LOCUS       NM_001037441            1221 bp    mRNA    linear   ROD 19-AUG-2024
DEFINITION  Rattus norvegicus killer cell lectin like receptor C1 (Klrc1),
            mRNA.
ACCESSION   NM_001037441
VERSION     NM_001037441.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1221)
  AUTHORS   Jiang,H.J., Wang,X.X., Luo,B.F., Cong,X., Jin,Q., Qin,H.,
            Zhang,H.Y., Kong,X.S., Wei,L. and Feng,B.
  TITLE     Direct antiviral agents upregulate natural killer cell potential
            activity in chronic hepatitis C patients
  JOURNAL   Clin Exp Med 19 (3), 299-308 (2019)
   PUBMED   31218578
REFERENCE   2  (bases 1 to 1221)
  AUTHORS   Liu,J., Liu,S., Xia,M., Xu,S., Wang,C., Bao,Y., Jiang,M., Wu,Y.,
            Xu,T. and Cao,X.
  TITLE     Rhomboid domain-containing protein 3 is a negative regulator of
            TLR3-triggered natural killer cell activation
  JOURNAL   Proc Natl Acad Sci U S A 110 (19), 7814-7819 (2013)
   PUBMED   23610400
REFERENCE   3  (bases 1 to 1221)
  AUTHORS   Harrison,R.J., Ettorre,A., Little,A.M. and Khakoo,S.I.
  TITLE     Association of NKG2A with treatment for chronic hepatitis C virus
            infection
  JOURNAL   Clin Exp Immunol 161 (2), 306-314 (2010)
   PUBMED   20550548
REFERENCE   4  (bases 1 to 1221)
  AUTHORS   Kaiser,B.K., Pizarro,J.C., Kerns,J. and Strong,R.K.
  TITLE     Structural basis for NKG2A/CD94 recognition of HLA-E
  JOURNAL   Proc Natl Acad Sci U S A 105 (18), 6696-6701 (2008)
   PUBMED   18448674
REFERENCE   5  (bases 1 to 1221)
  AUTHORS   Golden-Mason,L., Castelblanco,N., O'Farrelly,C. and Rosen,H.R.
  TITLE     Phenotypic and functional changes of cytotoxic CD56pos natural T
            cells determine outcome of acute hepatitis C virus infection
  JOURNAL   J Virol 81 (17), 9292-9298 (2007)
   PUBMED   17553896
REFERENCE   6  (bases 1 to 1221)
  AUTHORS   Koike,J., Wakao,H., Ishizuka,Y., Sato,T.A., Hamaoki,M., Seino,K.,
            Koseki,H., Nakayama,T. and Taniguchi,M.
  TITLE     Bone marrow allograft rejection mediated by a novel murine NK
            receptor, NKG2I
  JOURNAL   J Exp Med 199 (1), 137-144 (2004)
   PUBMED   14707119
  REMARK    Erratum:[J Exp Med. 2004 Feb 2;199(3):following 434]
REFERENCE   7  (bases 1 to 1221)
  AUTHORS   Berg,S.F., Dissen,E., Westgaard,I.H. and Fossum,S.
  TITLE     Two genes in the rat homologous to human NKG2
  JOURNAL   Eur J Immunol 28 (2), 444-450 (1998)
   PUBMED   9521051
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Oct 8, 2014 this sequence version replaced NM_001037441.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF021350.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676811 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-187               JAXUCZ010000004.1  164838260-164838446 c
            188-289             JAXUCZ010000004.1  164837838-164837939 c
            290-340             JAXUCZ010000004.1  164837276-164837326 c
            341-492             JAXUCZ010000004.1  164836690-164836841 c
            493-593             JAXUCZ010000004.1  164833670-164833770 c
            594-736             JAXUCZ010000004.1  164833222-164833364 c
            737-1221            JAXUCZ010000004.1  164828163-164828647 c
FEATURES             Location/Qualifiers
     source          1..1221
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..1221
                     /gene="Klrc1"
                     /gene_synonym="rNKG2A"
                     /note="killer cell lectin like receptor C1"
                     /db_xref="GeneID:29683"
                     /db_xref="RGD:2976"
     CDS             1..711
                     /gene="Klrc1"
                     /gene_synonym="rNKG2A"
                     /note="natural killer cell protein group 2-A (NKG2A)"
                     /codon_start=1
                     /product="killer cell lectin-like receptor subfamily C,
                     member 1"
                     /protein_id="NP_001032518.1"
                     /db_xref="GeneID:29683"
                     /db_xref="RGD:2976"
                     /translation="MSNDRVTYAELNVAKNSRYQHNKPRGSRSSISVIEQEIVYADFS
                     FKNPSQEQTRICRDCHCKGFPSPPEKLIAGTLGFISFVLIVAVVVITTVATPYTETKA
                     QINSSMTRTYQARPCTRCPDDWISYSHNCYYISVERKSWNDGLTSCISKNCSLLHIDS
                     EEEQAFLQSFSLVSWTGFFRKSRSQPWVWENGSTFKPKITEMLHDEYNCIMMSTSGLT
                     AENCTILHPYVCKCKLTN"
     exon            1..187
                     /gene="Klrc1"
                     /gene_synonym="rNKG2A"
                     /inference="alignment:Splign:2.1.0"
     exon            188..289
                     /gene="Klrc1"
                     /gene_synonym="rNKG2A"
                     /inference="alignment:Splign:2.1.0"
     exon            290..340
                     /gene="Klrc1"
                     /gene_synonym="rNKG2A"
                     /inference="alignment:Splign:2.1.0"
     exon            341..492
                     /gene="Klrc1"
                     /gene_synonym="rNKG2A"
                     /inference="alignment:Splign:2.1.0"
     exon            493..593
                     /gene="Klrc1"
                     /gene_synonym="rNKG2A"
                     /inference="alignment:Splign:2.1.0"
     exon            594..736
                     /gene="Klrc1"
                     /gene_synonym="rNKG2A"
                     /inference="alignment:Splign:2.1.0"
     exon            737..1221
                     /gene="Klrc1"
                     /gene_synonym="rNKG2A"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgagtaatg atcgagtcac ctatgcagaa ctgaatgtgg ccaagaactc aaggtaccag
       61 cacaacaaac caaggggcag tcgcagctcc atttcagtaa tagagcagga aatcgtttat
      121 gcggatttca gctttaaaaa tccttctcaa gagcagaccc ggatctgcag ggattgccac
      181 tgcaaaggtt ttccatctcc tccagaaaaa ctcattgctg ggaccctggg cttcatcagt
      241 tttgtcttaa ttgttgctgt ggttgtaatt actacagttg ccacaccata tactgaaaca
      301 aaggcacaga tcaactcctc aatgacgaga acctaccaag cacgaccttg tactcgttgt
      361 ccagatgatt ggatatcata ttcccacaac tgttattaca ttagtgtgga gagaaaatct
      421 tggaatgatg gtttgacgtc ctgcatttcc aaaaattgca gtctgcttca catagatagt
      481 gaagaggagc aggcttttct gcagtccttt tcactggtct catggactgg attctttcga
      541 aagagcagaa gtcagccctg ggtttgggaa aatggctcaa ctttcaaacc aaagataaca
      601 gagatgctgc atgatgaata taactgtatc atgatgtcaa cttctggtct cacggcagaa
      661 aactgtacca ttttacatcc atatgtttgt aagtgcaaat taaccaactg aaacacctgc
      721 atttgaagtc tgccagggac aaatcttaca tggctttgtt cctggaacca gcatggattt
      781 ctacggattt ggctgtcatt gagttttaga cactactacc tcagcttcct aagaagcttg
      841 gattactgcc ctaagccacc atgccaggtg ttctggttac ctcattgtaa acatgacaca
      901 acctgggaag aaggagtatc aattgacaaa ctgcctctgt cagattggct ttgtagtctc
      961 tactgtggca aactattctt aggaatgact gagatggaat ggcccttccc tttgtctgtg
     1021 acaccattcc tagccacata cccctgtgct ataaaagaat gactgaaatg gaagcatcaa
     1081 tcagtgttcc ttcctgcttt ctgctcccat ccctggtttc cctcctcagt tatggaagtg
     1141 acccaaaagt atatgttgaa ataaatccct gagttgcttt tgatcaaaat attttatcat
     1201 agcaacaaaa gccaaccacc a
//
