LOCUS       NM_001170405            1038 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus kallikrein related-peptidase 13 (Klk13), mRNA.
ACCESSION   NM_001170405 XM_001080409 XM_218643
VERSION     NM_001170405.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1038)
  AUTHORS   White,N.M., Mathews,M., Yousef,G.M., Prizada,A., Popadiuk,C. and
            Dore,J.J.
  TITLE     KLK6 and KLK13 predict tumor recurrence in epithelial ovarian
            carcinoma
  JOURNAL   Br J Cancer 101 (7), 1107-1113 (2009)
   PUBMED   19707197
REFERENCE   2  (bases 1 to 1038)
  AUTHORS   Lundwall,A. and Brattsand,M.
  TITLE     Kallikrein-related peptidases
  JOURNAL   Cell Mol Life Sci 65 (13), 2019-2038 (2008)
   PUBMED   18344018
  REMARK    Review article
REFERENCE   3  (bases 1 to 1038)
  AUTHORS   Yao,C., Karabasil,M.R., Purwanti,N., Li,X., Akamatsu,T.,
            Kanamori,N. and Hosoi,K.
  TITLE     Tissue kallikrein mK13 is a candidate processing enzyme for the
            precursor of interleukin-1beta in the submandibular gland of mice
  JOURNAL   J Biol Chem 281 (12), 7968-7976 (2006)
   PUBMED   16423834
REFERENCE   4  (bases 1 to 1038)
  AUTHORS   Iwai,N., Yasui,N., Naraba,H., Tago,N., Yamawaki,H. and Sumiya,H.
  TITLE     Klk1 as one of the genes contributing to hypertension in Dahl
            salt-sensitive rat
  JOURNAL   Hypertension 45 (5), 947-953 (2005)
   PUBMED   15809361
REFERENCE   5  (bases 1 to 1038)
  AUTHORS   Kapadia,C., Yousef,G.M., Mellati,A.A., Magklara,A., Wasney,G.A. and
            Diamandis,E.P.
  TITLE     Complex formation between human kallikrein 13 and serum protease
            inhibitors
  JOURNAL   Clin Chim Acta 339 (1-2), 157-167 (2004)
   PUBMED   14687906
REFERENCE   6  (bases 1 to 1038)
  AUTHORS   Petraki,C.D., Karavana,V.N. and Diamandis,E.P.
  TITLE     Human kallikrein 13 expression in normal tissues: an
            immunohistochemical study
  JOURNAL   J Histochem Cytochem 51 (4), 493-501 (2003)
   PUBMED   12642628
REFERENCE   7  (bases 1 to 1038)
  AUTHORS   Petraki,C.D., Gregorakis,A.K., Papanastasiou,P.A., Karavana,V.N.,
            Luo,L.Y. and Diamandis,E.P.
  TITLE     Immunohistochemical localization of human kallikreins 6, 10 and 13
            in benign and malignant prostatic tissues
  JOURNAL   Prostate Cancer Prostatic Dis 6 (3), 223-227 (2003)
   PUBMED   12970725
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Dec 20, 2009 this sequence version replaced
            XM_001080409.1, XM_218643.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments. A downstream translational start
            codon is selected for this RefSeq based on its better conservation
            in mammalian species and on the presence of a predicted signal
            peptide in the protein N-terminus. An upstream in-frame start codon
            is also present but is only present in rat; use of the upstream
            start codon would result in a protein that is 30 aa longer at the
            N-terminus and lacks a predicted signal peptide. Leaky scanning by
            ribosomes may allow translation initiation at the downstream start
            codon.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643294.2133.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: downstream AUG is associated
                                                with N-terminal localization
                                                signal
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-143               JAXUCZ010000001.1  103301935-103302077
            144-234             JAXUCZ010000001.1  103303161-103303251
            235-424             JAXUCZ010000001.1  103310362-103310551
            425-693             JAXUCZ010000001.1  103310656-103310924
            694-830             JAXUCZ010000001.1  103312901-103313037
            831-1038            JAXUCZ010000001.1  103313347-103313554
FEATURES             Location/Qualifiers
     source          1..1038
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1038
                     /gene="Klk13"
                     /gene_synonym="Klnl"
                     /note="kallikrein related-peptidase 13"
                     /db_xref="GeneID:292848"
                     /db_xref="RGD:1309337"
     exon            1..143
                     /gene="Klk13"
                     /gene_synonym="Klnl"
                     /inference="alignment:Splign:2.1.0"
     exon            144..234
                     /gene="Klk13"
                     /gene_synonym="Klnl"
                     /inference="alignment:Splign:2.1.0"
     CDS             183..1013
                     /gene="Klk13"
                     /gene_synonym="Klnl"
                     /note="kallikrein-13; kallikrein l"
                     /codon_start=1
                     /product="kallikrein-13 precursor"
                     /protein_id="NP_001163876.1"
                     /db_xref="GeneID:292848"
                     /db_xref="RGD:1309337"
                     /translation="MWPLVATIACLTLALSGGISRDYPKILNGTNGTSGFLPGGYTCL
                     PHSQPWQAALLVRGRLLCGGVLVHPKWVLTAAHCRKDGYTVHLGKHALGRVENGEQAM
                     EVVRSIPHPEYQVSPTHLNHDHDIMLLELKSPVQLSNHVRTLQLSADDCLPTGTCCRV
                     SGWGTTTSPQVNYPKTLQCANIELRSDEECRQVYPGKITANMLCAGTKEGGKDSCEGD
                     SGGPLICNGKLYGIISWGDFPCGQPNRPGVYTRVSKYLRWIQGTIRNTPEQGWTKGTQ
                     "
     exon            235..424
                     /gene="Klk13"
                     /gene_synonym="Klnl"
                     /inference="alignment:Splign:2.1.0"
     exon            425..693
                     /gene="Klk13"
                     /gene_synonym="Klnl"
                     /inference="alignment:Splign:2.1.0"
     exon            694..830
                     /gene="Klk13"
                     /gene_synonym="Klnl"
                     /inference="alignment:Splign:2.1.0"
     exon            831..1038
                     /gene="Klk13"
                     /gene_synonym="Klnl"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcgggctcc tcctgacagg agcccagggg cacttgatag ataccctctt aggcctggca
       61 cctatggtgg cttatgtctt gggaaagagg tgatgaacaa atgtggtcat atccttaaat
      121 ttcagaagaa aaaaaggttg gaggccccgc ccaccctgcc caccccccat cccggagcta
      181 tcatgtggcc cctagtggct accatcgctt gcctgacctt ggccttgtcc ggaggaatct
      241 cccgggacta ccccaagatt ctcaatggga ccaatgggac cagtggtttt ctcccaggtg
      301 gctacacctg ccttccccat tctcagcctt ggcaggcagc tctactggtc cgtggacgac
      361 ttctctgtgg aggggttctg gttcacccca aatgggtact cacagcagct cactgcagga
      421 aagatgggta cacagttcat ctgggcaagc atgccctggg gcgtgtggag aatggcgagc
      481 aggcaatgga ggtggtccgc tctatccccc atcctgaata ccaggtcagc cccacccacc
      541 tgaaccatga ccatgacatc atgcttctgg agttgaagtc tcctgtccag ctcagcaacc
      601 acgtccgtac tctgcagctc tcggcagacg actgcctgcc cactggcacc tgctgtcgtg
      661 tttctggctg gggcaccacc accagccccc aggtgaatta ccccaaaact ctgcagtgcg
      721 ccaacattga actgcgctca gatgaggagt gccggcaggt gtatcccggg aagatcactg
      781 ccaacatgct ctgtgctggt accaaagaag ggggaaagga ctcctgtgag ggtgattccg
      841 ggggtccact gatttgcaat ggcaaactct acggcatcat ctcatggggg gattttccat
      901 gtggacagcc caaccgacct ggcgtttaca cacgagtctc aaaatacctg cgttggatcc
      961 aggggaccat cagaaacact ccggagcagg gatggacaaa gggcacacaa taaaactgtg
     1021 ttcgtttgcc tgcctccc
//
