LOCUS       NM_019175               1110 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus kallikrein related-peptidase 6 (Klk6), mRNA.
ACCESSION   NM_019175
VERSION     NM_019175.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1110)
  AUTHORS   Guo J, Yang J, Fu J and Tripathi A.
  TITLE     Exercise improves the body function and protects the neuronal
            injury in Parkinson's disease rats by activating calpain 1 and
            kallikrein 6
  JOURNAL   Folia Neuropathol 60 (3), 301-307 (2022)
   PUBMED   36382482
  REMARK    GeneRIF: Exercise improves the body function and protects the
            neuronal injury in Parkinson's disease rats by activating calpain 1
            and kallikrein 6.
REFERENCE   2  (bases 1 to 1110)
  AUTHORS   Rovelet-Lecrux A, Legallic S, Wallon D, Flaman JM, Martinaud O,
            Bombois S, Rollin-Sillaire A, Michon A, Le Ber I, Pariente J, Puel
            M, Paquet C, Croisile B, Thomas-Anterion C, Vercelletto M, Levy R,
            Frebourg T, Hannequin D and Campion D.
  CONSRTM   Investigators of the GMAJ project
  TITLE     A genome-wide study reveals rare CNVs exclusive to extreme
            phenotypes of Alzheimer disease
  JOURNAL   Eur J Hum Genet 20 (6), 613-617 (2012)
   PUBMED   22166940
REFERENCE   3  (bases 1 to 1110)
  AUTHORS   Wang SM, Mao J, Li B, Wu W and Tang LL.
  TITLE     [Expression of KLK6 protein and mRNA in primary breast cancer and
            its clinical significance]
  JOURNAL   Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 24 (11), 1087-1089 (2008)
   PUBMED   18992199
REFERENCE   4  (bases 1 to 1110)
  AUTHORS   Shih IeM, Salani R, Fiegl M, Wang TL, Soosaipillai A, Marth C,
            Muller-Holzner E, Gastl G, Zhang Z and Diamandis EP.
  TITLE     Ovarian cancer specific kallikrein profile in effusions
  JOURNAL   Gynecol Oncol 105 (2), 501-507 (2007)
   PUBMED   17303231
REFERENCE   5  (bases 1 to 1110)
  AUTHORS   Scarisbrick IA, Sabharwal P, Cruz H, Larsen N, Vandell AG, Blaber
            SI, Ameenuddin S, Papke LM, Fehlings MG, Reeves RK, Blaber M,
            Windebank AJ and Rodriguez M.
  TITLE     Dynamic role of kallikrein 6 in traumatic spinal cord injury
  JOURNAL   Eur J Neurosci 24 (5), 1457-1469 (2006)
   PUBMED   16987227
REFERENCE   6  (bases 1 to 1110)
  AUTHORS   Scarisbrick IA, Blaber SI, Lucchinetti CF, Genain CP, Blaber M and
            Rodriguez M.
  TITLE     Activity of a newly identified serine protease in CNS demyelination
  JOURNAL   Brain 125 (Pt 6), 1283-1296 (2002)
   PUBMED   12023317
REFERENCE   7  (bases 1 to 1110)
  AUTHORS   Zarghooni M, Soosaipillai A, Grass L, Scorilas A, Mirazimi N and
            Diamandis EP.
  TITLE     Decreased concentration of human kallikrein 6 in brain extracts of
            Alzheimer's disease patients
  JOURNAL   Clin Biochem 35 (3), 225-231 (2002)
   PUBMED   12074831
REFERENCE   8  (bases 1 to 1110)
  AUTHORS   Blaber SI, Scarisbrick IA, Bernett MJ, Dhanarajan P, Seavy MA, Jin
            Y, Schwartz MA, Rodriguez M and Blaber M.
  TITLE     Enzymatic properties of rat myelencephalon-specific protease
  JOURNAL   Biochemistry 41 (4), 1165-1173 (2002)
   PUBMED   11802715
REFERENCE   9  (bases 1 to 1110)
  AUTHORS   Petraki CD, Karavana VN, Skoufogiannis PT, Little SP, Howarth DJ,
            Yousef GM and Diamandis EP.
  TITLE     The spectrum of human kallikrein 6 (zyme/protease M/neurosin)
            expression in human tissues as assessed by immunohistochemistry
  JOURNAL   J Histochem Cytochem 49 (11), 1431-1441 (2001)
   PUBMED   11668196
REFERENCE   10 (bases 1 to 1110)
  AUTHORS   Scarisbrick IA, Towner MD and Isackson PJ.
  TITLE     Nervous system-specific expression of a novel serine protease:
            regulation in the adult rat spinal cord by excitotoxic injury
  JOURNAL   J Neurosci 17 (21), 8156-8168 (1997)
   PUBMED   9334391
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF016269.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF016269.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1110
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1110
                     /gene="Klk6"
                     /gene_synonym="Klni; Prss9"
                     /note="kallikrein related-peptidase 6"
                     /db_xref="GeneID:29245"
                     /db_xref="RGD:3419"
     exon            1..38
                     /gene="Klk6"
                     /gene_synonym="Klni; Prss9"
                     /inference="alignment:Splign:2.1.0"
     exon            39..184
                     /gene="Klk6"
                     /gene_synonym="Klni; Prss9"
                     /inference="alignment:Splign:2.1.0"
     CDS             185..940
                     /gene="Klk6"
                     /gene_synonym="Klni; Prss9"
                     /note="kallikrein 6 (neurosin, zyme); kallikrein 6
                     (neurosin); kallikrein-6; protease serine 9 (neurosin);
                     protease, serine, 9; kallikrein i"
                     /codon_start=1
                     /product="kallikrein-6 precursor"
                     /protein_id="NP_062048.1"
                     /db_xref="GeneID:29245"
                     /db_xref="RGD:3419"
                     /translation="MPTKMLTVKTLALCLILAKSAWSEDQDKVVHGGPCLKNSHPFQA
                     ALYTSGHLLCGGVLVGPQWVLTAAHCKKPNLEVYLGKHNLRQTETFQRQISVDRTIVH
                     PRYNPQTHDNDIMMVHLKRPVKFSQRIQPLPLKKDCSEKNPDCQILGWGKMENGEFPD
                     TIQCADVQLVSREECERAYPGKITRSMVCAGDKREGNDSCQGDSGGPLVCGGHLRGIV
                     SWGDMPCGSKEKPGVYTDVCTHIRWIQNIIRNK"
     exon            185..245
                     /gene="Klk6"
                     /gene_synonym="Klni; Prss9"
                     /inference="alignment:Splign:2.1.0"
     exon            246..402
                     /gene="Klk6"
                     /gene_synonym="Klni; Prss9"
                     /inference="alignment:Splign:2.1.0"
     exon            403..650
                     /gene="Klk6"
                     /gene_synonym="Klni; Prss9"
                     /inference="alignment:Splign:2.1.0"
     exon            651..787
                     /gene="Klk6"
                     /gene_synonym="Klni; Prss9"
                     /inference="alignment:Splign:2.1.0"
     exon            788..1082
                     /gene="Klk6"
                     /gene_synonym="Klni; Prss9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacacggagg tcttcagcac ccacagaggg acttacaggt cggatcataa ggcaaccttc
       61 tgtcagtctg ctctgcccct tctcttgtgg agcaccctgc cttgctgact ttctctgcct
      121 gtgataggtg gtgtcgtttc ccccccacct aagttctggc aggtacactg ctggccagca
      181 gcagatgccc acgaagatgc tgacagtgaa gacgctggcc ctgtgcttga ttcttgctaa
      241 gtcagcctgg tcggaagatc aggataaggt ggtacatgga ggcccctgtt tgaagaactc
      301 tcaccctttc caagctgccc tctacacctc gggtcacttg ctgtgtggtg gggtcctcgt
      361 cggcccacag tgggtgctga cagctgccca ctgcaaaaaa ccgaatctgg aggtgtactt
      421 ggggaaacac aatctacggc aaactgagac tttccaaagg caaatctctg tggacaggac
      481 tattgtccat ccccgttaca atccccaaac ccatgacaat gatatcatga tggtgcatct
      541 gaaacgtcca gtcaaattct ctcaaaggat ccagcccctg cctttgaaga aagactgctc
      601 tgagaagaat cccgactgtc agatcctcgg ctggggcaag atggaaaacg gtgaattccc
      661 agataccatc cagtgtgctg atgtccagct ggtgtcccgg gaagagtgtg agcgcgccta
      721 ccctggcaag atcacccgaa gcatggtgtg cgcaggcgac aagagagaag ggaacgattc
      781 ctgccagggt gattctggag gtcccctggt atgcggtggt cacctccgag ggattgtgtc
      841 atggggtgac atgccctgtg gatcaaagga aaagccggga gtttacacag atgtctgcac
      901 tcatatcaga tggatccaaa acatcatcag aaacaagtga ctctggcatg agacatgcag
      961 ttcttgacct gtctctcccc tgaccctagc tggctacata ttctctctcc ctgaaaccct
     1021 gccccactct cagagccttc agatgtccag ctctgccccc tcatgcttaa taaatgcagt
     1081 gaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
