LOCUS       NM_173291               1163 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus killer cell lectin-like receptor subfamily A,
            member 22 (Klra22), mRNA.
ACCESSION   NM_173291
VERSION     NM_173291.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1163)
  AUTHORS   Gays,F., Taha,S. and Brooks,C.G.
  TITLE     The distal upstream promoter in Ly49 genes, Pro1, is active in
            mature NK cells and T cells, does not require TATA boxes, and
            displays enhancer activity
  JOURNAL   J Immunol 194 (12), 6068-6081 (2015)
   PUBMED   25926675
  REMARK    GeneRIF: The distal upstream promoter in Ly49 genes, Pro1, is
            active in mature NK cells and T cells, does not require TATA boxes,
            and displays enhancer activity
REFERENCE   2  (bases 1 to 1163)
  AUTHORS   Shegarfi,H., Naper,C., Rolstad,B. and Inngjerdingen,M.
  TITLE     Listeria monocytogenes infection affects a subset of
            Ly49-expressing NK cells in the rat
  JOURNAL   PLoS One 5 (12), e15579 (2010)
   PUBMED   21179539
  REMARK    GeneRIF: L. monocytogenes infection may have multiple effects on NK
            cells in vivo, and Ly49-expressing NK cells may be involved in the
            immune responses towards L. monocytogenes
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1163)
  AUTHORS   Nylenna,O., Naper,C., Vaage,J.T., Woon,P.Y., Gauguier,D.,
            Dissen,E., Ryan,J.C. and Fossum,S.
  TITLE     The genes and gene organization of the Ly49 region of the rat
            natural killer cell gene complex
  JOURNAL   Eur J Immunol 35 (1), 261-272 (2005)
   PUBMED   15593300
  REMARK    GeneRIF: molecular cloning and gene mapping
REFERENCE   4  (bases 1 to 1163)
  AUTHORS   Naper,C., Hayashi,S., Kveberg,L., Niemi,E.C., Lanier,L.L.,
            Vaage,J.T. and Ryan,J.C.
  TITLE     Ly-49s3 is a promiscuous activating rat NK cell receptor for
            nonclassical MHC class I-encoded target ligands
  JOURNAL   J Immunol 169 (1), 22-30 (2002)
   PUBMED   12077224
  REMARK    GeneRIF: Ly-49 stimulatory receptor 3 (Ly-49s3)is a promiscuous
            activating rat NK cell receptor for nonclassical MHC class I
            (RT1-C/E/M)-encoded target ligands.
REFERENCE   5  (bases 1 to 1163)
  AUTHORS   Dissen,E., Ryan,J.C., Seaman,W.E. and Fossum,S.
  TITLE     An autosomal dominant locus, Nka, mapping to the Ly-49 region of a
            rat natural killer (NK) gene complex, controls NK cell lysis of
            allogeneic lymphocytes
  JOURNAL   J Exp Med 183 (5), 2197-2207 (1996)
   PUBMED   8642329
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Nov 30, 2020 this sequence version replaced NM_173291.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY649838.1, U56822.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680432, SAMN16676789
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-109               JAXUCZ010000004.1  165742917-165743025 c
            110-261             JAXUCZ010000004.1  165741100-165741251 c
            262-342             JAXUCZ010000004.1  165739102-165739182 c
            343-564             JAXUCZ010000004.1  165737996-165738217 c
            565-707             JAXUCZ010000004.1  165736099-165736241 c
            708-811             JAXUCZ010000004.1  165733690-165733793 c
            812-967             JAXUCZ010000004.1  165721873-165722028 c
            968-1163            JAXUCZ010000004.1  165721602-165721797 c
FEATURES             Location/Qualifiers
     source          1..1163
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..1163
                     /gene="Klra22"
                     /gene_synonym="Klra1; Ly49; Ly49s2"
                     /note="killer cell lectin-like receptor subfamily A,
                     member 22"
                     /db_xref="GeneID:24933"
                     /db_xref="RGD:3023"
     exon            1..109
                     /gene="Klra22"
                     /gene_synonym="Klra1; Ly49; Ly49s2"
                     /inference="alignment:Splign:2.1.0"
     exon            110..261
                     /gene="Klra22"
                     /gene_synonym="Klra1; Ly49; Ly49s2"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..947
                     /gene="Klra22"
                     /gene_synonym="Klra1; Ly49; Ly49s2"
                     /note="Ly49 stimulatory receptor 2; Lymphocye antigen 49
                     complex"
                     /codon_start=1
                     /product="killer cell lectin-like receptor subfamily A,
                     member 22"
                     /protein_id="NP_775413.2"
                     /db_xref="GeneID:24933"
                     /db_xref="RGD:3023"
                     /translation="MNEQRFTFSTARFHKSSVLQNQERTEETQRPRKAGNRVCWQITV
                     TALGILCFFRLVSVAVMVINIFQYSQEKHELQETLSNLHHNYSTMQNDINLKEEMLRD
                     MSTEYSAVNHFLDFLNREKNRCYNKTKTVLDSSQHSGRGVEMHWFCYGIKCYYFIMDR
                     KTWSGCTQTCQNFSLPLLTIDDEDELMFLHLLVTPDSYWIGLSYDNKKSDWTWIDNNP
                     SKLALNTRKYNIKDGGCVFLSKTRLDNINCDNLFSCICGKRLDKFPD"
     exon            262..342
                     /gene="Klra22"
                     /gene_synonym="Klra1; Ly49; Ly49s2"
                     /inference="alignment:Splign:2.1.0"
     exon            343..564
                     /gene="Klra22"
                     /gene_synonym="Klra1; Ly49; Ly49s2"
                     /inference="alignment:Splign:2.1.0"
     exon            565..707
                     /gene="Klra22"
                     /gene_synonym="Klra1; Ly49; Ly49s2"
                     /inference="alignment:Splign:2.1.0"
     exon            708..811
                     /gene="Klra22"
                     /gene_synonym="Klra1; Ly49; Ly49s2"
                     /inference="alignment:Splign:2.1.0"
     exon            812..967
                     /gene="Klra22"
                     /gene_synonym="Klra1; Ly49; Ly49s2"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1163
                     /gene="Klra22"
                     /gene_synonym="Klra1; Ly49; Ly49s2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tacctttatt tttggagtct cttagaggag acaaatcagg gaagaccagc tgtccctcaa
       61 ttgggggatc aattccttct accagaatca cttctgtgta gagacacagg gcatatttta
      121 acacagaaga tactccaaat aatcccaaga tgaatgagca gaggttcact ttctcaactg
      181 caagatttca taaatcttca gtgctgcaga accaggagag gactgaggag actcagaggc
      241 ctagaaaagc tggaaacaga gtctgctggc agatcactgt gacagctctt ggaatcctgt
      301 gtttctttcg gctagtatcg gttgcagtga tggtgataaa catttttcag tacagtcaag
      361 aaaaacatga acttcaggaa acactatcca acctccacca taactacagc accatgcaaa
      421 atgacatcaa cttaaaggaa gaaatgctga gagatatgtc tacagagtat agtgctgtta
      481 atcattttct ggacttcctc aacagagaaa agaacagatg ttacaacaaa accaagactg
      541 ttttagattc ttcacagcac tcaggtagag gtgttgaaat gcactggttc tgttatggta
      601 taaaatgtta ttatttcatc atggacagaa aaacatggag tggatgtacc cagacctgtc
      661 agaatttcag tttgcccctt ctgacgatag atgatgagga tgaactgatg ttccttcatc
      721 tccttgttac tccagacagt tactggattg gattgtctta tgataataaa aaaagtgatt
      781 ggacatggat tgacaacaac ccatctaaac ttgccttgaa cacaaggaaa tacaatatta
      841 aggatggagg atgtgtattc ttatctaaaa caagactaga caatattaac tgtgataatt
      901 tattcagttg tatttgtggg aagagactgg ataaattccc tgactgacaa tccagtgaat
      961 gttaaagtct gcagggcaaa cagagagaca atctggaaga ttttgggaat gttctttgga
     1021 atcttacttg acagagcaga ggacatcttc cttccatctg gagacaagaa agatcctctg
     1081 ctgcatgcca caaagcctgg aggaatttgt catatttgtt tgcataaact cccacagaac
     1141 taaataaaga accataacaa aca
//
