LOCUS       NM_173292               1506 bp    mRNA    linear   ROD 26-APR-2024
DEFINITION  Rattus norvegicus killer cell lectin like receptor B1B (Klrb1b),
            mRNA.
ACCESSION   NM_173292 XM_346715
VERSION     NM_173292.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1506)
  AUTHORS   Engel,I., Zhao,M., Kappes,D., Taniuchi,I. and Kronenberg,M.
  TITLE     The transcription factor Th-POK negatively regulates Th17
            differentiation in Valpha14i NKT cells
  JOURNAL   Blood 120 (23), 4524-4532 (2012)
   PUBMED   23034280
REFERENCE   2  (bases 1 to 1506)
  AUTHORS   Turchinovich,G. and Hayday,A.C.
  TITLE     Skint-1 identifies a common molecular mechanism for the development
            of interferon-gamma-secreting versus interleukin-17-secreting
            gammadelta T cells
  JOURNAL   Immunity 35 (1), 59-68 (2011)
   PUBMED   21737317
REFERENCE   3  (bases 1 to 1506)
  AUTHORS   Hosoya,T., Kuroha,T., Moriguchi,T., Cummings,D., Maillard,I.,
            Lim,K.C. and Engel,J.D.
  TITLE     GATA-3 is required for early T lineage progenitor development
  JOURNAL   J Exp Med 206 (13), 2987-3000 (2009)
   PUBMED   19934022
REFERENCE   4  (bases 1 to 1506)
  AUTHORS   Aust,J.G., Gays,F., Mickiewicz,K.M., Buchanan,E. and Brooks,C.G.
  TITLE     The expression and function of the NKRP1 receptor family in C57BL/6
            mice
  JOURNAL   J Immunol 183 (1), 106-116 (2009)
   PUBMED   19535641
REFERENCE   5  (bases 1 to 1506)
  AUTHORS   Kveberg,L., Dai,K.Z., Westgaard,I.H., Daws,M.R., Fossum,S.,
            Naper,C. and Vaage,J.T.
  TITLE     Two major groups of rat NKR-P1 receptors can be distinguished based
            on chromosomal localization, phylogenetic analysis and Clr ligand
            binding
  JOURNAL   Eur J Immunol 39 (2), 541-551 (2009)
   PUBMED   19130483
REFERENCE   6  (bases 1 to 1506)
  AUTHORS   Carlyle,J.R., Martin,A., Mehra,A., Attisano,L., Tsui,F.W. and
            Zuniga-Pflucker,J.C.
  TITLE     Mouse NKR-P1B, a novel NK1.1 antigen with inhibitory function
  JOURNAL   J Immunol 162 (10), 5917-5923 (1999)
   PUBMED   10229828
REFERENCE   7  (bases 1 to 1506)
  AUTHORS   Kung,S.K., Su,R.C., Shannon,J. and Miller,R.G.
  TITLE     The NKR-P1B gene product is an inhibitory receptor on SJL/J NK
            cells
  JOURNAL   J Immunol 162 (10), 5876-5887 (1999)
   PUBMED   10229823
REFERENCE   8  (bases 1 to 1506)
  AUTHORS   Mendiratta,S.K., Martin,W.D., Hong,S., Boesteanu,A., Joyce,S. and
            Van Kaer,L.
  TITLE     CD1d1 mutant mice are deficient in natural T cells that promptly
            produce IL-4
  JOURNAL   Immunity 6 (4), 469-477 (1997)
   PUBMED   9133426
REFERENCE   9  (bases 1 to 1506)
  AUTHORS   Ryan,J.C., Turck,J., Niemi,E.C., Yokoyama,W.M. and Seaman,W.E.
  TITLE     Molecular cloning of the NK1.1 antigen, a member of the NKR-P1
            family of natural killer cell activation molecules
  JOURNAL   J Immunol 149 (5), 1631-1635 (1992)
   PUBMED   1506685
REFERENCE   10 (bases 1 to 1506)
  AUTHORS   Giorda,R., Rudert,W.A., Vavassori,C., Chambers,W.H., Hiserodt,J.C.
            and Trucco,M.
  TITLE     NKR-P1, a signal transduction molecule on natural killer cells
  JOURNAL   Science 249 (4974), 1298-1300 (1990)
   PUBMED   2399464
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Oct 5, 2022 this sequence version replaced NM_173292.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FJ158034.1, EF100684.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680412, SAMN06680413
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-117               JAXUCZ010000004.1  163647513-163647629 c
            118-216             JAXUCZ010000004.1  163642119-163642217 c
            217-291             JAXUCZ010000004.1  163641422-163641496 c
            292-446             JAXUCZ010000004.1  163640041-163640195 c
            447-562             JAXUCZ010000004.1  163639583-163639698 c
            563-1506            JAXUCZ010000004.1  163634357-163635300 c
FEATURES             Location/Qualifiers
     source          1..1506
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..1506
                     /gene="Klrb1b"
                     /gene_synonym="Nkr-p1b; Nkrp1b"
                     /note="killer cell lectin like receptor B1B"
                     /db_xref="GeneID:25192"
                     /db_xref="RGD:2975"
     exon            1..117
                     /gene="Klrb1b"
                     /gene_synonym="Nkr-p1b; Nkrp1b"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..704
                     /gene="Klrb1b"
                     /gene_synonym="Nkr-p1b; Nkrp1b"
                     /note="CD161 antigen-like family member B; natural killer
                     cell surface protein NKR-P1B"
                     /codon_start=1
                     /product="killer cell lectin-like receptor subfamily B
                     member 1B"
                     /protein_id="NP_775414.2"
                     /db_xref="GeneID:25192"
                     /db_xref="RGD:2975"
                     /translation="MDTAVVYADLHLARTGEPKREPPPSLSPDTCQCPRWHRLALKLG
                     CACLILLVLSVIGLGVLVLTLLQKPLIQNSPADVQENRTKTTDSPAKLKCPKDWHSHQ
                     DKCFHVSQTSITWKGSLADCGGKGATLLLVQDQEELRFLRNLTKRISSSFWIGLSYTL
                     SDEKWKWINGSTLNSDALNITGDTEKDSCASVSQDKVLSESCDSDNIWICQKELKRES
                     TCNDS"
     exon            118..216
                     /gene="Klrb1b"
                     /gene_synonym="Nkr-p1b; Nkrp1b"
                     /inference="alignment:Splign:2.1.0"
     exon            217..291
                     /gene="Klrb1b"
                     /gene_synonym="Nkr-p1b; Nkrp1b"
                     /inference="alignment:Splign:2.1.0"
     exon            292..446
                     /gene="Klrb1b"
                     /gene_synonym="Nkr-p1b; Nkrp1b"
                     /inference="alignment:Splign:2.1.0"
     exon            447..562
                     /gene="Klrb1b"
                     /gene_synonym="Nkr-p1b; Nkrp1b"
                     /inference="alignment:Splign:2.1.0"
     exon            563..1506
                     /gene="Klrb1b"
                     /gene_synonym="Nkr-p1b; Nkrp1b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cacaagtcca gtgtcaagtc cctccatcta cgatggacac ggcagtggtc tatgcggact
       61 tacacctagc caggaccgga gagcccaagc gcgagccacc tccatctctt tccccagaca
      121 cctgccagtg cccgcgctgg catcgattgg ctctgaaact cggctgtgct tgcctcatcc
      181 ttcttgtcct gagtgtgatt ggactcggtg tcttagtgct aacattatta caaaaaccat
      241 tgatacaaaa cagccctgcg gatgttcaag agaacaggac aaaaacaaca gatagtccag
      301 ctaagttaaa gtgcccaaaa gactggcatt cacaccaaga taaatgcttt catgtttctc
      361 aaacttccat cacttggaag ggaagtctag ctgactgtgg tggaaaagga gccacgttgc
      421 tgctcgttca agaccaagaa gaactgagat tcctacggaa cttgacaaag agaataagca
      481 gctcattctg gattggatta agttacacat tgtcagacga gaagtggaag tggataaacg
      541 gctcgacttt aaattctgat gcattaaaca tcactggtga cactgaaaag gacagctgtg
      601 cctccgtctc acaggacaaa gtgctttctg agagctgtga ttcagacaat atatggatct
      661 gccaaaagga actaaaacga gaaagcacgt gcaatgactc ctgactgcga atcgtacctc
      721 gattacttta ccatccacac cagatctctg cgcctgacct gtctctgctg cctgcttccc
      781 cgtgcagcag tggcacaaag catgggctct gaaagcactg tgagtcttac agattcttcg
      841 ttgcgtagat ataaacgtac gcagacccag atgtgccatc ctatgagggg agttctgtgg
      901 aaagaagacc aggcagctga ggggcgctgg attctaaccc aggagtctgt gcgatctttg
      961 ttggtctctg tgtctgaggt catcagcaga cgaccacgga aaactgttta caaagccccc
     1021 gctctcttgc ctaactcctc ccagccatca ctctgggctg tagagcatga attaaagcct
     1081 ttgaccttga ctgactccag aaagcccagg gttaagggat ttaaggaaaa gactgacagt
     1141 ggtttaagta gcgcccacaa aatcctgggt aaactgaact ctggtcatgt gacacctcca
     1201 ccaggccacg atgctcacca gcagaccctg ggccaatgct ggcaccttgg tgctaggctt
     1261 ctcagctcta taactggaag agaagagctt ttctttgaaa ggtttcggtt tatgtgacag
     1321 aaaagcaaac taaggtaact tagctcttcc cgcctgccgt cctttttcta gtttgcttgg
     1381 catttcttct ttccaggctt gggggaaatt aagctttaaa aagagataca tcttttggat
     1441 gtcccccttt ctaaaaattt gccaaactgt ccatgaaaat aaaaggagta agagtattga
     1501 atttaa
//
