgg agctgctggt gggctgcatt
      781 gcagagctgc gggaagagga tgaataccta cttagggcag gcgagaacga cttcagcgtc
      841 atgtactcca ctcgaaaaag gagtgcccag ctgtggcttg gcccagctgc ctttatcaac
      901 catgactgca aacccaactg caagtttgtg ccctcagatg gaaatactgc ctgtgtgaag
      961 gtgctacggg acattgagcc gggggatgaa gtaacttgct tctatggcga gggcttcttc
     1021 ggtgagaaga atgagcactg tgaatgctat acctgtgaga ggaaaggcga gggagctttc
     1081 agacttcagc ccagggagcc ggagctgagg ccacggcccc tggacaagta tgagctccga
     1141 gagacaaaga ggcgtctgca gcagtgtttg gacagcagcc agcagaacct gctgagcctg
     1201 cgggcctgct cccacctgtc cccactgcgc cctgacccat tctgtgctgc ctgccagccc
     1261 tcatgcctgc tgcctgtcag tccccacatg gactacttgc ccctctggct ccagtgggtg
     1321 cctcagcccc agcccagagt acgtccccgg aagcgccgcc gtcgccgccg ccgtcgcccc
     1381 aggatacccc aggcttcatt gtcccctgac ctgcacactg cctgtgtatc cctacaccga
     1441 tggggaggct gtggtcccca ctgccaacta cgggctgagg ccatggtgac cctacacctg
     1501 ctcccccaga ctcgctggac cccaaaacag gactggtact gggcccgacg ctatgggcta
     1561 ccttctgtgg tgcgcgttga actttcccct ctagccccag ccctaccagc tgctcctgct
     1621 cctgctggga acctaggtcc cacccccacc cctgacctca tacctaaaca ggcccttgcc
     1681 ttcgctcctt tctgcccacc taagcgcctc cggctagtgg tcagccatgg ttctattgat
     1741 ctggacatca atagtggtga gccatgatgg gctgcttaca gggagccctg aatggaaggt
     1801 agagtctctg tcttggaccc ctccagaagg gaaagaggaa actgaccctt aacccaggtc
     1861 tgatcttggg agtgtgttgt tggggacatc cctagagagt ttgatccttg ttgctctatg
     1921 gttgctgacc cctgagccag ccccaactca gcagggagcc ctggccattt gatgtcccca
     1981 tccctgtccc tgcccccacc tcaggactgt aggagtcatt cccctcccct cagcctcttc
     2041 ctccccaggg agcaaagcca taggggttgg gggccactcc atggcaactc tccagaaggc
     2101 caggcctcag gaggtggaat tgacttgggg gtttgccttc ccaaactact cccagagtgg
     2161 ggagtaagtt ggcgctcagc tctgcagttg atggaggtac gggctgtcag atggggtggg
     2221 ttgtacccag ggacacaacc ttggctctga acatgggtct cagggaggcc aggtgtgacc
     2281 tcatcttttt cacggtgcta tccctggtgc tactggggtg taggggaggc tccctctcct
     2341 ccccacacca gaatggggta tgatggggga ttggaagaac ttgaactttt tattaaaaca
     2401 ttgtaagccc t
//
