LOCUS       NM_001106254            1607 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus kallikrein-related peptidase 7 (Klk7), mRNA.
ACCESSION   NM_001106254 XM_001080426 XM_017588919 XM_218649
VERSION     NM_001106254.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1607)
  AUTHORS   Yamasaki,K., Schauber,J., Coda,A., Lin,H., Dorschner,R.A.,
            Schechter,N.M., Bonnart,C., Descargues,P., Hovnanian,A. and
            Gallo,R.L.
  TITLE     Kallikrein-mediated proteolysis regulates the antimicrobial effects
            of cathelicidins in skin
  JOURNAL   FASEB J 20 (12), 2068-2080 (2006)
   PUBMED   17012259
REFERENCE   2  (bases 1 to 1607)
  AUTHORS   Iwai,N., Yasui,N., Naraba,H., Tago,N., Yamawaki,H. and Sumiya,H.
  TITLE     Klk1 as one of the genes contributing to hypertension in Dahl
            salt-sensitive rat
  JOURNAL   Hypertension 45 (5), 947-953 (2005)
   PUBMED   15809361
REFERENCE   3  (bases 1 to 1607)
  AUTHORS   Ishida-Yamamoto,A., Deraison,C., Bonnart,C., Bitoun,E.,
            Robinson,R., O'Brien,T.J., Wakamatsu,K., Ohtsubo,S., Takahashi,H.,
            Hashimoto,Y., Dopping-Hepenstal,P.J., McGrath,J.A., Iizuka,H.,
            Richard,G. and Hovnanian,A.
  TITLE     LEKTI is localized in lamellar granules, separated from KLK5 and
            KLK7, and is secreted in the extracellular spaces of the
            superficial stratum granulosum
  JOURNAL   J Invest Dermatol 124 (2), 360-366 (2005)
   PUBMED   15675955
REFERENCE   4  (bases 1 to 1607)
  AUTHORS   Elmoujahed,A., Gutman,N., Brillard,M. and Gauthier,F.
  TITLE     Substrate specificity of two kallikrein family gene products
            isolated from the rat submaxillary gland
  JOURNAL   FEBS Lett 265 (1-2), 137-140 (1990)
   PUBMED   2194829
REFERENCE   5  (bases 1 to 1607)
  AUTHORS   Brady,J.M. and MacDonald,R.J.
  TITLE     The expression of two kallikrein gene family members in the rat
            kidney
  JOURNAL   Arch Biochem Biophys 278 (2), 342-349 (1990)
   PUBMED   2183721
REFERENCE   6  (bases 1 to 1607)
  AUTHORS   Chen,Y.P., Chao,J. and Chao,L.
  TITLE     Molecular cloning and characterization of two rat renal kallikrein
            genes
  JOURNAL   Biochemistry 27 (19), 7189-7196 (1988)
   PUBMED   2849988
REFERENCE   7  (bases 1 to 1607)
  AUTHORS   Kato,H., Nakanishi,E., Enjyoji,K., Hayashi,I., Oh-ishi,S. and
            Iwanaga,S.
  TITLE     Characterization of serine proteinases isolated from rat
            submaxillary gland: with special reference to the degradation of
            rat kininogens by these enzymes
  JOURNAL   J Biochem 102 (6), 1389-1404 (1987)
   PUBMED   3482210
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Feb 9, 2022 this sequence version replaced
            XM_017588919.2, NM_001106254.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.2039.1,
                                           SRR26643294.2183.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                JAXUCZ010000001.1  103403716-103403782
            68-209              JAXUCZ010000001.1  103404105-103404246
            210-457             JAXUCZ010000001.1  103404588-103404835
            458-594             JAXUCZ010000001.1  103404970-103405106
            595-1607            JAXUCZ010000001.1  103406895-103407907
FEATURES             Location/Qualifiers
     source          1..1607
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1607
                     /gene="Klk7"
                     /note="kallikrein-related peptidase 7"
                     /db_xref="GeneID:292852"
                     /db_xref="RGD:1306420"
     CDS             1..750
                     /gene="Klk7"
                     /EC_number="3.4.21.117"
                     /note="kallikrein 7 (chymotryptic, stratum corneum);
                     kallikrein related-peptidase 7 (chymotryptic, stratum
                     corneum); kallikrein-7"
                     /codon_start=1
                     /product="kallikrein-7 precursor"
                     /protein_id="NP_001099724.2"
                     /db_xref="GeneID:292852"
                     /db_xref="RGD:1306420"
                     /translation="MGVWLLSLLTVLLSLALETAGQGERIIDGYKCKEGSHPWQVALL
                     KGDQLHCGGVLVGESWVLTAAHCKMGQYTVHLGSDKIEDQSAQRIKASRSFRHPGYST
                     RTHVNDIMLVKMDKPVKMSDKVQKVKLPDHCEPPGTLCTVSGWGTTTSPDVTFPSDLM
                     CSDVKLISSQECKKVYKDLLGKTMLCAGIPDSKTNTCNGDSGGPLVCNDTLQGLVSWG
                     TYPCGQPNDPGVYTQVCKYQRWLEDTMKTYR"
     exon            1..67
                     /gene="Klk7"
                     /inference="alignment:Splign:2.1.0"
     exon            68..209
                     /gene="Klk7"
                     /inference="alignment:Splign:2.1.0"
     exon            210..457
                     /gene="Klk7"
                     /inference="alignment:Splign:2.1.0"
     exon            458..594
                     /gene="Klk7"
                     /inference="alignment:Splign:2.1.0"
     exon            595..1607
                     /gene="Klk7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgggagtct ggctcctttc cctgctaact gtgctgctgt ctttagccct ggaaactgct
       61 ggacaaggag aaaggattat agatggctac aagtgtaagg aaggctccca cccatggcag
      121 gtggctctgc tcaaaggcga tcagcttcat tgtggaggag tgctggtggg tgaaagctgg
      181 gtgctcacag cagcccactg caaaatgggt cagtacacgg tgcatctggg cagtgataag
      241 atagaggatc agagtgccca gaggatcaag gcttcaaggt cattccgaca ccctggctac
      301 tccacaagga cccatgtcaa tgacatcatg cttgtgaaga tggataagcc ggtcaagatg
      361 tcagacaagg tgcagaaagt caagcttcct gatcactgtg aacccccagg gacattgtgc
      421 accgtctctg gatggggcac cacaaccagc ccagatgtga ccttcccctc ggatcttatg
      481 tgctcggatg tgaagctcat ctcctcccag gagtgcaaga aggtgtataa ggatcttctg
      541 gggaaaacca tgctgtgtgc tggcattccc gactctaaga ctaacacatg caatggtgac
      601 tcaggggggc ccttggtgtg caatgacacc cttcaaggtc tggtgtcctg gggaacctac
      661 ccttgtggcc agccgaatga cccaggagtc tacactcaag tctgcaagta ccaacggtgg
      721 ttggaggaca ccatgaaaac ctatcgctaa cgtgccagga gggcaagctg ccagcctgga
      781 aggctgtgta aagccctgcc tggctttacc tttcctccag gacatagcaa aacctcaaca
      841 ctacgttaag tttataagcc aatcagaacc ccagagacca aaaagcaaat caagtcagga
      901 gactgagaac ctgagggcta tggaagatgc cagaagaact aaaacttcca aatgcagtag
      961 cttgaggatt cctacggtcc tttattggaa agtggctgct aactgtgaga ccttcatcca
     1021 ctgccttgga ctcaggccat ccatttctag agttctttaa aaaaaataga atcaaatttg
     1081 gattcattac attacttatt gtagaggaaa aagaacggaa actgtcaaca tgttcacaat
     1141 agtagattat ttcagtgaaa gttcgatttc tctcactatg aagttgtggg aaataccgcg
     1201 tatgctgtgg tgctcagcct tgtccccgag ggactgttgt tgtctgatgt ttaatgggga
     1261 catgggctgg acatacccaa tgaatactga tgagacagaa taaaatctaa gtgatatcga
     1321 tgtgtgtgct catagcctgg aaaataatgt tggggagctg ggagcattga tggtggaggg
     1381 aagagaccta tgaggaagag ttggcaagat ggctcagtgg gtaagaacac ttgctgccaa
     1441 gcctgacatg acctctgggg cctgcacggt ggaagggagt aactgattcc tgcatacttc
     1501 cccctgacct ccagatgtgc gaaggcacat gtgtacctgc acacatacat tgacacaaaa
     1561 ccagattgaa gtgtaaataa agtcttcttc atatttttaa cttttaa
//
