LOCUS       NM_001085403            1627 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus killer cell lectin like receptor B1C (Klrb1c),
            mRNA.
ACCESSION   NM_001085403 XM_001067366
VERSION     NM_001085403.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1627)
  AUTHORS   Kveberg,L., Sudworth,A., Todros-Dawda,I., Inngjerdingen,M. and
            Vaage,J.T.
  TITLE     Functional characterization of a conserved pair of NKR-P1 receptors
            expressed by NK cells and T lymphocytes in liver and gut
  JOURNAL   Eur J Immunol 45 (2), 501-512 (2015)
   PUBMED   25382546
  REMARK    GeneRIF: NKR-P1F and NKR-P1G receptors expressed by NK cells and T
            lymphocytes in liver and gut have been functionally characterized.
REFERENCE   2  (bases 1 to 1627)
  AUTHORS   Engel,I., Zhao,M., Kappes,D., Taniuchi,I. and Kronenberg,M.
  TITLE     The transcription factor Th-POK negatively regulates Th17
            differentiation in Valpha14i NKT cells
  JOURNAL   Blood 120 (23), 4524-4532 (2012)
   PUBMED   23034280
REFERENCE   3  (bases 1 to 1627)
  AUTHORS   Turchinovich,G. and Hayday,A.C.
  TITLE     Skint-1 identifies a common molecular mechanism for the development
            of interferon-gamma-secreting versus interleukin-17-secreting
            gammadelta T cells
  JOURNAL   Immunity 35 (1), 59-68 (2011)
   PUBMED   21737317
REFERENCE   4  (bases 1 to 1627)
  AUTHORS   Aliahmad,P., de la Torre,B. and Kaye,J.
  TITLE     Shared dependence on the DNA-binding factor TOX for the development
            of lymphoid tissue-inducer cell and NK cell lineages
  JOURNAL   Nat Immunol 11 (10), 945-952 (2010)
   PUBMED   20818394
REFERENCE   5  (bases 1 to 1627)
  AUTHORS   Spreu,J., Kuttruff,S., Stejfova,V., Dennehy,K.M., Schittek,B. and
            Steinle,A.
  TITLE     Interaction of C-type lectin-like receptors NKp65 and KACL
            facilitates dedicated immune recognition of human keratinocytes
  JOURNAL   Proc Natl Acad Sci U S A 107 (11), 5100-5105 (2010)
   PUBMED   20194751
REFERENCE   6  (bases 1 to 1627)
  AUTHORS   Carlyle,J.R., Martin,A., Mehra,A., Attisano,L., Tsui,F.W. and
            Zuniga-Pflucker,J.C.
  TITLE     Mouse NKR-P1B, a novel NK1.1 antigen with inhibitory function
  JOURNAL   J Immunol 162 (10), 5917-5923 (1999)
   PUBMED   10229828
REFERENCE   7  (bases 1 to 1627)
  AUTHORS   Kung,S.K., Su,R.C., Shannon,J. and Miller,R.G.
  TITLE     The NKR-P1B gene product is an inhibitory receptor on SJL/J NK
            cells
  JOURNAL   J Immunol 162 (10), 5876-5887 (1999)
   PUBMED   10229823
REFERENCE   8  (bases 1 to 1627)
  AUTHORS   Mendiratta,S.K., Martin,W.D., Hong,S., Boesteanu,A., Joyce,S. and
            Van Kaer,L.
  TITLE     CD1d1 mutant mice are deficient in natural T cells that promptly
            produce IL-4
  JOURNAL   Immunity 6 (4), 469-477 (1997)
   PUBMED   9133426
REFERENCE   9  (bases 1 to 1627)
  AUTHORS   Appasamy,P.M., Kenniston,T.W., Brissette-Storkus,C.S. and
            Chambers,W.H.
  TITLE     NKR-P1dim/TCR alpha beta + T cells and natural killer cells share
            expression of NKR-P1A and NKR-P1D
  JOURNAL   Nat Immun 15 (5), 259-268 (1996)
   PUBMED   9390275
REFERENCE   10 (bases 1 to 1627)
  AUTHORS   Ryan,J.C., Turck,J., Niemi,E.C., Yokoyama,W.M. and Seaman,W.E.
  TITLE     Molecular cloning of the NK1.1 antigen, a member of the NKR-P1
            family of natural killer cell activation molecules
  JOURNAL   J Immunol 149 (5), 1631-1635 (1992)
   PUBMED   1506685
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Oct 22, 2022 this sequence version replaced NM_001085403.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FM117337.1, X97477.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-122               JAXUCZ010000004.1  164068249-164068370
            123-221             JAXUCZ010000004.1  164075677-164075775
            222-296             JAXUCZ010000004.1  164076401-164076475
            297-451             JAXUCZ010000004.1  164076995-164077149
            452-567             JAXUCZ010000004.1  164077480-164077595
            568-1627            JAXUCZ010000004.1  164079665-164080724
FEATURES             Location/Qualifiers
     source          1..1627
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..1627
                     /gene="Klrb1c"
                     /gene_synonym="Klrb1f; NKR-P1F"
                     /note="killer cell lectin like receptor B1C"
                     /db_xref="GeneID:683758"
                     /db_xref="RGD:1583336"
     exon            1..122
                     /gene="Klrb1c"
                     /gene_synonym="Klrb1f; NKR-P1F"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..691
                     /gene="Klrb1c"
                     /gene_synonym="Klrb1f; NKR-P1F"
                     /note="NKR-P1B protein; natural killer cell surface
                     protein NKR-P1F; killer cell lectin-like receptor
                     subfamily B member 1B; killer cell lectin-like receptor
                     subfamily B member 1C"
                     /codon_start=1
                     /product="killer cell lectin-like receptor subfamily B
                     member 1F"
                     /protein_id="NP_001078872.1"
                     /db_xref="GeneID:683758"
                     /db_xref="RGD:1583336"
                     /translation="MDTSRVYGNVKTFRSPGHKQASFPSLSTDACRCPHWHHLALKLG
                     CATLILLLLTLIGLSVFVRFLVQKPLIEKCSMAAQENGTEPTGRSAILECPRHWQPHR
                     NKCLIISQISRPWAEGLVACSMKEATLLIIENEEELKFVQNILKGRQQLFFIGLNYVQ
                     TEMTWKWINGSVLKPNILRITGSEVENSCALISHTEVFSDSCSSDNHWICQKTLKHV"
     exon            123..221
                     /gene="Klrb1c"
                     /gene_synonym="Klrb1f; NKR-P1F"
                     /inference="alignment:Splign:2.1.0"
     exon            222..296
                     /gene="Klrb1c"
                     /gene_synonym="Klrb1f; NKR-P1F"
                     /inference="alignment:Splign:2.1.0"
     exon            297..451
                     /gene="Klrb1c"
                     /gene_synonym="Klrb1f; NKR-P1F"
                     /inference="alignment:Splign:2.1.0"
     exon            452..567
                     /gene="Klrb1c"
                     /gene_synonym="Klrb1f; NKR-P1F"
                     /inference="alignment:Splign:2.1.0"
     exon            568..1627
                     /gene="Klrb1c"
                     /gene_synonym="Klrb1f; NKR-P1F"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atctgttact gttcacagtt ctcatctctt gtctccaatg gacacatcaa gagtctatgg
       61 taatgtaaag acatttaggt ctccagggca taagcaagca tcattcccat ctctctccac
      121 agatgcttgt cggtgcccac actggcatca tttggctctg aaacttggct gtgctacgct
      181 gatccttctt ctcttgaccc tgattggact cagtgtcttc gtgagattcc tagtgcaaaa
      241 accactaata gaaaaatgca gtatggctgc tcaagagaat gggactgaac caacagggag
      301 atcagccata ctagaatgcc cgagacattg gcaaccacac cggaacaaat gcttaattat
      361 ttctcaaatt tccagacctt gggcagaagg tctagttgcc tgttctatga aagaagccac
      421 tttgttgatc attgaaaatg aagaagaact gaagtttgtg cagaacattt taaagggaag
      481 acagcagtta ttttttattg gactaaatta tgtacaaacg gagatgacct ggaagtggat
      541 aaatggctct gttttaaagc ctaacatatt acggatcact ggttcggagg tagagaacag
      601 ctgtgccctc atctcacaca cagaagtgtt ttcagattcc tgttcttcag acaaccattg
      661 gatctgccaa aagaccctga aacatgtctg aaaacctgtg tcctgactcc tgattgtgaa
      721 tctcatcttg attacttcat agtccacgcc agatctctgc actgaacatt gtctgctgct
      781 ggcccaccca gggcatagtt agtggcacaa agtatggact ccaaaaccac tgttactttt
      841 actggtgctc atctccactt tattatgtaa atgtacacag acagatgtgt cattctagga
      901 gaagagttta tcaaaggaag cacaggccag cagggggcac tggaggcctt gtgtggtcct
      961 tgcttatctc tgtgtcttag gtcatctaca gacagctgtg gaaaactgtc tgtaaagttt
     1021 ggattttaac cccatccctg ctgcaagcca tttcacattt gggctgtaga atcttgatta
     1081 aaagtcttgt tgttgactga cagcagaggc tcagagttga ggatcttgag atgggaagaa
     1141 tttgtattga tggacactca caaattagtt tattaataat agactaatcc tgtgacaatg
     1201 agcgtgactt tatgtaaact gaactctgcc cacaggatac ctcttaccct gtggtgatgc
     1261 accagcagac tctgggcaga tgctggtcca ttgatactga gcttatcagt ctcctgagct
     1321 gtgtgaaagt gagatgtctt cttctccagt gtactattaa aacaacaaca agaacagcaa
     1381 caacaacaac aacaacaaca acaagattta gacaaggact tctctctttc cactgtccac
     1441 agccatccca ttcatttttc tcatgacttc tttcttccac acctctctat aatttatggc
     1501 ttatgtgcaa atagtaggaa gtatgcagtt acatatttgg taactgtagt agaaaataaa
     1561 tgatgtcttt ttaattttta aattatagaa aataagtatt tcaaaaataa atattctgat
     1621 aaaataa
//
