LOCUS       NM_181372                982 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus killer cell lectin like receptor E1 (Klre1),
            transcript variant 1, mRNA.
ACCESSION   NM_181372 XM_017592593
VERSION     NM_181372.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 982)
  AUTHORS   Saether,P.C., Westgaard,I.H., Hoelsbrekken,S.E., Benjamin,J.,
            Lanier,L.L., Fossum,S. and Dissen,E.
  TITLE     KLRE/I1 and KLRE/I2: a novel pair of heterodimeric receptors that
            inversely regulate NK cell cytotoxicity
  JOURNAL   J Immunol 181 (5), 3177-3182 (2008)
   PUBMED   18713988
  REMARK    GeneRIF: KLRE-KLRI1 heterodimer is a functional inhibitory
            heterodimer in NK cells; KLRE1-KLRI2 heterodimer is a functional
            activating heterodimer in NK cells
REFERENCE   2  (bases 1 to 982)
  AUTHORS   Westgaard,I.H., Dissen,E., Torgersen,K.M., Lazetic,S., Lanier,L.L.,
            Phillips,J.H. and Fossum,S.
  TITLE     The lectin-like receptor KLRE1 inhibits natural killer cell
            cytotoxicity
  JOURNAL   J Exp Med 197 (11), 1551-1561 (2003)
   PUBMED   12782717
  REMARK    GeneRIF: cloning and functional characterization of a novel natural
            killer (NK) cell receptor termed KLRE1
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On or before Mar 27, 2023 this sequence version replaced
            XM_017592593.2, NM_181372.2.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN16676784,
                              SAMN16676785 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-153               JAXUCZ010000004.1  164719604-164719756
            154-353             JAXUCZ010000004.1  164721730-164721929
            354-455             JAXUCZ010000004.1  164724336-164724437
            456-494             JAXUCZ010000004.1  164724708-164724746
            495-640             JAXUCZ010000004.1  164725392-164725537
            641-741             JAXUCZ010000004.1  164726447-164726547
            742-982             JAXUCZ010000004.1  164727424-164727664
FEATURES             Location/Qualifiers
     source          1..982
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..982
                     /gene="Klre1"
                     /note="killer cell lectin like receptor E1"
                     /db_xref="GeneID:297645"
                     /db_xref="RGD:727903"
     exon            1..153
                     /gene="Klre1"
                     /inference="alignment:Splign:2.1.0"
     exon            154..353
                     /gene="Klre1"
                     /inference="alignment:Splign:2.1.0"
     CDS             173..853
                     /gene="Klre1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     killer cell lectin-like receptor, subfamily E, member 1;
                     NK cell lectin-like receptor family E, member 1; killer
                     cell lectin-like receptor, family E, member 1"
                     /codon_start=1
                     /product="killer cell lectin-like receptor subfamily E
                     member 1 isoform 1"
                     /protein_id="NP_852037.1"
                     /db_xref="GeneID:297645"
                     /db_xref="RGD:727903"
                     /translation="MNQTLIICSTLNVNSQQKSKAKNSMKNTFHSNELSSIEQRQKYQ
                     KHLKKDKKTAEDITGVGNCSPPWRLISSVLFVVCLLLMAVAMVMTIFTTRLSSERSSS
                     NIHQEGLHHPCPENWVWFRCSCYYFSKEKLVWRESQRACLSFNSSLIRMNKEEMDFFS
                     LKSFFWVGVYYDETSKQWLWDDHSVLPSGMFSGLESSPKNFCASYKSKEAYLAENCST
                     KLMYICKK"
     exon            354..455
                     /gene="Klre1"
                     /inference="alignment:Splign:2.1.0"
     exon            456..494
                     /gene="Klre1"
                     /inference="alignment:Splign:2.1.0"
     exon            495..640
                     /gene="Klre1"
                     /inference="alignment:Splign:2.1.0"
     exon            641..741
                     /gene="Klre1"
                     /inference="alignment:Splign:2.1.0"
     exon            742..982
                     /gene="Klre1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atcaatgagg actttgctat gaggctgtga agtgtgttca agcagcttcc caccctgctc
       61 ccagttctgt cttacatgtt ctgctcctga ttctgctgat tagcacatat taaagtttta
      121 acatccgatc ctggaatttc ctccttgctt cagaattttt gtctttataa agatgaatca
      181 aacactcata atctgttcta ccctaaatgt taattcccag cagaagagca aagcaaaaaa
      241 cagtatgaag aatacatttc attcaaatga attgtcatcc attgagcaga ggcaaaaata
      301 ccaaaaacat cttaagaagg acaaaaagac agcagaagac atcactggtg tagggaattg
      361 ctcccctccg tggaggctca tctctagtgt gctctttgtg gtctgccttc tcctgatggc
      421 tgtagccatg gtgatgacca ttttcaccac aaggttatct tctgaaagat catcttctaa
      481 tattcatcag gaaggactcc atcatccctg cccagagaac tgggtttggt tcaggtgcag
      541 ctgttactac ttctccaagg aaaagctagt ttggagagag agtcagcgtg cctgcttgtc
      601 cttcaattct agtctcataa ggatgaacaa agaggagatg gatttcttct ctttgaagtc
      661 tttcttttgg gttggagttt actacgatga aaccagcaaa cagtggctgt gggacgacca
      721 ttcagttcta cccagtggga tgttttctgg tcttgaatct agtccgaaaa acttctgtgc
      781 atcttataaa tcaaaagaag cctatttggc agaaaactgt tcaaccaaac taatgtacat
      841 ttgcaagaag tagcatatat aatcctataa gttcataaaa gatatgaaaa ttaaagtctt
      901 aatttttgtc tggagtgctt actttaggaa ggaaatgtgg caaatggtta cttttgctta
      961 aataaaattg tattcaaata ta
//
