LOCUS       NM_001005382             780 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus kallikrein 1-related peptidase C12 (Klk1c12),
            mRNA.
ACCESSION   NM_001005382 XM_218567
VERSION     NM_001005382.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 780)
  AUTHORS   Wang,T., Wan,Z.H., Liu,J.H., Chen,M.Y., Chen,R.B., Yang,W.M. and
            Ye,Z.Q.
  TITLE     Age-related changes in kallikreins-kinins system in rat corpus
            cavernosum
  JOURNAL   Int J Androl 34 (1), 33-40 (2011)
   PUBMED   20345876
  REMARK    GeneRIF: expression of KLKI and B2R changed in an age-dependent
            pattern in the corpus cavernosum and have a tendency to decline
            during ageing
REFERENCE   2  (bases 1 to 780)
  AUTHORS   Stone,O.A., Richer,C., Emanueli,C., van Weel,V., Quax,P.H.,
            Katare,R., Kraenkel,N., Campagnolo,P., Barcelos,L.S., Siragusa,M.,
            Sala-Newby,G.B., Baldessari,D., Mione,M., Vincent,M.P.,
            Benest,A.V., Al Haj Zen,A., Gonzalez,J., Bates,D.O.,
            Alhenc-Gelas,F. and Madeddu,P.
  TITLE     Critical role of tissue kallikrein in vessel formation and
            maturation: implications for therapeutic revascularization
  JOURNAL   Arterioscler Thromb Vasc Biol 29 (5), 657-664 (2009)
   PUBMED   19164804
  REMARK    GeneRIF: Ad.hKLK1(kallikrein 1) induced mature neovasculature with
            increased vessel diameter through kinin-B2 receptor-mediated
            recruitment of pericytes and vascular smooth muscle cells
REFERENCE   3  (bases 1 to 780)
  AUTHORS   Pawluczyk,I.Z., Tan,E.K., Lodwick,D. and Harris,K.
  TITLE     Kallikrein gene 'knock-down' by small interfering RNA transfection
            induces a profibrotic phenotype in rat mesangial cells
  JOURNAL   J Hypertens 26 (1), 93-101 (2008)
   PUBMED   18090545
  REMARK    GeneRIF: The kallikrein exerts antifibrotic, renoprotective effects
            that are independent of its classical haemodynamic actions.
REFERENCE   4  (bases 1 to 780)
  AUTHORS   Oddo,E.M., De Luca Sarobe,V., Krmar,R., Martin,R.S., Ibarra,F.R.
            and Arrizurieta,E.E.
  TITLE     Urinary kallikrein and blood pressure--gender-different response to
            potassium supplementation in SHR. Role of aldosterone
  JOURNAL   Nephron Physiol 108 (3), p37-p45 (2008)
   PUBMED   18311071
  REMARK    GeneRIF: These results further support the hypothesis that the
            kallikrein kinin system plays a role in blood pressure regulation
            and they also show a gender different response to potassium load in
            relation to UKa and blood pressure.
REFERENCE   5  (bases 1 to 780)
  AUTHORS   Kizuki,K., Iwadate,H. and Ookubo,R.
  TITLE     Growth-stimulating effect of kallikrein on rat neural stem
            cells--II. Immunocytochemical analysis and specificity of the
            enzyme for neural stem cells
  JOURNAL   Yakugaku Zasshi 127 (5), 919-922 (2007)
   PUBMED   17473535
REFERENCE   6  (bases 1 to 780)
  AUTHORS   Hettinger,U., Lukasova,M., Lewicka,S. and Hilgenfeldt,U.
  TITLE     Regulatory effects of salt diet on renal
            renin-angiotensin-aldosterone, and kallikrein-kinin systems
  JOURNAL   Int Immunopharmacol 2 (13-14), 1975-1980 (2002)
   PUBMED   12489811
REFERENCE   7  (bases 1 to 780)
  AUTHORS   Iwadate,H., Kawamata,K., Kudo,M. and Kizuki,K.
  TITLE     Biochemical and immunohistochemical demonstration of tissue
            kallikrein in the neuronal nuclei of the developing rat brains
  JOURNAL   Brain Res 863 (1-2), 87-93 (2000)
   PUBMED   10773196
REFERENCE   8  (bases 1 to 780)
  AUTHORS   Tschope,C., Walther,T., Yu,M., Reinecke,A., Koch,M., Seligmann,C.,
            Heringer,S.B., Pesquero,J.B., Bader,M., Schultheiss,H. and Unger,T.
  TITLE     Myocardial expression of rat bradykinin receptors and two tissue
            kallikrein genes in experimental diabetes
  JOURNAL   Immunopharmacology 44 (1-2), 35-42 (1999)
   PUBMED   10604522
REFERENCE   9  (bases 1 to 780)
  AUTHORS   MacDonald,R.J., Southard-Smith,E.M. and Kroon,E.
  TITLE     Disparate tissue-specific expression of members of the tissue
            kallikrein multigene family of the rat
  JOURNAL   J Biol Chem 271 (23), 13684-13690 (1996)
   PUBMED   8662704
REFERENCE   10 (bases 1 to 780)
  AUTHORS   Chen,Y.P., Chao,J. and Chao,L.
  TITLE     Molecular cloning and characterization of two rat renal kallikrein
            genes
  JOURNAL   Biochemistry 27 (19), 7189-7196 (1988)
   PUBMED   2849988
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 14, 2016 this sequence version replaced NM_001005382.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760389, SAMEA5760434
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                JAXUCZ010000001.1  103518631-103518676 c
            47-200              JAXUCZ010000001.1  103516593-103516746 c
            201-487             JAXUCZ010000001.1  103515390-103515676 c
            488-624             JAXUCZ010000001.1  103515157-103515293 c
            625-780             JAXUCZ010000001.1  103514639-103514794 c
FEATURES             Location/Qualifiers
     source          1..780
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..780
                     /gene="Klk1c12"
                     /gene_synonym="Klk1; Klk12; RSKG-3"
                     /note="kallikrein 1-related peptidase C12"
                     /db_xref="GeneID:292855"
                     /db_xref="RGD:1303192"
     CDS             1..780
                     /gene="Klk1c12"
                     /gene_synonym="Klk1; Klk12; RSKG-3"
                     /EC_number="3.4.21.35"
                     /note="glandular kallikrein-12, submandibular/renal;
                     tissue kallikrein; kallikrein 1; glandular kallikrein-7,
                     submandibular/renal"
                     /codon_start=1
                     /product="glandular kallikrein-12, submandibular/renal
                     precursor"
                     /protein_id="NP_001005382.2"
                     /db_xref="GeneID:292855"
                     /db_xref="RGD:1303192"
                     /translation="MWLQILFLFLSVGRIDAAPPGQSRVVGGYKCEKNSQPWQVAVIN
                     RYLCGGVLIDPSWVITAAHCYSHNYHVLLGRNNLFKDEPFAQYRFVNQSFPHPDYNPF
                     FMKNHTLFPGDDHSNDLMLLHLSEPADITDGVKVIDLPTEEPKVGSTCLASGWSSTKP
                     LEWEFPDDLQCVNINILSNEKCIKAHTQMVTDVMLCAGELEGGKDTCNGDSGGPLLCD
                     GVLQGITSWSSVPCGETNRPAIYTKLIKFTSWIKEVMKENS"
     exon            1..46
                     /gene="Klk1c12"
                     /gene_synonym="Klk1; Klk12; RSKG-3"
                     /inference="alignment:Splign:2.1.0"
     exon            47..200
                     /gene="Klk1c12"
                     /gene_synonym="Klk1; Klk12; RSKG-3"
                     /inference="alignment:Splign:2.1.0"
     exon            201..487
                     /gene="Klk1c12"
                     /gene_synonym="Klk1; Klk12; RSKG-3"
                     /inference="alignment:Splign:2.1.0"
     exon            488..624
                     /gene="Klk1c12"
                     /gene_synonym="Klk1; Klk12; RSKG-3"
                     /inference="alignment:Splign:2.1.0"
     exon            625..780
                     /gene="Klk1c12"
                     /gene_synonym="Klk1; Klk12; RSKG-3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgtggctcc agatcctgtt cctcttcctg tccgtgggac gaattgatgc tgcacctcct
       61 ggccagtctc gggttgttgg aggatataaa tgtgagaaga attcccaacc ctggcaagtg
      121 gctgtcatca acagatacct ctgcgggggt gtcctgatag accccagctg ggtgatcacg
      181 gctgcccact gctatagcca caattaccat gttttgctgg gccgaaacaa cctatttaaa
      241 gatgaaccct ttgcacagta ccggtttgtc aaccaaagct tccctcaccc tgactacaac
      301 ccattcttca tgaagaacca caccctattt cctggggatg accacagcaa tgacctgatg
      361 ctgctgcacc tcagtgagcc tgcggacatc acagatgggg tgaaggtcat cgatctgccc
      421 actgaggagc ccaaggtggg gagcacctgc cttgcctcag gttggagcag taccaaaccc
      481 cttgagtggg aattccctga tgatctccag tgtgtgaaca tcaatattct ctctaatgag
      541 aagtgcatca aagcccacac acagatggtg acagatgtca tgctgtgtgc aggagagttg
      601 gaaggaggca aagacacttg caatggtgac tcaggaggcc ccctcctctg tgatggtgtg
      661 cttcaaggca tcacgtcctg gagctctgtc ccatgtggcg aaaccaatag gccagctatc
      721 tacaccaaac ttattaagtt cacctcctgg ataaaagaag ttatgaagga aaactcctga
//
