LOCUS       NM_031649               1392 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Rattus norvegicus killer cell lectin like receptor G1 (Klrg1),
            mRNA.
ACCESSION   NM_031649
VERSION     NM_031649.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1392)
  AUTHORS   Zhu,Y., Ma,A., Zhang,H. and Li,C.
  TITLE     PPARgamma activation attenuates glycated-serum induced pancreatic
            beta-cell dysfunction through enhancing Pdx1 and Mafa protein
            stability
  JOURNAL   PLoS One 8 (2), e56386 (2013)
   PUBMED   23424659
  REMARK    GeneRIF: a key role of PPARgamma in regulating pancreatic beta-cell
            function by improving the stability of Pdx1 and Mafa proteins
REFERENCE   2  (bases 1 to 1392)
  AUTHORS   Barisas,B.G., Smith,S.M., Liu,J., Song,J., Hagen,G.M., Pecht,I. and
            Roess,D.A.
  TITLE     Compartmentalization of the Type I Fc epsilon receptor and MAFA on
            mast cell membranes
  JOURNAL   Biophys Chem 126 (1-3), 209-217 (2007)
   PUBMED   16797115
  REMARK    GeneRIF: This provides additional indication of constitutive
            interactions between Fc epsilon RI and MAFA.
REFERENCE   3  (bases 1 to 1392)
  AUTHORS   Wang,H., Brun,T., Kataoka,K., Sharma,A.J. and Wollheim,C.B.
  TITLE     MAFA controls genes implicated in insulin biosynthesis and
            secretion
  JOURNAL   Diabetologia 50 (2), 348-358 (2007)
   PUBMED   17149590
  REMARK    GeneRIF: Regulates beta-cell-specific gene expression and function.
REFERENCE   4  (bases 1 to 1392)
  AUTHORS   Nomura,S., Nakamura,T., Hashimoto,T., Nishio,Y., Maegawa,H.,
            Kudo,M. and Kashiwagi,A.
  TITLE     MafA differentiates rat intestinal cells into insulin-producing
            cells
  JOURNAL   Biochem Biophys Res Commun 349 (1), 136-143 (2006)
   PUBMED   16934222
  REMARK    GeneRIF: overexpression in the intestine induces intestinal
            epithelial cells newly to produce and release insulin
REFERENCE   5  (bases 1 to 1392)
  AUTHORS   Abramson,J., Licht,A. and Pecht,I.
  TITLE     Selective inhibition of the Fc epsilon RI-induced de novo synthesis
            of mediators by an inhibitory receptor
  JOURNAL   EMBO J 25 (2), 323-334 (2006)
   PUBMED   16407976
  REMARK    GeneRIF: (MAFA), selectively regulates the Fc-epsilon-RI
            stimulus-response coupling network and the subsequent de novo
            production and secretion of inflammatory mediators.
            Erratum:[EMBO J. 2019 Feb 1;38(3):e101419. doi:
            10.15252/embj.2018101419.. PMID: 30709914]
REFERENCE   6  (bases 1 to 1392)
  AUTHORS   Song,J., Hagen,G., Smith,S.M., Roess,D.A., Pecht,I. and
            Barisas,B.G.
  TITLE     Interactions of the mast cell function-associated antigen with the
            type I Fcepsilon receptor
  JOURNAL   Mol Immunol 38 (16-18), 1315-1321 (2002)
   PUBMED   12217401
  REMARK    GeneRIF: Interactions of the mast cell function-associated antigen
            with the type I Fcepsilon receptor (mast cell function-associated
            antigen)
REFERENCE   7  (bases 1 to 1392)
  AUTHORS   Abramson,J., Xu,R. and Pecht,I.
  TITLE     An unusual inhibitory receptor--the mast cell function-associated
            antigen (MAFA)
  JOURNAL   Mol Immunol 38 (16-18), 1307-1313 (2002)
   PUBMED   12217400
  REMARK    GeneRIF: The functional activities of an inhibitory receptor-the
            mast cell function-associated antigen [review] (mast cell
            function-associated antigen)
            Review article
REFERENCE   8  (bases 1 to 1392)
  AUTHORS   Abramson,J. and Pecht,I.
  TITLE     Clustering the mast cell function-associated antigen (MAFA) leads
            to tyrosine phosphorylation of p62Dok and SHIP and affects RBL-2H3
            cell cycle
  JOURNAL   Immunol Lett 82 (1-2), 23-28 (2002)
   PUBMED   12008030
  REMARK    GeneRIF: Clustering the mast cell function-associated antigen
            (MAFA) leads to tyrosine phosphorylation of p62Dok and SHIP and
            affects RBL-2H3 cell cycle.
REFERENCE   9  (bases 1 to 1392)
  AUTHORS   Bocek,P. Jr., Guthmann,M.D. and Pecht,I.
  TITLE     Analysis of the genes encoding the mast cell function-associated
            antigen and its alternatively spliced transcripts
  JOURNAL   J Immunol 158 (7), 3235-3243 (1997)
   PUBMED   9120279
REFERENCE   10 (bases 1 to 1392)
  AUTHORS   Guthmann,M.D., Tal,M. and Pecht,I.
  TITLE     A secretion inhibitory signal transduction molecule on mast cells
            is another C-type lectin
  JOURNAL   Proc Natl Acad Sci U S A 92 (20), 9397-9401 (1995)
   PUBMED   7568140
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Oct 5, 2022 this sequence version replaced NM_031649.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X79812.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680423, SAMN06680432
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-135               JAXUCZ010000004.1  157139238-157139372 c
            136-240             JAXUCZ010000004.1  157136118-157136222 c
            241-410             JAXUCZ010000004.1  157134764-157134933 c
            411-508             JAXUCZ010000004.1  157129916-157130013 c
            509-1392            JAXUCZ010000004.1  157127571-157128454 c
FEATURES             Location/Qualifiers
     source          1..1392
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..1392
                     /gene="Klrg1"
                     /gene_synonym="MAFA"
                     /note="killer cell lectin like receptor G1"
                     /db_xref="GeneID:58975"
                     /db_xref="RGD:61978"
     exon            1..135
                     /gene="Klrg1"
                     /gene_synonym="MAFA"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..620
                     /gene="Klrg1"
                     /gene_synonym="MAFA"
                     /note="mast cell function-associated antigen; killer cell
                     lectin-like receptor subfamily G, member 1"
                     /codon_start=1
                     /product="killer cell lectin-like receptor subfamily G
                     member 1"
                     /protein_id="NP_113837.1"
                     /db_xref="GeneID:58975"
                     /db_xref="RGD:61978"
                     /translation="MADNSIYSTLELPAAPRVQDDSRWKVKAVLHRPCVSYLVMVALG
                     LLTVILMSLLLYQRTLCCGSKGFMCSQCSRCPNLWMRNGSHCYYFSMEKRDWNSSLKF
                     CADKGSHLLTFPDNQGVNLFQEYVGEDFYWIGLRDIDGWRWEDGPALSLSILSNSVVQ
                     KCGTIHRCGLHASSCEVALQWICEKVLP"
     exon            136..240
                     /gene="Klrg1"
                     /gene_synonym="MAFA"
                     /inference="alignment:Splign:2.1.0"
     exon            241..410
                     /gene="Klrg1"
                     /gene_synonym="MAFA"
                     /inference="alignment:Splign:2.1.0"
     exon            411..508
                     /gene="Klrg1"
                     /gene_synonym="MAFA"
                     /inference="alignment:Splign:2.1.0"
     exon            509..1392
                     /gene="Klrg1"
                     /gene_synonym="MAFA"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caccctgctt actgtcgtca ctccctgctg agtgtgaagg gcgttgggtg gagatggccg
       61 acaactctat ctactcaaca ttagagctgc ctgctgcacc tcgagtccaa gatgactcca
      121 gatggaaggt caaagctgtc ttacaccgac cctgtgtttc ctaccttgtg atggtggctt
      181 tggggctttt gactgtgatt ctcatgagtc tactgttgta ccaacggact ctgtgctgtg
      241 gctccaaggg ctttatgtgt tcccagtgct ccaggtgccc caacctctgg atgaggaacg
      301 ggagccactg ttactacttc tcaatggaga aaagggactg gaactctagt ctgaagttct
      361 gtgcagacaa aggctcgcat ctccttacat ttccggacaa ccagggagtg aacctgttcc
      421 aggagtatgt gggcgaggac ttttactgga ttggcttgag ggacatcgat ggctggaggt
      481 gggaagatgg cccagctctc agcttaagca ttctctctaa cagcgtggta cagaagtgtg
      541 gcaccatcca caggtgtggc ctccacgcct ccagttgtga ggttgctttg cagtggatct
      601 gtgagaaggt cctgccctga aggattccac tgtgtcccaa gcctcagatc tgccacatgt
      661 cttcaaaaag agggaatggg catggggaac ctctgttcac aaaggtgtct ttagcaaatg
      721 ccaaacctgt tatgatatgc cattagacag gcgttagcat tccttcctgg gagctggcat
      781 ttttcaactg ggctttctca gtcatgttag ccatttaaag cctaaatctg ggcaaatgaa
      841 atagataaaa tttattttga tggctcttac tgcacaaact caccctggct ttctcatccc
      901 atactctgcc atatctatca aagatatgtg caaaactatt catctgcaga agaaccccca
      961 ccacggtcaa taacacatta catagacatc gagtagagac agaaaagcaa acacctcctg
     1021 ttctcactcc tgcttggaag ctgaagtagc tcaagcctga ggtgtaggga gaagtgcagt
     1081 ggttaccaga gtccaggaga ctgaagggat ggtagaggtt ggttaatggt ttggctggtg
     1141 tggggtgacc atcatgatta atgattgttg tatgtttgcc aatatgttgt gaacttccgg
     1201 atagcgaggt ggaaggaccg tgggtgttac caaatgcctg caggagagat gtgctgagaa
     1261 ccctgactgg atgatttcca cacacattga aatatcacac tgtgccccat aaatgtgtac
     1321 aatcattatc tatccctaat ttccctaaaa attaaagaag tcccaattaa aataaaaaat
     1381 acctttctgc ta
//
