LOCUS       NM_001271315             817 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus kallikrein 1-related peptidase C3 (Klk1c3), mRNA.
ACCESSION   NM_001271315 XM_002725575 XM_002728758 XM_006223254 XM_006229169
VERSION     NM_001271315.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 817)
  AUTHORS   Yao,Y.Y., Yin,H., Shen,B., Smith,R.S. Jr., Liu,Y., Gao,L., Chao,L.
            and Chao,J.
  TITLE     Tissue kallikrein promotes neovascularization and improves cardiac
            function by the Akt-glycogen synthase kinase-3beta pathway
  JOURNAL   Cardiovasc Res 80 (3), 354-364 (2008)
   PUBMED   18689794
  REMARK    GeneRIF: Tissue kallikrein protects against acute-phase myocardial
            infarction by promoting neovascularization, restoring regional
            blood flow and improving cardiac function through the kinin B2
            receptor-Akt-GSK-3beta and VEGF signalling pathways.
REFERENCE   2  (bases 1 to 817)
  AUTHORS   Yin,H., Chao,L. and Chao,J.
  TITLE     Nitric oxide mediates cardiac protection of tissue kallikrein by
            reducing inflammation and ventricular remodeling after myocardial
            ischemia/reperfusion
  JOURNAL   Life Sci 82 (3-4), 156-165 (2008)
   PUBMED   18068196
  REMARK    GeneRIF: Tissue kallikrein improves cardiac function, prevents
            inflammation and limits left ventricular remodeling after
            myocardial ischemia/reperfusion.
REFERENCE   3  (bases 1 to 817)
  AUTHORS   Iwai,N., Yasui,N., Naraba,H., Tago,N., Yamawaki,H. and Sumiya,H.
  TITLE     Klk1 as one of the genes contributing to hypertension in Dahl
            salt-sensitive rat
  JOURNAL   Hypertension 45 (5), 947-953 (2005)
   PUBMED   15809361
REFERENCE   4  (bases 1 to 817)
  AUTHORS   Olsson,A.Y., Lilja,H. and Lundwall,A.
  TITLE     Taxon-specific evolution of glandular kallikrein genes and
            identification of a progenitor of prostate-specific antigen
  JOURNAL   Genomics 84 (1), 147-156 (2004)
   PUBMED   15203212
REFERENCE   5  (bases 1 to 817)
  AUTHORS   Kroon,E., MacDonald,R.J. and Hammer,R.E.
  TITLE     The transcriptional regulatory strategy of the rat tissue
            kallikrein gene family
  JOURNAL   Genes Funct 1 (5-6), 309-319 (1997)
   PUBMED   17366701
  REMARK    GeneRIF: KLK3 rat gene was expressed at high levels in the
            submandibular glands of transgenic mice.
REFERENCE   6  (bases 1 to 817)
  AUTHORS   MacDonald,R.J., Southard-Smith,E.M. and Kroon,E.
  TITLE     Disparate tissue-specific expression of members of the tissue
            kallikrein multigene family of the rat
  JOURNAL   J Biol Chem 271 (23), 13684-13690 (1996)
   PUBMED   8662704
REFERENCE   7  (bases 1 to 817)
  AUTHORS   Wines,D.R., Brady,J.M., Southard,E.M. and MacDonald,R.J.
  TITLE     Evolution of the rat kallikrein gene family: gene conversion leads
            to functional diversity
  JOURNAL   J Mol Evol 32 (6), 476-492 (1991)
   PUBMED   1908019
REFERENCE   8  (bases 1 to 817)
  AUTHORS   Shai,S.Y., Woodley-Miller,C., Chao,J. and Chao,L.
  TITLE     Characterization of genes encoding rat tonin and a kallikrein-like
            serine protease
  JOURNAL   Biochemistry 28 (13), 5334-5343 (1989)
   PUBMED   2550051
REFERENCE   9  (bases 1 to 817)
  AUTHORS   Ashley,P.L. and MacDonald,R.J.
  TITLE     Tissue-specific expression of kallikrein-related genes in the rat
  JOURNAL   Biochemistry 24 (17), 4520-4527 (1985)
   PUBMED   3851673
REFERENCE   10 (bases 1 to 817)
  AUTHORS   Ashley,P.L. and MacDonald,R.J.
  TITLE     Kallikrein-related mRNAs of the rat submaxillary gland: nucleotide
            sequences of four distinct types including tonin
  JOURNAL   Biochemistry 24 (17), 4512-4520 (1985)
   PUBMED   2998455
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Dec 15, 2013 this sequence version replaced
            XM_006229169.1, XM_006223254.1, XM_002725575.2, XM_002728758.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN11044071
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                JAXUCZ010000001.1  103808150-103808195
            47-200              JAXUCZ010000001.1  103809841-103809994
            201-475             JAXUCZ010000001.1  103810856-103811130
            476-612             JAXUCZ010000001.1  103811227-103811363
            613-817             JAXUCZ010000001.1  103811727-103811931
FEATURES             Location/Qualifiers
     source          1..817
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..817
                     /gene="Klk1c3"
                     /gene_synonym="Klk-3; Klk1c10l2; KLK3; rGK-3; RSGK-50;
                     RSKG-50"
                     /note="kallikrein 1-related peptidase C3"
                     /db_xref="GeneID:292872"
                     /db_xref="RGD:735032"
     CDS             1..768
                     /gene="Klk1c3"
                     /gene_synonym="Klk-3; Klk1c10l2; KLK3; rGK-3; RSGK-50;
                     RSKG-50"
                     /EC_number="3.4.21.35"
                     /note="S1 kallikrein; submaxillary gland S1 kallikrein;
                     kallikrein 3; kallikrein 1-related peptidase c10-like 2;
                     tissue kallikrein; glandular kallikrein-3, submandibular;
                     glandular kallikrein-3, submandibular-like"
                     /codon_start=1
                     /product="glandular kallikrein-3, submandibular precursor"
                     /protein_id="NP_001258244.1"
                     /db_xref="GeneID:292872"
                     /db_xref="RGD:735032"
                     /translation="MWFLILFLALSLGQIDAAPPGQSRVVGGFKCEKNSQPWQVAVIN
                     EDLCGGVLIDPSWVITAAHCYSDNYHVLLGQNNLSEDVQHRLVSQSFRHPDYKPFLMR
                     NHTRKPKDYSNDLMLLHLSEPADITDGVKVIDLPTKEPKVGSTCLVSGWGSTNPSEWE
                     FPDDLQCVNIHLLSNEKCIKAYKEKVTDLMLCAGELEGGKDTCRGDSGGPLICDGVLQ
                     GITSWGSVPCGEPNKPGIYTKLIKFTSWIKEVMKKNP"
     exon            1..46
                     /gene="Klk1c3"
                     /gene_synonym="Klk-3; Klk1c10l2; KLK3; rGK-3; RSGK-50;
                     RSKG-50"
                     /inference="alignment:Splign:2.1.0"
     exon            47..200
                     /gene="Klk1c3"
                     /gene_synonym="Klk-3; Klk1c10l2; KLK3; rGK-3; RSGK-50;
                     RSKG-50"
                     /inference="alignment:Splign:2.1.0"
     exon            201..475
                     /gene="Klk1c3"
                     /gene_synonym="Klk-3; Klk1c10l2; KLK3; rGK-3; RSGK-50;
                     RSKG-50"
                     /inference="alignment:Splign:2.1.0"
     exon            476..612
                     /gene="Klk1c3"
                     /gene_synonym="Klk-3; Klk1c10l2; KLK3; rGK-3; RSGK-50;
                     RSKG-50"
                     /inference="alignment:Splign:2.1.0"
     exon            613..817
                     /gene="Klk1c3"
                     /gene_synonym="Klk-3; Klk1c10l2; KLK3; rGK-3; RSGK-50;
                     RSKG-50"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgtggttcc tgatcctgtt ccttgccctg tccctgggac agattgatgc tgcacctcct
       61 ggccagtctc gagttgttgg aggatttaaa tgtgagaaga attcccaacc ctggcaagtg
      121 gctgtcatca atgaagacct atgcgggggt gtcctgatag accccagctg ggtgatcaca
      181 gctgcccact gctatagtga caattaccat gttttgctgg gtcaaaataa cctatctgaa
      241 gatgttcagc accggcttgt cagccaaagc ttccgacacc ctgactacaa accattcctc
      301 atgaggaacc acacccgaaa acctaaggac tacagcaatg acctgatgct gctccacctc
      361 agcgagcctg cggacatcac agatggggtg aaggtcatcg atctgcccac gaaggagccc
      421 aaggtgggga gcacctgcct tgtctcaggc tggggcagca ccaacccctc tgagtgggaa
      481 ttccctgatg atctccagtg tgtgaacatc cacctactgt ctaatgagaa gtgcatcaaa
      541 gcctacaaag aaaaggtgac agatctgatg ctgtgtgcag gagagttgga aggaggcaaa
      601 gacacttgca ggggtgactc aggaggcccc ctcatctgtg atggtgtgct ccagggcatc
      661 acatcatggg gctctgtccc atgcggtgaa cccaataagc caggcatcta caccaaactt
      721 attaagttca cctcctggat aaaagaagtt atgaagaaaa acccctgagt gtcacactgt
      781 accctgatct caataaaacc caccatgcag cacacat
//
