LOCUS       NM_031523                873 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus kallikrein 1-related peptidase B3 (Klk1b3), mRNA.
ACCESSION   NM_031523 XM_001081892
VERSION     NM_031523.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 873)
  AUTHORS   Fu,S.S., Li,F.J., Wang,Y.Y., You,A.B., Qie,Y.L., Meng,X., Li,J.R.,
            Li,B.C., Zhang,Y. and Da Li,Q.
  TITLE     Kallikrein gene-modified EPCs induce angiogenesis in rats with
            ischemic hindlimb and correlate with integrin alphavbeta3
            expression
  JOURNAL   PLoS One 8 (9), e73035 (2013)
   PUBMED   24019890
  REMARK    GeneRIF: ability of hTK gene-transduced EPCs can be enhanced in
            vitro, in which integrin alphavbeta3 plays a role in the process
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 873)
  AUTHORS   Dai,J., Agelan,A., Yang,A., Zuluaga,V., Sexton,D., Colman,R.W. and
            Wu,Y.
  TITLE     Role of plasma kallikrein-kinin system activation in synovial
            recruitment of endothelial progenitor cells in experimental
            arthritis
  JOURNAL   Arthritis Rheum 64 (11), 3574-3582 (2012)
   PUBMED   22739815
  REMARK    GeneRIF: Observations demonstrate a novel role of plasma kallikrein
            and bradykinin activation in the synovial recruitment of
            endothelial stem cells in arthritis, acting via kallikrein
            activation and B2R-dependent mechanisms.
REFERENCE   3  (bases 1 to 873)
  AUTHORS   Sridharan,V., Tripathi,P., Sharma,S.K., Moros,E.G., Corry,P.M.,
            Lieblong,B.J., Kaschina,E., Unger,T., Thone-Reineke,C.,
            Hauer-Jensen,M. and Boerma,M.
  TITLE     Cardiac inflammation after local irradiation is influenced by the
            kallikrein-kinin system
  JOURNAL   Cancer Res 72 (19), 4984-4992 (2012)
   PUBMED   22865451
  REMARK    GeneRIF: Results suggest that the results suggest that the
            kallikrein-kinin system (KKS) plays a role in the effects of
            radiation on cardiac function and recruitment of inflammatory
            cells.
REFERENCE   4  (bases 1 to 873)
  AUTHORS   Gao,L., Chao,L. and Chao,J.
  TITLE     A novel signaling pathway of tissue kallikrein in promoting
            keratinocyte migration: activation of proteinase-activated receptor
            1 and epidermal growth factor receptor
  JOURNAL   Exp Cell Res 316 (3), 376-389 (2010)
   PUBMED   19879874
  REMARK    GeneRIF: The study demonstrates a novel role of TK in skin wound
            healing uncovering new signaling pathway mediated by TK in
            promoting keratinocyte migration through activation of the
            PAR(1)-PKC-Src-MMP pathway and HB-EGF/AR shedding-dependent EGFR
            transactivation.
REFERENCE   5  (bases 1 to 873)
  AUTHORS   Stampachiacchiere,B., Aloe,L., Micera,A. and Bonini,S.
  TITLE     Allergic bronchial airway inflammation in nerve growth factor
            (NGF)-deprived rats: evidence suggesting a neuroimmunomodulatory
            role of NGF
  JOURNAL   Exp Lung Res 32 (7), 305-320 (2006)
   PUBMED   17060174
  REMARK    GeneRIF: The present findings suggest that at least NGF does not
            act as a proper proinflammatory factor but most probably as a
            neuroimmune modulator molecule of the allergic state.
REFERENCE   6  (bases 1 to 873)
  AUTHORS   Wines,D.R., Brady,J.M., Pritchett,D.B., Roberts,J.L. and
            MacDonald,R.J.
  TITLE     Organization and expression of the rat kallikrein gene family
  JOURNAL   J Biol Chem 264 (13), 7653-7662 (1989)
   PUBMED   2708383
REFERENCE   7  (bases 1 to 873)
  AUTHORS   Inoue,H., Fukui,K. and Miyake,Y.
  TITLE     Identification and structure of the rat true tissue kallikrein gene
            expressed in the kidney
  JOURNAL   J Biochem 105 (5), 834-840 (1989)
   PUBMED   2753879
REFERENCE   8  (bases 1 to 873)
  AUTHORS   Gerald,W.L., Chao,J. and Chao,L.
  TITLE     Immunological identification of rat tissue kallikrein cDNA and
            characterization of the kallikrein gene family
  JOURNAL   Biochim Biophys Acta 866 (1), 1-14 (1986)
   PUBMED   3004582
REFERENCE   9  (bases 1 to 873)
  AUTHORS   Ashley,P.L. and MacDonald,R.J.
  TITLE     Kallikrein-related mRNAs of the rat submaxillary gland: nucleotide
            sequences of four distinct types including tonin
  JOURNAL   Biochemistry 24 (17), 4512-4520 (1985)
   PUBMED   2998455
REFERENCE   10 (bases 1 to 873)
  AUTHORS   Swift,G.H., Dagorn,J.C., Ashley,P.L., Cummings,S.W. and
            MacDonald,R.J.
  TITLE     Rat pancreatic kallikrein mRNA: nucleotide sequence and amino acid
            sequence of the encoded preproenzyme
  JOURNAL   Proc Natl Acad Sci U S A 79 (23), 7263-7267 (1982)
   PUBMED   6961406
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M11563.1.
            
            On Jun 25, 2006 this sequence version replaced XM_001081892.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M11563.1, BC078784.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMN16418988
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..873
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..873
                     /gene="Klk1b3"
                     /gene_synonym="Klk1; Klk1c1; Klna4; Ngfg; rGK-1; rK-1"
                     /note="kallikrein 1-related peptidase B3"
                     /db_xref="GeneID:24594"
                     /db_xref="RGD:3175"
     exon            1..88
                     /gene="Klk1b3"
                     /gene_synonym="Klk1; Klk1c1; Klna4; Ngfg; rGK-1; rK-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..828
                     /gene="Klk1b3"
                     /gene_synonym="Klk1; Klk1c1; Klna4; Ngfg; rGK-1; rK-1"
                     /EC_number="3.4.21.35"
                     /note="PS kallikrein; kallikrein a4; gamma-NGF; pancreatic
                     kallikrein; true tissue kallikrein; nerve growth factor
                     gamma polypeptide; nerve growth factor gamma chain;
                     kallikrein 1"
                     /codon_start=1
                     /product="kallikrein 1-related peptidase B3 precursor"
                     /protein_id="NP_113711.1"
                     /db_xref="GeneID:24594"
                     /db_xref="RGD:3175"
                     /translation="MPVTMWFLILFLALSLGRNDAAPPVQSRVVGGYNCEMNSQPWQV
                     AVYYFGEYLCGGVLIDPSWVITAAHCATDNYQVWLGRNNLYEDEPFAQHRLVSQSFPH
                     PGFNQDLIWNHTRQPGDDYSNDLMLLHLSQPADITDGVKVIDLPIEEPKVGSTCLASG
                     WGSITPDGLELSDDLQCVNIDLLSNEKCVEAHKEEVTDLMLCAGEMDGGKDTCKGDSG
                     GPLICNGVLQGITSWGFNPCGEPKKPGIYTKLIKFTPWIKEVMKENP"
     exon            89..248
                     /gene="Klk1b3"
                     /gene_synonym="Klk1; Klk1c1; Klna4; Ngfg; rGK-1; rK-1"
                     /inference="alignment:Splign:2.1.0"
     exon            249..535
                     /gene="Klk1b3"
                     /gene_synonym="Klk1; Klk1c1; Klna4; Ngfg; rGK-1; rK-1"
                     /inference="alignment:Splign:2.1.0"
     exon            536..672
                     /gene="Klk1b3"
                     /gene_synonym="Klk1; Klk1c1; Klna4; Ngfg; rGK-1; rK-1"
                     /inference="alignment:Splign:2.1.0"
     exon            673..873
                     /gene="Klk1b3"
                     /gene_synonym="Klk1; Klk1c1; Klna4; Ngfg; rGK-1; rK-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agctccaagc tcagcacctg ctgctcctgc atgcctgtta ccatgtggtt cctgatcctg
       61 ttcctcgccc tgtccctggg acggaatgat gctgcacctc ccgtccagtc tcgggttgtt
      121 ggaggatata actgtgagat gaattcccaa ccctggcaag tggctgtgta ctacttcggc
      181 gaatacctat gtgggggtgt cctgatagac cccagctggg tgatcacagc tgctcactgc
      241 gcaaccgaca attaccaggt ttggctgggc cgaaacaacc tatatgaaga tgaacccttt
      301 gctcagcacc ggcttgtcag ccaaagcttc cctcaccccg gtttcaacca ggacctcata
      361 tggaaccaca cccgacaacc tggggacgac tacagcaatg atttgatgct gctccacctc
      421 agccagcctg cggacatcac agatggtgtg aaggtcatcg atctgcccat tgaggagccc
      481 aaggtgggga gcacctgcct tgcctcgggc tggggcagca tcacacctga cggattggaa
      541 ttaagtgatg atctccagtg tgtgaacatc gatcttctgt ctaatgagaa gtgcgtcgag
      601 gcacacaaag aagaggtgac agatctcatg ctgtgtgcag gagagatgga tgggggcaaa
      661 gacacttgca agggtgactc aggaggcccc ctcatctgta atggtgtgct ccaaggcatc
      721 acgtcctggg gctttaaccc atgcggtgaa cccaagaagc caggcatcta caccaaactt
      781 attaagttca ccccctggat aaaagaagtt atgaaggaaa acccctgagt gtcacacagt
      841 cccctggtct caataaaacc caccatgcag cac
//
