LOCUS       NM_001100851            6802 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus lysine methyltransferase 2E (Kmt2e), mRNA.
ACCESSION   NM_001100851 XM_001059700 XM_231287
VERSION     NM_001100851.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6802)
  AUTHORS   Mas-Y-Mas,S., Barbon,M., Teyssier,C., Demene,H., Carvalho,J.E.,
            Bird,L.E., Lebedev,A., Fattori,J., Schubert,M., Dumas,C.,
            Bourguet,W. and le Maire,A.
  TITLE     The Human Mixed Lineage Leukemia 5 (MLL5), a Sequentially and
            Structurally Divergent SET Domain-Containing Protein with No
            Intrinsic Catalytic Activity
  JOURNAL   PLoS One 11 (11), e0165139 (2016)
   PUBMED   27812132
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6802)
  AUTHORS   Ding,X., Jiang,W., Zhou,P., Liu,L., Wan,X., Yuan,X., Wang,X.,
            Chen,M., Chen,J., Yang,J., Kong,C., Li,B., Peng,C., Wong,C.C.,
            Hou,F. and Zhang,Y.
  TITLE     Mixed Lineage Leukemia 5 (MLL5) Protein Stability Is Cooperatively
            Regulated by O-GlcNac Transferase (OGT) and Ubiquitin Specific
            Protease 7 (USP7)
  JOURNAL   PLoS One 10 (12), e0145023 (2015)
   PUBMED   26678539
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6802)
  AUTHORS   Nin,D.S., Yew,C.W., Tay,S.K. and Deng,L.W.
  TITLE     Targeted silencing of MLL5beta inhibits tumor growth and promotes
            gamma-irradiation sensitization in HPV16/18-associated cervical
            cancers
  JOURNAL   Mol Cancer Ther 13 (11), 2572-2582 (2014)
   PUBMED   25172963
REFERENCE   4  (bases 1 to 6802)
  AUTHORS   Dong,S., Walker,M.F., Carriero,N.J., DiCola,M., Willsey,A.J.,
            Ye,A.Y., Waqar,Z., Gonzalez,L.E., Overton,J.D., Frahm,S.,
            Keaney,J.F. 3rd, Teran,N.A., Dea,J., Mandell,J.D., Hus Bal,V.,
            Sullivan,C.A., DiLullo,N.M., Khalil,R.O., Gockley,J., Yuksel,Z.,
            Sertel,S.M., Ercan-Sencicek,A.G., Gupta,A.R., Mane,S.M.,
            Sheldon,M., Brooks,A.I., Roeder,K., Devlin,B., State,M.W., Wei,L.
            and Sanders,S.J.
  TITLE     De novo insertions and deletions of predominantly paternal origin
            are associated with autism spectrum disorder
  JOURNAL   Cell Rep 9 (1), 16-23 (2014)
   PUBMED   25284784
REFERENCE   5  (bases 1 to 6802)
  AUTHORS   Lucena-Araujo,A.R., Kim,H.T., Jacomo,R.H., Melo,R.A.,
            Bittencourt,R., Pasquini,R., Pagnano,K., Fagundes,E.M., de Lourdes
            Chauffaille,M., Chiattone,C.S., Lima,A.S., Kwaan,H.C.,
            Gallagher,R., Niemeyer,C.M., Schrier,S.L., Tallman,M.S.,
            Grimwade,D., Ganser,A., Berliner,N., Ribeiro,R.C., Lo-Coco,F.,
            Lowenberg,B., Sanz,M.A. and Rego,E.M.
  TITLE     Prognostic impact of KMT2E transcript levels on outcome of patients
            with acute promyelocytic leukaemia treated with all-trans retinoic
            acid and anthracycline-based chemotherapy: an International
            Consortium on Acute Promyelocytic Leukaemia study
  JOURNAL   Br J Haematol 166 (4), 540-549 (2014)
   PUBMED   24796963
REFERENCE   6  (bases 1 to 6802)
  AUTHORS   Zhou,P., Wang,Z., Yuan,X., Zhou,C., Liu,L., Wan,X., Zhang,F.,
            Ding,X., Wang,C., Xiong,S., Wang,Z., Yuan,J., Li,Q. and Zhang,Y.
  TITLE     Mixed lineage leukemia 5 (MLL5) protein regulates cell cycle
            progression and E2F1-responsive gene expression via association
            with host cell factor-1 (HCF-1)
  JOURNAL   J Biol Chem 288 (24), 17532-17543 (2013)
   PUBMED   23629655
REFERENCE   7  (bases 1 to 6802)
  AUTHORS   Black,J.C., Van Rechem,C. and Whetstine,J.R.
  TITLE     Histone lysine methylation dynamics: establishment, regulation, and
            biological impact
  JOURNAL   Mol Cell 48 (4), 491-507 (2012)
   PUBMED   23200123
  REMARK    Review article
REFERENCE   8  (bases 1 to 6802)
  AUTHORS   Madan,V., Madan,B., Brykczynska,U., Zilbermann,F., Hogeveen,K.,
            Dohner,K., Dohner,H., Weber,O., Blum,C., Rodewald,H.R.,
            Sassone-Corsi,P., Peters,A.H. and Fehling,H.J.
  TITLE     Impaired function of primitive hematopoietic cells in mice lacking
            the Mixed-Lineage-Leukemia homolog MLL5
  JOURNAL   Blood 113 (7), 1444-1454 (2009)
   PUBMED   18952892
REFERENCE   9  (bases 1 to 6802)
  AUTHORS   Heuser,M., Yap,D.B., Leung,M., de Algara,T.R., Tafech,A.,
            McKinney,S., Dixon,J., Thresher,R., Colledge,B., Carlton,M.,
            Humphries,R.K. and Aparicio,S.A.
  TITLE     Loss of MLL5 results in pleiotropic hematopoietic defects, reduced
            neutrophil immune function, and extreme sensitivity to DNA
            demethylation
  JOURNAL   Blood 113 (7), 1432-1443 (2009)
   PUBMED   18854576
REFERENCE   10 (bases 1 to 6802)
  AUTHORS   Vieillard,V., Strominger,J.L. and Debre,P.
  TITLE     NK cytotoxicity against CD4+ T cells during HIV-1 infection: a gp41
            peptide induces the expression of an NKp44 ligand
  JOURNAL   Proc Natl Acad Sci U S A 102 (31), 10981-10986 (2005)
   PUBMED   16046540
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000004.1 and CK367010.1.
            
            On May 14, 2021 this sequence version replaced NM_001100851.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the genome
            assembly. The genomic coordinates used for the transcript record
            were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760389
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-356               JAXUCZ010000004.1  12619366-12619721   c
            357-541             JAXUCZ010000004.1  12603360-12603544   c
            542-656             JAXUCZ010000004.1  12593309-12593423   c
            657-886             JAXUCZ010000004.1  12591331-12591560   c
            887-967             JAXUCZ010000004.1  12588257-12588337   c
            968-1026            JAXUCZ010000004.1  12581973-12582031   c
            1027-1199           JAXUCZ010000004.1  12580174-12580346   c
            1200-1238           JAXUCZ010000004.1  12577046-12577084   c
            1239-1469           JAXUCZ010000004.1  12574875-12575105   c
            1470-1600           JAXUCZ010000004.1  12574643-12574773   c
            1601-1718           JAXUCZ010000004.1  12572670-12572787   c
            1719-1828           JAXUCZ010000004.1  12571372-12571481   c
            1829-2093           JAXUCZ010000004.1  12568844-12569108   c
            2094-2192           JAXUCZ010000004.1  12568047-12568145   c
            2193-2357           JAXUCZ010000004.1  12562119-12562283   c
            2358-2666           JAXUCZ010000004.1  12561030-12561338   c
            2667-2921           JAXUCZ010000004.1  12558160-12558414   c
            2922-3066           JAXUCZ010000004.1  12557853-12557997   c
            3067-3317           JAXUCZ010000004.1  12557204-12557454   c
            3318-3374           JAXUCZ010000004.1  12556812-12556868   c
            3375-3938           JAXUCZ010000004.1  12556121-12556684   c
            3939-4225           JAXUCZ010000004.1  12554779-12555065   c
            4226-4314           JAXUCZ010000004.1  12554050-12554138   c
            4315-4440           JAXUCZ010000004.1  12553817-12553942   c
            4441-4526           JAXUCZ010000004.1  12553582-12553667   c
            4527-5096           JAXUCZ010000004.1  12552276-12552845   c
            5097-5099           CK367010.1         408-410
            5100-6802           JAXUCZ010000004.1  12550570-12552272   c
FEATURES             Location/Qualifiers
     source          1..6802
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q11"
     gene            1..6802
                     /gene="Kmt2e"
                     /gene_synonym="Mll5"
                     /note="lysine methyltransferase 2E"
                     /db_xref="GeneID:311968"
                     /db_xref="RGD:1309641"
     exon            1..356
                     /gene="Kmt2e"
                     /gene_synonym="Mll5"
                     /inference="alignment:Splign:2.1.0"
     exon            357..541
                     /gene="Kmt2e"
                     /gene_synonym="Mll5"
                     /inference="alignment:Splign:2.1.0"
     CDS             471..6041
                     /gene="Kmt2e"
                     /gene_synonym="Mll5"
                     /EC_number="2.1.1.354"
                     /note="histone-lysine N-methyltransferase MLL5;
                     myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax
                     homolog, Drosophila); histone-lysine N-methyltransferase
                     2E; lysine (K)-specific methyltransferase 2E"
                     /codon_start=1
                     /product="inactive histone-lysine N-methyltransferase 2E"
                     /protein_id="NP_001094321.2"
                     /db_xref="GeneID:311968"
                     /db_xref="RGD:1309641"
                     /translation="MSIAIPLGVDTTETSYLEMAAGSEPESVEASPVVVEKSNSYPHQ
                     LYTSSSHHSHSYIGLPYADHNYGARPPPTPPASPPPSGLISKNEVGIFTTPHFDETSS
                     ATTISTSEDGSYGTDVTRCICGFTHDDGYMICCDKCSVWQHIDCMGIDRQHIPDTYLC
                     ERCQPRSLDKERAVLLQRRKRENMSDGDTSATESGDEVPVELYTAFQHTPTSITLAAS
                     RAPKVTDKRRKKSGEKEQNFPKCKKAFREGSRKSSRVKGSAPEIDPSSDGSNFVWETK
                     IKAWMDRYEEANNNQYSEGVQREAQRLAQRLGSGSDSKDMSKPELSVNSSLFRPPVES
                     HIQKNKKILKSAKDLPPDALIIEYRGKFMLREQFEANGYFFKRPYPFVLFYSKFHGLE
                     MCVDARTFGNEARFIRRSCTPNAEVRHEIEEGTIHLYIYSTQSIPKGTEITIAFDFDY
                     GNCKYKVDCACLKENPECPVLKRSSESTENINSGYETRRKKGKKEKDISKEKDIQNQN
                     ITLDCEGTNNKIRSPETKQRKLSPLRLSVSNNQEPDFIDDMEEKTPISTEVEMESEEQ
                     IAERRRKMTREERKMEAILQAFARLEKREKRREQALERISTAKTEVRPECKESQVISD
                     ADVVQEQVKEETAIKPTAAKVNRTKQRKSFSRSRTHIGQQRRRHRTVSMCSDIQPSSP
                     DVEVMSQQNDIENTVLAIEPETEAAVAEIITEVEAPALNKCPTKYPKTKKHLVNEWLS
                     EKNEKTGKPSDSLSERPLRITTDPEVLATQLNSLPGLTYSPHVYSTPKHYIRFTSPFL
                     SEKKRRKETTENISGSCKKRWLKQALEEENSTVLHRYHSPCQERPRSPTVNGESKSPL
                     LLSDSCSLPDLTTPLKKRRLYQLLDSAYSESSTPTPSPYATPTHTDITPTDPAFATPP
                     RIKSDDETYRNSYKPIYSPVTPVTPGTPGNTMHFENISSPESSPEIKRCTYNQEGYDR
                     PSTMLTLGPFRNSNLNELGLQEIKTIGYTSPRSRTEVNRPCPGEKESVSDLQLGLDAV
                     EPAALQKTMETPAHDRTEPSSQLDSTHSGRGTMYSSWVKSPDRTGVNFSVNSNLRDLT
                     PSHQLEIGGGFRISESKCLTQDDARGMFMETAVFCPSEDGLVSGFGRTVNDSLIDGSC
                     TPQNPPQKKKVSLLEYRKRQREARKSGSKPENLALISVSPHPSGTLSSSGDGCVHSSE
                     NGEQPENRASLPLAPPAAACTASCEEGSSDCPVRDANPTEKTDPEVQWTASTSVEQVR
                     ERSYQRALLLSDHRKDKDGGGESPCVSCSPSHVQSSPSSHSNHIPQVPAQSLAPPLTE
                     PMADLDPEGTEATSTSECPSPDTSQSPSKTSKPGSPGPINPAQSHGKMLTKPDSHWEA
                     TATVSEAESSVHLKPELQQKQLSSNTPALSKNHPPQAHVRNANDQLPQKLPSAPTKLH
                     CPPSPHTENPPQSSTPHTPVQHGYLSPKPPSQHLGSPFRPHHSQSPQVGTPQRETPRS
                     LYPAAQNLQANAQQAPCGALFTQTPSGQSSAAYSPFNQQALSSPAPPPPPPPPPSAYY
                     QNQQPSANFQNYNQLKGSLSQQTVFTSGPNQALPGTTSQPSVPGHHVTPGHFLPSQNP
                     TIHHQTAAAVVPPPPPPPPAPGPHLVQQPNSHQQHSVAHVVGTVHAVTPGSHIHSQTV
                     GHHLPPPPPPPGPAPHHHPPPHPSTGLQSLQAQHQHVVNSAPPPPPPPPPPASVLVSG
                     HHSASGQALHHPPHQGPPLFPVSVHPAVPPYPSQATHHTTLGPGPQHQPSGTGPHCPL
                     PVPGPHLQPQGPNSIPTPTASGFCPHPHPGSVALPHGVQGPQQASPVPGQIPIHRAQV
                     PPTFQNNYHGSGWH"
     exon            542..656
                     /gene="Kmt2e"
                     /gene_synonym="Mll5"
                     /inference="alignment:Splign:2.1.0"
     exon            657..886
                     /gene="Kmt2e"
                     /gene_synonym="Mll5"
                     /inference="alignment:Splign:2.1.0"
     exon            887..967
                     /gene="Kmt2e"
                     /gene_synonym="Mll5"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1026
                     /gene="Kmt2e"
                     /gene_synonym="Mll5"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1199
                     /gene="Kmt2e"
                     /gene_synonym="Mll5"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1238
                     /gene="Kmt2e"
                     /gene_synonym="Mll5"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1469
                     /gene="Kmt2e"
                     /gene_synonym="Mll5"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1600
                     /gene="Kmt2e"
                     /gene_synonym="Mll5"
                     /inference="alignment:Splign:2.1.0"
     exon            1601..1718
                     /gene="Kmt2e"
                     /gene_synonym="Mll5"
                     /inference="alignment:Splign:2.1.0"
     exon            1719..1828
                     /gene="Kmt2e"
                     /gene_synonym="Mll5"
                     /inference="alignment:Splign:2.1.0"
     exon            1829..2093
                     /gene="Kmt2e"
                     /gene_synonym="Mll5"
                     /inference="alignment:Splign:2.1.0"
     exon            2094..2192
                     /gene="Kmt2e"
                     /gene_synonym="Mll5"
                     /inference="alignment:Splign:2.1.0"
     exon            2193..2357
                     /gene="Kmt2e"
                     /gene_synonym="Mll5"
                     /inference="alignment:Splign:2.1.0"
     exon            2358..2666
                     /gene="Kmt2e"
                     /gene_synonym="Mll5"
                     /inference="alignment:Splign:2.1.0"
     exon            2667..2921
                     /gene="Kmt2e"
                     /gene_synonym="Mll5"
                     /inference="alignment:Splign:2.1.0"
     exon            2922..3066
                     /gene="Kmt2e"
                     /gene_synonym="Mll5"
                     /inference="alignment:Splign:2.1.0"
     exon            3067..3317
                     /gene="Kmt2e"
                     /gene_synonym="Mll5"
                     /inference="alignment:Splign:2.1.0"
     exon            3318..3374
                     /gene="Kmt2e"
                     /gene_synonym="Mll5"
                     /inference="alignment:Splign:2.1.0"
     exon            3375..3938
                     /gene="Kmt2e"
                     /gene_synonym="Mll5"
                     /inference="alignment:Splign:2.1.0"
     exon            3939..4225
                     /gene="Kmt2e"
                     /gene_synonym="Mll5"
                     /inference="alignment:Splign:2.1.0"
     exon            4226..4314
                     /gene="Kmt2e"
                     /gene_synonym="Mll5"
                     /inference="alignment:Splign:2.1.0"
     exon            4315..4440
                     /gene="Kmt2e"
                     /gene_synonym="Mll5"
                     /inference="alignment:Splign:2.1.0"
     exon            4441..4526
                     /gene="Kmt2e"
                     /gene_synonym="Mll5"
                     /inference="alignment:Splign:2.1.0"
     exon            4527..6802
                     /gene="Kmt2e"
                     /gene_synonym="Mll5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccgccgccg ccgccgccgt cgccgccatt ttcccagagc gagaagcagt gacactgagc
       61 gggcgcaggg ggccgagtcg gagatcgagc ttgagttcgg gagcggcagc agagggggca
      121 tagacactct gagcagcctc ggcgtctcct cagcattcct gactgtggcc cgcagtgccc
      181 gactcctggg ttctcactga agacgctgcg cgctgctgct tggggagggg gtgtggagcc
      241 ggttctgcga ccgcagtggc tgtcgtcggg ggtcgaccga gcgctgaggt gtggagagcc
      301 tcgcccgggg tcgagccgat aacagggttc gggtgtctgg tgtgtgacca tcacagggtt
      361 tgtggatgca cttagatgtt tgcaatgagc actgtggctg gcatgcccca gtattttgga
      421 taccaatgca taggactcca tagtaatcgg atttaccaga ggcgaacgtc atgagcatag
      481 cgatcccatt gggggttgat acaacagaaa catcctactt ggaaatggct gcaggctcag
      541 aaccagaatc cgtagaagct agccctgtgg tagttgagaa atccaacagt tatccccacc
      601 agttatatac cagcagctcc catcattcac acagctacat tggtttgccc tatgcggacc
      661 ataattatgg tgctcgtcct cctccaacac ctccagcatc cccgcctcca tcaggtctca
      721 ttagcaaaaa cgaagtaggc atattcacca ctcctcactt tgacgagact tccagtgcta
      781 ctacaatcag cacgtctgaa gatgggagct acggcactga cgtgacccgg tgcatatgtg
      841 gctttacaca cgatgacggc tacatgatct gctgtgacaa atgcagtgtt tggcaacata
      901 ttgactgcat ggggattgac aggcagcata ttcctgatac atatctatgt gaacgttgtc
      961 agcccaggag tttggataaa gagagggcag tgctactgca acgccggaaa agagaaaata
     1021 tgtcagatgg tgacaccagt gcaactgaaa gtggcgatga ggtccccgtg gaattataca
     1081 ctgcattcca gcacactcca acttcaatca ccttagctgc ttccagagcc cccaaggtca
     1141 ctgataagag gaggaaaaaa agtggggaga aagaacaaaa ctttccaaaa tgtaaaaaag
     1201 catttcgtga aggatctagg aaatcatcaa gggttaaggg ttcagcacca gaaattgatc
     1261 cttcgtctga tggttcaaat tttgtatggg agacaaaaat caaagcatgg atggatcgct
     1321 acgaagaagc aaataataac cagtatagcg agggcgtgca gagagaggcg caaagactag
     1381 cgcaaagact cggcagtggg agtgacagca aagacatgag taaaccagaa ttgagtgtca
     1441 acagctccct cttcagacct cctgtagaga gccatataca gaagaataaa aaaattctga
     1501 aatctgccaa agacttgcct cctgatgcac ttatcattga atacagagga aagtttatgc
     1561 tgagagaaca gtttgaagca aatggatatt tctttaaaag gccataccct tttgttttat
     1621 tctactccaa gttccatggg ctagaaatgt gtgttgatgc aaggactttt gggaatgagg
     1681 ctcgattcat caggcgttct tgtacaccga atgcagaggt gaggcatgaa attgaagagg
     1741 ggaccataca tctctacatt tactctacac agagtattcc aaaagggact gaaattacta
     1801 ttgcctttga ttttgactat gggaattgta aatacaaggt ggactgtgcg tgcctcaagg
     1861 aaaatccaga gtgccctgtt ctaaagcgca gctcagaatc tacagaaaac attaatagtg
     1921 gttatgagac cagaagaaaa aaaggaaaaa aagagaaaga catttcaaaa gaaaaagata
     1981 tacaaaatca aaatattact ttggactgtg aaggaacaaa caacaaaata aggagtccag
     2041 aaacaaaaca gagaaagctt tctccattaa ggctgtcagt gtccaacaac caggaaccag
     2101 attttattga tgatatggaa gaaaaaactc ctattagcac tgaagttgaa atggaatcag
     2161 aggagcagat tgcggagagg aggaggaaga tgacaagaga agaaagaaaa atggaagcaa
     2221 ttctgcaagc ttttgccaga cttgaaaaga gagagaagag acgagaacaa gctttggaaa
     2281 ggatcagcac agccaagacg gaagtcaggc ccgagtgtaa ggagtcgcag gtcatctctg
     2341 acgctgacgt ggtccaggaa caagtaaagg aagaaactgc tatcaagcca actgctgcca
     2401 aagtgaacag aactaagcag agaaaaagct tttctcgtag taggactcat attggacagc
     2461 agcgtcggag acacagaacc gtcagcatgt gttcagacat acagccatcc tctcccgacg
     2521 ttgaagttat gtcacaacag aatgatattg aaaacactgt gcttgctata gaaccagaaa
     2581 ctgaagctgc agtagcagag ataatcactg aagtggaagc tccagcactt aataaatgtc
     2641 ccacaaagta ccccaaaaca aagaagcact tggtcaatga atggttaagt gagaagaatg
     2701 agaagacagg aaaaccttca gacagccttt cagaaaggcc tctgcgcata actacagatc
     2761 cagaggtgtt agctacacag ctcaattctt tgccaggtct cacttacagc ccccatgtat
     2821 actctactcc taagcattac attagattca catcaccatt cctttcggaa aaaaagagaa
     2881 gaaaagaaac tactgaaaac atttctggct catgcaaaaa gcgatggttg aagcaagccc
     2941 tggaagaaga aaattcaaca gttttacaca gatatcattc accgtgtcag gaaaggccca
     3001 ggagccctac agttaatggt gaaagtaaaa gtcccctgct gctgagcgac agctgctccc
     3061 tcccagattt aaccacacca ctaaaaaagc gaagacttta ccaattgtta gactcggctt
     3121 actcagaaag ctccacccct actccttcac catacgccac cccaactcac acggacatca
     3181 ctcctaccga cccagcattt gctactcccc cacggatcaa atcagatgat gaaacttaca
     3241 gaaatagtta taaacccata tattcaccag tgaccccagt gacccctggc acaccaggaa
     3301 acaccatgca ctttgagaat atttcttccc cagaaagttc tccagaaata aagagatgca
     3361 cttacaatca agagggatat gaccgacctt caaccatgct aacgctgggg ccttttagaa
     3421 attccaacct aaatgagcta ggcctgcaag aaataaagac cattggttac accagcccca
     3481 ggagcaggac tgaggttaat aggccttgcc caggagaaaa ggagtctgtg tcagaccttc
     3541 aactgggact cgatgcagtc gagccagctg ccttacagaa aaccatggaa accccagccc
     3601 atgacaggac tgagcccagc agccaactgg attcgaccca ctctggacga ggcacaatgt
     3661 attcatcctg ggtaaagagt cctgacagaa caggagttaa cttctcagta aactccaact
     3721 tgagggactt aacaccctct catcagttgg agattggagg cggcttccga atcagtgagt
     3781 ccaagtgcct gacgcaggat gatgctagag gcatgtttat ggagacagct gtcttttgtc
     3841 cctctgaaga tgggcttgtc tctggttttg gacggactgt taatgacagt ttgatcgacg
     3901 ggagctgcac gccccagaat ccaccacaaa agaaaaaggt ctctctacta gaataccgta
     3961 agagacaacg tgaagctagg aagagtggtt ctaagccaga gaaccttgct ttgattagtg
     4021 tgtcacctca cccaagtggg actctaagca gcagtggcga tggctgtgtc cacagcagtg
     4081 agaacgggga gcagccagaa aaccgggcta gcttgccttt agcaccgcca gctgccgcct
     4141 gcaccgcctc ctgtgaagaa ggcagcagtg actgtcctgt cagagacgcc aaccccactg
     4201 agaagacaga cccagaagtt cagtggactg cttccacctc agtggagcaa gtgagagaga
     4261 gaagctatca gagagcgtta ttgctcagtg accaccgcaa agacaaagac ggcgggggag
     4321 agtcaccatg tgtctcatgt tcaccgagtc atgttcagtc ttcaccttca tctcattcaa
     4381 accacattcc ccaggtgccc gctcagagcc tagcccctcc tttgactgaa cctatggcag
     4441 accttgatcc tgaaggtaca gaagccacaa gtacaagtga atgtccatcc cctgacactt
     4501 ctcagagccc ttctaaaaca agcaagcctg gttcaccagg gccaatcaat cctgctcagt
     4561 cacatgggaa aatgctcaca aaaccagatt cccactggga ggcaactgcc actgtatcag
     4621 aagctgagag cagtgttcac ctaaaaccag agcttcagca aaaacagctg tcaagtaaca
     4681 ccccagcact ttcaaagaac catcctcctc aggcccacgt tcgaaatgca aacgatcaac
     4741 ttccgcaaaa gctgccttct gcaccaacaa aattgcactg tcctccgtcc cctcacacag
     4801 aaaaccctcc ccagtcctcc acgcctcaca cgcctgtgca gcatggttac ctctcaccaa
     4861 agcctccttc acagcaccta ggatctccct tcaggcctca ccattcacag tcacctcaag
     4921 tcggaactcc tcaacgcgag actccgagaa gtttgtatcc agcggcacag aaccttcaag
     4981 ctaatgctca gcaggcacct tgtggagcgt tatttaccca gacaccctca ggccagtcct
     5041 cggcagcata cagtccgttc aaccaacagg ctctgagcag cccggccccg ccccccccac
     5101 cccctccgcc tccttcagca tactatcaaa accagcagcc ctctgcaaac tttcagaact
     5161 acaatcagct aaaaggtagt ctttcccaac aaactgtgtt tacatctgga ccaaatcaag
     5221 cacttcctgg caccacaagc cagccatccg ttcctggaca ccatgttact ccgggccatt
     5281 ttctgccgtc tcaaaaccct accattcacc atcaaactgc tgctgctgtg gtcccacccc
     5341 cgcctccacc accgcctgct ccaggacctc acctcgtaca acagccaaac tcacatcagc
     5401 agcactctgt agcacatgta gttgggacag ttcatgctgt cacccctggg tcacacattc
     5461 attctcaaac tgttggacac catttaccac cacctcctcc acctcctggt cctgccccac
     5521 atcaccatcc tccaccccat ccttccacag gactgcaaag tctgcaagca caacaccagc
     5581 atgtagtaaa ctcagcaccc ccaccgcccc ctcctcctcc tcctccagcc agtgttctgg
     5641 tttctgggca tcattcagca tcaggtcaag ccttacatca cccacctcat caaggacctc
     5701 cactttttcc tgtgagtgtt catccggctg taccgccgta cccctcacaa gccacacatc
     5761 acaccacttt gggaccggga ccccaacacc agccttccgg aacagggcca cattgtccat
     5821 taccagttcc aggtcctcat ctccagcccc aaggaccaaa cagtattcca acacctactg
     5881 cttcagggtt ctgtcctcat cctcaccctg gctctgtggc cctgccacat ggggtgcaag
     5941 gacctcagca ggcatcgcca gtgcctggac agattccaat tcacagagca caggtgccac
     6001 caacatttca aaacaattac cacggttcag ggtggcatta aaatggactc caataacatt
     6061 ttttaaaatg ttctgtaaga taaactgtat atttcatatg tacctgttaa ggtacttttt
     6121 aaagcttgta catgaaactt tgtataaaaa agacaaaaac aaaacaaaca aacaaaaaaa
     6181 aaacaaaaca ccagtgctct tccattgtat ttttcccatt tttgcttttt aagattccgt
     6241 atgaaatgtg ctaagccagt cgtaggcatc ttaattctgt aagtgagcat tccaactgtc
     6301 ttttctgacc agagagctga tgtacatgac cttaaatttc attgttgcag ttaaattcat
     6361 ttagtgacta ttttctgtat tattttatac atatgcatta agtatacagc taaagaaagc
     6421 actaaggatt ttctttttta tggtcagcag ttctttgagt gcaccttagg tctgaaaatg
     6481 caatacaggt ttttataatt tggtgtggac atggctcatt ttgttttatc agttttttgc
     6541 aagcaaaatg taatttaatg tgtagataat ttctagtgtc tcctgacaga tgtaaatact
     6601 gcatttcttt tgcgtgtata attgcttccc acccttttca tttggtatat agcattgtac
     6661 atatgcaagt ctttgcaaaa gtgtgatctc tgtggagtag tacagcacat ggcctttcct
     6721 ttttatttca gtatgctgtc acattgaagc actggctggg cattttaatt catgttaata
     6781 aaccacaatt atgtcagttt ta
//
