LOCUS       NM_001107509            1302 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus kallikrein related-peptidase 8 (Klk8), mRNA.
ACCESSION   NM_001107509 XM_001077419 XM_218648
VERSION     NM_001107509.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1302)
  AUTHORS   Sun,H., Li,J., Wang,Q., Li,F., Zhang,M., Su,Y., Song,M. and Feng,J.
  TITLE     Kallikrein-related peptidase-8 (KLK8) aggravated hypoxia-induced
            right ventricular hypertrophy by targeting P38 MAPK/P53 signaling
            pathway
  JOURNAL   Tissue Cell 78, 101874 (2022)
   PUBMED   35994918
  REMARK    GeneRIF: Kallikrein-related peptidase-8 (KLK8) aggravated
            hypoxia-induced right ventricular hypertrophy by targeting P38
            MAPK/P53 signaling pathway.
REFERENCE   2  (bases 1 to 1302)
  AUTHORS   Huang,M., Du,J., Wang,Y., Ma,S., Hu,T., Shang,J., Yu,Q., Zhu,X.,
            Zhang,G. and Cong,B.
  TITLE     Tissue kallikrein-related peptidase8 protects rat heart against
            acute ischemia reperfusion injury
  JOURNAL   Int J Biol Macromol 140, 1126-1133 (2019)
   PUBMED   31449861
  REMARK    GeneRIF: KLK8 protects the heart against
            ischemia/reperfusion-induced cardiac injury.
REFERENCE   3  (bases 1 to 1302)
  AUTHORS   Cao,B., Yu,Q., Zhao,W., Tang,Z., Cong,B., Du,J., Lu,J., Zhu,X. and
            Ni,X.
  TITLE     Kallikrein-related peptidase 8 is expressed in myocardium and
            induces cardiac hypertrophy
  JOURNAL   Sci Rep 7, 20024 (2016)
   PUBMED   26823023
  REMARK    GeneRIF: our data suggest that KLK8 may promote cardiomyocyte
            hypertrophy through EGF signaling- and PARs-dependent but a kinin
            receptor-independent pathway. It is implied that different KLK
            family members can subtly regulate cardiac function and remodeling.
            Erratum:[Sci Rep. 2016 Apr 29;6:25038. doi: 10.1038/srep25038..
            Cong, Binghai [corrected to Cong, Binhai]. PMID: 27125362]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1302)
  AUTHORS   Ramachandran,R., Eissa,A., Mihara,K., Oikonomopoulou,K.,
            Saifeddine,M., Renaux,B., Diamandis,E. and Hollenberg,M.D.
  TITLE     Proteinase-activated receptors (PARs): differential signalling by
            kallikrein-related peptidases KLK8 and KLK14
  JOURNAL   Biol Chem 393 (5), 421-427 (2012)
   PUBMED   22505524
  REMARK    GeneRIF: KLK8 and KLK14 can signal differentially via the PARs to
            affect tissue function
REFERENCE   5  (bases 1 to 1302)
  AUTHORS   Scott,F.L., Sun,J., Whisstock,J.C., Kato,K. and Bird,P.I.
  TITLE     SerpinB6 is an inhibitor of kallikrein-8 in keratinocytes
  JOURNAL   J Biochem 142 (4), 435-442 (2007)
   PUBMED   17761692
REFERENCE   6  (bases 1 to 1302)
  AUTHORS   Hirata,A., Yoshida,S., Inoue,N., Matsumoto-Miyai,K., Ninomiya,A.,
            Taniguchi,M., Matsuyama,T., Kato,K., Iizasa,H., Kataoka,Y.,
            Yoshida,N. and Shiosaka,S.
  TITLE     Abnormalities of synapses and neurons in the hippocampus of
            neuropsin-deficient mice
  JOURNAL   Mol Cell Neurosci 17 (3), 600-610 (2001)
   PUBMED   11273653
REFERENCE   7  (bases 1 to 1302)
  AUTHORS   Kitayoshi,H., Inoue,N., Kuwae,K., Chen,Z.L., Sato,H., Ohta,T.,
            Hosokawa,K., Itami,S., Yoshikawa,K., Yoshida,S. and Shiosaka,S.
  TITLE     Effect of 12-O-tetradecanoyl-phorbol ester and incisional wounding
            on neuropsin mRNA and its protein expression in murine skin
  JOURNAL   Arch Dermatol Res 291 (6), 333-338 (1999)
   PUBMED   10421059
REFERENCE   8  (bases 1 to 1302)
  AUTHORS   Tomizawa,K., He,X., Yamanaka,H., Shiosaka,S. and Yoshida,S.
  TITLE     Injury induces neuropsin mRNA in the central nervous system
  JOURNAL   Brain Res 824 (2), 308-311 (1999)
   PUBMED   10196465
REFERENCE   9  (bases 1 to 1302)
  AUTHORS   Davies,B.J., Pickard,B.S., Steel,M., Morris,R.G. and Lathe,R.
  TITLE     Serine proteases in rodent hippocampus
  JOURNAL   J Biol Chem 273 (36), 23004-23011 (1998)
   PUBMED   9722524
REFERENCE   10 (bases 1 to 1302)
  AUTHORS   Shimizu,C., Yoshida,S., Shibata,M., Kato,K., Momota,Y.,
            Matsumoto,K., Shiosaka,T., Midorikawa,R., Kamachi,T., Kawabe,A. and
            Shiosaka,S.
  TITLE     Characterization of recombinant and brain neuropsin, a
            plasticity-related serine protease
  JOURNAL   J Biol Chem 273 (18), 11189-11196 (1998)
   PUBMED   9556608
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473979.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_218648.3, XM_001077419.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760393, SAMN13663615
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1302
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1302
                     /gene="Klk8"
                     /gene_synonym="bsp1; Klnh"
                     /note="kallikrein related-peptidase 8"
                     /db_xref="GeneID:308565"
                     /db_xref="RGD:1305998"
     exon            1..547
                     /gene="Klk8"
                     /gene_synonym="bsp1; Klnh"
                     /inference="alignment:Splign:2.1.0"
     CDS             478..1260
                     /gene="Klk8"
                     /gene_synonym="bsp1; Klnh"
                     /EC_number="3.4.21.118"
                     /note="kallikrein-8; NP; neuropsin; serine protease 19;
                     brain serine protease 1; kallikrein 8 (neuropsin/ovasin);
                     kallikrein h"
                     /codon_start=1
                     /product="kallikrein-8 precursor"
                     /protein_id="NP_001100979.1"
                     /db_xref="GeneID:308565"
                     /db_xref="RGD:1305998"
                     /translation="MGRPPPCAIQTWILLFLLMGAWAGLTRAQGSKILEGQECKPHSQ
                     PWQTALFQGERLVCGGVLVGDRWVLTAAHCKKDKYSVRLGDHSLQKRDEPEQEIQVAR
                     SIQHPCFNSSNPEDHSHDIMLIRLQNSANLGDKVKPIELANLCPKVGQKCIISGWGTV
                     TSPQENFPNTLNCAEVKIYSQNKCERAYPGKITEGMVCAGSSNGADTCQGDSGGPLVC
                     NGVLQGITSWGSDPCGKPEKPGVYTKICRYTNWIKKTMGKRD"
     exon            548..707
                     /gene="Klk8"
                     /gene_synonym="bsp1; Klnh"
                     /inference="alignment:Splign:2.1.0"
     exon            708..970
                     /gene="Klk8"
                     /gene_synonym="bsp1; Klnh"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1104
                     /gene="Klk8"
                     /gene_synonym="bsp1; Klnh"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1302
                     /gene="Klk8"
                     /gene_synonym="bsp1; Klnh"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacacaccga agggaagtcc gggggccgct tccaccgagt ccgagtgacc ccgccccctg
       61 cattctggaa ggtgaggcgc agaagtcccc agacatggac ctcaggcgca gggactttcc
      121 ccttccgtga gcccaggatc tcacattctt tctctcagga tcttcgagcg ggtcttctaa
      181 actccctcct ccccaggacg ttggagtcac agcctcagat ctttctctcc aatcccacga
      241 gtgggtcaga actccttcct ttaaaatgtc gggattccca ccagcaagct ctcccctaca
      301 ctaaaattcg ggaagtctag agctctgccc cagcttcctc agaccccagc tccatcctcc
      361 agcaagactc aagacagctc cggaaacacc tccttccccc agttccccag acaacaagat
      421 ctcaggctcc tccctcggga cttcctctca gttccaccct cttcttcagg gtccaccatg
      481 ggacgccccc caccctgtgc aatccagacg tggatccttc tgtttctgct aatgggagcg
      541 tgggcaggac tcaccagagc tcagggctcc aagatcctgg aaggtcagga gtgtaaaccc
      601 cactcccaac cttggcagac agccttgttc cagggcgaga gactggtctg cgggggtgtc
      661 ctggtcggag acagatgggt cctaactgca gcccactgca aaaaagacaa gtactccgtg
      721 cgtctgggtg atcacagcct tcagaaaaga gatgagcccg agcaagagat ccaggtggct
      781 cggtctatcc agcatccttg cttcaacagt agcaacccag aggatcacag ccatgacata
      841 atgctcattc gactgcagaa ctcagcaaac ctcggggaca aagtgaagcc catcgagctg
      901 gccaatctgt gtcccaaagt tggccagaag tgcatcatat caggctgggg cactgtcacc
      961 agccctcaag agaactttcc aaacaccctc aactgtgcag aagtgaaaat ctactcccag
     1021 aacaagtgtg agagagccta cccagggaag atcaccgagg gtatggtctg tgctggcagc
     1081 agcaacgggg ccgacacgtg ccagggcgac tcgggaggtc ctctggtgtg caacggggtg
     1141 ctccaaggca tcacctcgtg gggctcagac ccctgtggga aacctgagaa acccggagtc
     1201 tacaccaaaa tctgtcgcta cactaactgg atcaagaaga ccatgggcaa gagggactga
     1261 tcctggggat gggcggtcaa taaagaccac tgctggctcc tc
//
