LOCUS       NM_012677                858 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus kallikrein 1-related peptidase C2 (Klk1c2), mRNA.
ACCESSION   NM_012677
VERSION     NM_012677.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 858)
  AUTHORS   Ribeiro,A.A., Palomino,Z., Lima,M.P., Souza,L.E., Ferreira,D.S.,
            Pesquero,J.B., Irigoyen,M.C., Pesquero,J.L. and Casarini,D.E.
  TITLE     Characterization of the renal renin-angiotensin system in
            transgenic mice that express rat tonin
  JOURNAL   J Renin Angiotensin Aldosterone Syst 16 (4), 947-955 (2015)
   PUBMED   26216430
  REMARK    GeneRIF: the environment of tonin abundance may increase N-domain
            ACE activity liberated by a secretase able to cleave somatic ACE.
REFERENCE   2  (bases 1 to 858)
  AUTHORS   Cardoso,C.C., Alenina,N., Ferreira,A.J., Qadri,F., Lima,M.P.,
            Gross,V., Todiras,M., Pesquero,J.B., Pesquero,J.L. and Bader,M.
  TITLE     Increased blood pressure and water intake in transgenic mice
            expressing rat tonin in the brain
  JOURNAL   Biol Chem 391 (4), 435-441 (2010)
   PUBMED   20180641
  REMARK    GeneRIF: Tonin in the brain may represent an alternative pathway
            for angiotensin II generation with effects on the cardiovascular
            system.
REFERENCE   3  (bases 1 to 858)
  AUTHORS   Iwai,N., Yasui,N., Naraba,H., Tago,N., Yamawaki,H. and Sumiya,H.
  TITLE     Klk1 as one of the genes contributing to hypertension in Dahl
            salt-sensitive rat
  JOURNAL   Hypertension 45 (5), 947-953 (2005)
   PUBMED   15809361
REFERENCE   4  (bases 1 to 858)
  AUTHORS   Olsson,A.Y., Lilja,H. and Lundwall,A.
  TITLE     Taxon-specific evolution of glandular kallikrein genes and
            identification of a progenitor of prostate-specific antigen
  JOURNAL   Genomics 84 (1), 147-156 (2004)
   PUBMED   15203212
REFERENCE   5  (bases 1 to 858)
  AUTHORS   Kroon,E., MacDonald,R.J. and Hammer,R.E.
  TITLE     The transcriptional regulatory strategy of the rat tissue
            kallikrein gene family
  JOURNAL   Genes Funct 1 (5-6), 309-319 (1997)
   PUBMED   17366701
  REMARK    GeneRIF: KLK2 rat gene was expressed at high levels in the
            submandibular glands of transgenic mice.
REFERENCE   6  (bases 1 to 858)
  AUTHORS   Moreau,T., Brillard-Bourdet,M., Bouhnik,J. and Gauthier,F.
  TITLE     Protein products of the rat kallikrein gene family. Substrate
            specificities of kallikrein rK2 (tonin) and kallikrein rK9
  JOURNAL   J Biol Chem 267 (14), 10045-10051 (1992)
   PUBMED   1315752
REFERENCE   7  (bases 1 to 858)
  AUTHORS   Kamada,M., Furuhata,N., Yamaguchi,T., Ikekita,M., Kizuki,K. and
            Moriya,H.
  TITLE     Observation of tissue prokallikrein activation by some serine
            proteases, arginine esterases in rat submandibular gland
  JOURNAL   Biochem Biophys Res Commun 166 (1), 231-237 (1990)
   PUBMED   2302205
REFERENCE   8  (bases 1 to 858)
  AUTHORS   Shai,S.Y., Woodley-Miller,C., Chao,J. and Chao,L.
  TITLE     Characterization of genes encoding rat tonin and a kallikrein-like
            serine protease
  JOURNAL   Biochemistry 28 (13), 5334-5343 (1989)
   PUBMED   2550051
REFERENCE   9  (bases 1 to 858)
  AUTHORS   Wines,D.R., Brady,J.M., Pritchett,D.B., Roberts,J.L. and
            MacDonald,R.J.
  TITLE     Organization and expression of the rat kallikrein gene family
  JOURNAL   J Biol Chem 264 (13), 7653-7662 (1989)
   PUBMED   2708383
REFERENCE   10 (bases 1 to 858)
  AUTHORS   Fujinaga,M. and James,M.N.
  TITLE     Rat submaxillary gland serine protease, tonin. Structure solution
            and refinement at 1.8 A resolution
  JOURNAL   J Mol Biol 195 (2), 373-396 (1987)
   PUBMED   2821276
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M11565.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M11565.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN06621351,
                                           SAMN09345330 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..858
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..858
                     /gene="Klk1c2"
                     /gene_synonym="KLK2; Klna1; rGK-2; Ton"
                     /note="kallikrein 1-related peptidase C2"
                     /db_xref="GeneID:24841"
                     /db_xref="RGD:3888"
     exon            1..81
                     /gene="Klk1c2"
                     /gene_synonym="KLK2; Klna1; rGK-2; Ton"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..815
                     /gene="Klk1c2"
                     /gene_synonym="KLK2; Klna1; rGK-2; Ton"
                     /EC_number="3.4.21.35"
                     /note="tonin; S2 kallikrein; RSKG-5; esterase 1; glandular
                     kallikrein-2; kallikrein a1"
                     /codon_start=1
                     /product="tonin precursor"
                     /protein_id="NP_036809.1"
                     /db_xref="GeneID:24841"
                     /db_xref="RGD:3888"
                     /translation="MWLQILSLVLSVGRIDAAPPGQSRIVGGYKCEKNSQPWQVAVIN
                     EYLCGGVLIDPSWVITAAHCYSNNYQVLLGRNNLFKDEPFAQRRLVRQSFRHPDYIPL
                     IVTNDTEQPVHDHSNDLMLLHLSEPADITGGVKVIDLPTKEPKVGSTCLASGWGSTNP
                     SEMVVSHDLQCVNIHLLSNEKCIETYKDNVTDVMLCAGEMEGGKDTCAGDSGGPLICD
                     GVLQGITSGGATPCAKPKTPAIYAKLIKFTSWIKKVMKENP"
     exon            82..235
                     /gene="Klk1c2"
                     /gene_synonym="KLK2; Klna1; rGK-2; Ton"
                     /inference="alignment:Splign:2.1.0"
     exon            236..522
                     /gene="Klk1c2"
                     /gene_synonym="KLK2; Klna1; rGK-2; Ton"
                     /inference="alignment:Splign:2.1.0"
     exon            523..659
                     /gene="Klk1c2"
                     /gene_synonym="KLK2; Klna1; rGK-2; Ton"
                     /inference="alignment:Splign:2.1.0"
     exon            660..858
                     /gene="Klk1c2"
                     /gene_synonym="KLK2; Klna1; rGK-2; Ton"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agatcaccac ctgcttctcc tggacacctg ataccatgtg gctccagatc ctgtccctag
       61 tcctgtccgt gggacgaatt gatgctgcac ctcctggcca gtctcggatt gttggaggat
      121 ataagtgtga gaagaattcc caaccctggc aagtggctgt catcaatgaa tacctctgcg
      181 ggggtgtcct gatagacccc agctgggtga tcacggctgc ccactgctat agcaacaatt
      241 accaggtttt gctgggccga aacaacctat ttaaagatga accctttgct cagcgccggc
      301 ttgtcaggca aagcttccga caccctgact atatcccact catcgtgacg aatgacactg
      361 aacaacctgt gcatgaccac agcaatgacc tgatgctgct ccacctcagc gagcctgctg
      421 acatcacagg tggtgtgaag gttatcgatc tgcccactaa ggagcccaag gtggggagca
      481 cctgccttgc ctcaggctgg ggcagcacca acccctctga gatggtagta agtcatgatc
      541 tccagtgtgt gaacatccac ctactgtcta atgagaagtg catcgaaacc tacaaagaca
      601 atgtgacaga tgtcatgctg tgtgcaggag agatggaagg aggaaaagac acttgtgcgg
      661 gtgactcagg aggccccctc atctgtgatg gtgtgctcca aggcatcaca tcggggggcg
      721 ctaccccatg tgctaaaccc aaaacaccgg caatctatgc caaacttatt aagttcacct
      781 cctggataaa aaaagttatg aaggaaaacc cctgagtgtc acactgtgcc ccggtctcaa
      841 taaaacccac catgcagc
//
