LOCUS       NM_001010964            1014 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus killer cell lectin like receptor B1A (Klrb1a),
            mRNA.
ACCESSION   NM_001010964 XM_342765
VERSION     NM_001010964.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1014)
  AUTHORS   Kovalska,J., Cervinkova,M., Chmelikova,E., Planska,D., Cizkova,J.
            and Horak,V.
  TITLE     Immunohistochemical Evidence of the Involvement of Natural Killer
            (CD161+) Cells in Spontaneous Regression of Lewis Rat Sarcoma
  JOURNAL   In Vivo 33 (1), 47-52 (2019)
   PUBMED   30587601
  REMARK    GeneRIF: Based on the differences in number and distribution of the
            immune cell subpopulations, we believe that natural killer
            (CD161(+)) cells play a major role in the destruction of cancer
            cells during Spontaneous regression tumours in this Lewis rat model
REFERENCE   2  (bases 1 to 1014)
  AUTHORS   Aust,J.G., Gays,F., Mickiewicz,K.M., Buchanan,E. and Brooks,C.G.
  TITLE     The expression and function of the NKRP1 receptor family in C57BL/6
            mice
  JOURNAL   J Immunol 183 (1), 106-116 (2009)
   PUBMED   19535641
REFERENCE   3  (bases 1 to 1014)
  AUTHORS   Kveberg,L., Dai,K.Z., Westgaard,I.H., Daws,M.R., Fossum,S.,
            Naper,C. and Vaage,J.T.
  TITLE     Two major groups of rat NKR-P1 receptors can be distinguished based
            on chromosomal localization, phylogenetic analysis and Clr ligand
            binding
  JOURNAL   Eur J Immunol 39 (2), 541-551 (2009)
   PUBMED   19130483
REFERENCE   4  (bases 1 to 1014)
  AUTHORS   Voigt,S., Mesci,A., Ettinger,J., Fine,J.H., Chen,P., Chou,W. and
            Carlyle,J.R.
  TITLE     Cytomegalovirus evasion of innate immunity by subversion of the
            NKR-P1B:Clr-b missing-self axis
  JOURNAL   Immunity 26 (5), 617-627 (2007)
   PUBMED   17462921
REFERENCE   5  (bases 1 to 1014)
  AUTHORS   Li,J., Rabinovich,B.A., Hurren,R., Shannon,J. and Miller,R.G.
  TITLE     Expression cloning and function of the rat NK activating and
            inhibitory receptors NKR-P1A and -P1B
  JOURNAL   Int Immunol 15 (3), 411-416 (2003)
   PUBMED   12618485
REFERENCE   6  (bases 1 to 1014)
  AUTHORS   Campbell,K.S. and Giorda,R.
  TITLE     The cytoplasmic domain of rat NKR-P1 receptor interacts with the
            N-terminal domain of p56(lck) via cysteine residues
  JOURNAL   Eur J Immunol 27 (1), 72-77 (1997)
   PUBMED   9022000
  REMARK    Erratum:[Eur J Immunol. 1997 Mar;27(3):802. doi:
            10.1002/eji.1830270333.. PMID: 9079826]
REFERENCE   7  (bases 1 to 1014)
  AUTHORS   Giorda,R., Weisberg,E.P., Ip,T.K. and Trucco,M.
  TITLE     Genomic structure and strain-specific expression of the natural
            killer cell receptor NKR-P1
  JOURNAL   J Immunol 149 (6), 1957-1963 (1992)
   PUBMED   1517565
REFERENCE   8  (bases 1 to 1014)
  AUTHORS   Giorda,R., Rudert,W.A., Vavassori,C., Chambers,W.H., Hiserodt,J.C.
            and Trucco,M.
  TITLE     NKR-P1, a signal transduction molecule on natural killer cells
  JOURNAL   Science 249 (4974), 1298-1300 (1990)
   PUBMED   2399464
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001010964.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M62891.1, FJ416340.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-104               JAXUCZ010000004.1  163590044-163590147 c
            105-203             JAXUCZ010000004.1  163587838-163587936 c
            204-275             JAXUCZ010000004.1  163586638-163586709 c
            276-430             JAXUCZ010000004.1  163580692-163580846 c
            431-546             JAXUCZ010000004.1  163580234-163580349 c
            547-1014            JAXUCZ010000004.1  163576672-163577139 c
FEATURES             Location/Qualifiers
     source          1..1014
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..1014
                     /gene="Klrb1a"
                     /gene_synonym="NKR-P1A; Nkrp1a"
                     /note="killer cell lectin like receptor B1A"
                     /db_xref="GeneID:362443"
                     /db_xref="RGD:1586149"
     exon            1..104
                     /gene="Klrb1a"
                     /gene_synonym="NKR-P1A; Nkrp1a"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..688
                     /gene="Klrb1a"
                     /gene_synonym="NKR-P1A; Nkrp1a"
                     /note="NKR-P1 3.2.3; antigen 3.2.3; CD161 antigen-like
                     family member A; killer cell lectin-like receptor
                     subfamily B, member 1A; natural killer cell surface
                     protein P1-3.2.3"
                     /codon_start=1
                     /product="killer cell lectin-like receptor subfamily B
                     member 1A"
                     /protein_id="NP_001010964.1"
                     /db_xref="GeneID:362443"
                     /db_xref="RGD:1586149"
                     /translation="MDTARVYLSLKPSKTAAGAQCVSPPSLPPDACRCPRSHRLALKL
                     SCAGLILLVLALVGMSILVRVLVQKPSVEPCRVLIQENLSKTGSPAKLKCPKDWLSHR
                     DKCFHVSQTSITWKESLADCGGKGATLLLVQDQEELRFLRNLTKRISSSFWIGLSYTL
                     SDENWKWINGSTLNSDVLSITGDTEKDSCASVSQDKVLSESCDSDNIWVCQKELKCEC
                     MCNDS"
     exon            105..203
                     /gene="Klrb1a"
                     /gene_synonym="NKR-P1A; Nkrp1a"
                     /inference="alignment:Splign:2.1.0"
     exon            204..275
                     /gene="Klrb1a"
                     /gene_synonym="NKR-P1A; Nkrp1a"
                     /inference="alignment:Splign:2.1.0"
     exon            276..430
                     /gene="Klrb1a"
                     /gene_synonym="NKR-P1A; Nkrp1a"
                     /inference="alignment:Splign:2.1.0"
     exon            431..546
                     /gene="Klrb1a"
                     /gene_synonym="NKR-P1A; Nkrp1a"
                     /inference="alignment:Splign:2.1.0"
     exon            547..1014
                     /gene="Klrb1a"
                     /gene_synonym="NKR-P1A; Nkrp1a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcctctccca agtacaatgg acacagcacg tgtctacctc agtttaaagc catccaagac
       61 tgccgcgggg gctcagtgtg tatcacctcc atctcttccc ccagatgcct gtcggtgccc
      121 acgttcacac aggttggctt tgaagctcag ctgcgctggg ctgatccttc ttgtcttggc
      181 cctggttggg atgagtattt tagtgcgagt cttagttcaa aaaccatcag tggagccatg
      241 ccgagtgctt attcaagaga acctgagtaa aacaggtagt ccagctaagt taaagtgccc
      301 aaaagactgg ctttcacacc gagataaatg ctttcatgtt tctcaaactt ccatcacttg
      361 gaaggaaagt ctagctgact gtggtggaaa aggagccacg ttgctgctcg ttcaagacca
      421 agaagaactg agattcctac ggaacttgac aaagagaata agcagctcat tctggattgg
      481 attaagttac acattgtcag acgagaactg gaagtggata aacggctcga ctttaaattc
      541 tgatgtatta agcatcactg gtgacactga aaaggacagc tgtgcctccg tctcacagga
      601 caaagtgctt tctgagagct gtgattcaga caatatatgg gtctgccaaa aggaactaaa
      661 atgtgaatgc atgtgtaatg actcctgact gcgaatcaca cctggattac tttaccatcc
      721 acaccagatc tctgcctgac ctgtctgtct ctgctgcctg cctcccagtg cagcactggc
      781 acaaagcatg gactctgaaa gcactgagtc ttatagagtc ttcgttgtgt agatgtaaac
      841 gtacgcagac acagatgtgc catcctgtga gggagttctg tggaaagaag accaggcagc
      901 tgagggtcac tggattctaa tcctggagtc tgtgtgacct tcgttggtct ctgtgtctga
      961 ggtcatctgc aaaatagcca tttgcaaaaa tcattaaaat gctcctctgc aggg
//
