LOCUS       NM_021593               3447 bp    mRNA    linear   ROD 22-SEP-2024
DEFINITION  Rattus norvegicus kynurenine 3-monooxygenase (Kmo), mRNA.
ACCESSION   NM_021593
VERSION     NM_021593.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3447)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 3447)
  AUTHORS   Kim,H.T., Na,B.K., Chung,J., Kim,S., Kwon,S.K., Cha,H., Son,J.,
            Cho,J.M. and Hwang,K.Y.
  TITLE     Structural Basis for Inhibitor-Induced Hydrogen Peroxide Production
            by Kynurenine 3-Monooxygenase
  JOURNAL   Cell Chem Biol 25 (4), 426-438 (2018)
   PUBMED   29429898
REFERENCE   3  (bases 1 to 3447)
  AUTHORS   Gao,J., Yao,L., Xia,T., Liao,X., Zhu,D. and Xiang,Y.
  TITLE     Biochemistry and structural studies of kynurenine 3-monooxygenase
            reveal allosteric inhibition by Ro 61-8048
  JOURNAL   FASEB J 32 (4), 2036-2045 (2018)
   PUBMED   29208702
REFERENCE   4  (bases 1 to 3447)
  AUTHORS   Wang,J., Li,X., He,S., Hu,L., Guo,J., Huang,X., Hu,J., Qi,Y.,
            Chen,B., Shang,D. and Wen,Y.
  TITLE     Regulation of the kynurenine metabolism pathway by Xiaoyao San and
            the underlying effect in the hippocampus of the depressed rat
  JOURNAL   J Ethnopharmacol 214, 13-21 (2018)
   PUBMED   29217494
REFERENCE   5  (bases 1 to 3447)
  AUTHORS   Reus,G.Z., Becker,I.R.T., Scaini,G., Petronilho,F., Oses,J.P.,
            Kaddurah-Daouk,R., Ceretta,L.B., Zugno,A.I., Dal-Pizzol,F.,
            Quevedo,J. and Barichello,T.
  TITLE     The inhibition of the kynurenine pathway prevents behavioral
            disturbances and oxidative stress in the brain of adult rats
            subjected to an animal model of schizophrenia
  JOURNAL   Prog Neuropsychopharmacol Biol Psychiatry 81, 55-63 (2018)
   PUBMED   29030243
REFERENCE   6  (bases 1 to 3447)
  AUTHORS   Erickson,J.B., Flanagan,E.M., Russo,S. and Reinhard,J.F. Jr.
  TITLE     A radiometric assay for kynurenine 3-hydroxylase based on the
            release of 3H2O during hydroxylation of L-[3,5-3H]kynurenine
  JOURNAL   Anal Biochem 205 (2), 257-262 (1992)
   PUBMED   1332540
REFERENCE   7  (bases 1 to 3447)
  AUTHORS   Okayama,A., Ogawa,Y., Goto,S., Yamatodani,A., Wada,H., Okuno,E.,
            Takikawa,O. and Kido,R.
  TITLE     Enzymatic studies on tryptophan metabolism disorder in rats
            chronically exposed to carbon disulfide
  JOURNAL   Toxicol Appl Pharmacol 94 (3), 356-361 (1988)
   PUBMED   3400092
REFERENCE   8  (bases 1 to 3447)
  AUTHORS   Kohler,C., Eriksson,L.G., Flood,P.R., Hardie,J.A., Okuno,E. and
            Schwarcz,R.
  TITLE     Quinolinic acid metabolism in the rat brain. Immunohistochemical
            identification of 3-hydroxyanthranilic acid oxygenase and
            quinolinic acid phosphoribosyltransferase in the hippocampal region
  JOURNAL   J Neurosci 8 (3), 975-987 (1988)
   PUBMED   3346732
REFERENCE   9  (bases 1 to 3447)
  AUTHORS   Takeuchi,F. and Shibata,Y.
  TITLE     Kynurenine metabolism in vitamin-B-6-deficient rat liver after
            tryptophan injection
  JOURNAL   Biochem J 220 (3), 693-699 (1984)
   PUBMED   6466295
REFERENCE   10 (bases 1 to 3447)
  AUTHORS   Battie,C. and Verity,M.A.
  TITLE     Presence of kynurenine hydroxylase in developing rat brain
  JOURNAL   J Neurochem 36 (3), 1308-1310 (1981)
   PUBMED   6259288
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Nov 24, 2020 this sequence version replaced NM_021593.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ210049.1, AF056031.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-145               JAXUCZ010000013.1  90089521-90089665
            146-215             JAXUCZ010000013.1  90095711-90095780
            216-313             JAXUCZ010000013.1  90096101-90096198
            314-403             JAXUCZ010000013.1  90097472-90097561
            404-452             JAXUCZ010000013.1  90102009-90102057
            453-540             JAXUCZ010000013.1  90106263-90106350
            541-706             JAXUCZ010000013.1  90107831-90107996
            707-778             JAXUCZ010000013.1  90108383-90108454
            779-900             JAXUCZ010000013.1  90109274-90109395
            901-1048            JAXUCZ010000013.1  90112384-90112531
            1049-1106           JAXUCZ010000013.1  90113904-90113961
            1107-1189           JAXUCZ010000013.1  90115704-90115786
            1190-1291           JAXUCZ010000013.1  90117337-90117438
            1292-1351           JAXUCZ010000013.1  90117526-90117585
            1352-3447           JAXUCZ010000013.1  90119013-90121108
FEATURES             Location/Qualifiers
     source          1..3447
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q24"
     gene            1..3447
                     /gene="Kmo"
                     /note="kynurenine 3-monooxygenase"
                     /db_xref="GeneID:59113"
                     /db_xref="RGD:620610"
     exon            1..145
                     /gene="Kmo"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..1528
                     /gene="Kmo"
                     /EC_number="1.14.13.9"
                     /function="monooxygenase"
                     /note="kynurenine 3-hydroxylase"
                     /codon_start=1
                     /product="kynurenine 3-monooxygenase"
                     /protein_id="NP_067604.1"
                     /db_xref="GeneID:59113"
                     /db_xref="RGD:620610"
                     /translation="MASSDTEGKRVVVIGGGLVGALNACFLAKRNFQVDVYEAREDIR
                     VANFMRGRSINLALSYRGRQALKAVGLEDQIVSKGVPMKARMIHSLSGKKSAIPYGNK
                     SQYILSISREKLNKDLLTAVESYPNAKVHFGHKLSKCCPEEGILTMLGPNKVPRDITC
                     DLIVGCDGAYSTVRAHLMKKPRFDYSQQYIPHGYMELTIPPKNGEYAMEPNCLHIWPR
                     NAFMMIALPNMDKSFTCTLFMSFEEFEKLPTHSDVLDFFQKNFPDAIPLMGEQALMRD
                     FFLLPAQPMISVKCSPFHLKSRCVLMGDAAHAIVPFFGQGMNAGFEDCLVFDELMDKF
                     NNDLSVCLPEFSRFRIPDDHAISDLSMYNYIEMRAHVNSRWFLFQRLLDKFLHALMPS
                     TFIPLYTMVAFTRIRYHEAVLRWHWQKKVINRGLFVLGSLVAIGSAYILVHHLSPRPL
                     ELLRSAWTGTSGHWNRSADISPRVPWSH"
     exon            146..215
                     /gene="Kmo"
                     /inference="alignment:Splign:2.1.0"
     exon            216..313
                     /gene="Kmo"
                     /inference="alignment:Splign:2.1.0"
     exon            314..403
                     /gene="Kmo"
                     /inference="alignment:Splign:2.1.0"
     exon            404..452
                     /gene="Kmo"
                     /inference="alignment:Splign:2.1.0"
     exon            453..540
                     /gene="Kmo"
                     /inference="alignment:Splign:2.1.0"
     exon            541..706
                     /gene="Kmo"
                     /inference="alignment:Splign:2.1.0"
     exon            707..778
                     /gene="Kmo"
                     /inference="alignment:Splign:2.1.0"
     exon            779..900
                     /gene="Kmo"
                     /inference="alignment:Splign:2.1.0"
     exon            901..1048
                     /gene="Kmo"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1106
                     /gene="Kmo"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1189
                     /gene="Kmo"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1291
                     /gene="Kmo"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1351
                     /gene="Kmo"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..3447
                     /gene="Kmo"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaaggctctg ggcttctggc aataaaaaga tcacaaaaca tcagcatgta gtgcagagag
       61 ttcctacctg agcagaggta ttctggcagc aatggcatcg tcggacactg aaggaaaaag
      121 agtggttgtt atcggtggtg gtttggttgg agcattgaac gcgtgctttc tcgcaaagag
      181 gaatttccaa gttgatgtgt acgaagctag ggaagatatt cgagtggcta actttatgcg
      241 tggaagaagc attaatttgg ccctttctta tagaggacgg caggccttga aggccgttgg
      301 tctggaagat cagatcgtgt ccaaaggtgt gcccatgaaa gccagaatga tccactctct
      361 ctcgggaaag aagtctgcaa ttccctatgg gaacaagtca cagtatatcc tttcaataag
      421 cagagaaaag ttaaacaagg atctgctgac tgccgtggag tcctacccca atgcaaaggt
      481 gcactttggc cacaagctgt caaaatgctg tccggaggaa gggatactca cgatgcttgg
      541 acccaacaaa gttcccagag acatcacgtg tgacctcatt gtaggatgtg atggggccta
      601 ctcaactgtc agagctcacc tcatgaagaa gccccgtttt gattacagtc agcaatatat
      661 ccctcatggc tatatggagc tgacaattcc acctaagaac ggggagtatg ccatggaacc
      721 taactgtctt cacatttggc ctagaaatgc ctttatgatg atcgccctac cgaacatgga
      781 caaatctttc acatgcacct tgttcatgtc ctttgaggag tttgaaaagc ttccaacgca
      841 tagtgatgtg ctggacttct tccagaagaa ctttccagat gccatccctc tgatgggcga
      901 gcaagccctc atgagagatt tctttctgtt gcctgcccag cccatgatat cagtaaagtg
      961 ctctcccttc cacctgaagt cacgctgtgt gctgatggga gatgcagctc atgccatcgt
     1021 cccatttttt gggcaaggaa tgaatgcggg ctttgaagac tgcttggtat ttgatgagtt
     1081 aatggacaaa ttcaataatg atcttagtgt gtgccttcct gaattctcaa gatttaggat
     1141 tcctgatgac catgcaattt cagacctgtc tatgtacaat tacatagaga tgcgagcgca
     1201 tgtcaactct aggtggttcc tgtttcaaag gctcctggat aaatttcttc atgcactaat
     1261 gccatccact ttcatccctc tctataccat ggtcgccttc accagaataa gataccacga
     1321 ggcagtgctg cgctggcatt ggcaaaaaaa ggtgataaac agaggactct ttgtccttgg
     1381 gtccctggta gccattggaa gtgcctacat actcgtgcac cacctgtccc cgagacctct
     1441 ggaactcctg agatctgcct ggacgggaac ctctggccac tggaatagga gtgcagacat
     1501 ttctccacga gttccatgga gtcactagga caaatgcccc agttcactat ccatagtgtc
     1561 aacgttccgg gtagcaaatg cttgattcct cttcaatatc aagggagaaa ctcatgttcc
     1621 cattgccgtc ttcagttcac tatgggaaaa tcattgtcag catataatta agttcggagt
     1681 ggagggctgt ttttacagtg tctcattatt ttgcatgctt ggactgggtt caatttttaa
     1741 atttaaaaac acaataacca aagtctcttt cacttctcaa aaaaattttt tttcctatag
     1801 aggacaatac aggatcaaaa acaccaggac tgaaaaccac agcttgcctg gtgctaattc
     1861 ctctttatag cagtggtggg gtttgctagt tcatagccac ttgctaaagg tagaggtgtg
     1921 aatgttccaa acagggtgtt ccaaagagtt ccaggataaa tctgttaaat tatttcccag
     1981 tccccagacc tcagaattat tactgttttg aagataagga aagggctatt aatggcatct
     2041 taagtgaagg ataagaaagg gttgttagta gtaatacatt tataccaggg tggagaggag
     2101 atgggagggt gttttctaga agcatagaga cgcacagttc attgcatttc agacatgcag
     2161 aagtgattcg ttgactgtcc cacagacaga atcggaagtt aacttcatca tcagagactg
     2221 ggacacttag aaattctttt cattgtcaat tttgagagct acaataatag ttatctagga
     2281 aatccaaaac tgaggttata aagataaaac aatttggcat tttccataat gccaaaagca
     2341 tcctcgagtc ttaacagtct atgtttgagg tgtagggaaa gaaaaatcat tcttttcctg
     2401 gtaagggatg tagctcagtg gggagtgtag catgggtaga gcccagggtt agattcacca
     2461 gcactgcaaa aataaacaga acaatagttt aggagcatgc atgtatattt catatggaca
     2521 tgggaaacgc tcagaaatga gctgacttag gggctaggga gatggctcag ctgttaagta
     2581 tgtgtgccac tcctgaagag gctcctagtt ccgtccccag cacccatttc aggcagccca
     2641 gttggaactc cagctccagg agatccaacc cctctggctt ccttgggccc ctgcacccat
     2701 gtgcatataa ccacacatgg ctccacaagg gaattaaaag tctttaacaa tcataatttc
     2761 tggaagaggc aagggggtgt atgggaggag ttagacggaa aaaaagtaag ggaggaaatg
     2821 atgcaattta aagttaaaca aaagaatagt taaaaggggg gatccatgtg atatgcaaca
     2881 ttgttgggaa atagcttaaa taaaaatcta gtacattaaa aaaaatttaa gagacacggg
     2941 agctggctta caaagttcta actcctgtca tcttcaacag gaagtaaact tttagatgag
     3001 aaaaagggga aaggatcgaa attcctaggg tagcaatcct tagggggtcg ccttagaaag
     3061 tggggggagg cttttcttct gcttctcagt gacttccaaa tcaaggtaac cctgcaaatt
     3121 ggagcacatt tgagggctat tctgttctct cccaggaatg aacaatgaca cgtggggagg
     3181 tctcttcact cacatggagc ctatataagc aatgaaaact aaagaatcca ttggatggag
     3241 ctggtgaggt ggctcactga gaagaggtgc ttgctgtggt ttgatctctg ggacccacat
     3301 ggtggaagga gagaacgcat tcccacaagc tgtcctctga tttagtgtat gtgtgcatac
     3361 atgcacagta tgacatgaat gtgtgcacat atgcacacat acactaaata actcaacata
     3421 ataaaatata aataataata atacaca
//
