LOCUS       NM_001135173             820 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus kallikrein 1-related peptidase C10 (Klk1c10),
            mRNA.
ACCESSION   NM_001135173 XM_001080455 XM_214947
VERSION     NM_001135173.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 820)
  AUTHORS   Olsson,A.Y., Lilja,H. and Lundwall,A.
  TITLE     Taxon-specific evolution of glandular kallikrein genes and
            identification of a progenitor of prostate-specific antigen
  JOURNAL   Genomics 84 (1), 147-156 (2004)
   PUBMED   15203212
REFERENCE   2  (bases 1 to 820)
  AUTHORS   Ma,J.X., Chao,J. and Chao,L.
  TITLE     Molecular cloning and characterization of rKlk10, a cDNA encoding
            T-kininogenase from rat submandibular gland and kidney
  JOURNAL   Biochemistry 31 (44), 10922-10928 (1992)
   PUBMED   1420203
REFERENCE   3  (bases 1 to 820)
  AUTHORS   Gutman,N., Elmoujahed,A., Brillard,M., Du Sorbier,B.M. and
            Gauthier,F.
  TITLE     Microheterogeneity of rat submaxillary gland kallikrein k10, a
            member of the kallikrein family
  JOURNAL   Eur J Biochem 197 (2), 425-429 (1991)
   PUBMED   2026164
REFERENCE   4  (bases 1 to 820)
  AUTHORS   Xiong,W., Chen,L.M. and Chao,J.
  TITLE     Purification and characterization of a kallikrein-like
            T-kininogenase
  JOURNAL   J Biol Chem 265 (5), 2822-2827 (1990)
   PUBMED   2303430
REFERENCE   5  (bases 1 to 820)
  AUTHORS   Kato,H., Nakanishi,E., Enjyoji,K., Hayashi,I., Oh-ishi,S. and
            Iwanaga,S.
  TITLE     Characterization of serine proteinases isolated from rat
            submaxillary gland: with special reference to the degradation of
            rat kininogens by these enzymes
  JOURNAL   J Biochem 102 (6), 1389-1404 (1987)
   PUBMED   3482210
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Sep 26, 2008 this sequence version replaced
            XM_001080455.1, XM_214947.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMN11044071 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                JAXUCZ010000001.1  103543541-103543586 c
            47-200              JAXUCZ010000001.1  103541457-103541610 c
            201-487             JAXUCZ010000001.1  103540320-103540606 c
            488-624             JAXUCZ010000001.1  103540087-103540223 c
            625-820             JAXUCZ010000001.1  103539527-103539722 c
FEATURES             Location/Qualifiers
     source          1..820
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..820
                     /gene="Klk1c10"
                     /gene_synonym="Klk10; rGK-10"
                     /note="kallikrein 1-related peptidase C10"
                     /db_xref="GeneID:292858"
                     /db_xref="RGD:1561403"
     CDS             1..780
                     /gene="Klk1c10"
                     /gene_synonym="Klk10; rGK-10"
                     /EC_number="3.4.21.35"
                     /note="endopeptidase K; proteinase B antigen; glandular
                     kallikrein-10-like; K10; tissue kallikrein;
                     T-kininogenase"
                     /codon_start=1
                     /product="glandular kallikrein-10 precursor"
                     /protein_id="NP_001128645.1"
                     /db_xref="GeneID:292858"
                     /db_xref="RGD:1561403"
                     /translation="MWFLILFLALSLGGIDAAPPGQSRIVGGYKCEKNSQPWQVAIIN
                     EYLCGGVLIDPSWVITAAHCYSNYYHVLLGRNNLFEDEPFAQYRFVNQSFPHPDYKPF
                     LMRNHTRQRGDDYSNDLMLLHLSEPADITDGVKVIDLPTEEPKVGSTCLASGWGSTKP
                     LNWELPDDLQCVNIHLLSNEKCIEAYEQKVTDLMLCAGEMDGRKDTCKGDSGGPLICD
                     GVLQGITSWGNVPCAEPYNPGVYTKLIKFTSWIKEVMKENP"
     exon            1..46
                     /gene="Klk1c10"
                     /gene_synonym="Klk10; rGK-10"
                     /inference="alignment:Splign:2.1.0"
     exon            47..200
                     /gene="Klk1c10"
                     /gene_synonym="Klk10; rGK-10"
                     /inference="alignment:Splign:2.1.0"
     exon            201..487
                     /gene="Klk1c10"
                     /gene_synonym="Klk10; rGK-10"
                     /inference="alignment:Splign:2.1.0"
     exon            488..624
                     /gene="Klk1c10"
                     /gene_synonym="Klk10; rGK-10"
                     /inference="alignment:Splign:2.1.0"
     exon            625..820
                     /gene="Klk1c10"
                     /gene_synonym="Klk10; rGK-10"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgtggttcc tgatcctgtt cctcgccctg tctctgggag ggattgatgc tgcacctcct
       61 ggccaatctc ggattgttgg aggatataaa tgtgagaaga attcccaacc ctggcaagtg
      121 gctatcatca atgaatacct atgcgggggt gtcctgatag acccgagctg ggtgatcacg
      181 gctgcccact gctatagcaa ctattaccat gttttgttgg gtcgaaacaa cctatttgaa
      241 gatgaaccct ttgctcagta ccggtttgtc aaccaaagct tccctcaccc tgactacaag
      301 ccatttctca tgaggaacca cacccgacaa cgtggagacg actacagcaa tgacctgatg
      361 ctgctccacc tcagcgagcc tgctgacatc acagatgggg tgaaggtcat tgatctgccc
      421 acggaggagc ccaaggtggg gagcacctgc cttgcctcgg gctggggcag caccaaaccc
      481 ctgaattggg aattacctga tgatctccag tgtgtgaaca tccacctact gtctaatgag
      541 aagtgcatcg aagcctacga acagaaggtg acagatctca tgctgtgtgc aggagagatg
      601 gatggacgca aagacacttg caagggtgac tcaggaggcc ccctcatctg tgatggtgtg
      661 cttcaaggca tcacatcgtg gggcaatgtc ccatgtgctg aaccctataa cccaggtgtc
      721 tacactaaac ttattaagtt cacctcctgg ataaaagaag ttatgaagga aaacccctga
      781 gtgtcacact gtcccctgat ctcaataaaa ctcaccatgc
//
