LOCUS       NP_001012667             243 aa            linear   ROD 27-MAR-2024
DEFINITION  killer cell lectin-like receptor subfamily I member 1 [Rattus
            norvegicus].
ACCESSION   NP_001012667
VERSION     NP_001012667.1
DBSOURCE    REFSEQ: accession NM_001012649.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 243)
  AUTHORS   Saether,P.C., Westgaard,I.H., Hoelsbrekken,S.E., Benjamin,J.,
            Lanier,L.L., Fossum,S. and Dissen,E.
  TITLE     KLRE/I1 and KLRE/I2: a novel pair of heterodimeric receptors that
            inversely regulate NK cell cytotoxicity
  JOURNAL   J Immunol 181 (5), 3177-3182 (2008)
   PUBMED   18713988
  REMARK    GeneRIF: KLRE1-KLRI1 heterodimer is a functional inhibitory
            heterodimer in NK cells
REFERENCE   2  (residues 1 to 243)
  AUTHORS   Saether,P.C., Westgaard,I.H., Flornes,L.M., Hoelsbrekken,S.E.,
            Ryan,J.C., Fossum,S. and Dissen,E.
  TITLE     Molecular cloning of KLRI1 and KLRI2, a novel pair of lectin-like
            natural killer-cell receptors with opposing signalling motifs
  JOURNAL   Immunogenetics 56 (11), 833-839 (2005)
   PUBMED   15650876
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY286494.1, FQ233804.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMEA5760434 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..243
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     Protein         1..243
                     /product="killer cell lectin-like receptor subfamily I
                     member 1"
                     /calculated_mol_wt=28044
     Region          16..21
                     /region_name="ITIM motif 1.
                     /evidence=ECO:0000250|UniProtKB:P27812"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5DT39.1)"
     Region          47..52
                     /region_name="ITIM motif 2.
                     /evidence=ECO:0000250|UniProtKB:P27812"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5DT39.1)"
     Site            81..101
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5DT39.1)"
     Site            123
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (Q5DT39.1)"
     Region          130..239
                     /region_name="CLECT_NK_receptors_like"
                     /note="C-type lectin-like domain (CTLD) of the type found
                     in natural killer cell receptors (NKRs); cd03593"
                     /db_xref="CDD:153063"
     Site            order(183,224,226..227)
                     /site_type="other"
                     /note="ligand binding surface [chemical binding]"
                     /db_xref="CDD:153063"
     Site            191
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (Q5DT39.1)"
     Site            194
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (Q5DT39.1)"
     Site            200
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (Q5DT39.1)"
     Site            214
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (Q5DT39.1)"
     CDS             1..243
                     /gene="Klri1"
                     /coded_by="NM_001012649.2:201..932"
                     /db_xref="GeneID:503651"
                     /db_xref="RGD:1359344"
ORIGIN      
        1 mphskhrdyt adkqdipyte lkackspwkh rtpavkqspv vlseeqlkya eltfhrtpql
       61 qprkqtvrrk rqgpksavwr vvtcvlgvlc vvlmitmgil vpklfsgqee qyretslhhl
      121 lkndsscdpc shdwiafgnn fylffrgtks waesksacee lnshlldids kaelenlllf
      181 eingwilvkk nqtnwsssen etklqhtlid ekknhscryl rgsqfiaddc sskkpyacef
      241 nkm
//
