LOCUS       NM_001004101            1265 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus kallikrein-related peptidase 4 (Klk4), mRNA.
ACCESSION   NM_001004101 XM_579126
VERSION     NM_001004101.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1265)
  AUTHORS   Yamakoshi,Y., Richardson,A.S., Nunez,S.M., Yamakoshi,F.,
            Milkovich,R.N., Hu,J.C., Bartlett,J.D. and Simmer,J.P.
  TITLE     Enamel proteins and proteases in Mmp20 and Klk4 null and
            double-null mice
  JOURNAL   Eur J Oral Sci 119 Suppl 1 (Suppl 1), 206-216 (2011)
   PUBMED   22243248
REFERENCE   2  (bases 1 to 1265)
  AUTHORS   Smith,C.E., Richardson,A.S., Hu,Y., Bartlett,J.D., Hu,J.C. and
            Simmer,J.P.
  TITLE     Effect of kallikrein 4 loss on enamel mineralization: comparison
            with mice lacking matrix metalloproteinase 20
  JOURNAL   J Biol Chem 286 (20), 18149-18160 (2011)
   PUBMED   21454549
REFERENCE   3  (bases 1 to 1265)
  AUTHORS   Simmer,J.P., Hu,Y., Lertlam,R., Yamakoshi,Y. and Hu,J.C.
  TITLE     Hypomaturation enamel defects in Klk4 knockout/LacZ knockin mice
  JOURNAL   J Biol Chem 284 (28), 19110-19121 (2009)
   PUBMED   19578120
REFERENCE   4  (bases 1 to 1265)
  AUTHORS   Papachristopoulou,G., Avgeris,M. and Scorilas,A.
  TITLE     Expression analysis and study of KLK4 in benign and malignant
            breast tumours
  JOURNAL   Thromb Haemost 101 (2), 381-387 (2009)
   PUBMED   19190825
REFERENCE   5  (bases 1 to 1265)
  AUTHORS   Mange,A., Desmetz,C., Berthes,M.L., Maudelonde,T. and Solassol,J.
  TITLE     Specific increase of human kallikrein 4 mRNA and protein levels in
            breast cancer stromal cells
  JOURNAL   Biochem Biophys Res Commun 375 (1), 107-112 (2008)
   PUBMED   18687310
REFERENCE   6  (bases 1 to 1265)
  AUTHORS   Xi,Z., Kaern,J., Davidson,B., Klokk,T.I., Risberg,B., Trope,C. and
            Saatcioglu,F.
  TITLE     Kallikrein 4 is associated with paclitaxel resistance in ovarian
            cancer
  JOURNAL   Gynecol Oncol 94 (1), 80-85 (2004)
   PUBMED   15262123
REFERENCE   7  (bases 1 to 1265)
  AUTHORS   Hart,P.S., Hart,T.C., Michalec,M.D., Ryu,O.H., Simmons,D., Hong,S.
            and Wright,J.T.
  TITLE     Mutation in kallikrein 4 causes autosomal recessive hypomaturation
            amelogenesis imperfecta
  JOURNAL   J Med Genet 41 (7), 545-549 (2004)
   PUBMED   15235027
REFERENCE   8  (bases 1 to 1265)
  AUTHORS   Puente,X.S. and Lopez-Otin,C.
  TITLE     A genomic analysis of rat proteases and protease inhibitors
  JOURNAL   Genome Res 14 (4), 609-622 (2004)
   PUBMED   15060002
REFERENCE   9  (bases 1 to 1265)
  AUTHORS   Day,C.H., Fanger,G.R., Retter,M.W., Hylander,B.L., Penetrante,R.B.,
            Houghton,R.L., Zhang,X., McNeill,P.D., Filho,A.M., Nolasco,M.,
            Badaro,R., Cheever,M.A., Reed,S.G., Dillon,D.C. and Watanabe,Y.
  TITLE     Characterization of KLK4 expression and detection of KLK4-specific
            antibody in prostate cancer patient sera
  JOURNAL   Oncogene 21 (46), 7114-7120 (2002)
   PUBMED   12370833
REFERENCE   10 (bases 1 to 1265)
  AUTHORS   Simmer,J.P. and Hu,J.C.
  TITLE     Expression, structure, and function of enamel proteinases
  JOURNAL   Connect Tissue Res 43 (2-3), 441-449 (2002)
   PUBMED   12489196
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Oct 17, 2022 this sequence version replaced NM_001004101.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: BN000381.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMN13663598,
                                    SAMN13663603 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                JAXUCZ010000001.1  103480731-103480770
            41-112              JAXUCZ010000001.1  103481136-103481207
            113-278             JAXUCZ010000001.1  103483267-103483432
            279-529             JAXUCZ010000001.1  103483677-103483927
            530-666             JAXUCZ010000001.1  103484015-103484151
            667-1265            JAXUCZ010000001.1  103485365-103485963
FEATURES             Location/Qualifiers
     source          1..1265
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1265
                     /gene="Klk4"
                     /gene_synonym="Emsp1; Klnb1"
                     /note="kallikrein-related peptidase 4"
                     /db_xref="GeneID:408210"
                     /db_xref="RGD:1303228"
     exon            1..40
                     /gene="Klk4"
                     /gene_synonym="Emsp1; Klnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            41..112
                     /gene="Klk4"
                     /gene_synonym="Emsp1; Klnb1"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..819
                     /gene="Klk4"
                     /gene_synonym="Emsp1; Klnb1"
                     /function="serine protease"
                     /note="kallikrein 4 (prostase, enamel matrix, prostate);
                     Enamel matrix serine proteinase 1; kallikrein-4;
                     kallikrein b1"
                     /codon_start=1
                     /product="kallikrein-4 precursor"
                     /protein_id="NP_001004101.1"
                     /db_xref="GeneID:408210"
                     /db_xref="RGD:1303228"
                     /translation="MMVTARTPWGWFLGYLILEVTGSSASSISSRIIQGQDCLPHSQP
                     WQAALFSEDNAFFCSGVLVHPQWVLSAAHCIQDSYTVGLGLHNLEGSQEPGSRMLEAH
                     LSIQHPNYNDPSFANDLMLIKLNESVMESNTIRRIPVASQCPTPGDTCLVSGWGRLKN
                     GKLPSLLQCVNLSVASEETCRLLYDPVYHLSMFCAGGGPDRKDTCNGDSGGPIVCNRS
                     LQGLVSMGQGECGQPGIPSVYTNLCKFTNWIWTTIQTR"
     exon            113..278
                     /gene="Klk4"
                     /gene_synonym="Emsp1; Klnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            279..529
                     /gene="Klk4"
                     /gene_synonym="Emsp1; Klnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            530..666
                     /gene="Klk4"
                     /gene_synonym="Emsp1; Klnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            667..1265
                     /gene="Klk4"
                     /gene_synonym="Emsp1; Klnb1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aactcaactc agctcagtgg cagaatccgg agctcagagg gagccaatat gatggtcact
       61 gcacgaaccc cctggggctg gttcctgggg tacctcatcc ttgaggtcac aggatcctcc
      121 gcctcaagca tcagcagccg gatcatacaa ggccaggatt gcctcccaca ctcgcaaccc
      181 tggcaggcgg cactgttctc agaagacaat gcttttttct gctcgggcgt tctggtgcat
      241 ccgcagtggg tgctgtcagc agcacactgc atacaggact cctacaccgt gggactgggc
      301 ctgcacaacc tggaaggctc ccaagagcct ggcagtcgga tgttagaggc ccacctctcc
      361 atccagcacc cgaactacaa tgacccttct tttgccaacg acctcatgct catcaagctg
      421 aatgaatcag tgatggagtc taacaccatc aggcgcattc ctgtggcttc ccagtgcccc
      481 actcctgggg atacctgcct agtttctggt tggggtcgac taaagaatgg gaaactgccc
      541 agcctcctgc agtgtgtgaa tctctcggta gcatctgagg agacttgcag gctgctgtat
      601 gaccccgtgt accacctcag catgttctgc gccggaggag gacccgatcg aaaggacacg
      661 tgcaatgggg actctggggg tcccatagtg tgcaacagat ccctacaagg gctcgtgtct
      721 atgggacaag gagaatgcgg gcagcctggc ataccaagtg tctacaccaa tctctgcaag
      781 ttcactaact ggatctggac caccattcag acaagatagc tctggactga ctacaccgtc
      841 cacatgaagc ctgctgaggg aacctgagac tcaggattgc tcccagccct tctccctcag
      901 atctacaagt tcaggtccca gcctcctccc tcagactcac aagtccagac tccaatctcc
      961 tccctcagac tcacaagtcc agactccaat ctccttcctc agactcacaa gtccagactc
     1021 caatctcctc tcccagaacc aaggattcag accacaacac cctctttcag gctcagggaa
     1081 ccatgccaca acctcctcct gggacgcagg agtgcaaccc acctgcacgt tcctctgtgt
     1141 gcagtgtcct ctagtagccc agtgttgacc cagccttgcc tttacaccat taggctagtc
     1201 cctcccgctc cccaaacacc ttgtgtctcc tcagggaacc acaaataaaa gaactctcaa
     1261 tactg
//
