LOCUS       NM_175759                859 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus kallikrein 1-related peptidase C9 (Klk1c9), mRNA.
ACCESSION   NM_175759
VERSION     NM_175759.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 859)
  AUTHORS   Iwai,N., Yasui,N., Naraba,H., Tago,N., Yamawaki,H. and Sumiya,H.
  TITLE     Klk1 as one of the genes contributing to hypertension in Dahl
            salt-sensitive rat
  JOURNAL   Hypertension 45 (5), 947-953 (2005)
   PUBMED   15809361
REFERENCE   2  (bases 1 to 859)
  AUTHORS   Olsson,A.Y., Lilja,H. and Lundwall,A.
  TITLE     Taxon-specific evolution of glandular kallikrein genes and
            identification of a progenitor of prostate-specific antigen
  JOURNAL   Genomics 84 (1), 147-156 (2004)
   PUBMED   15203212
REFERENCE   3  (bases 1 to 859)
  AUTHORS   Kroon,E., MacDonald,R.J. and Hammer,R.E.
  TITLE     The transcriptional regulatory strategy of the rat tissue
            kallikrein gene family
  JOURNAL   Genes Funct 1 (5-6), 309-319 (1997)
   PUBMED   17366701
  REMARK    GeneRIF: Klks3 rat gene was expressed at high levels in the
            submandibular glands of transgenic mice.
REFERENCE   4  (bases 1 to 859)
  AUTHORS   Moreau,T., Brillard-Bourdet,M., Bouhnik,J. and Gauthier,F.
  TITLE     Protein products of the rat kallikrein gene family. Substrate
            specificities of kallikrein rK2 (tonin) and kallikrein rK9
  JOURNAL   J Biol Chem 267 (14), 10045-10051 (1992)
   PUBMED   1315752
REFERENCE   5  (bases 1 to 859)
  AUTHORS   Berg,T., Schoyen,H., Wassdal,I., Hull,R., Gerskowitch,V.P. and
            Toft,K.
  TITLE     Characterization of a new kallikrein-like enzyme (KLP-S3) of the
            rat submandibular gland
  JOURNAL   Biochem J 281 (Pt 3) (Pt 3), 819-828 (1992)
   PUBMED   1536657
REFERENCE   6  (bases 1 to 859)
  AUTHORS   Yamaguchi,T., Carretero,O.A. and Scicli,A.G.
  TITLE     A novel serine protease with vasoconstrictor activity coded by the
            kallikrein gene S3
  JOURNAL   J Biol Chem 266 (8), 5011-5017 (1991)
   PUBMED   1900513
REFERENCE   7  (bases 1 to 859)
  AUTHORS   Ashley,P.L. and MacDonald,R.J.
  TITLE     Kallikrein-related mRNAs of the rat submaxillary gland: nucleotide
            sequences of four distinct types including tonin
  JOURNAL   Biochemistry 24 (17), 4512-4520 (1985)
   PUBMED   2998455
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M11566.1.
            
            On Jun 3, 2003 this sequence version replaced NM_175759.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M11566.1, BC061771.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..859
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..859
                     /gene="Klk1c9"
                     /gene_synonym="Klk9; Klks3; Klna2; rGK-9; rK9"
                     /note="kallikrein 1-related peptidase C9"
                     /db_xref="GeneID:292868"
                     /db_xref="RGD:727805"
     exon            1..82
                     /gene="Klk1c9"
                     /gene_synonym="Klk9; Klks3; Klna2; rGK-9; rK9"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..816
                     /gene="Klk1c9"
                     /gene_synonym="Klk9; Klks3; Klna2; rGK-9; rK9"
                     /EC_number="3.4.21.35"
                     /note="submandibular enzymatic vasoconstrictor;
                     submandibular glandular kallikrein-9; SEV; KLK-S3; S3
                     kallikrein; tissue kallikrein; submaxillary gland S3
                     kallikrein; kallikrein, submaxillary gland S3; kallikrein
                     a2"
                     /codon_start=1
                     /product="submandibular glandular kallikrein-9 precursor"
                     /protein_id="NP_786935.1"
                     /db_xref="GeneID:292868"
                     /db_xref="RGD:727805"
                     /translation="MWFLILFLALSLGQIDAAPPGQSRVVGGYNCETNSQPWQVAVIG
                     TTFCGGVLIDPSWVITAAHCYSKNYRVLLGRNNLVKDEPFAQRRLVSQSFQHPDYIPV
                     FMRNHTRQRAYDHNNDLMLLHLSKPADITGGVKVIDLPTEEPKVGSICLASGWGMTNP
                     SEMKLSHDLQCVNIHLLSNEKCIETYKNIETDVTLCAGEMDGGKDTCTGDSGGPLICD
                     GVLQGLTSGGATPCAKPKTPAIYAKLIKFTSWIKKVMKENP"
     exon            83..236
                     /gene="Klk1c9"
                     /gene_synonym="Klk9; Klks3; Klna2; rGK-9; rK9"
                     /inference="alignment:Splign:2.1.0"
     exon            237..523
                     /gene="Klk1c9"
                     /gene_synonym="Klk9; Klks3; Klna2; rGK-9; rK9"
                     /inference="alignment:Splign:2.1.0"
     exon            524..660
                     /gene="Klk1c9"
                     /gene_synonym="Klk9; Klks3; Klna2; rGK-9; rK9"
                     /inference="alignment:Splign:2.1.0"
     exon            661..859
                     /gene="Klk1c9"
                     /gene_synonym="Klk9; Klks3; Klna2; rGK-9; rK9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagatcacca cctgctgcta ctggacacac gatatcatgt ggttcctgat cctgttcctc
       61 gccctgtccc tgggacagat tgatgctgca cctcctggcc agtctcgggt tgttggagga
      121 tataactgtg agacgaattc ccaaccctgg caagtggctg tcattggtac aactttctgc
      181 gggggtgtcc tgatagaccc cagctgggtg atcacagctg cccactgcta tagcaagaat
      241 tatcgtgttt tgctgggccg aaacaaccta gttaaagatg aaccctttgc tcagcgccgg
      301 cttgtcagcc aaagcttcca acaccctgac tacatcccag tcttcatgag gaaccacacc
      361 cgacaacgtg cgtatgacca caacaatgac ctgatgctgc tccacctcag caagcctgct
      421 gacatcacag gtggtgtgaa ggtcatcgat ctgcccactg aggagcccaa agtggggagc
      481 atctgccttg cctcaggctg gggcatgacc aacccctctg agatgaaatt aagtcatgat
      541 ctccagtgtg tgaacatcca ccttctgtct aatgagaagt gcatcgaaac ctacaaaaac
      601 attgagacag atgtcacgct gtgtgcagga gagatggatg ggggcaaaga cacttgcacg
      661 ggtgactcag gaggccccct catctgtgat ggtgtgctcc agggcctcac atcggggggc
      721 gctaccccat gcgctaaacc caaaacaccg gcaatctatg ccaaacttat taagttcacc
      781 tcctggataa aaaaagttat gaaggaaaac ccctgagtgt cacactgtgc cctggtctca
      841 ataaaaccca ccatgcagc
//
