LOCUS       NM_001108512            6095 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus lysine methyltransferase 5B (Kmt5b), mRNA.
ACCESSION   NM_001108512 XM_001068585 XM_341971
VERSION     NM_001108512.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6095)
  AUTHORS   Bromberg,K.D., Mitchell,T.R., Upadhyay,A.K., Jakob,C.G.,
            Jhala,M.A., Comess,K.M., Lasko,L.M., Li,C., Tuzon,C.T., Dai,Y.,
            Li,F., Eram,M.S., Nuber,A., Soni,N.B., Manaves,V., Algire,M.A.,
            Sweis,R.F., Torrent,M., Schotta,G., Sun,C., Michaelides,M.R.,
            Shoemaker,A.R., Arrowsmith,C.H., Brown,P.J., Santhakumar,V.,
            Martin,A., Rice,J.C., Chiang,G.G., Vedadi,M., Barsyte-Lovejoy,D.
            and Pappano,W.N.
  TITLE     The SUV4-20 inhibitor A-196 verifies a role for epigenetics in
            genomic integrity
  JOURNAL   Nat Chem Biol 13 (3), 317-324 (2017)
   PUBMED   28114273
REFERENCE   2  (bases 1 to 6095)
  AUTHORS   Southall,S.M., Cronin,N.B. and Wilson,J.R.
  TITLE     A novel route to product specificity in the Suv4-20 family of
            histone H4K20 methyltransferases
  JOURNAL   Nucleic Acids Res 42 (1), 661-671 (2014)
   PUBMED   24049080
REFERENCE   3  (bases 1 to 6095)
  AUTHORS   Wu,H., Siarheyeva,A., Zeng,H., Lam,R., Dong,A., Wu,X.H., Li,Y.,
            Schapira,M., Vedadi,M. and Min,J.
  TITLE     Crystal structures of the human histone H4K20 methyltransferases
            SUV420H1 and SUV420H2
  JOURNAL   FEBS Lett 587 (23), 3859-3868 (2013)
   PUBMED   24396869
REFERENCE   4  (bases 1 to 6095)
  AUTHORS   Black,J.C., Van Rechem,C. and Whetstine,J.R.
  TITLE     Histone lysine methylation dynamics: establishment, regulation, and
            biological impact
  JOURNAL   Mol Cell 48 (4), 491-507 (2012)
   PUBMED   23200123
  REMARK    Review article
REFERENCE   5  (bases 1 to 6095)
  AUTHORS   Shi,X., Kachirskaia,I., Yamaguchi,H., West,L.E., Wen,H., Wang,E.W.,
            Dutta,S., Appella,E. and Gozani,O.
  TITLE     Modulation of p53 function by SET8-mediated methylation at lysine
            382
  JOURNAL   Mol Cell 27 (4), 636-646 (2007)
   PUBMED   17707234
REFERENCE   6  (bases 1 to 6095)
  AUTHORS   Schotta,G., Lachner,M., Sarma,K., Ebert,A., Sengupta,R., Reuter,G.,
            Reinberg,D. and Jenuwein,T.
  TITLE     A silencing pathway to induce H3-K9 and H4-K20 trimethylation at
            constitutive heterochromatin
  JOURNAL   Genes Dev 18 (11), 1251-1262 (2004)
   PUBMED   15145825
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001108512.1.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR26643287.2741.1, SRR26643429.4359.1
                                    [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA5760383, SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-313               JAXUCZ010000001.1  210429672-210429984
            314-619             JAXUCZ010000001.1  210430275-210430580
            620-855             JAXUCZ010000001.1  210447430-210447665
            856-1003            JAXUCZ010000001.1  210453854-210454001
            1004-1072           JAXUCZ010000001.1  210457686-210457754
            1073-1238           JAXUCZ010000001.1  210462720-210462885
            1239-1348           JAXUCZ010000001.1  210463430-210463539
            1349-1515           JAXUCZ010000001.1  210465130-210465296
            1516-1535           JAXUCZ010000001.1  210465531-210465550
            1536-1672           JAXUCZ010000001.1  210465632-210465768
            1673-1869           JAXUCZ010000001.1  210467935-210468131
            1870-6095           JAXUCZ010000001.1  210474817-210479042
FEATURES             Location/Qualifiers
     source          1..6095
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..6095
                     /gene="Kmt5b"
                     /gene_synonym="Suv420h1"
                     /note="lysine methyltransferase 5B"
                     /db_xref="GeneID:361688"
                     /db_xref="RGD:1311637"
     exon            1..313
                     /gene="Kmt5b"
                     /gene_synonym="Suv420h1"
                     /inference="alignment:Splign:2.1.0"
     exon            314..619
                     /gene="Kmt5b"
                     /gene_synonym="Suv420h1"
                     /inference="alignment:Splign:2.1.0"
     exon            620..855
                     /gene="Kmt5b"
                     /gene_synonym="Suv420h1"
                     /inference="alignment:Splign:2.1.0"
     CDS             696..3347
                     /gene="Kmt5b"
                     /gene_synonym="Suv420h1"
                     /EC_number="2.1.1.361"
                     /EC_number="2.1.1.362"
                     /note="histone-lysine N-methyltransferase SUV420H1;
                     suv4-20h1; su(var)4-20 homolog 1; suppressor of
                     variegation 4-20 homolog 1; lysine (K)-specific
                     methyltransferase 5B; lysine-specific methyltransferase
                     5B; [histone H4]-lysine20 N-methyltransferase KMT5B;
                     [histone H4]-N-methyl-L-lysine20 N-methyltransferase
                     KMT5B"
                     /codon_start=1
                     /product="histone-lysine N-methyltransferase KMT5B"
                     /protein_id="NP_001101982.1"
                     /db_xref="GeneID:361688"
                     /db_xref="RGD:1311637"
                     /translation="MKWLGDSKNMVVNGRRNGSKLSNDHQQNQSKLQHAGKDALKTGR
                     NAVERRPNRCHGNSGFEGQSRYVPSSGMSAKELCENDDLATSLVLDPYLGFQTHKMNT
                     SAFPSRSSRHISKADSFSHNNPMRFRPIKGRQEELKEVIERFKKDEHLEKAFKCLTSG
                     EWARHYFLNKNKMQEKLFKEHVFIYLRMFATDSGFEILPCNRYSSEQNGAKIVATKEW
                     KRNDKIELLVGCIAELSEIEENMLLRHGENDFSVMYSTRKNCAQLWLGPAAFINHDCR
                     PNCKFVSTGRDTACVKALRDIEPGEEISCYYGDGFFGENNEFCECYTCERRGTGAFKS
                     RVGLPAPAPVINSKYGLRETDKRLNRLKKLGDSSKSSDSQSVSSNTDADTTQEKDNAT
                     SNRKSSVGVKKNSKSRALTRQSMPRVPAASNSTSPKLVHMNNSRVPKKLRKPAKPLLS
                     KIKLRNHCKRLDQKSTSRKLEMGNLVLKEPKVVLYKNLPIKKEREAEGPVHAAVGSGC
                     LTRHAAREHRQNPGRGAHSQGDSLPCTYTTRRSLRTRTGLKETTDIKLAPSPLDGYKN
                     GILEPYPDSGQQPTPEVLEELAPETALREEASQECPKSDSCPSRKKFRQGKPVKHLAK
                     TEDCSPEHSFPGKDGLPDLPGPHPDQGEPSGTVRVPVSYTDSAPSPVGCSIVTPDSFT
                     TKDSFRTAQSKKKRRVTRYDAQLILENSSGIPKLTLRRRHDSSSKTNDHESDSVNSSK
                     ISIKLSKDHESDSNLYVAKLSNGVSSGPGSSSTKLKIQLKRDEESRGPCAEGLHENGV
                     CCSDPLSLLESQMEVDDYSQYEEDSTDDSSSSEGEEEEEDCEDDFDDDFIPLPPAKRL
                     RLIVGKDSIDIDISSRRREDQSLRLNA"
     exon            856..1003
                     /gene="Kmt5b"
                     /gene_synonym="Suv420h1"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1072
                     /gene="Kmt5b"
                     /gene_synonym="Suv420h1"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1238
                     /gene="Kmt5b"
                     /gene_synonym="Suv420h1"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1348
                     /gene="Kmt5b"
                     /gene_synonym="Suv420h1"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1515
                     /gene="Kmt5b"
                     /gene_synonym="Suv420h1"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1535
                     /gene="Kmt5b"
                     /gene_synonym="Suv420h1"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..1672
                     /gene="Kmt5b"
                     /gene_synonym="Suv420h1"
                     /inference="alignment:Splign:2.1.0"
     exon            1673..1869
                     /gene="Kmt5b"
                     /gene_synonym="Suv420h1"
                     /inference="alignment:Splign:2.1.0"
     exon            1870..6095
                     /gene="Kmt5b"
                     /gene_synonym="Suv420h1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggttgagcc cgaagagagt aaagagtggc caagtcgtgg agaggttgtc actcagtagg
       61 tgctcaagga gcggccggtg gcagcacggg ggacccaacg cacgttccct ccccacctcc
      121 cgagtggtaa cgctccggtg gcccacatgg ttttgaaggg tgtttctgct tccaacgaca
      181 cccatcccca caacaaagaa actcgccatc ccaagccgcc tcccctcggt gcaccccgga
      241 ggcacagcgg gaccgaatcg ccgtgcgccc gcagctgccc tcccccgaaa tcgcagatgg
      301 ggagctgtcc ctgaattccg tcgaagcctt cacggccact agcgcggggc aaaggaacgc
      361 gcacgctcgg tgtcggcgtg gtgtccctcc gccgtcatcc gtggactcat tttcgtgtcc
      421 ttccaccgag cccgggcggt gtccgggtgg ctcaccgggg gcggcgacgc gtctgcggcg
      481 cggcagcgag gcacgggggc tatgaggtga ggacgcccgg ggaccggagg cggcacccgg
      541 cgctgcgcga gaacgcagga cgcgaagccc cgaagccggc ggatgccccc cagatcccgc
      601 gactgcgcgc gaggtggagg agagaacatt gaaattattc tctaagctat ctgaagagag
      661 tgactaaatg ctcctgggtc aggctgtctg tgggtatgaa gtggttggga gactccaaga
      721 acatggtggt gaatggcagg agaaatggaa gcaagttgtc taatgaccat cagcagaatc
      781 aatccaaatt acagcacgcg ggcaaggacg ccctgaagac tggcagaaac gctgttgaga
      841 ggcggcccaa cagatgtcat ggtaactcgg gatttgaagg gcagagtcgc tatgtgccat
      901 cctctggaat gtccgccaag gagctctgtg agaacgatga cttagcaacc agtttggttc
      961 ttgatcccta tttaggtttt caaacacaca aaatgaacac tagcgccttt ccttcgagga
     1021 gctcgagaca tatttccaaa gctgacagtt tttctcacaa caaccctatg agatttcgac
     1081 ctataaaagg aaggcaggaa gagctaaagg aagtaattga acgctttaag aaagatgaac
     1141 acttagagaa agcttttaaa tgtttgactt caggtgaatg ggcacgacat tattttctca
     1201 acaaaaacaa aatgcaggag aaattattca aagaacatgt ctttatttac ttgcggatgt
     1261 ttgcaactga cagtggattt gaaatattgc cttgtaatag atactcttca gaacaaaatg
     1321 gagccaagat agttgcaaca aaagagtgga aacgaaatga caaaatagaa ttactggtgg
     1381 gttgtattgc cgaactttca gaaattgagg agaacatgct acttagacac ggagaaaacg
     1441 acttcagtgt catgtattcc acaaggaaaa attgtgctca actctggctc ggtcctgctg
     1501 catttataaa tcatgattgc agacctaact gtaagtttgt gtcaactggc cgagatacag
     1561 catgtgttaa ggctctgaga gatattgaac ctggagaaga aatttcttgt tattatggag
     1621 atgggttttt tggagaaaat aatgagttct gcgaatgtta cacttgcgaa agacggggaa
     1681 ctggtgcttt taaatcacga gtaggactgc ctgcgcctgc tcctgttatc aatagcaaat
     1741 acggacttag agaaacagat aaacgcttaa ataggcttaa aaagttaggt gacagcagca
     1801 aaagctcaga cagtcagtct gtcagctcta atacagacgc agacaccact caggaaaaag
     1861 acaatgcaac ttctaaccga aagtcttcag ttggtgtgaa aaagaacagc aagagcagag
     1921 cactgacgag gcagtccatg ccaagagtcc cagcggcttc caactctacc tcacctaagc
     1981 tagtgcacat gaacaattcc agggtaccaa agaaactgag aaagccggcg aagcctttac
     2041 tttccaagat caaactgagg aatcactgca agcggctgga ccagaagagc acatcccgga
     2101 agctcgagat ggggaactta gtgcttaagg agcccaaagt tgtgctatat aaaaatttgc
     2161 caattaagaa agagagggag gcagagggac cagtccatgc tgcagtgggg agtgggtgct
     2221 tgactagaca tgctgcgaga gaacacaggc agaaccctgg gagaggtgct cactcgcagg
     2281 gcgacagttt gccctgcacc tacacaaccc ggcgctcttt gaggacaagg acaggtctga
     2341 aggagaccac tgacatcaag cttgcaccaa gtcccttgga tggctataaa aatggtatac
     2401 tggaacctta cccagacagt ggccagcagc caaccccaga ggtgctggaa gaactggctc
     2461 ctgagactgc tctcagggag gaagcatccc aggagtgtcc caagagtgac tcctgccctt
     2521 cacgaaagaa atttcgacaa gggaaacccg tgaaacactt agcaaagaca gaggattgca
     2581 gtccagagca cagcttccct gggaaagacg ggctgccaga tttgccaggg ccccatcccg
     2641 accagggtga gcccagtggc acggtcaggg tgcctgtgag ctacacagac tctgctccct
     2701 cacctgttgg ctgctccatt gtcacacccg acagcttcac aacaaaagac agcttcagaa
     2761 ctgcacaaag taaaaagaag cggcgggtca ccaggtacga tgcacagctg atcctagaga
     2821 acagctctgg aatccccaag ttgacgcttc gcaggcggca tgacagcagc agcaagacaa
     2881 atgaccatga gagtgatagt gtaaactcct caaaaatcag catcaagctc agcaaagacc
     2941 atgaaagtga cagtaacctc tatgttgcaa agcttagcaa tggggttagc tcggggccag
     3001 gcagcagctc tactaagctc aagattcaac tcaagcggga tgaggagagc agggggccat
     3061 gtgcagaagg gcttcatgag aacggtgtgt gctgcagtga ccccctgtcc ctgctagagt
     3121 cccagatgga ggtggatgac tatagtcagt atgaggagga cagcacagat gactcgtcat
     3181 cttctgaggg ggaggaggaa gaggaggact gtgaggatga cttcgatgat gacttcatcc
     3241 ctcttcctcc cgcaaagcgg ctgaggctaa ttgttggtaa agactccata gatatcgaca
     3301 tttcttcaag gagaagagaa gatcagtctc taagactgaa cgcatgagcg ctcactcatt
     3361 gtcctgggga actaaaaagt aaaaatccca gccacagctt ctcagcgcag cacttctgtg
     3421 gtctcatcac ctgtaggcat aatactgtag aaagtgtaca gcatcctgac tcttaagtct
     3481 gatttgtgca aatttttatt gtacttttta aatagccttc ttatgtgcaa ttccgaggga
     3541 aagccctgtt gtaagataga ggctccagta aactatccag tgacagcagc tctccacata
     3601 ggaccttcag acactaatgt ggttacacca tgttgtcacc tatgagagca agcgccagcc
     3661 agccttcttc cgtagatgac taagccgtag ttagggcgga gcagagcagc cttgtgggaa
     3721 gggtttccag catctgctcc tatcaccagc attgacctct ggcttttggt ttatttgcta
     3781 gatgtttccc ccttggagtt gtgtcggttt cacactgttt accggcccag gtgtcctgtc
     3841 cgtggccttc gttatcatag cagaccattg gctggaagtc agattgattt ctttgaagaa
     3901 aaaattaact taaatgcagt cttctgcgtg acagctcctt ctcagtacat tatatgtacg
     3961 ggctggtggt gtgcaggatg agttttcaga gcaacttatt tattgcttgt cttgtaaatt
     4021 aaagaccgtg tatttaacac tttccaatcc ttttagataa aattgttctt tgcaagaatg
     4081 attggtgctt attttttcaa acctttgctg tgaacagcgt ggcgacagcg agcagcgttt
     4141 gtctgatgaa ctccagctat cttaatttgg gtcttcaagt ttctgttgca cttgtaaaat
     4201 gctacaagga atattaaaag aaattattca ctttaactta taatagttta tgaaataaga
     4261 acctgagtca cagcttttgt tctgtggtaa cctatacaaa catttgtctt tgggattcaa
     4321 tgtaaagagc tgaaaacgat gtatatgttg taaatatttg tgtgttgtga gaaatttttg
     4381 tcataagaaa ttaaaagaac ttaccaggaa ggtttttaag tttagaaata ttcatgccaa
     4441 taaaatagga aattataaat atatagtgta agcactgcat cagtgggcgt tcttggctta
     4501 tgttagttta ttatgaaagt atcagatttt tttgattata ttatcagtca aacaaaaaga
     4561 ggagtcagat ttaatttgtt tttgaagcac tttgagaaga gaaattaact ttaacttaat
     4621 gagcaatttt tgattactgc tttatgttcg atacaggctt gtttgtttct ctggattatt
     4681 ttacaaatca aagaatttga gaatatcagt cagtctgtag caggtgtttg acaccagtgg
     4741 gtctgtttat ttcctgggaa atatgtaggt accctttcag atagatacat agtgttccta
     4801 aacgacacaa gctagtggac tctgttccgg cgtgtcagaa gggacctgca gggagggaaa
     4861 ggtccaacaa agagcttctc agtgcttccc tgttgctgac gacactatgg tattcagctt
     4921 ggggacactt ggatccttaa aaccgttgct tagaggttcc agttacaaat tagtaagatt
     4981 catgagtgtt tctaggatac gatgtctttg ctcctgtgca tgatagaatc cctgctgtgg
     5041 tcctgtacag tcttgtcctt gccatgcggt ctcaccctct tgggtgtcta tctcactggt
     5101 aagcagaagg gaagacagca tgctcgcgcg cacacacaca cacacacaca cacacacaca
     5161 cacacacaca cacacccatt tgctatagcc gtgaagaaag gcagccctgt gtctcaagat
     5221 ctcctgtgtc aaggcatcca gaacaccttc catgatgctt ccagtcccca tgggatcccc
     5281 aagtgtaagt gtgagccacg tgccacctcc aggaagctga aggtgagctt aggagcctgc
     5341 acagggcagc tggtcacctg cattcccatg ttctcttggg ctgttgagac taaatcctcc
     5401 cgtttctttg aataccaaca atagccattt caggaatttc aatcttaagg aaaaagtaac
     5461 aaaataacat atttcccatt ttctccattt ttaagcttaa ttttagtaac ttatttatga
     5521 tgtttatttt agttttgttg tggcctcgtc tggaggccga ccttcccatg ggtctaagag
     5581 cagtgacatt gtgaggagtt gctgcctctc aggagttgta tgcacaagca ttcagcagtg
     5641 ctgctgatgc cgtctaggga accttatttc cgtttctcaa ggcaggggcc tcagactgtt
     5701 ctcgatctgc tgtagaactt cactgtgggg gtgccagaac cccacactct tgaccagtct
     5761 ggaagaggtt acactcaata aaactctcag ctcgagctta tgcaatgatt ggtaaagttt
     5821 ttggcaattg taagaattag gaaatgatcc tagaaatata tgtaaagtat tcaattttca
     5881 atcatttttc aaattactgt tttaaattgt tttgctgagt tgtaatactt ttgagataca
     5941 atgtattcct tgtactgaaa gaatgaaaaa ggactttttc agcatttgag gtaagttctt
     6001 taacgtttca ttaaaaaaca ttttttacaa atattttgta catgcacttg cagtattgag
     6061 gttaatcatt ttaataaatt cggaaattaa aatga
//
