LOCUS       NM_133512               1159 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Rattus norvegicus killer cell lectin like receptor K1 (Klrk1),
            mRNA.
ACCESSION   NM_133512
VERSION     NM_133512.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1159)
  AUTHORS   Pasanen,A., Karjalainen,M.K., Kummola,L., Waage,J., Bonnelykke,K.,
            Ruotsalainen,M., Piippo-Savolainen,E., Goksor,E., Nuolivirta,K.,
            Chawes,B., Vissing,N., Bisgaard,H., Jartti,T., Wennergren,G.,
            Junttila,I., Hallman,M., Korppi,M. and Ramet,M.
  TITLE     NKG2D gene variation and susceptibility to viral bronchiolitis in
            childhood
  JOURNAL   Pediatr Res 84 (3), 451-457 (2018)
   PUBMED   29967528
REFERENCE   2  (bases 1 to 1159)
  AUTHORS   Nabekura,T., Gotthardt,D., Niizuma,K., Trsan,T., Jenus,T.,
            Jonjic,S. and Lanier,L.L.
  TITLE     Cutting Edge: NKG2D Signaling Enhances NK Cell Responses but Alone
            Is Insufficient To Drive Expansion during Mouse Cytomegalovirus
            Infection
  JOURNAL   J Immunol 199 (5), 1567-1571 (2017)
   PUBMED   28760883
REFERENCE   3  (bases 1 to 1159)
  AUTHORS   Xu,X., Zhang,J., Zhan,S., Li,Z., Liu,X., Zhang,H., Jiang,Y. and
            Hu,X.
  TITLE     TGF-beta1 improving abnormal pregnancy outcomes induced by
            Toxoplasma gondii infection: Regulating NKG2D/DAP10 and killer
            subset of decidual NK cells
  JOURNAL   Cell Immunol 317, 9-17 (2017)
   PUBMED   28438315
REFERENCE   4  (bases 1 to 1159)
  AUTHORS   Qu,M., Yuan,X., Liu,D., Ma,Y., Zhu,J., Cui,J., Yu,M., Li,C. and
            Guo,D.
  TITLE     Bone Marrow-Derived Mesenchymal Stem Cells Attenuate
            Immune-Mediated Liver Injury and Compromise Virus Control During
            Acute Hepatitis B Virus Infection in Mice
  JOURNAL   Stem Cells Dev 26 (11), 818-827 (2017)
   PUBMED   28318408
REFERENCE   5  (bases 1 to 1159)
  AUTHORS   Lenartic,M., Jelencic,V., Zafirova,B., Ozanic,M., Marecic,V.,
            Jurkovic,S., Sexl,V., Santic,M., Wensveen,F.M. and Polic,B.
  TITLE     NKG2D Promotes B1a Cell Development and Protection against
            Bacterial Infection
  JOURNAL   J Immunol 198 (4), 1531-1542 (2017)
   PUBMED   28087665
REFERENCE   6  (bases 1 to 1159)
  AUTHORS   Hayakawa,Y., Kelly,J.M., Westwood,J.A., Darcy,P.K., Diefenbach,A.,
            Raulet,D. and Smyth,M.J.
  TITLE     Cutting edge: tumor rejection mediated by NKG2D receptor-ligand
            interaction is dependent upon perforin
  JOURNAL   J Immunol 169 (10), 5377-5381 (2002)
   PUBMED   12421908
  REMARK    GeneRIF: NKG2D acts as a natural cytotoxicity receptor to stimulate
            perforin-mediated elimination of ligand-expressing tumor cells.
REFERENCE   7  (bases 1 to 1159)
  AUTHORS   Girardi,M., Oppenheim,D.E., Steele,C.R., Lewis,J.M., Glusac,E.,
            Filler,R., Hobby,P., Sutton,B., Tigelaar,R.E. and Hayday,A.C.
  TITLE     Regulation of cutaneous malignancy by gammadelta T cells
  JOURNAL   Science 294 (5542), 605-609 (2001)
   PUBMED   11567106
REFERENCE   8  (bases 1 to 1159)
  AUTHORS   Wu,J., Song,Y., Bakker,A.B., Bauer,S., Spies,T., Lanier,L.L. and
            Phillips,J.H.
  TITLE     An activating immunoreceptor complex formed by NKG2D and DAP10
  JOURNAL   Science 285 (5428), 730-732 (1999)
   PUBMED   10426994
REFERENCE   9  (bases 1 to 1159)
  AUTHORS   Berg,S.F., Dissen,E., Westgaard,I.H. and Fossum,S.
  TITLE     Molecular characterization of rat NKR-P2, a lectin-like receptor
            expressed by NK cells and resting T cells
  JOURNAL   Int Immunol 10 (4), 379-385 (1998)
   PUBMED   9620593
REFERENCE   10 (bases 1 to 1159)
  AUTHORS   Yarbrough,W.G., Quarmby,V.E., Simental,J.A., Joseph,D.R., Sar,M.,
            Lubahn,D.B., Olsen,K.L., French,F.S. and Wilson,E.M.
  TITLE     A single base mutation in the androgen receptor gene causes
            androgen insensitivity in the testicular feminized rat
  JOURNAL   J Biol Chem 265 (15), 8893-8900 (1990)
   PUBMED   2341409
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FQ241294.1 and AF009511.1.
            
            On Jul 25, 2012 this sequence version replaced NM_133512.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ241294.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5756307,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-716               FQ241294.1         1-716
            717-1159            AF009511.1         671-1113
FEATURES             Location/Qualifiers
     source          1..1159
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..1159
                     /gene="Klrk1"
                     /gene_synonym="NKG2D; Nkrp2"
                     /note="killer cell lectin like receptor K1"
                     /db_xref="GeneID:24934"
                     /db_xref="RGD:3180"
     exon            1..50
                     /gene="Klrk1"
                     /gene_synonym="NKG2D; Nkrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            51..199
                     /gene="Klrk1"
                     /gene_synonym="NKG2D; Nkrp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..741
                     /gene="Klrk1"
                     /gene_synonym="NKG2D; Nkrp2"
                     /note="NKLLR; NK cell receptor D; NK lectin-like receptor;
                     NKG2-D-activating NK receptor; NKR-P2, ortholog of human
                     NKG2D; killer cell lectin-like receptor subfamily K,
                     member 1"
                     /codon_start=1
                     /product="NKG2-D type II integral membrane protein"
                     /protein_id="NP_598196.1"
                     /db_xref="GeneID:24934"
                     /db_xref="RGD:3180"
                     /translation="MSKCHNYDLKPAKWDTSQEHQKQRSALPTSRPGENGIIRRRSSI
                     EELKISPLFVVRVLVAAMTIRFTVITLTWLAVFITLLCNKEVSVSSREGYCGPCPNDW
                     ICHRNNCYQFFNENKAWNQSQASCLSQNSSLLKIYSKEEQDFLKLVKSYHWMGLVQSP
                     ANGSWQWEDGSSLSPNELTLVKTPSGTCAVYGSSFKAYTEDCSNPNTYICMKRAV"
     exon            200..238
                     /gene="Klrk1"
                     /gene_synonym="NKG2D; Nkrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            239..331
                     /gene="Klrk1"
                     /gene_synonym="NKG2D; Nkrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            332..367
                     /gene="Klrk1"
                     /gene_synonym="NKG2D; Nkrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            368..519
                     /gene="Klrk1"
                     /gene_synonym="NKG2D; Nkrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            520..623
                     /gene="Klrk1"
                     /gene_synonym="NKG2D; Nkrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            624..1158
                     /gene="Klrk1"
                     /gene_synonym="NKG2D; Nkrp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagtagaagg ctttgattca caagaaacag gacctccctt ctctgctcag gcagtccatg
       61 gacttgtgtc aacttgaatt gcttcctcca gagatgagca aatgccataa ttatgacctc
      121 aagccagcaa agtgggatac ttctcaagag catcagaaac aaagatctgc actccctacc
      181 agccgacctg gagagaatgg tatcataaga cgaaggtctt ctatagaaga actcaaaata
      241 tctccactgt tcgttgttcg agtccttgtt gcagccatga ccattcgctt caccgttatc
      301 acattgacat ggcttgctgt tttcataact ttgttatgca acaaggaagt ttcagtttcc
      361 tcaagagagg gctactgtgg cccatgccct aacgactgga tatgtcacag aaacaactgt
      421 taccaatttt ttaatgagaa caaagcctgg aaccagagcc aagcttcctg tttgtctcaa
      481 aattccagcc tgctgaagat atacagtaaa gaagaacagg atttcttaaa gctggttaag
      541 tcctatcact ggatgggact agtccagagc ccagcaaatg gctcctggca gtgggaagat
      601 ggctcctctc tatcacccaa cgagttaaca ctggtgaaaa caccaagcgg aacctgtgct
      661 gtctatggct caagctttaa ggcctacaca gaagactgtt caaatccaaa cacatacatc
      721 tgtatgaaaa gggcagtgta aagatttcat taaccgtctc acagaaacag ccaggacaag
      781 agaattgtcc caggagaaac tggaactaat gagactcaac ataagacaaa cataaaagaa
      841 cagtactgcg ccctccacag aactaatagt tggacatatc gtgtccggta aaacaagggg
      901 agcctgtggg gccaaggaac tatgaggcag gggatggagg gagcaagagg actaagagtt
      961 tggttgaggc ctatccaaac ccgggaaatc tggccctgcc ctactggagg aggccttgtt
     1021 gcccagtaga ctctccctta taagatcaag tctatcaaca cctggaattc ttccaagata
     1081 tcccctacac actccctaaa agtttaaata gcccctttcc ccccaattaa atgacctatc
     1141 ttattcaaga tgcctcaaa
//
