LOCUS       NM_001413637            2775 bp    mRNA    linear   ROD 17-JUN-2024
DEFINITION  Rattus norvegicus lysine methyltransferase 5A (Kmt5a), transcript
            variant 2, mRNA.
ACCESSION   NM_001413637 XM_039089770
VERSION     NM_001413637.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2775)
  AUTHORS   Li,Y., Cheng,M., Jin,J., Zhang,D., Zhang,S., Bai,Y. and Xu,J.
  TITLE     Interaction of Sp1 and Setd8 promotes vascular smooth muscle cells
            apoptosis by activating Mark4 in vascular calcification
  JOURNAL   Aging (Albany NY) 16 (3), 2438-2456 (2024)
   PUBMED   38301049
  REMARK    GeneRIF: Interaction of Sp1 and Setd8 promotes vascular smooth
            muscle cells apoptosis by activating Mark4 in vascular
            calcification.
REFERENCE   2  (bases 1 to 2775)
  AUTHORS   Li,J., Song,H., Chen,T., Zhang,S., Zhang,C., Ma,C., Zhang,L.,
            Wang,T., Qian,Y. and Deng,X.
  TITLE     Lysine Methyltransferase 5A Promotes the Progression of Growth
            Hormone Pituitary Neuroendocrine Tumors through the
            Wnt/beta-Catenin Signaling Pathway
  JOURNAL   Neuroendocrinology 114 (6), 589-601 (2024)
   PUBMED   38565081
  REMARK    GeneRIF: Lysine Methyltransferase 5A Promotes the Progression of
            Growth Hormone Pituitary Neuroendocrine Tumors through the
            Wnt/beta-Catenin Signaling Pathway.
REFERENCE   3  (bases 1 to 2775)
  AUTHORS   Li,X., Qian,Y., Shen,W., Zhang,S., Han,H., Zhang,Y., Liu,S., Lv,S.
            and Zhang,X.
  TITLE     Mechanism of SET8 Activates the Nrf2-KEAP1-ARE Signaling Pathway to
            Promote the Recovery of Motor Function after Spinal Cord Injury
  JOURNAL   Mediators Inflamm 2023, 4420592 (2023)
   PUBMED   36936537
  REMARK    GeneRIF: Mechanism of SET8 Activates the Nrf2-KEAP1-ARE Signaling
            Pathway to Promote the Recovery of Motor Function after Spinal Cord
            Injury.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2775)
  AUTHORS   Barrett,E., Loverin,A., Wang,H., Carlson,M., Larsen,T.D.,
            Almeida,M.M., Whitman,J., Baack,M.L. and Joss-Moore,L.A.
  TITLE     Uteroplacental Insufficiency with Hypoxia Upregulates Placental
            PPARgamma-KMT5A Axis in the Rat
  JOURNAL   Reprod Sci 28 (5), 1476-1488 (2021)
   PUBMED   33398850
  REMARK    GeneRIF: Uteroplacental Insufficiency with Hypoxia Upregulates
            Placental PPARgamma-KMT5A Axis in the Rat.
REFERENCE   5  (bases 1 to 2775)
  AUTHORS   Pan,C., Chen,H., Wang,L., Yang,S., Fu,H., Zheng,Y., Miao,M. and
            Jiao,B.
  TITLE     Down-regulation of MiR-127 facilitates hepatocyte proliferation
            during rat liver regeneration
  JOURNAL   PLoS One 7 (6), e39151 (2012)
   PUBMED   22720056
REFERENCE   6  (bases 1 to 2775)
  AUTHORS   Kalakonda,N., Fischle,W., Boccuni,P., Gurvich,N., Hoya-Arias,R.,
            Zhao,X., Miyata,Y., Macgrogan,D., Zhang,J., Sims,J.K., Rice,J.C.
            and Nimer,S.D.
  TITLE     Histone H4 lysine 20 monomethylation promotes transcriptional
            repression by L3MBTL1
  JOURNAL   Oncogene 27 (31), 4293-4304 (2008)
   PUBMED   18408754
REFERENCE   7  (bases 1 to 2775)
  AUTHORS   Sims,J.K. and Rice,J.C.
  TITLE     PR-Set7 establishes a repressive trans-tail histone code that
            regulates differentiation
  JOURNAL   Mol Cell Biol 28 (14), 4459-4468 (2008)
   PUBMED   18474616
REFERENCE   8  (bases 1 to 2775)
  AUTHORS   Shi,X., Kachirskaia,I., Yamaguchi,H., West,L.E., Wen,H., Wang,E.W.,
            Dutta,S., Appella,E. and Gozani,O.
  TITLE     Modulation of p53 function by SET8-mediated methylation at lysine
            382
  JOURNAL   Mol Cell 27 (4), 636-646 (2007)
   PUBMED   17707234
REFERENCE   9  (bases 1 to 2775)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
REFERENCE   10 (bases 1 to 2775)
  AUTHORS   Ahmed,F., Torrado,M., Zinovieva,R.D., Senatorov,V.V., Wistow,G. and
            Tomarev,S.I.
  TITLE     Gene expression profile of the rat eye iridocorneal angle: NEIBank
            expressed sequence tag analysis
  JOURNAL   Invest Ophthalmol Vis Sci 45 (9), 3081-3090 (2004)
   PUBMED   15326124
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Nov 4, 2022 this sequence version replaced XM_039089770.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582424.105086.1,
                                           SRR26643299.50406.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMEA5760433 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-233               JAXUCZ010000012.1  37817794-37818026   c
            234-390             JAXUCZ010000012.1  37816196-37816352   c
            391-610             JAXUCZ010000012.1  37812506-37812725   c
            611-698             JAXUCZ010000012.1  37812054-37812141   c
            699-758             JAXUCZ010000012.1  37806822-37806881   c
            759-949             JAXUCZ010000012.1  37802837-37803027   c
            950-2775            JAXUCZ010000012.1  37800344-37802169   c
FEATURES             Location/Qualifiers
     source          1..2775
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q15"
     gene            1..2775
                     /gene="Kmt5a"
                     /gene_synonym="Pr-set7; RGD1305893; Setd8"
                     /note="lysine methyltransferase 5A"
                     /db_xref="GeneID:689820"
                     /db_xref="RGD:1587560"
     exon            1..233
                     /gene="Kmt5a"
                     /gene_synonym="Pr-set7; RGD1305893; Setd8"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..1160
                     /gene="Kmt5a"
                     /gene_synonym="Pr-set7; RGD1305893; Setd8"
                     /EC_number="2.1.1.354"
                     /note="isoform 2 is encoded by transcript variant 2; SET
                     domain-containing 8; histone-lysine N-methyltransferase
                     SETD8; histone methyltransferase Pr-set7/Set8; N-lysine
                     methyltransferase SETD8; SET domain containing (lysine
                     methyltransferase) 8; lysine (K)-specific
                     methyltransferase 5A; N-lysine methyltransferase KMT5A"
                     /codon_start=1
                     /product="N-lysine methyltransferase KMT5A isoform 2"
                     /protein_id="NP_001400566.1"
                     /db_xref="GeneID:689820"
                     /db_xref="RGD:1587560"
                     /translation="MGEAGAVGRRRPFPGAPRRRWWRRQQQQQQRRRQRWWPGRGEGE
                     GAGRAAMGLAGLQENVFAGQSKIYAYMSPNKCSGMRSPLQEENSVAHHEVKCPGKPLA
                     GIYRKREEKRNAGNVIRSAVKSEEQKSKDTRRGPLAPFPNQKPEATEPPKTPPPSCDS
                     TSVAVAKQALKKPLKGKQAPRKKSQGKTQQNRKLTDFYPVRRSSRKSKAELQSEERKK
                     IDELIESGKEEGMKIDLIDGKGRGVIATKRFSRGDFVVEYHGDLIEITDAKKREALYA
                     QDPSTGCYMYYFQYLSKTYCVDATQETNRLGRLINHSKCGNCQTKLHDIDGVPHLILI
                     ASRDIAAGEELLYDYGDRSKASIEAYPWLKH"
     exon            234..390
                     /gene="Kmt5a"
                     /gene_synonym="Pr-set7; RGD1305893; Setd8"
                     /inference="alignment:Splign:2.1.0"
     exon            391..610
                     /gene="Kmt5a"
                     /gene_synonym="Pr-set7; RGD1305893; Setd8"
                     /inference="alignment:Splign:2.1.0"
     exon            611..698
                     /gene="Kmt5a"
                     /gene_synonym="Pr-set7; RGD1305893; Setd8"
                     /inference="alignment:Splign:2.1.0"
     exon            699..758
                     /gene="Kmt5a"
                     /gene_synonym="Pr-set7; RGD1305893; Setd8"
                     /inference="alignment:Splign:2.1.0"
     exon            759..949
                     /gene="Kmt5a"
                     /gene_synonym="Pr-set7; RGD1305893; Setd8"
                     /inference="alignment:Splign:2.1.0"
     exon            950..2775
                     /gene="Kmt5a"
                     /gene_synonym="Pr-set7; RGD1305893; Setd8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtccccggcc tcgctcccgg ccccggctgc ggcgcgcgcg ggcgcccggc ctgctgcggg
       61 ccatgggcga agcgggcgcc gtggggcgcc gccggccctt tcccggggcg ccgcggcggc
      121 gctggtggcg gcggcagcag cagcagcagc agcggcggcg gcagcgctgg tggccgggcc
      181 gcggcgaggg cgagggcgcc ggccgtgccg ccatgggcct agccgggctg caggagaacg
      241 tgtttgctgg gcagtcaaag atctatgcct acatgagtcc gaacaaatgc tctggaatgc
      301 gttctccact gcaggaagag aactccgtcg cacatcatga ggtcaaatgc ccggggaaac
      361 cattggccgg aatctacagg aagcgagaag agaaaagaaa cgctgggaat gttatccgaa
      421 gcgctgtgaa gtcagaagaa cagaagagca aagataccag gagaggtccc ctggcgcctt
      481 ttccaaacca aaaacctgaa gcaacagaac ctccaaaaac tccacccccg tcatgtgatt
      541 ctaccagtgt agcggttgct aagcaagccc tgaaaaagcc cctcaagggc aagcaggccc
      601 ctcggaagaa gtctcaaggg aagacacagc agaatagaaa actcacagat ttctaccccg
      661 tgcgaaggag ctccaggaag agcaaagctg agctgcagtc tgaagaaagg aagaagatag
      721 atgagctaat tgagagcggg aaggaagagg gcatgaagat tgatctaatc gatggcaaag
      781 gcaggggtgt gattgctacc aagcgattct cccggggaga ctttgtggta gaataccatg
      841 gagacctcat tgaaatcacc gatgccaaga agcgggaggc tctgtatgca caggacccct
      901 ccacgggctg ctacatgtac tattttcaat atctgagcaa aacctactgc gtggatgcca
      961 ctcaagaaac gaaccgcctg gggagactga tcaatcacag taagtgtggg aattgccaga
     1021 ccaaactgca tgacatcgac ggcgtgcctc acctcatcct catagcctcc cgagacattg
     1081 cggccgggga ggagctcctg tacgactatg gagaccggag caaggcctcc atcgaagcct
     1141 acccttggct gaagcactaa ccaaccatgt ggcctccctg cctccctgcc accctgcctc
     1201 cttcaaagga caaagtgccc tcaaagggaa atgaattttt tacacacaca cacacacaca
     1261 cacacacaca cacacacaca cacacacaca cactcacact cactcttagc taattacttc
     1321 aaatgttttt aaaaagtata ttaaagatgc cttttcatgt agtatttaaa tatctgttac
     1381 aggtttccaa ggtggacttg aacagatggc cttatattac caaaactttt atattctagt
     1441 tgtttttcta cctttttgca tacaagctga acatttgtgc ttcccgcgca gtgtaagact
     1501 cggcacaggt tttagagaat ggagttgaac atgaactagg aagccgggct ctgcccaaga
     1561 tgaaagccag gactcccccg caccccacgt ccgaggacag gccggtgtga gggtgctgcc
     1621 acccccacgc acagcctgga cgggatgtct ccaagctctt gttctcctca acgtcttgac
     1681 aggtgtacac attgacgtgt atgaatattt tttagcaaaa gtttcacagt aagctagtct
     1741 tcccctctgc tttctccaaa gcttactgag cccggggctc ggaggcccgg ccaggaacag
     1801 acctcttcca caggcttacg gcttttccag gcaccttgaa gcatcagggt gggcagtcag
     1861 actagaggcg ggccgggaaa agcactgttc tcctgcccaa gaagggcagg tctcctgaaa
     1921 ctgcattaat tctttataga aatgtgaaca ctgaatttat tttaaaaaat aataataaaa
     1981 aaacaaaata gtaaaaaaaa atttaaaaag aaaaaaaatg gaaaaaaaaa acccacagaa
     2041 aacaacttaa catgtatata ggttttgaag ggagtgaaat gaatgcagtt ttcttttctt
     2101 ctggggttta tttttctttt tggcttggct ggttggtttg tgtagagaag atttgagatg
     2161 gtactctatt ctaatcaaaa gtgaggtttg tagtgggacc agaaattact aagcccacac
     2221 cccctcccca accccaattc tgctacgtgg gaagttctct acctgctgtc aaggcagaac
     2281 ccctggtctc ccgtgaagat gccgtcagtc ctgtgggcat cagacaccag atgtgtttgg
     2341 ctctagggta cctggcagcc cgcaaggctt agcagccaga gatcaggagg atccttcagt
     2401 tgtaacctgt gatagcaaga gtaggcttcc ttctccctcc ttggggagga ctaaccattc
     2461 accttcagtc cagggggcct ggggttcagg agccaggtgt aagagcctac ccttgtcccc
     2521 agtacctcca tctcccagcc tcatgatggt gctacctaag aaagtcttcc ccgcaccctt
     2581 tgctagccca gtcagtggtc agacttggag gaggatccga caggagggtg taactgtgag
     2641 ataaaatgtc ttggttgtac ctgtttgtgg cttagctttg tatttaaata gcaaacaaaa
     2701 aaaggaaata aacttgaaac ttatttgtca tcttaaaaat aaagcaaaaa aattaaagta
     2761 tttatttcca ggcaa
//
